... their effect on the progression of CKD. Adult male SD (Sprague–Dawley) rats subjected to 5/6 NPX (nephrectomy) received a single intravenous infusion of 0.5×10 6 AD-MSCs or MSC culture medium alone. The therapeutic effect was evaluated by plasma creatinine measurement, structural analysis and angiogenic...

...S. Strandgaard; A. Kamper; P. Skaarup; N. H. Holstein-Rathlou; P. P. Leyssac; O. Munck 1. Glomerular and tubular function was studied before and 2 months after unilateral nephrectomy in 14 healthy kidney donors by measurement of the clearances of 51 Cr-labelled ethylenediaminetetra-acetate, lithium...

... occlusion or nephrectomy, caused an immediate rise in solution excretion from the contralateral kidney, but C in remained unchanged. Unflushed severely damaged kidneys showed no compensatory response to unilateral nephrectomy, whereas kidneys flushed with PBS50 exhibited increases in solute excretion...

... and heart rate increased from 79.2 ± 5.9 to 123.2 ± 5.9 beats/min. Blood flow increased significantly in the myocardium, fat and skeletal muscle vascular bed. 3. In another group of six dogs subjected to a similar protocol 24 h after bilateral nephrectomy, mean arterial pressure fell from 102.2 ± 5.3...

... with regard to these circulating vasoconstrictor effects. 2. Total nephrectomy of salt-fed S rats also alters circulating humoral agents so that vasoconstrictor responses to sympathetic nerve stimulation and to noradrenaline infusions are markedly diminished in a perfused hindquarters preparation. 3. Both...

... to be postulated. © 1981 The Biochemical Society and the Medical Research Society 1981 experimental hypertension haemodynamics nephrectomy ClinicalScience (1981) 61, 117s-119s 117s Haemodynamic changes after surgical reversal of chronic two-kidney, one-clip hypertension in the rat G. I . R U S S E L L...

...Eiki Murakami; Kunio Hiwada; Tatsuo Kokubu 1. The effects of prostaglandin (PG) E 1 , PGE 2 and PGF 2α on plasma renin substrate concentration in rats and renin substrate production by perfused rat liver were investigated. 2. After bilateral nephrectomy, both plasma renin substrate concentration...

... metabolite of vitamin D depends on the concentration of its precursor, 25-hydroxycholecalciferol. 8 2 1980 2 7 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 25,26-dihydroxycholecalciferol 25-hydroxycholecalciferol nephrectomy radioimmunoassay vitamin D...

...-loading respectively. Renin measured at an incubation pH of 5·3 showed little relationship with plasma renin. 3. Aortic renin (pH 6·5) was elevated in Goldblatt-two kidney hypertension and slowly fell for 24 h after bilateral nephrectomy whereas the fall in plasma renin was complete by the first hour...

... angiotensin II antagonist hypertension nephrectomy renin Clinical Science and Molecular Medicine (1978) J4,633-637 Effect of administration of Sar1-Ala8-angiotensin II during the development and maintenance of renal hypertension in the rat M. FERNANDES, R. FIORENTINI, G. ONESTI, G. BELLINI*, A. B. GOULD...

... after sub-total nephrectomy demonstrated less bone growth than the age-matched control animals. These differences diminished in successive 4 week periods and were not significant at 12 weeks after operation. 3. The major differences in bone mineral composition between the uraemic rats and the control...

... show only a partial response. Previous salt depletion of this model enhances the blood pressure response to nephrectomy. 4. Sodium retention plays no part in the development or maintenance of Goldblatt 2 kidney hypertension. However, although sodium retention is normally involved in the Goldblatt 1...

... a significant impairment, and bilateral nephrectomy a very marked impairment, of disappearance of the labelled insulin, suggesting that changes in the removal of this tracer may nevertheless parallel changes in the metabolism of native insulin. 4. Simultaneous intravenous injection of unlabelled bovine insulin...

... patients. Five patients were also studied before nephrectomy and six after successful renal transplantation. 2. Before nephrectomy, the resting concentrations of plasma aldosterone were usually raised. In the three patients out of five tested, the response to intravenous ACTH was marked. In two out of four...

... in general. © 1994 The Biochemical Society and the Medical Research Society 1994 renin hepatectomy nephrectomy dog Clinical Science and Molecular Medicine (1973) 45,225s-228s. THE CLEARANCE O F ENDOGENOUS R E N I N I N THE ANHEPATIC ANEPHRIC DOG R. F A G A R D , E. EYSKENS, H . DELOOZ, E...

...PH. J. Bordier; S. Tun Chot; J. B. Eastwood; A. Fournier; H. E. De Wardener 1. Iliac bone biopsies were obtained from nine patients 3 months to 6 years after bilateral nephrectomy. 2. In eight of the nine patients no histological evidence of vitamin D abnormality was seen in the bones after...