...P. M. G. Bouloux; E. Newbould; R. Causon; L. Perry; L. H. Rees; G. M. Besser; A. Grossman 1. Although the opiate antagonist naloxone has been shown to affect sympathoadrenomedullary function in some studies, this has not been a uniform finding in all investigations, using different doses...

... saline or naloxone (10 mg intravenously, followed by a continuous infusion of 10 mg/h). 2. Intra-arterial pressure and heart rate were continuously monitored, but were not affected by naloxone. 3. At rest, opioid antagonism produced a rise in plasma renin activity and in plasma adrenocorticotropin...

... cholecystitis, there is active fluid secretion by the epithelial cells into the gall-bladder lumen, when the intraluminal hydrostatic pressure is low. This fluid secretion to the lumen was abolished by intravenous administration of enkephalin, an effect that was blocked by naloxone pretreatment. The flux...

...: − 1.6 sd 1.2 litres min −1 % −1 S ao 2 : somatostatin: − 0.6 sd 0.7) but the mean hypercapnic response was unchanged (control: 2.0 sd 0.8 litre min −1 mmHg −1 ; somatostatin: 2.3 sd 1.2). There was no change in resting V ˙ O 2 or V ˙ CO 2 during somatostatin infusion. 3. The opiate antagonist, naloxone...

...Margareta Bramnert; Hökfelt Bernt 1. There is evidence that opioid peptides influence blood pressure and heart rate in animals and man. In the present investigation the effect of naloxone on the exercise-induced increase in blood pressure, heart rate, plasma catecholamines, plasma renin activity...

...S. M. Gardiner; T. Bennett 1. The effects of naloxone on blood pressure recovery after either rapid arterial haemorrhage or prolonged venous haemorrhage were studied in rats lacking vasopressin (Brattleboro strain) and in control (Long Evans) rats. 2. To produce similar reductions in blood pressure...

... pressure was described by the same curve in sham-operated and adrenalectomized rats, indicating that, in the latter, there was no change in baroreflex setting or sensitivity. 4. Intravenous administration of naloxone (2mg/kg) had no effect on systemic arterial blood pressure in adrenalectomized rats...

..., naloxone 0.2 mg/kg or saline. Blood pressure, heart rate and plasma noradrenaline were determined supine and after a 5 min, 70° head-up tilt at 0, 3/4, 2, 3, 4, 5 and 6 h. 3. Study 2: seven subjects, after baseline recordings of blood pressure and heart rate received six incremental infusions of sodium...

... of −8.9 ± 1.9, −11.1 ± 5.2 and −19.8 ± 8.4 mmHg. 3. The pressor responses to 170 nmol of d -Ala 2 -Met-enkephalin were blocked by intracerebroventricular pretreatment with the opiate receptor antagonists diprenorphine and naloxone at doses of 10–500 nmol. The depressor effects under anaesthesia were...