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Keywords: neutral endopeptidase 24.11
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Articles
Y. Arco JENG, Paula SAVAGE, Michael E. BEIL, Charles W. BRUSEO, Denton HOYER, Cynthia A. FINK, Angelo J. TRAPANI
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 98S–101S.
Published: 01 September 2002
...) is a potent vasorelaxant and diuretic agent, which is mainly degraded by neutral endopeptidase 24.11 (NEP) in vivo . Thus, compounds that can suppress the biosynthesis of ETs by inhibiting endothelin converting enzymes (ECEs), which catalyse the final step of post-translational processing...
Articles
Angelo J. TRAPANI, Michael E. BEIL, Charles W. BRUSEO, Cynthia A. FINK, Denton HOYER, Paula SAVAGE, Arco Y. JENG
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 102S–106S.
Published: 01 September 2002
...Angelo J. TRAPANI; Michael E. BEIL; Charles W. BRUSEO; Cynthia A. FINK; Denton HOYER; Paula SAVAGE; Arco Y. JENG CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC 50 values of 11 and 5nM respectively...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 128S–131S.
Published: 01 September 2002
...), compared with ET-1, on the release of eicosanoids in the isolated and perfused guinea pig lung. We also clarified the implication of ET receptors in these effects using selective ET A or ET B receptor antagonists, BQ-123 and BQ-788 respectively. Finally, using the neutral endopeptidase 24.11 (NEP 24.11...
