... destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with β-cell autoimmunity in patients with Type 1 diabetes. The present study aims to investigate the impact of NE inhibition on development of autoimmune diabetes in NOD mice...

... angiotensin II Apolipoprotein E dendritic cells neutrophil elastase Abdominal aortic aneurysm (AAA) is an important cause of sudden death in older adults [ 1 ]. It was estimated that AAA rupture was responsible for 166000 deaths worldwide in 2016 [ 2 ]. Currently the only treatment available...

... such as mild lymphoedema, lymph leakage and compromised lymph drainage. In the present study, using a mouse post-surgical tail lymphoedema model, we show that the acute phase of acquired lymphoedema correlates with EMILIN1 degradation due to neutrophil elastase (NE) released by infiltrating neutrophils...

...% active. 4. The absolute neutrophil elastase (NE) inhibitory capacity was similar in both groups (median 185 μg of NE inhibited/ml of sputum, range 80–480, for the α 1 PI-deficient group; median 175, range 80–300, for the bronchitic group). A substantial proportion of NE inhibition in secretions could...

... bronchitic BAL fluid ( P < 0.005). However, the α 1 PI was only about 50% active as an inhibitor in both groups. 4. There was no difference in the amount of neutrophil elastase (NE) inhibited per ml of lavage fluid or per mol of the measured inhibitors in the secretions, but both groups inhibited more...