...Eiji KUBOTA; Rachael G. DEAN; Richard A. HUBNER; David J. CASLEY; Colin I. JOHNSTON; Louise M. BURRELL Vasopeptidase inhibitors simultaneously inhibit angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The present study characterized the tissue distributions of ACE and NEP...

...J. G. LAINCHBURY; M. G. NICHOLLS; E. A. ESPINER; H. IKRAM; T. G. YANDLE; A. M. RICHARDS 1. The cardiac natriuretic peptides, atrial natriuretic peptide and brain natriuretic peptide, are degraded via clearance receptors and the enzyme neutral endopeptidase (EC 3.4.24.11). We studied the regional...

...Louise M. Burrell; Nicole Farina; John Risvanis; David Woollard; David Casely; Colin I. Johnston 1. Inhibition of neutral endopeptidase (NEP), the degradative enzyme for atrial natriuretic peptide, was studied in vitro and in vivo using a previously characterized NEP inhibitor radioligand, 125 I...

...Christine Fagny; Arnaud Marchant; Eric De Prez; Michel Goldman; Monique Deschodt-Lanckman 1. As lipopolysaccharide is a major stimulator of neutrophil responses during Gram-negative bacterial infections, we studied its effect on the membrane expression of neutral endopeptidase 24.11/CD10...

...Janice E. O'Connell; Alan G. Jardine; David L. Davies; James McQueen; John M. C. Connell 1. Acute pharmacological inhibition of the enzyme neutral endopeptidase (EC 3.4.24.11), which cleaves the cardiac hormone atrial natriuretic peptide, raises endogenous levels of the hormone. Short-term...

...Marcello Fanciullacci; Massimo Alessandri; Maria Nicolodi; Sergio Michelacci; Federigo Sicuteri 1. Converting enzyme and neutral endopeptidase activities were both measured every 3 h by a fluorimetric method in plasma and cerebrospinal fluid of patients diagnosed as migraineurs with aura after...