...Mavin Macauley; Fiona E Smith; Peter E Thelwall; Kieren G Hollingsworth; Roy Taylor Storage of food-derived glucose as muscle and liver glycogen is vital to avoid damaging swings plasma osmolarity. We report that in Type 2 diabetes, muscle glycogen storage was completely inactive although liver...

... 6.6±0.5 mg·kg ffm −1 ·min −1 ; where ffm, is fat-free mass). The increment in muscle glycogen concentration was 2-fold higher in controls compared with the diabetic group, and acipimox administration to the diabetic group did not increase this (2.0±0.8 compared with 1.9±1.1 mmol/l; P <0.05; control...

... significant. Muscle glycogen oxidation was lower in diabetes patients than in control subjects (Type II diabetes, 25.16±13.82 μ molμkg -1 μmin -1 ; control, 42.04±10.58 μ molμkg -1 μmin -1 ; P <0.05) and plasma glucose contributed more to energy expenditure in Type II diabetes (26±3% in diabetic versus 15...