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Roel Bijkerk, Marina A. Aleksinskaya, Jacques M.G.J. Duijs, Jennifer Veth, Bettina Husen, Dania Reiche, Cornelia Prehn, Jerzy Adamski, Ton J. Rabelink, Jo G.R. De Mey, Anton Jan van Zonneveld
Clin Sci (Lond) (2019) 133 (2): 239–252.
Published: 22 January 2019
... excessive accumulation of myofibroblast-derived extracellular matrix. Natriuretic peptides have been demonstrated to have cyclic guanosine monophosphate (cGMP)-dependent anti-fibrotic properties likely due to interference with pro-fibrotic tissue growth factor β (TGF-β) signaling. However, in vivo...
Includes: Supplementary data
Yasunori Enomoto, Sayomi Matsushima, Kiyoshi Shibata, Yoichiro Aoshima, Haruna Yagi, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Takafumi Suda, Toshihide Iwashita
Clin Sci (Lond) (2018) 132 (14): 1565–1580.
Published: 31 July 2018
... actin (αSMA)-positive myofibroblasts is important in the progression of idiopathic pulmonary fibrosis (IPF), few biomarkers reflecting the fibrotic process have been discovered. We performed microarray analyses between FACS-sorted steady-state fibroblasts (lineage (CD45, TER-119, CD324, CD31, LYVE-1...
Includes: Supplementary data
Daniel W. Lambert, Louise A. Lambert, Nicola E. Clarke, Nigel M. Hooper, Karen E. Porter, Anthony J. Turner
Clin Sci (Lond) (2014) 127 (4): 243–249.
Published: 10 April 2014
... cardiac myofibroblasts was examined. Putative miRNA-binding sites were identified in the 3′-UTR of the ACE2 transcript using online prediction algorithms. Two of these, miR-200b and miR-421 , were selected for further analysis. A reporter system using the 3′-UTR of ACE2 fused to the coding region of...
Clin Sci (Lond) (2007) 112 (5): 265–280.
Published: 01 February 2007
... antifibrotic therapies in the near future. In this review, we examine how the innate and adaptive immune response interacts with other key cell types in the liver, such as the myofibroblast, regulating the process of hepatic fibrosis and, where relevant, resolution of fibrosis with remodelling. Emphasis is...
Frederic Lefebvre, Annick Préfontaine, Angelino Calderone, Alexandre Caron, Jean-François Jasmin, Louis Villeneuve, Jocelyn Dupuis
Clin Sci (Lond) (2006) 111 (3): 217–224.
Published: 15 August 2006
...Frederic Lefebvre; Annick Préfontaine; Angelino Calderone; Alexandre Caron; Jean-François Jasmin; Louis Villeneuve; Jocelyn Dupuis Lung structural remodelling, characterized by myofibroblast proliferation and collagen deposition, contributes to impaired functional capacity in CHF (congestive heart...
Masashi Kawamoto, Takakuni Matsunami, Ronald F. Ertl, YUH Fukuda, Maki Ogawa, John R. Spurzem, Nobuaki Yamanaka, Stephen I. Rennard
Clin Sci (Lond) (1997) 93 (4): 355–362.
Published: 01 October 1997
... (α-SM) actin as a marker for myofibroblasts, cellular fibronectin (cFn) and VLA-5. 3. Cells which had migrated to the bottom side of the filter were more likely to express α-SM actin, 29.1 ± 3.4% of cells, compared with cells which did not migrate through the filter, 12.4 ± 1.3% ( P < 0.05). The...