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Keyword: myocardial infarction
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Articles
Clin Sci (Lond) (2019) 133 (8): 939-951.
Published: 29 April 2019
... their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day...
Articles
Clin Sci (Lond) (2019) 133 (8): 933-937.
Published: 18 April 2019
... intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Ischemic preconditioning (IPC) is defined by episodes of ‘sub-lethal’ ischemia and...
Articles
Clin Sci (Lond) (2019) 133 (3): 425-441.
Published: 05 February 2019
... facilitated CM proliferation. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of CMs. Supperession of let-7i-5p promoted the recovery of heart function post-myocardial infarction by enhancing E2F2 and CCND2. Collectively, our results revealed that...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (24): 2547-2564.
Published: 13 December 2018
... 2018 22 11 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . myocardial infarction orexins orexin receptors...
Articles
Clin Sci (Lond) (2018) 132 (6): 641-654.
Published: 26 March 2018
... vivo , and HF following experimental myocardial infarction (MI) in vivo . Methods and results: Doxycycline-regulated cardiomyocyte-specific overexpression and activity of hPMCA4b produced adaptive changes in expression levels of Ca 2+ -regulatory genes, and induced hypertrophy without significant...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (24): 2919-2932.
Published: 08 December 2017
...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (17): 2303-2317.
Published: 10 August 2017
... and its pathophysiological mechanisms following acute myocardial infarction (MI) in adult rat offspring exposed to prenatal hypoxia. Male and female rat offspring, which experienced normoxia (21% O 2 ) or hypoxia (11% O 2 ) in utero underwent sham or MI surgery at 12 weeks of age. Echocardiographic...
Articles
Clin Sci (Lond) (2017) 131 (12): 1215-1224.
Published: 31 May 2017
... both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...
Articles
Clin Sci (Lond) (2016) 130 (23): 2105-2120.
Published: 20 October 2016
... myocardial infarction (MI) does not improve cardiac function. The reduction in engraftment signals observed following this time interval might impair the effects of delayed BMC treatment. In the present study, we aimed to determine whether ultrasound-targeted microbubble destruction (UTMD) treatment could...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (22): 2017-2027.
Published: 06 October 2016
... responsiveness to catecholamine stimulation at the level of the cardiomyocyte. βAR cardiac contractility cardiomyocyte myocardial infarction V1AR • Cardiac V1AR expression is increased in small and large animal models of left ventricular dysfunction, as well as in patients with HFrEF...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1089-1104.
Published: 23 May 2016
...Xiao-Ming Gao; Xiao-Lei Moore; Yang Liu; Yang Liu; Xin-Yu Wang; Li-Ping Han; Yidan Su; Alan Tsai; Qi Xu; Ming Zhang; Gavin W. Lambert; Helen Kiriazis; Wei Gao; Anthony M. Dart; Xiao-Jun Du Acute myocardial infarction (AMI) is characterized by a rapid increase in circulating platelet size but the...
Articles
Clin Sci (Lond) (2016) 130 (7): 463-478.
Published: 17 February 2016
... chemokines heart failure myocardial infarction myocarditis transplant coronary artery disease Death rates from cardiovascular diseases (CVDs) have declined, yet the burden remains high. It has been estimated that 17.5 million people globally died from CVDs in 2012 [ 1 ], and it has been computed...
Articles
Clin Sci (Lond) (2016) 130 (5): 365-376.
Published: 26 January 2016
... whether ERβ restricted to cardiomyocytes contributes to the observed cardioprotection, we tested the effects of cardiomyocyte-specific ERβ-OE (ERβ overexpression) on survival, cardiac remodelling and function after MI (myocardial infarction) and studied the molecular pathways potentially involved. Female...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (2): 187-198.
Published: 30 April 2015
... ischaemia-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI). animal model inflammation innate immunity myocardial infarction oxidative stress toll-like receptors • MI triggers an...
Articles
Clin Sci (Lond) (2015) 128 (12): 923-936.
Published: 27 March 2015
..., including cardiac hypertrophy. However, the role of Vinexin-β in myocardial infarction (MI) remains unknown. In this study, dramatically up-regulated Vinexin-β expression was observed in both ischaemic human hearts and infarcted animal hearts. To explore the potential involvement of Vinexin-β in MI further...
Articles
Clin Sci (Lond) (2014) 127 (3): 149-161.
Published: 03 April 2014
... and atherosclerosis. Although initial studies over a decade ago reported increases in circulating MIF levels following acute MI (myocardial infarction), the dynamic changes in MIF and its pathophysiological significance following MI have been unknown until recently. In the present review, we summarize...
Articles
Clin Sci (Lond) (2013) 125 (8): 401-407.
Published: 14 June 2013
... mRNA was examined in atherosclerotic vascular tissue and the impact on MI (myocardial infarction) of a polymorphism in the CARD8 gene determined. CARD8 mRNA was analysed by microarray of human atherosclerotic tissue and compared with transplant donor arterial tissue. Microarray analysis was performed...
Articles
Clin Sci (Lond) (2013) 124 (2): 87-96.
Published: 26 September 2012
.... Blockade of AT 2 R and/or B 1 R worsens cardiac remodelling and dysfunction following MI (myocardial infarction) in B 2 R −/− (B 2 -receptor-knockout mice). B 2 R −/− mice and WT (wild-type) controls were subjected to sham MI or MI and treated for 4 weeks with (i) vehicle, (ii) a B 1 R-ant (B 1 R...
Articles
Clin Sci (Lond) (2013) 124 (2): 65-76.
Published: 12 September 2012
... (email l.burrell@unimelb.edu.au ). 21 5 2012 18 6 2012 3 7 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 angiotensin-converting enzyme 2 (ACE2) coronary artery disease hypertension left ventricular hypertrophy myocardial infarction renin...
Articles
Clin Sci (Lond) (2012) 123 (11): 649-658.
Published: 01 August 2012
...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...
Articles
Clin Sci (Lond) (2011) 121 (1): 1-10.
Published: 18 March 2011
... expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...
Articles
Clin Sci (Lond) (2011) 120 (10): 451-462.
Published: 28 January 2011
... 8 12 2010 8 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 β-catenin limb ischaemia myocardial infarction signal transduction remote ischaemic preconditioning The phenomenon of local IPC (ischaemic preconditioning) induced by short periods of...
Articles
Clin Sci (Lond) (2011) 120 (9): 377-402.
Published: 18 January 2011
... hypoxia, ischaemia and oxidative stress, thus mediating functional homoeostatic adjustments. In contrast, its deprivation results in apoptosis and dysfunction. Many prospective epidemiological surveys have associated low IGF-1 levels with late mortality, MI (myocardial infarction), HF (heart failure) and...
Articles
Clin Sci (Lond) (2011) 120 (6): 231-238.
Published: 03 December 2010
...Leong L. Ng; Sohail Q. Khan; Hafid Narayan; Paulene Quinn; Iain B. Squire; Joan E. Davies A multimarker approach may be useful for risk stratification in AMI (acute myocardial infarction) patients, particularly utilizing pathways that are pathophysiologically distinct. Our aim was to assess the...
Articles
Clin Sci (Lond) (2010) 119 (8): 353-359.
Published: 06 July 2010
... of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction). We hypothesized that putative functional genetic variation in the two genes encoding uPA and uPAR...
Articles
Clin Sci (Lond) (2010) 119 (4): 175-183.
Published: 18 May 2010
...Lu Fang; Xiao-Jun Du; Xiao-Ming Gao; Anthony M. Dart Inflammation and ECM (extracellular matrix) remodelling play important roles in LV (left ventricular) remodelling following acute MI (myocardial infarction). Previous studies show elevated plasma MMP (matrix metalloproteinase) levels in patients...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 118 (10): 593-605.
Published: 23 February 2010
... compilation © 2010 Biochemical Society 2010 atherosclerosis heart failure myocardial infarction nuclear factor-κB (NF-κB) percutaneous coronary intervention (PCI) vein grafting The NF-κB family ( Figure 1 ) consists of five members: p65 ( RelA ), RelB ( RelB ), c-Rel ( Rel ), p105/p50...
Articles
Clin Sci (Lond) (2010) 118 (8): 527-535.
Published: 02 February 2010
... elevation AMI (acute myocardial infarction) of admission blood glucose concentration and of diabetes diagnosis. We carried out a retrospective cohort study in 4702 consecutive patients with STEMI (ST elevation AMI) occurring from 1 April 1993 to 31 December 2005, assessed for mortality at 30 days and 1 year...
Articles
Clin Sci (Lond) (2010) 118 (4): 249-257.
Published: 09 November 2009
... coronary syndrome for death, readmission with HF (heart failure) or recurrent MI (myocardial infarction) and to compare them with established markers, NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the GRACE (Global Registry of Acute Coronary Events) score. A single blood test was taken 4 days...
Articles
Clin Sci (Lond) (2009) 118 (3): 195-201.
Published: 02 November 2009
... setting. Poor reliability of the measurements might be a possible explanation for this. In the present study, we assessed the reliability of short-term HRV indexes in post-MI (myocardial infarction) patients. We studied 61 MI patients [50 males; age, 59±8 years; and LVEF (left ventricular ejection...
Articles
Clin Sci (Lond) (2009) 117 (1): 13-15.
Published: 02 June 2009
... the prediction of mortality after acute myocardial infarction, using a combination of statistical methods. Correspondence: Professor Torbjørn Omland (email torbjorn.omland@medisin.uio.no ). 26 3 2009 7 4 2009 7 4 2009 © The Authors Journal compilation © 2009 Biochemical...
Articles
Clin Sci (Lond) (2009) 117 (1): 31-39.
Published: 02 June 2009
...Sohail Q. Khan; Hafid Narayan; Kelvin H. Ng; Onkar S. Dhillon; Dominic Kelly; Paulene Quinn; Iain B. Squire; Joan E. Davies; Leong L. Ng The GRACE (Global Registry of Acute Coronary Events) risk score has been shown to offer predictive power with regard to death and AMI (acute myocardial infarction...
Articles
Clin Sci (Lond) (2009) 116 (8): 651-658.
Published: 16 March 2009
... Journal compilation © 2009 Biochemical Society 2009 acute coronary syndrome leucocyte mortality myocardial infarction statin unstable angina Considerable evidence exists that elevated leucocyte count, a non-specific marker of inflammation, is a risk factor for future cardiovascular...
Articles
Clin Sci (Lond) (2009) 116 (1): 37-39.
Published: 28 November 2008
... stephan.von.haehling@web.de ). 13 10 2008 29 10 2008 29 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 atorvastatin heart failure inflammation interleukin-10 myocardial infarction Statins can lower serum cholesterol levels. That fact is beyond doubt...
Articles
Clin Sci (Lond) (2009) 116 (1): 45-52.
Published: 28 November 2008
...Christian Stumpf; Sebastian Petzi; Katrin Seybold; Gerald Wasmeier; Martin Arnold; Dorette Raaz; Atilla Yilmaz; Werner G. Daniel; Christoph D. Garlichs LV (left ventricular) remodelling is the basic mechanism of HF (heart failure) following MI (myocardial infarction). Although there is evidence...
Articles
Clin Sci (Lond) (2008) 115 (10): 309-315.
Published: 15 October 2008
... (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) and stroke in Icelandic and Scottish populations. Both genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene...
Articles
Clin Sci (Lond) (2008) 115 (10): 301-308.
Published: 15 October 2008
... (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPAR α gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium...
Articles
Clin Sci (Lond) (2008) 115 (7): 203-218.
Published: 03 September 2008
... remodelling after myocardial infarction, atherosclerosis and vascular restenosis will be examined, with attention paid to genetically modified murine model systems and to the use of pharmacological inhibitors of protein kinases. Despite the complexities of this field of research, attractive targets for...
Articles
Clin Sci (Lond) (2008) 115 (4): 129-131.
Published: 15 July 2008
... g.pasterkamp@umcutrecht.nl ). 14 3 2008 3 4 2008 3 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 atherosclerosis inflammation myocardial infarction ruptured plaque thrombosis Toll-like receptor (TLR) The search for biomarkers that reflect...
Articles
Clin Sci (Lond) (2008) 115 (4): 133-140.
Published: 15 July 2008
... receptor 4) mediates the synthesis of cytokines in circulating monocytes of patients with AMI (acute myocardial infarction); however, it remains unclear whether TLRs are expressed at the site of the ruptured plaque in these patients. The aim of the present study was to determine whether TLR2 and TLR4 are...
Articles
Clin Sci (Lond) (2008) 115 (3): 99-106.
Published: 02 July 2008
...Lu Fang; Xiao-Ming Gao; Chrishan S. Samuel; Yidan Su; Yean Leng Lim; Anthony M. Dart; Xiao-Jun Du The mechanism of cardiac rupture after MI (myocardial infarction) is not fully understood. Rupture has not been reported in most laboratory species, including the rat, but does occur in mice. We have...
Articles
Clin Sci (Lond) (2007) 113 (9): 393.
Published: 01 October 2007
...Ze-Zhou Song Correspondence: Mr Ze-Zhou Song (email zezhou_song@126.com ). 22 5 2007 4 6 2007 4 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 ischaemic heart disease longitudinal strain myocardial infarction two-dimensional speckle...
Articles
Clin Sci (Lond) (2007) 113 (8): 349-356.
Published: 12 September 2007
...;A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with ( n =176) or without ( n =377) Type 2 diabetes, aged 40–65 years with previous myocardial infarction (∼50%) or angiographically confirmed CAD (∼50...
Articles
Clin Sci (Lond) (2007) 113 (6): 287-296.
Published: 13 August 2007
... deformation indices. In the present study, we tested whether peak systolic ϵ ∥ (longitudinal strain) values measured by 2D-STE could identify areas of MI (myocardial infarction) as determined by CE MRI (contrast-enhanced magnetic resonance imaging). Conventional echocardiographic apical long-axis recordings...
Articles
Clin Sci (Lond) (2007) 113 (4): 213-218.
Published: 13 July 2007
... associated with an increased risk for MI (myocardial infarction) in a prospective Caucasian cohort. In another nested case-control study, however, the CFH -Y402H variant did not carry susceptibility to MI. The aim of the present study was to test for an association between the CFH -Y402H variant and MI in a...
Articles
Clin Sci (Lond) (2007) 112 (9): 477-484.
Published: 02 April 2007
... myocardial infarction) and its relationship with prognosis, together with a known risk marker N-BNP (N-terminal pro-B-type natriuretic peptide). Plasma from 396 consecutive patients with AMI was obtained for measurement of ORP150 and N-BNP. Mortality and cardiovascular morbidity (acute coronary syndromes...
Articles
Clin Sci (Lond) (2007) 112 (7): 411-416.
Published: 01 March 2007
... (arachidonate 5-lipoxygenase-activating protein), the main regulator of 5-lipoxygenase, have been associated with a doubling of the risk of myocardial infarction. Studies have also shown that treatment with a leukotriene inhibitor reduces biomarkers of coronary risk in patients carrying HapA, raising the...
Articles
Clin Sci (Lond) (2007) 112 (7): 385-391.
Published: 01 March 2007
...Dimitrios A. Elaiopoulos; Dimitrios G. Tsalikakis; Maria G. Agelaki; Giannis G. Baltogiannis; Agathokleia C. Mitsi; Dimitrios I. Fotiadis; Theofilos M. Kolettis GH (growth hormone) administration during acute MI (myocardial infarction) ameliorates subsequent LV (left ventricular) dysfunction. In...
Articles
Clin Sci (Lond) (2007) 112 (5): 291-298.
Published: 01 February 2007
... coronary artery disease cellular adhesion molecule galectin-2 gene polymorphism inflammation lymphotoxin-α (LTA) myocardial infarction Inflammation plays an important role in the development and progression of atherosclerosis and is likely to play a critical role in the pathogenesis of plaque...
Articles
Clin Sci (Lond) (2007) 112 (4): 251-256.
Published: 17 January 2007
... natriuretic peptide), a marker of MACE. We studied 356 patients with ACS {276 men; mean age, 63.0±12.8 years; 80.6% STEMI [ST segment elevation MI (myocardial infarction)]; and 19.4% NSTEMI (non-STEMI)}. Blood measurement was made at 25–48 h after the onset of chest pain. The plasma concentration of...