..., a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration...

... 07 04 2021 13 04 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 adipose inflammation Antithrombotic drugs cardiovascular disease Metabolic dysfunction neurodegeneration Hemostasis is maintained through various...

... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 blood brain barrier epilepsy glial cell neurodegeneration pericytes traumatic brain injury Accumulating evidence advocates for a role of cerebrovascular dysfunction in central...

[email protected] ) 21 03 2017 03 11 2017 17 11 2017 21 11 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 autonomic nervous system neurodegeneration sympathetic nervous system Pure autonomic failure (PAF) is a rare...

... 2016 brain copper neurodegeneration Parkinson's disease therapy Pathologically, Parkinson's disease is characterized by the formation of primarily intracellular α-synuclein-containing inclusion bodies called Lewy bodies. The current understanding of neuronal death in Parkinson's disease...

... and signs of neurodegeneration. Given the importance of both apoptosis and autophagy for neuronal survival in adult neurons, understanding how BCL-2 homologues co-ordinately regulate these processes will allow a better understanding of the cellular processes leading to neurodegeneration. In the present...

... disease neurodegeneration neurotransplantation stem cell treatment HD (Huntington's disease) is an inherited neurodegenerative disorder, with the most common age of onset between 30–50 years of age, and with a mean disease duration of approx. 15–20 years from diagnosis to death. The incidence...

... ). 17 5 2005 12 7 2005 28 7 2005 The Biochemical Society 2006 gene transfer interfering RNA (RNAi) lentivirus neurodegeneration ocular disease retinal disorder viral vector Viral vectors currently provide the vehicle of choice for gene therapy clinical trials...