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Keywords: nephrotic syndromeClose
Clin Sci (Lond) (2019) 133 (3): 443–447.
Published: 08 February 2019
... glomerulosclerosis glomerulonephritis nephrotic syndrome podocalyxin podocytopathy podocytes Our understanding of the genetic contributions to the incidence of podocytopathy has increased rapidly in the last two decades, largely due to the advent of next generation sequencing technologies. In a fascinating...
Clin Sci (Lond) (2004) 107 (6): 533–538.
Published: 24 November 2004
... endothelial cell glomerular filtration nephrotic syndrome podocyte proteinuria Figure 4 Transmission electron micrograph of the glomerular capillary from a patient with MCN Arrows indicate flattening (‘effacement’) of podocyte foot processes (compare with the normal appearance of foot...
Clin Sci (Lond) (2004) 107 (2): 125–136.
Published: 27 July 2004
...José G. van den BERG; Jan J. WEENING Idiopathic NS (nephrotic syndrome) is characterized by massive proteinuria, due to a leak in the glomerular barrier to proteins. Genetic defects that affect the function and the composition of the glomerular capillary wall, in particular of the visceral...
Clin Sci (Lond) (2003) 104 (4): 389–395.
Published: 13 March 2003
...A. AUDIGÉ; Z.R. YU; B.M. FREY; D.E. UEHLINGER; F.J. FREY; B. VOGT In experimental nephrotic syndrome, urinary sodium excretion is decreased during the early phase of the disease. The molecular mechanism(s) leading to salt retention has not been completely elucidated. The rate-limiting constituent...
K. TENBROCK, A. SCHUBERT, L. STAPENHORST, M.J. KEMPER, J. GELLERMANN, K. TIMMERMANN, D.E. MÜLLER-WIEFEL, U. QUERFELD, B. HOPPE, D. MICHALK
Clin Sci (Lond) (2002) 102 (5): 507–512.
Published: 18 April 2002
... and allergy. Although several studies have described an association between atopy and idiopathic childhood nephrotic syndrome (NS), it is not clear whether this association is of a causal nature. Furthermore, it is not known whether these polymorphisms are associated with the clinical course of NS. A total...
Clin Sci (Lond) (1993) 84 (6): 627–632.
Published: 01 June 1993
...Ton J. Rabelink; Joost A. Bijlsma; Hein A. Koomans 1. In previous studies we found that albumin infusions caused only a modest natriuresis in the nephrotic syndrome, suggesting that hypovolaemia played no part in the sodium retention of these patients. However, this finding was inconclusive, since...
G. L. Warwick, C. J. Packard, L. Murray, D. Grierson, J. P. Stewart, J. Shepherd, J. M. Boulton-Jones
Clin Sci (Lond) (1992) 82 (6): 701–708.
Published: 01 June 1992
... synthesis. 5. These results suggest that, as in patients with primary moderate hyperlipidaemia, the significant cholesterol-lowering effect of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors in the nephrotic syndrome is accompanied by variable changes in lipoprotein metabolism. The reasons...
Clin Sci (Lond) (1991) 80 (6): 599–604.
Published: 01 June 1991
...B. Vogt; H. Favre 1. In the nephrotic syndrome the kidneys retain salt and water, which leads to oedema formation. The site of this sodium retention has been localized in the cortical collecting tubule by micropuncture studies. Whether or not this phenomenon is an intrinsic renal problem...
Clin Sci (Lond) (1990) 79 (6): 591–598.
Published: 01 December 1990
...J. D. Firth 1. In minimal change nephrotic syndrome the occurrence of heavy proteinuria can be explained on the basis of a reduction in charge selectivity of the glomerular filtration barrier, and it has been proposed that this might be caused by the neutralization of anionic groups...
Clin Sci (Lond) (1990) 79 (6): 559–574.
Published: 01 December 1990
.... angiotensin II atrial natriuretic peptide diuretics endothelin inhibition of metabolism isolated perfused rat kidney nephrotic syndrome noradrenaline puromycin aminonucleoside 22 2 1990 8 6 1990 29 6 1990 © 1990 The Biochemical Society and the Medical Research Society 1990...
Clin Sci (Lond) (1990) 79 (2): 123–129.
Published: 01 August 1990
... nephrotic syndrome sodium excretion Clinical Science (1990) 79,123-129 123 Sodium and water excretion in nephrotic patients: effects of changes in renal haemodynamics MICHAEL ALLON, CHARLES B. PASQUE AND MAFUANO RODRIGUEZ Nephrology Section, University of Oklahoma School of Medicine, and Veterans...
A. Godfrey B. Clark, Robert W. Vaughan, Henry A. F. Stephens, Cyril Chantler, D. Gwyn Williams, Kenneth I. Welsh
Clin Sci (Lond) (1990) 78 (4): 391–397.
Published: 01 April 1990
... that it contributes a second susceptibility allele. 3. A weak association between the uncommon HLA-DP-Cp63 allele and the disease was also observed. 4. Our data suggest that the immune events in steroid-sensitive nephrotic syndrome are defined by a particular immunogenetic background involving the β-chain genes...
Clin Sci (Lond) (1989) 77 (4): 445–451.
Published: 01 October 1989
...H. Mansy; T. H. J. Goodship; J. S. Tapson; G. H. Hartley; Pauline Keavey; R. Wilkinson 1. Twelve patients with the nephrotic syndrome were prescribed for 4 week periods a normal protein diet (NPD) containing 1 g of protein/kg ideal body weight. They were then prescribed for further 4 week periods...
Clin Sci (Lond) (1989) 77 (1): 43–48.
Published: 01 July 1989
...Alan H. Wilkinson; Cecilia Gillespie; Barry Hartley; D. Gwyn Williams 1. Intraortic suprarenal infusion in vivo of New Zealand White rabbits with plasma from patients with the nephrotic syndrome reduced the number of anionic sites labelled by the cationic polymer polyethyleneimine in the lamina...
Clin Sci (Lond) (1989) 76 (4): 387–395.
Published: 01 April 1989
... The Biochemical Society and the Medical Research Society 1989 isolated perfused kidney nephrotic syndrome puromycin aminonucleoside Clinical Science (1989) 76,387-395 387 Abnormal sodium handling occurs in the isolated perfused kidney of the nephrotic rat JOHN D. FIRTH, ANTHONY E. G. MINE AND JOHN G. G...
Clin Sci (Lond) (1988) 75 (3): 271–276.
Published: 01 September 1988
...J. A. Joles; H. A. Koomans; P. Boer; E. J. Dorhout Mees 1. The role of hypoproteinaemia in the sodium retention seen in conditions such as the nephrotic syndrome is incompletely known. 2. To define the influence of severe hypoproteinaemia on kidney function, we studied the effect of an intravenous...
Seiya Okuda, Kenichi Motomura, Tohru Sanai, Hideki Hirakata, Fumio Nanishi, Kaotu Onoyama, Masatoshi Fujishima
Clin Sci (Lond) (1987) 73 (1): 33–39.
Published: 01 July 1987
... glomerular sclerosis can be prevented by appropriate restriction of dietary protein; however, severe protein restriction does aggravate nutritional states. adriamycin focal glomerular sclerosis nephrotic syndrome nutrition protein restriction renal failure 5 12 1986 22 1 1987 ©...
Clin Sci (Lond) (1986) 71 (1): 23–29.
Published: 01 July 1986
... of chronic progressive renal disease, as induced by adriamycin. © 1986 The Biochemical Society and the Medical Research Society 1986 23 12 1985 30 1 1986 adriamycin focal glomerular sclerosis hypertension nephrotic syndrome spontaneous hypertension ClinicalScience (1986) 71,23...
Clin Sci (Lond) (1986) 71 (1): 97–104.
Published: 01 July 1986
...E. B. Pedersen; H. Danielsen; S. S. Sørensen; B. Jespersen 1. An oral water load of 20 ml/kg body wt. was given to eight patients with nephrotic syndrome before and after remission of the syndrome, and to 13 healthy control subjects. Urine volume ( D ), free water clearance ( C water ), plasma...
Clin Sci (Lond) (1985) 69 (4): 395–401.
Published: 01 October 1985
... was observed between the circadian rhythm of proteinuria and the type of glomerulopathy. 15 3 1985 9 4 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 circadian rhythm nephrotic syndrome proteinuria Clinical Science (1985) 69, 395-401 395 A circadian rhythm...
Clin Sci (Lond) (1982) 63 (3): 317–319.
Published: 01 September 1982
... Society and the Medical Research Society 1982 natriuretic factor sodium excretion nephrotic syndrome Clinical Science (1982) 63,317-3 19 317 SHORT COMMUNICA TION Absence of production of natriuretic factor following acute saline expansion in nephrotic rats H . F A V R E A N D M. G O U R J O N...
Clin Sci (Lond) (1981) 61 (5): 605–610.
Published: 01 November 1981
... handling and aldosterone levels on immersion. 6 4 1981 27 4 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 nephrotic syndrome tubular function urinary chloride urinary sodium water water immersion Renal salt and water handling in water immersion...
Clin Sci Mol Med (1977) 52 (2): 149–151.
Published: 01 February 1977
...R. G. W. L. Tiggeler; R. A. P. Koene; P. G. A. B. Wijdeveld 1. In four patients with nephrotic syndrome indomethacin not only reduced proteinuria but also inhibited the natriuretic effect of high doses of frusemide. 2. The inhibition of natriuresis by indomethacin could not be antagonized...
Clin Sci Mol Med (1974) 46 (3): 283–294.
Published: 01 March 1974
...H. G. Preuss; F. R. Weiss; R. M. Iammarino; W. J. Hammack; H. V. Murdaugh, Jr 1. The effects were investigated of non-dialysable substances obtained from urines of patients with nephrotic syndrome and those with myelomatosis (heavily laden with light chains) on renal function in a system in vitro...