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Keywords: myofilaments
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Articles

Effects of the Ca2+ sensitizer EMD 57033 on intracellular Ca2+ in rat ventricular myocytes: relevance to arrhythmogenesis during positive inotropy

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Makoto KAWAI, John A. LEE, Clive H. ORCHARD
Journal: Clinical Science
Clin Sci (Lond) (2000) 99 (6): 547–554.
https://doi.org/10.1042/cs0990547
Published: 23 November 2000
...-mail [email protected] ). 8 3 2000 5 7 2000 15 8 2000 The Biochemical Society and the Medical Research Society © 2000 2000 arrhythmias heart inotropic agents intracellular Ca2+ myofilaments sarcoplasmic reticulum 547Clinical Science (2000) 99, 547 554 (Printed in Great...
View articletitled, Effects of the Ca2+ sensitizer EMD 57033 on intracellular Ca2+ in rat ventricular myocytes: relevance to arrhythmogenesis during positive inotropy
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Articles

EMD 57033 Enhances Arrhythmias Associated with Increased Wall-Stress in the Working Rat Heart

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Stephen J. Evans, Allan J. Levi, John A. Lee, John V. Jones
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (1): 59–67.
https://doi.org/10.1042/cs0890059
Published: 01 July 1995
...Stephen J. Evans; Allan J. Levi; John A. Lee; John V. Jones 1. EMD 57033 produces a positive inotropic effect by increasing the sensitivity of cardiac muscle myofilaments to calcium. Since the elevation in intracellular calcium produced by conventional inotropic compounds is thought...
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Articles

A novel thiadiazinone derivative fully reverses acidosis-induced depression of force in cardiac muscle by a calcium-sensitizing effect

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J. A. Lee, N. Shah, J. White, C. H. Orchard
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (2): 141–144.
https://doi.org/10.1042/cs0840141
Published: 01 February 1993
... by reducing myofilament Ca2 + responsiveness in intact heart muscle [5-71. As well as decreasing force, acidosis has a number of other effects [S], including increasing the amplitude of the Ca2 + transient [the systolic rise in intracellular [Ca"] ([Ca2+Ii) that initiates contraction] [5, 61 and increasing...
View articletitled, A novel thiadiazinone derivative fully reverses acidosis-induced depression of force in cardiac muscle by a calcium-sensitizing effect
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