...Jiaying Qiu; Siwan Peng; Ruobing Qu; Liucheng Wu; Lingyan Xing; Luzhong Zhang; Junjie Sun Neurodegenerative diseases (NDs) involve the progressive loss of neuronal structure or function in the brain and spinal cord. Despite their diverse etiologies, NDs manifest similar pathologies. Emerging...

... limits the cytotoxic effectiveness of the latter. Similarly, numerous recent studies have linked altered HDAC6 activity to the pathogenesis of neurodegenerative diseases that are characterized by misfolded protein accumulation. It seems likely though that the function of HDAC6 is not limited...

... hepatotoxicity neurodegenerative disease oxidative stress reserve capacity Complex and chronic diseases with underlying mechanisms involving dysfunctional metabolism are a growing healthcare problem in the developed world [ 1 – 3 ]. The availability of low-cost high-calorie foods in combination...

... is involved in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and cerebral ischaemic insults), cancer, obesity and diabetes. In the present review, we consider the importance of ER stress under pathological conditions in mammals. Furthermore, we discuss the therapeutic potential...

... © 2009 Biochemical Society 2009 autophagy cancer cell death heart neurodegenerative disease survival A fine balance between protein synthesis, organelle biogenesis and degradation is essential for cell growth and development. Moreover, to maintain vital cellular functions...

.... Correspondence: Professor Moses V. Chao (email [email protected] ). 20 5 2005 19 7 2005 16 8 2005 The Biochemical Society 2006 neurotrophin nervous system neurodegenerative disease Trk receptor The neurotrophins are the best understood trophic factors...