...Maarten M. Steinz; Estela Santos-Alves; Johanna T. Lanner Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and the presence of serum autoantibodies. In addition, skeletal muscle weakness is a common comorbidity that contributes to inability to work and reduced...

... enzyme 2 (ACE2)-angiotensin 1-7 (A1-7)-A1-7 receptor (Mas) axis plays a protective role in the renin–angiotensin system (RAS). We recently found that ACE2 knockout (ACE2KO) mice exhibit earlier aging-associated muscle weakness, and that A1-7 alleviates muscle weakness in aging mice. In the present study...

.... INTRODUCTION Patients recovering from severe catabolic diseases (e.g. major surgery, sepsis or burn injury) often experience muscle weakness and increased fatigu- ability, sometimes for months after discharge from the hospital. Decreases in both muscle tension and endurance performance have been suggested...