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1-50 of 103
Keywords: myocardial infarction
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Erin B. Taylor, Luciano D. Mendoza, Jayla D. Sandifer, Jemylle G. Morato, Nikaela M. Aitken, Katherine R. O'Quinn, Indu Raman, Chengsong Zhu, Robert W. Spitz, John E. Hall, Alan J. Mouton
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (12): 627–648.
Published: 17 June 2025
...Erin B. Taylor; Luciano D. Mendoza; Jayla D. Sandifer; Jemylle G. Morato; Nikaela M. Aitken; Katherine R. O'Quinn; Indu Raman; Chengsong Zhu; Robert W. Spitz; John E. Hall; Alan J. Mouton Myocardial infarction (MI) causes a robust inflammatory response, which is necessary for remodeling and scar...
Includes: Supplementary data
Articles
Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 47–63.
Published: 05 January 2023
... mortality rate substantially. Premenopausal females appear to be more protected, suggesting a potential protective role of female sex hormones. Here, we tested the hypothesis that ovariectomy (OVX) eliminates the beneficial effect of female sex on renal protection following acute myocardial infarction (MI...
Includes: Supplementary data
Articles
Visualization of regenerating and repairing hearts
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (10): 787–798.
Published: 27 May 2022
... response to injury over extended periods of time. imaging techniques model organisms myocardial infarction regeneration stem cell therapy wound healing The adult human heart is unable to functionally regenerate after injury, ultimately leading to heart failure and mortality. Heart failure...
Articles
Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats
Available to PurchaseJan Neckář, Petra Alánová, Veronika Olejníčková, František Papoušek, Lucie Hejnová, Jan Šilhavý, Michal Behuliak, Michal Bencze, Jaroslav Hrdlička, Marek Vecka, Dagmar Jarkovská, Jitka Švíglerová, Eliška Mistrová, Milan Štengl, Jiří Novotný, Bohuslav Ošťádal, Michal Pravenec, František Kolář
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2143–2163.
Published: 17 September 2021
... Increased level of C-reactive protein (CRP) is a risk factor for cardiovascular diseases, including myocardial infarction and hypertension. Here, we analyzed the effects of CRP overexpression on cardiac susceptibility to ischemia/reperfusion (I/R) injury in adult spontaneously hypertensive rats (SHR...
Includes: Supplementary data
Articles
Role of endoplasmic reticulum stress in renal damage after myocardial infarction
Available to PurchaseBeatriz Delgado-Valero, Lucía de la Fuente-Chávez, Ana Romero-Miranda, María Visitación Bartolomé, Bunty Ramchandani, Fabián Islas, María Luaces, Victoria Cachofeiro, Ernesto Martínez-Martínez
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
...Beatriz Delgado-Valero; Lucía de la Fuente-Chávez; Ana Romero-Miranda; María Visitación Bartolomé; Bunty Ramchandani; Fabián Islas; María Luaces; Victoria Cachofeiro; Ernesto Martínez-Martínez Myocardial infarction (MI) is associated with renal alterations resulting in poor outcomes in patients...
Includes: Supplementary data
Articles
IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture
Available to PurchaseRana Ghali, Nada J. Habeichi, Abdullah Kaplan, Cynthia Tannous, Emna Abidi, Amira Bekdash, Rima Farhat, Hana Itani, Abdo Jurjus, George W. Booz, Ziad Mallat, Fouad A. Zouein
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1191–1218.
Published: 03 June 2020
...Rana Ghali; Nada J. Habeichi; Abdullah Kaplan; Cynthia Tannous; Emna Abidi; Amira Bekdash; Rima Farhat; Hana Itani; Abdo Jurjus; George W. Booz; Ziad Mallat; Fouad A. Zouein Myocardial infarction (MI) is the leading cause of mortality worldwide. Interleukin (IL)-33 (IL-33) is a cytokine present...
Includes: Supplementary data
Articles
Therapeutic potential of miR-21 regulation by human peripheral blood derived-small extracellular vesicles in myocardial infarction
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (8): 985–999.
Published: 24 April 2020
... to be involved in the initiation and development of myocardial infarction (MI). Here, we examined whether miR-21 regulation using human peripheral blood-derived sEVs (PB-sEVs) could serve as a potential therapeutic strategy for MI. First, we examined miR-21 levels in hypoxic conditions and validated the ability...
Includes: Supplementary data
Articles
Targeting mitochondria to protect the heart: a matter of balance?
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Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 885–888.
Published: 14 April 2020
... by Portland Press Limited on behalf of the Biochemical Society 2020 Cardiac myocyte Ischemia-reperfusion injury Mitochondrial dynamics Mitochondrial fusion Myocardial infarction Heart attacks are a leading cause of death worldwide with no effective pharmacological strategies to limit permanent...
Articles
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats
Available to PurchaseJan Neckář, Md. Abdul Hye Khan, Garrett J. Gross, Michaela Cyprová, Jaroslav Hrdlička, Alena Kvasilová, John R. Falck, William B. Campbell, Lenka Sedláková, Šárka Škutová, Veronika Olejníčková, Martina Gregorovičová, David Sedmera, František Kolář, John D. Imig
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (8): 939–951.
Published: 29 April 2019
...) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p.o., 9...
Articles
Protective cardiac conditioning by an atypical cytokine
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Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (8): 933–937.
Published: 18 April 2019
... intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Ischemic preconditioning (IPC) is defined by episodes of ‘sub-lethal’ ischemia...
Articles
Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2
Available to PurchaseYinlan Hu, Guoqing Jin, Bing Li, Yanmei Chen, Lintao Zhong, Guojun Chen, Xiaoqiang Chen, Jiayuan Zhong, Wangjun Liao, Yulin Liao, Yuegang Wang, Jianping Bin
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (3): 425–441.
Published: 05 February 2019
... facilitated CM proliferation. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of CMs. Supperession of let-7i-5p promoted the recovery of heart function post-myocardial infarction by enhancing E2F2 and CCND2. Collectively, our results revealed...
Includes: Supplementary data
Articles
Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection
Open AccessVanlata H. Patel, Emmanouil Karteris, Jing Chen, Ioannis Kyrou, Harman S. Mattu, Georgios K. Dimitriadis, Glenn Rodrigo, Charalambos Antoniades, Alexios Antonopoulos, Bee K. Tan, Edward W. Hillhouse, Andre Ng, Harpal S. Randeva
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (24): 2547–2564.
Published: 13 December 2018
... 2018 22 11 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . myocardial infarction orexins orexin receptors...
Articles
Cardiac-specific inducible overexpression of human plasma membrane Ca 2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury
Available to PurchaseAl Muktafi Sadi, Talat Afroze, M. Ahsan Siraj, Abdul Momen, Colin White-Dzuro, Dorrin Zarrin-Khat, Shivalika Handa, Kiwon Ban, M. Golam Kabir, Maria G. Trivieri, Robert Gros, Peter Backx, Mansoor Husain
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 641–654.
Published: 26 March 2018
... vivo , and HF following experimental myocardial infarction (MI) in vivo . Methods and results: Doxycycline-regulated cardiomyocyte-specific overexpression and activity of hPMCA4b produced adaptive changes in expression levels of Ca 2+ -regulatory genes, and induced hypertrophy without significant...
Includes: Supplementary data
Articles
Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction
Available to PurchaseDezhong Yang, Wenbin Fu, Liangpeng Li, Xuewei Xia, Qiao Liao, Rongchuan Yue, Hongmei Chen, Xiongwen Chen, Songzhu An, Chunyu Zeng, Wei Eric Wang
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2919–2932.
Published: 08 December 2017
...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...
Includes: Supplementary data
Articles
Cardiovascular susceptibility to in vivo ischemic myocardial injury in male and female rat offspring exposed to prenatal hypoxia
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2303–2317.
Published: 10 August 2017
... and its pathophysiological mechanisms following acute myocardial infarction (MI) in adult rat offspring exposed to prenatal hypoxia. Male and female rat offspring, which experienced normoxia (21% O 2 ) or hypoxia (11% O 2 ) in utero underwent sham or MI surgery at 12 weeks of age. Echocardiographic data...
Articles
Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease
Available to PurchaseCarolina N. França, Maria C.O. Izar, Marinella N.S. Hortêncio, Jônatas B. do Amaral, Carlos E.S. Ferreira, Izabela D. Tuleta, Francisco A.H. Fonseca
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1215–1224.
Published: 31 May 2017
... in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...
Articles
Ultrasound-targeted microbubble destruction enhances delayed BMC delivery and attenuates post-infarction cardiac remodelling by inducing engraftment signals
Available to PurchaseYanmei Chen, Chuanxi Zhang, Shuxin Shen, Shengcun Guo, Lintao Zhong, Xinzhong Li, Guojun Chen, Gangbin Chen, Xiang He, Chixiong Huang, Nvqin He, Wangjun Liao, Yulin Liao, Jianping Bin
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (23): 2105–2120.
Published: 20 October 2016
... myocardial infarction (MI) does not improve cardiac function. The reduction in engraftment signals observed following this time interval might impair the effects of delayed BMC treatment. In the present study, we aimed to determine whether ultrasound-targeted microbubble destruction (UTMD) treatment could...
Includes: Supplementary data
Articles
Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction
Available to PurchaseMelissa A. Wasilewski, Laurel A. Grisanti, Jianliang Song, Rhonda L. Carter, Ashley A. Repas, Valerie D. Myers, Erhe Gao, Walter J. Koch, Joseph Y. Cheung, Arthur M. Feldman, Douglas G. Tilley
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2017–2027.
Published: 06 October 2016
... V1AR inhibition may offer a novel approach to enhancing cardiac contractile performance. βAR cardiac contractility cardiomyocyte myocardial infarction V1AR Data are presented as mean ± standard error of the mean (S.E.M.). Statistical analyses were performed using either a two-tailed...
Includes: Supplementary data
Articles
Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction
Available to PurchaseXiao-Ming Gao, Xiao-Lei Moore, Yang Liu, Xin-Yu Wang, Li-Ping Han, Yidan Su, Alan Tsai, Qi Xu, Ming Zhang, Gavin W. Lambert, Helen Kiriazis, Wei Gao, Anthony M. Dart, Xiao-Jun Du
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1089–1104.
Published: 23 May 2016
...Xiao-Ming Gao; Xiao-Lei Moore; Yang Liu; Xin-Yu Wang; Li-Ping Han; Yidan Su; Alan Tsai; Qi Xu; Ming Zhang; Gavin W. Lambert; Helen Kiriazis; Wei Gao; Anthony M. Dart; Xiao-Jun Du Acute myocardial infarction (AMI) is characterized by a rapid increase in circulating platelet size but the mechanism...
Articles
Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
..., and may additionally have utility as diagnostic and prognostic biomarkers. 21 9 2015 1 12 2015 3 12 2015 © 2016 Authors; published by Portland Press Limited 2016 atherosclerosis cardiac hypertrophy CXCL chemokines heart failure myocardial infarction myocarditis transplant...
Articles
Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice
Available to PurchaseIris Schuster, Shokoufeh Mahmoodzadeh, Elke Dworatzek, Frédéric Jaisser, Smail Messaoudi, Ingo Morano, Vera Regitz-Zagrosek
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (5): 365–376.
Published: 26 January 2016
... restricted to cardiomyocytes contributes to the observed cardioprotection, we tested the effects of cardiomyocyte-specific ERβ-OE (ERβ overexpression) on survival, cardiac remodelling and function after MI (myocardial infarction) and studied the molecular pathways potentially involved. Female and male mice...
Includes: Supplementary data
Articles
Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse
Available to PurchaseRoumen Parapanov, Jérôme Lugrin, Nathalie Rosenblatt-Velin, François Feihl, Bernard Waeber, Giuseppina Milano, Catherine Vergely, Na Li, Pal Pacher, Lucas Liaudet
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (2): 187–198.
Published: 30 April 2015
...-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI). animal model inflammation innate immunity myocardial infarction oxidative stress toll-like receptors • MI triggers an inflammatory...
Articles
Vinexin-β exacerbates cardiac dysfunction post-myocardial infarction via mediating apoptotic and inflammatory responses
Available to PurchaseXiaoxiong Liu, Nian Wan, Xiao-Jing Zhang, Yichao Zhao, Yan Zhang, Gangying Hu, Fengwei Wan, Rui Zhang, Xueyong Zhu, Hao Xia, Hongliang Li
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (12): 923–936.
Published: 27 March 2015
..., including cardiac hypertrophy. However, the role of Vinexin-β in myocardial infarction (MI) remains unknown. In this study, dramatically up-regulated Vinexin-β expression was observed in both ischaemic human hearts and infarcted animal hearts. To explore the potential involvement of Vinexin-β in MI further...
Articles
Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (3): 149–161.
Published: 03 April 2014
... and atherosclerosis. Although initial studies over a decade ago reported increases in circulating MIF levels following acute MI (myocardial infarction), the dynamic changes in MIF and its pathophysiological significance following MI have been unknown until recently. In the present review, we summarize recent...
Articles
CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation
Available to PurchaseGeena Varghese Paramel, Lasse Folkersen, Rona J. Strawbridge, Ali Ateia Elmabsout, Eva Särndahl, Pia Lundman, Jan-Håkan Jansson, Göran K. Hansson, Allan Sirsjö, Karin Fransén
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (8): 401–407.
Published: 14 June 2013
... mRNA was examined in atherosclerotic vascular tissue and the impact on MI (myocardial infarction) of a polymorphism in the CARD8 gene determined. CARD8 mRNA was analysed by microarray of human atherosclerotic tissue and compared with transplant donor arterial tissue. Microarray analysis was performed...
Articles
Protective role of AT 2 and B 1 receptors in kinin B 2 -receptor-knockout mice with myocardial infarction
Available to PurchaseJiang Xu, Oscar A. Carretero, Liping Zhu, Edward G. Shesely, Nour-Eddine Rhaleb, Xiangguo Dai, Luchen Wang, James J. Yang, Xiao-Ping Yang
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... of AT 2 R and/or B 1 R worsens cardiac remodelling and dysfunction following MI (myocardial infarction) in B 2 R −/− (B 2 -receptor-knockout mice). B 2 R −/− mice and WT (wild-type) controls were subjected to sham MI or MI and treated for 4 weeks with (i) vehicle, (ii) a B 1 R-ant (B 1 R antagonist; 300...
Articles
The ACE2 gene: its potential as a functional candidate for cardiovascular disease
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (2): 65–76.
Published: 12 September 2012
...), with permission from Elsevier. angiotensin-converting enzyme 2 (ACE2) coronary artery disease hypertension left ventricular hypertrophy myocardial infarction renin–angiotensin system (RAS) ACE2 has been identified in many tissues, including the heart [ 5 , 7 , 8 ], blood vessels [ 9 – 11...
Articles
Combination renin–angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (11): 649–658.
Published: 01 August 2012
...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...
Articles
Role of Toll-like receptors in cardiovascular diseases
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Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (1): 1–10.
Published: 18 March 2011
... are expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...
Articles
Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin
Available to PurchaseJing Li, Wanli Xuan, Ran Yan, Michael B. Tropak, Emilie Jean-St-Michel, Wenbin Liang, Rachel Gladstone, Peter H. Backx, Rajesh K. Kharbanda, Andrew N. Redington
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (10): 451–462.
Published: 28 January 2011
... [email protected] ). 17 9 2010 17 11 2010 8 12 2010 8 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 β-catenin limb ischaemia myocardial infarction signal transduction remote ischaemic preconditioning The phenomenon of local IPC...
Articles
IGF-1 and atherothrombosis: relevance to pathophysiology and therapy
Available to PurchaseElena Conti, Maria Beatrice Musumeci, Marco De Giusti, Eleonora Dito, Vittoria Mastromarino, Camillo Autore, Massimo Volpe
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (9): 377–402.
Published: 18 January 2011
... hypoxia, ischaemia and oxidative stress, thus mediating functional homoeostatic adjustments. In contrast, its deprivation results in apoptosis and dysfunction. Many prospective epidemiological surveys have associated low IGF-1 levels with late mortality, MI (myocardial infarction), HF (heart failure...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (6): 231–238.
Published: 03 December 2010
...Leong L. Ng; Sohail Q. Khan; Hafid Narayan; Paulene Quinn; Iain B. Squire; Joan E. Davies A multimarker approach may be useful for risk stratification in AMI (acute myocardial infarction) patients, particularly utilizing pathways that are pathophysiologically distinct. Our aim was to assess...
Articles
Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction
Available to PurchaseJing Xu, Wenlong Li, Xunna Bao, Hu Ding, Jingzhou Chen, Weili Zhang, Kai Sun, Jizheng Wang, Xiaojian Wang, Hu Wang, Hui Yu, Weihua Song, Weiwei Ma, Lin Zhang, Changxin Wang, Daowen Wang, Rutai Hui
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (8): 353–359.
Published: 06 July 2010
... of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction). We hypothesized that putative functional genetic variation in the two genes encoding uPA and uPAR ( PLAU and PLAUR...
Articles
Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (4): 175–183.
Published: 18 May 2010
...Lu Fang; Xiao-Jun Du; Xiao-Ming Gao; Anthony M. Dart Inflammation and ECM (extracellular matrix) remodelling play important roles in LV (left ventricular) remodelling following acute MI (myocardial infarction). Previous studies show elevated plasma MMP (matrix metalloproteinase) levels in patients...
Includes: Supplementary data
Articles
Role of nuclear factor κB in cardiovascular health and disease
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Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (10): 593–605.
Published: 23 February 2010
... and physiological context. The present review will focus on recent studies on the function of NF-κB in the cardiovascular system. atherosclerosis heart failure myocardial infarction nuclear factor-κB (NF-κB) percutaneous coronary intervention (PCI) vein grafting An important event in the initiation...
Articles
Prognostic value of admission blood glucose concentration and diabetes diagnosis on survival after acute myocardial infarction: results from 4702 index cases in routine practice
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Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (8): 527–535.
Published: 02 February 2010
... elevation AMI (acute myocardial infarction) of admission blood glucose concentration and of diabetes diagnosis. We carried out a retrospective cohort study in 4702 consecutive patients with STEMI (ST elevation AMI) occurring from 1 April 1993 to 31 December 2005, assessed for mortality at 30 days and 1 year...
Articles
Reliability of heart rate variability measurements in patients with a history of myocardial infarction
Available to PurchaseRoberto Maestri, Grzegorz Raczak, Ludmila Danilowicz-Szymanowicz, Antoni Torunski, Adam Sukiennik, Jacek Kubica, Maria Teresa La Rovere, Gian Domenico Pinna
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (3): 195–201.
Published: 01 February 2010
... setting. Poor reliability of the measurements might be a possible explanation for this. In the present study, we assessed the reliability of short-term HRV indexes in post-MI (myocardial infarction) patients. We studied 61 MI patients [50 males; age, 59±8 years; and LVEF (left ventricular ejection...
Articles
Matrix metalloproteinase-2 predicts mortality in patients with acute coronary syndrome
Available to PurchaseOnkar S. Dhillon, Sohail Q. Khan, Hafid K. Narayan, Kelvin H. Ng, Noor Mohammed, Paulene A. Quinn, Iain B. Squire, Joan E. Davies, Leong L. Ng
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (4): 249–257.
Published: 09 November 2009
... coronary syndrome for death, readmission with HF (heart failure) or recurrent MI (myocardial infarction) and to compare them with established markers, NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the GRACE (Global Registry of Acute Coronary Events) score. A single blood test was taken 4 days...
Articles
New statistical methods for the evaluation of cardiovascular risk markers: what the clinician should know
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Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (1): 13–15.
Published: 02 June 2009
..., for the prediction of mortality after acute myocardial infarction, using a combination of statistical methods. Correspondence: Professor Torbjørn Omland (email [email protected] ). 26 3 2009 7 4 2009 7 4 2009 © The Authors Journal compilation © 2009 Biochemical Society...
Articles
N-terminal pro-B-type natriuretic peptide complements the GRACE risk score in predicting early and late mortality following acute coronary syndrome
Available to PurchaseSohail Q. Khan, Hafid Narayan, Kelvin H. Ng, Onkar S. Dhillon, Dominic Kelly, Paulene Quinn, Iain B. Squire, Joan E. Davies, Leong L. Ng
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (1): 31–39.
Published: 02 June 2009
...Sohail Q. Khan; Hafid Narayan; Kelvin H. Ng; Onkar S. Dhillon; Dominic Kelly; Paulene Quinn; Iain B. Squire; Joan E. Davies; Leong L. Ng The GRACE (Global Registry of Acute Coronary Events) risk score has been shown to offer predictive power with regard to death and AMI (acute myocardial infarction...
Articles
Total leucocyte count, but not C-reactive protein, predicts 1-year mortality in patients with acute coronary syndromes treated with percutaneous coronary intervention
Available to PurchaseGjin Ndrepepa, Siegmund Braun, Raisuke Iijima, Dritan Keta, Robert A. Byrne, Stefanie Schulz, Julinda Mehilli, Albert Schömig, Adnan Kastrati
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (8): 651–658.
Published: 16 March 2009
... of this association from coronary risk factors and C-reactive protein has been inadequately studied. In the present study, this prospective registry included 4329 patients with ACS treated with PCI (percutaneous coronary intervention): 1059 patients with STEMI [ST-segment elevation MI (myocardial infarction)], 1753...
Articles
Statins for heart failure: still caught in no man's land?
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Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (1): 37–39.
Published: 28 November 2008
[email protected] ). 13 10 2008 29 10 2008 29 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 atorvastatin heart failure inflammation interleukin-10 myocardial infarction Statins can lower serum cholesterol levels. That fact is beyond doubt. Patients...
Articles
Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction
Available to PurchaseChristian Stumpf, Sebastian Petzi, Katrin Seybold, Gerald Wasmeier, Martin Arnold, Dorette Raaz, Atilla Yilmaz, Werner G. Daniel, Christoph D. Garlichs
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (1): 45–52.
Published: 28 November 2008
...Christian Stumpf; Sebastian Petzi; Katrin Seybold; Gerald Wasmeier; Martin Arnold; Dorette Raaz; Atilla Yilmaz; Werner G. Daniel; Christoph D. Garlichs LV (left ventricular) remodelling is the basic mechanism of HF (heart failure) following MI (myocardial infarction). Although there is evidence...
Articles
Genetic variation in the arachidonate 5-lipoxygenase-activating protein ( ALOX5AP ) is associated with myocardial infarction in the German population
Available to PurchasePatrick Linsel-Nitschke, Anika Götz, Anja Medack, Inke R. König, Petra Bruse, Wolfgang Lieb, Björn Mayer, Klaus Stark, Christian Hengstenberg, Marcus Fischer, Andrea Baessler, Andreas Ziegler, Heribert Schunkert, Jeanette Erdmann
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (10): 309–315.
Published: 15 October 2008
...-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) and stroke in Icelandic and Scottish populations. Both genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly...
Articles
Association between PPAR α gene polymorphisms and myocardial infarction
Available to PurchaseWibke Reinhard, Klaus Stark, Kamil Sedlacek, Marcus Fischer, Andrea Baessler, Katharina Neureuther, Stefan Weber, Bernhard Kaess, Silke Wiedmann, Stefan Mitsching, Wolfgang Lieb, Jeanette Erdmann, Christa Meisinger, Angela Doering, Ralf Tolle, Andreas Jeron, Guenter Riegger, Christian Hengstenberg
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (10): 301–308.
Published: 15 October 2008
... (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPAR α gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium...
Articles
MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (7): 203–218.
Published: 03 September 2008
... myocardial infarction, atherosclerosis and vascular restenosis will be examined, with attention paid to genetically modified murine model systems and to the use of pharmacological inhibitors of protein kinases. Despite the complexities of this field of research, attractive targets for pharmacological therapy...
Articles
Immune regulatory cells: circulating biomarker factories in cardiovascular disease
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Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (4): 129–131.
Published: 15 July 2008
... with cardiovascular end points. Finally, the cells expressing TLRs also demonstrated enhanced levels of responsiveness in patients who suffered from an acute coronary syndrome {AMI [acute MI (myocardial infarction)]} following cell stimulation. This resulted in an increase in TLR2 and TLR4 on local and systemic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (4): 133–140.
Published: 15 July 2008
... receptor 4) mediates the synthesis of cytokines in circulating monocytes of patients with AMI (acute myocardial infarction); however, it remains unclear whether TLRs are expressed at the site of the ruptured plaque in these patients. The aim of the present study was to determine whether TLR2 and TLR4...
Articles
Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction
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Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (3): 99–106.
Published: 02 July 2008
...Lu Fang; Xiao-Ming Gao; Chrishan S. Samuel; Yidan Su; Yean Leng Lim; Anthony M. Dart; Xiao-Jun Du The mechanism of cardiac rupture after MI (myocardial infarction) is not fully understood. Rupture has not been reported in most laboratory species, including the rat, but does occur in mice. We have...
Articles
Global longitudinal strain by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease
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Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (9): 393.
Published: 01 October 2007
...Ze-Zhou Song References 1 Gjesdal O. Hopp E. Vartdal T. Global longitudinal strain by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease Clin. Sci. 2007 113 287 296 2 Song Z. Z...
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