... natriuretic peptide). We consecutively evaluated a catheterization laboratory cohort of 2700 patients with symptomatic CAD (coronary artery disease) [74.1% male; ACS (acute coronary syndrome), n =1316; SAP (stable angina pectoris), n =1384] presenting to the Cardiology Department of a large primary care...

...Maheshwar Pauriah; Faisel Khan; Tiong K. Lim; Douglas H. Elder; Valerie Godfrey; Gwen Kennedy; Jill J. F. Belch; Nuala A. Booth; Allan D. Struthers; Chim C. Lang BNP (B-type natriuretic peptide) has been reported to be elevated in preclinical states of vascular damage. To elucidate the relationship...

...Miriam T. Rademaker; Christopher J. Charles; Iain C. Melton; A. Mark Richards; Christopher M. Frampton; Jeff Siou; Fujian Qu; Neal L. Eigler; Dan Gutfinger; Richard W. Troughton Monitoring of HF (heart failure) with intracardiac pressure, intrathoracic impedance and/or natriuretic peptide levels...

...Hafid Narayan; Noor Mohammed; Paulene A. Quinn; Iain B. Squire; Joan E. Davies; Leong L. Ng Proguanylin and prouroguanylin are the inactive precursors of guanylin and uroguanylin, natriuretic peptides involved in the regulation of sodium balance. Urinary uroguanylin levels have been found...

...Carmine Savoia; Massimo Volpe; Alessandro Alonzo; Chiara Rossi; Speranza Rubattu Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator...

...Paul R. Kalra; Jonathan R. Clague; Andrew J. Coats; Stefan D. Anker; Philip A. Poole-Wilson; Allan D. Struthers CNP (C-type natriuretic peptide) is a vasodilatory peptide produced by vascular endothelium and the human heart with a short half-life. CNP has been identified within the human kidney...

... hypoxia and hypercapnia (i.e. HVR and HCVR), compared with those with normal chemosensitivity, had significantly (all P <0.01) higher noradrenaline (norepinephrine) and BNP (B-type natriuretic peptide) levels, higher prevalence of daytime and night-time CSR, worse NYHA (New York Heart Association...

.... van Gilst W. H. van Veldhuisen D. J. Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure J. Am. Coll. Cardiol. 2004 44 63 67 8 de Lemos J. A. Morrow D. A. Bentley J. H. The prognostic value of B-type natriuretic peptide...

... unit/ml EPO; P <0.005 compared with vehicle). Perfusate ET-1 (endothelin-1) increased transiently during EPO infusion, and the ET A/ ET B antagonist bosentan abolished the inotropic response to EPO. BNP (B-type natriuretic peptide) secretion (28±8%; P <0.05) and nuclear transcription factor GATA...

... myocardial infarction) and its relationship with prognosis, together with a known risk marker N-BNP (N-terminal pro-B-type natriuretic peptide). Plasma from 396 consecutive patients with AMI was obtained for measurement of ORP150 and N-BNP. Mortality and cardiovascular morbidity (acute coronary syndromes...

...Angelika Hammerer-Lercher; Johann Fersterer; Sigrid Holzmann; Johannes Bonatti; Elfriede Ruttmann; Daniel Hoefer; Johannes Mair; Bernd Puschendorf In the present study, we investigated the vasodilator properties of A-type, B-type and C-type natriuretic peptides (ANP, BNP and CNP respectively...

...Susan J. CARR; Sunita BAVANANDAN; Barbara FENTUM; Leong NG In the present study, we investigated the potential of N-BNP (N-terminal B-type natriuretic peptide) as a prognostic marker for risk of CV (cardiovascular) events, overall mortality and progression to ESRD (end-stage renal disease...

...Iain B. SQUIRE; Russell J. O'BRIEN; Bettina DEMME; Joan E. DAVIES; Leong L. NG Elevated plasma natriuretic peptide levels after AMI (acute myocardial infarction) are associated with adverse outcome. The aim of the present study was to examine the relationship of plasma N-ANP (N-terminal pro-atrial...

... secretion of the natriuretic peptides, hormones with actions beneficial in this disease. The present study investigates the roles of AngII and ET-1 in regulating the stretch-induced release of the natriuretic peptides during the development of heart failure. On seven separate days, eight sheep underwent...

... receiver operating characteristic (ROC) curves for diagnosis of all HF cases yielded an area under the curve (AUC) of 0.76, ROC AUCs for patients with early HF (NYHA class I and II) were better (0.91). ROC AUCs for logistic models incorporating N-terminal probrain natriuretic peptide (N-BNP) and UCN were...

... proteins. We hypothesized that plasma levels of N-terminal pro-brain natriuretic peptide (NT-BNP) would respond more vigorously after MI than those of other natriuretic peptides. We also sought to compare this response with that of the established myocardial injury markers troponin T (TnT), myoglobin...

...L. L. NG; S. GEERANAVAR; S. C. JENNINGS; I. LOKE; R. J. O'BRIEN In the present study, we assessed the use of urinary natriuretic peptides [N-terminal proatrial natriuretic peptide (N-ANP) and N-terminal pro-brain natriuretic peptide (N-BNP) and C-type natriuretic peptide (CNP)] in the diagnosis...

...Matthias SCHMITT; John R. COCKCROFT; Michael P. FRENNEAUX Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide system has been a story of scientific success. However, bridging the gap between bench and bedside has proved difficult, and as yet has...

..., P = 0.015). Chronic volume loading with 2, 3 and 4litres/day intravenous saline (each for 7 days) showed no evidence of renal sodium or volume retention in sheep with experimental MI compared with six normal control sheep. Plasma levels of brain natriuretic peptide (BNP), N-terminal pro-BNP and cGMP...

...Takashi YAMAMOTO; Atsuyuki WADA; Masato OHNISHI; Takayoshi TSUTAMOTO; Masanori FUJII; Takehiro MATSUMOTO; Tomoyuki TAKAYAMA; Xinwen WANG; Kiyoshi KUROKAWA; Masahiko KINOSHITA Endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) play important roles in the regulation of body fluid balance...