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Keywords: myocardial infarction
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Articles
Clin Sci (Lond) (2025) 139 (12): 627–648.
Published: 17 June 2025
...Erin B. Taylor; Luciano D. Mendoza; Jayla D. Sandifer; Jemylle G. Morato; Nikaela M. Aitken; Katherine R. O'Quinn; Indu Raman; Chengsong Zhu; Robert W. Spitz; John E. Hall; Alan J. Mouton Myocardial infarction (MI) causes a robust inflammatory response, which is necessary for remodeling and scar...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (10): 787–798.
Published: 27 May 2022
... response to injury over extended periods of time. imaging techniques model organisms myocardial infarction regeneration stem cell therapy wound healing The adult human heart is unable to functionally regenerate after injury, ultimately leading to heart failure and mortality. Heart failure...
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Clin Sci (Lond) (2021) 135 (17): 2143–2163.
Published: 17 September 2021
... Increased level of C-reactive protein (CRP) is a risk factor for cardiovascular diseases, including myocardial infarction and hypertension. Here, we analyzed the effects of CRP overexpression on cardiac susceptibility to ischemia/reperfusion (I/R) injury in adult spontaneously hypertensive rats (SHR...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
...Beatriz Delgado-Valero; Lucía de la Fuente-Chávez; Ana Romero-Miranda; María Visitación Bartolomé; Bunty Ramchandani; Fabián Islas; María Luaces; Victoria Cachofeiro; Ernesto Martínez-Martínez Myocardial infarction (MI) is associated with renal alterations resulting in poor outcomes in patients...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (8): 985–999.
Published: 24 April 2020
... to be involved in the initiation and development of myocardial infarction (MI). Here, we examined whether miR-21 regulation using human peripheral blood-derived sEVs (PB-sEVs) could serve as a potential therapeutic strategy for MI. First, we examined miR-21 levels in hypoxic conditions and validated the ability...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (7): 885–888.
Published: 14 April 2020
... by Portland Press Limited on behalf of the Biochemical Society 2020 Cardiac myocyte Ischemia-reperfusion injury Mitochondrial dynamics Mitochondrial fusion Myocardial infarction Heart attacks are a leading cause of death worldwide with no effective pharmacological strategies to limit permanent...
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Clin Sci (Lond) (2019) 133 (8): 933–937.
Published: 18 April 2019
... intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Ischemic preconditioning (IPC) is defined by episodes of ‘sub-lethal’ ischemia...
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Clin Sci (Lond) (2019) 133 (3): 425–441.
Published: 05 February 2019
... facilitated CM proliferation. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of CMs. Supperession of let-7i-5p promoted the recovery of heart function post-myocardial infarction by enhancing E2F2 and CCND2. Collectively, our results revealed...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (24): 2919–2932.
Published: 08 December 2017
...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (17): 2303–2317.
Published: 10 August 2017
... and its pathophysiological mechanisms following acute myocardial infarction (MI) in adult rat offspring exposed to prenatal hypoxia. Male and female rat offspring, which experienced normoxia (21% O 2 ) or hypoxia (11% O 2 ) in utero underwent sham or MI surgery at 12 weeks of age. Echocardiographic data...
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Clin Sci (Lond) (2017) 131 (12): 1215–1224.
Published: 31 May 2017
... in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...
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Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
..., and may additionally have utility as diagnostic and prognostic biomarkers. 21 9 2015 1 12 2015 3 12 2015 © 2016 Authors; published by Portland Press Limited 2016 atherosclerosis cardiac hypertrophy CXCL chemokines heart failure myocardial infarction myocarditis transplant...
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Clin Sci (Lond) (2015) 128 (12): 923–936.
Published: 27 March 2015
..., including cardiac hypertrophy. However, the role of Vinexin-β in myocardial infarction (MI) remains unknown. In this study, dramatically up-regulated Vinexin-β expression was observed in both ischaemic human hearts and infarcted animal hearts. To explore the potential involvement of Vinexin-β in MI further...
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Clin Sci (Lond) (2014) 127 (3): 149–161.
Published: 03 April 2014
... and atherosclerosis. Although initial studies over a decade ago reported increases in circulating MIF levels following acute MI (myocardial infarction), the dynamic changes in MIF and its pathophysiological significance following MI have been unknown until recently. In the present review, we summarize recent...
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Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... of AT 2 R and/or B 1 R worsens cardiac remodelling and dysfunction following MI (myocardial infarction) in B 2 R −/− (B 2 -receptor-knockout mice). B 2 R −/− mice and WT (wild-type) controls were subjected to sham MI or MI and treated for 4 weeks with (i) vehicle, (ii) a B 1 R-ant (B 1 R antagonist; 300...
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Clin Sci (Lond) (2013) 124 (2): 65–76.
Published: 12 September 2012
...), with permission from Elsevier. angiotensin-converting enzyme 2 (ACE2) coronary artery disease hypertension left ventricular hypertrophy myocardial infarction renin–angiotensin system (RAS) ACE2 has been identified in many tissues, including the heart [ 5 , 7 , 8 ], blood vessels [ 9 – 11...
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Clin Sci (Lond) (2011) 121 (1): 1–10.
Published: 18 March 2011
... are expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...
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Clin Sci (Lond) (2011) 120 (9): 377–402.
Published: 18 January 2011
... hypoxia, ischaemia and oxidative stress, thus mediating functional homoeostatic adjustments. In contrast, its deprivation results in apoptosis and dysfunction. Many prospective epidemiological surveys have associated low IGF-1 levels with late mortality, MI (myocardial infarction), HF (heart failure...
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Clin Sci (Lond) (2011) 120 (6): 231–238.
Published: 03 December 2010
...Leong L. Ng; Sohail Q. Khan; Hafid Narayan; Paulene Quinn; Iain B. Squire; Joan E. Davies A multimarker approach may be useful for risk stratification in AMI (acute myocardial infarction) patients, particularly utilizing pathways that are pathophysiologically distinct. Our aim was to assess...
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Clin Sci (Lond) (2010) 119 (8): 353–359.
Published: 06 July 2010
... of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction). We hypothesized that putative functional genetic variation in the two genes encoding uPA and uPAR ( PLAU and PLAUR...
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Clin Sci (Lond) (2010) 119 (4): 175–183.
Published: 18 May 2010
...Lu Fang; Xiao-Jun Du; Xiao-Ming Gao; Anthony M. Dart Inflammation and ECM (extracellular matrix) remodelling play important roles in LV (left ventricular) remodelling following acute MI (myocardial infarction). Previous studies show elevated plasma MMP (matrix metalloproteinase) levels in patients...
Includes: Supplementary data
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Clin Sci (Lond) (2010) 118 (10): 593–605.
Published: 23 February 2010
... and physiological context. The present review will focus on recent studies on the function of NF-κB in the cardiovascular system. atherosclerosis heart failure myocardial infarction nuclear factor-κB (NF-κB) percutaneous coronary intervention (PCI) vein grafting An important event in the initiation...
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Clin Sci (Lond) (2010) 118 (3): 195–201.
Published: 01 February 2010
... setting. Poor reliability of the measurements might be a possible explanation for this. In the present study, we assessed the reliability of short-term HRV indexes in post-MI (myocardial infarction) patients. We studied 61 MI patients [50 males; age, 59±8 years; and LVEF (left ventricular ejection...
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Clin Sci (Lond) (2010) 118 (4): 249–257.
Published: 09 November 2009
... coronary syndrome for death, readmission with HF (heart failure) or recurrent MI (myocardial infarction) and to compare them with established markers, NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the GRACE (Global Registry of Acute Coronary Events) score. A single blood test was taken 4 days...
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Clin Sci (Lond) (2009) 117 (1): 13–15.
Published: 02 June 2009
..., for the prediction of mortality after acute myocardial infarction, using a combination of statistical methods. Correspondence: Professor Torbjørn Omland (email [email protected] ). 26 3 2009 7 4 2009 7 4 2009 © The Authors Journal compilation © 2009 Biochemical Society...
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Clin Sci (Lond) (2009) 116 (1): 37–39.
Published: 28 November 2008
[email protected] ). 13 10 2008 29 10 2008 29 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 atorvastatin heart failure inflammation interleukin-10 myocardial infarction Statins can lower serum cholesterol levels. That fact is beyond doubt. Patients...
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Clin Sci (Lond) (2009) 116 (1): 45–52.
Published: 28 November 2008
...Christian Stumpf; Sebastian Petzi; Katrin Seybold; Gerald Wasmeier; Martin Arnold; Dorette Raaz; Atilla Yilmaz; Werner G. Daniel; Christoph D. Garlichs LV (left ventricular) remodelling is the basic mechanism of HF (heart failure) following MI (myocardial infarction). Although there is evidence...
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Clin Sci (Lond) (2008) 115 (10): 301–308.
Published: 15 October 2008
... (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPAR α gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium...
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Clin Sci (Lond) (2008) 115 (7): 203–218.
Published: 03 September 2008
... myocardial infarction, atherosclerosis and vascular restenosis will be examined, with attention paid to genetically modified murine model systems and to the use of pharmacological inhibitors of protein kinases. Despite the complexities of this field of research, attractive targets for pharmacological therapy...
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Clin Sci (Lond) (2008) 115 (4): 129–131.
Published: 15 July 2008
... with cardiovascular end points. Finally, the cells expressing TLRs also demonstrated enhanced levels of responsiveness in patients who suffered from an acute coronary syndrome {AMI [acute MI (myocardial infarction)]} following cell stimulation. This resulted in an increase in TLR2 and TLR4 on local and systemic...
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Clin Sci (Lond) (2008) 115 (4): 133–140.
Published: 15 July 2008
... receptor 4) mediates the synthesis of cytokines in circulating monocytes of patients with AMI (acute myocardial infarction); however, it remains unclear whether TLRs are expressed at the site of the ruptured plaque in these patients. The aim of the present study was to determine whether TLR2 and TLR4...
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Clin Sci (Lond) (2008) 115 (3): 99–106.
Published: 02 July 2008
...Lu Fang; Xiao-Ming Gao; Chrishan S. Samuel; Yidan Su; Yean Leng Lim; Anthony M. Dart; Xiao-Jun Du The mechanism of cardiac rupture after MI (myocardial infarction) is not fully understood. Rupture has not been reported in most laboratory species, including the rat, but does occur in mice. We have...
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