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Keywords: neurodegeneration
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Clin Sci (Lond) (2024) 138 (8): 515–536.
Published: 23 April 2024
..., a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration...
Clin Sci (Lond) (2018) 132 (3): 361–374.
Published: 08 February 2018
... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 blood brain barrier epilepsy glial cell neurodegeneration pericytes traumatic brain injury Accumulating evidence advocates for a role of cerebrovascular dysfunction in central...
Clin Sci (Lond) (2018) 132 (1): 1–16.
Published: 02 January 2018
... of the Biochemical Society 2018 autonomic nervous system neurodegeneration sympathetic nervous system Pure autonomic failure (PAF) is a rare sporadic disorder characterized by profound orthostatic hypotension in association with other features of autonomic failure, but in the absence of neurological...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (8): 565–574.
Published: 08 March 2016
... brain copper neurodegeneration Parkinson's disease therapy A complex and self-perpetuating cascade of events, including oxidative stress, protein aggregation, mitochondrial dysfunction and inflammation are responsible for neuronal death in Parkinson's disease [ 1 ]. Changes in brain...
Clin Sci (Lond) (2010) 118 (3): 173–181.
Published: 26 October 2009
... and signs of neurodegeneration. Given the importance of both apoptosis and autophagy for neuronal survival in adult neurons, understanding how BCL-2 homologues co-ordinately regulate these processes will allow a better understanding of the cellular processes leading to neurodegeneration. In the present...
Clin Sci (Lond) (2006) 110 (1): 73–88.
Published: 12 December 2005
... ( Table 1 ). clinical trial gene therapy Huntington's disease neurodegeneration neurotransplantation stem cell treatment HD (Huntington's disease) is an inherited neurodegenerative disorder, with the most common age of onset between 30–50 years of age, and with a mean disease duration...
Clin Sci (Lond) (2006) 110 (1): 37–46.
Published: 12 December 2005
...) lentivirus neurodegeneration ocular disease retinal disorder viral vector In terms of long-term expression of a therapeutic transgene, retroviral- and lentiviral-based vectors provide the most promising gene therapy vehicles, since the viral genome is stably integrated into that of the host cell...