... functional outcomes and overall prognosis [ 12 ]. However, in fully sedated patients, early ambulation is not feasible and, as such, alternative strategies should be defined to alleviate muscle wasting. Neuromuscular electrical stimulation (NMES) is an effective means to invoke involuntary muscle...

.... Our study indicates that Ang-(1–7) is novel molecule with a potential therapeutical use to improve muscle wasting associated, at least, with pathologies that present high levels of AngII. 1 These authors contributed equally to the present work • We have studied the role of non...

...Maria Klaude; Maiko Mori; Inga Tjäder; Thomas Gustafsson; Jan Wernerman; Olav Rooyackers Muscle wasting negatively affects morbidity and mortality in critically ill patients. This progressive wasting is accompanied by, in general, a normal muscle PS (protein synthesis) rate. In the present study...

...Maria Klaude; Katarina Fredriksson; Inga Tjäder; Folke Hammarqvist; Bo Ahlman; Olav Rooyackers; Jan Wernerman Patients with sepsis in the ICU (intensive care unit) are characterized by skeletal muscle wasting. This leads to muscle dysfunction that also influences the respiratory capacity, resulting...

...R. Thomas JAGOE; Christopher P.F. REDFERN; Russell G. ROBERTS; G. John GIBSON; Timothy H.J. GOODSHIP Muscle wasting is a common and prominent feature of advanced cancer, including lung cancer. Evidence from animal experiments suggests that accelerated proteolysis via the ubiquitin-proteasome...

... changes were of greater magnitude than the general muscle wasting and the decreased rate of synthesis of mixed protein observed in the zymosan-treated rats. 4. We conclude that the acute phase of critical illness in zymosan-treated rats is characterized by a substantial reduction in muscle mitochondria...

... illness, muscle wasting, protein synthesis rates, zymosan. Abbreviations: BCAA, branchedxhain amino acids; FSR, fractional protein synthesis rate; SA, specific activity. Correspondence: Dr Olav E. Rooyackers, Department of Human Biology, University of Limburg, PO Box 616, 6200 MD Maastricht...

..., whole-body leucine flux was normal, whole-body leucine oxidation was increased, and whole-body protein synthesis was depressed. 4. These results indicate that the predominant mechanism of muscle wasting in emphysema is a fall in muscle protein synthesis, which is accompanied by an overall fall in whole...

...Richard T. Moxley; Robert C. Griggs; Gilbert B. Forbes; David Goldblatt; Katherine Donohoe 1. The effect of muscle wasting on glucose tolerance was studied. Oral glucose tolerance testing was performed in three groups of wasted patients: myotonic dystrophy (11); amyotrophic lateral sclerosis (10...