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Clin Sci (Lond) (2022) 136 (13): 1047–1052.
Published: 06 July 2022
...Erin B. Taylor Dysregulation of neutrophil extracellular trap (NET) formation has been shown to mediate disease pathology in multiple viral infections, including SARS-CoV-2. At the beginning of COVID-19 pandemic, Thierry and Roch wrote a perspective on the mechanisms by which severe SARS-CoV-2...
Médea Padra, Anders Andersson, Bettina Levänen, Pushpa Premaratne, Helga Asgeirsdottir, Sara Tengvall, Karin Christenson, Marit Stockfelt, Steven Bozinovski, Shigemi Yoshihara, Ann-Sofie Lantz, Lena Palmberg, Barbro Dahlén, Kjell Larsson, Ingemar Qvarfordt, Sara K. Lindén, Anders Lindén
Clin Sci (Lond) (2020) 134 (10): 1107–1125.
Published: 21 May 2020
... complexes of mucins. All LTS displayed an enhanced (median) level of MUC5AC compared with HNS. LTS− displayed a higher level of large MUC5AC complexes than HNS while LTS+ displayed a similar trend. In all LTS, total MUC5AC correlated with blood leukocytes, BAL neutrophil elastase and net gelatinase activity...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (7): 839–851.
Published: 04 April 2019
...Suchita Nadkarni; Hazem Lashin; Jane Hollywood; Bhaskar Dasgupta; Justin C. Mason; Mauro Perretti We have reported the existence of a distinct neutrophil phenotype in giant cell arteritis (GCA) patients arising at week 24 of steroid treatment. In the present study, we investigated whether...
Xuhua Yu, Huei Jiunn Seow, Hao Wang, Desiree Anthony, Steven Bozinovski, Lin Lin, Ji-Ming Ye, Ross Vlahos
Clin Sci (Lond) (2019) 133 (4): 551–564.
Published: 18 February 2019
... that initiates and drives the long-term progression of disease. In particular, there are no effective therapeutics that target neutrophilic inflammation in COPD, which is known to cause tissue damage by degranulation of a suite of proteolytic enzymes including neutrophil elastase (NE). Matrine, an alkaloid...
Clin Sci (Lond) (2017) 131 (11): 1147–1159.
Published: 22 May 2017
...Yujie Wang; Man Jia; Xiaoyi Yan; Limin Cao; Peter J. Barnes; Ian M. Adcock; Mao Huang; Xin Yao Airway remodelling is an important component of chronic obstructive pulmonary disease (COPD). Neutrophil gelatinase-associated lipocalin (NGAL) from neutrophils may drive COPD epithelial–mesenchymal...
Sandeep Dhall, João P. Silva, Yan Liu, Michael Hrynyk, Monika Garcia, Alex Chan, Julia Lyubovitsky, Ronald J. Neufeld, Manuela Martins-Green
Clin Sci (Lond) (2015) 129 (12): 1115–1129.
Published: 22 October 2015
...-treated wounds, the pattern of neutrophil inflammatory response suggests faster clearing of the burned dead tissue. We also observe faster resolution of the pro-inflammatory macrophages. We also found that insulin stimulates collagen deposition and maturation with the fibres organized more like a basket...
Clin Sci (Lond) (2002) 103 (6): 577–585.
Published: 14 November 2002
...M. NYS; G. DEBY-DUPONT; Y. HABRAKEN; S. LEGRAND-POELS; D. LEDOUX; J.-L. CANIVET; P. DAMAS; M. LAMY In bronchoalveolar lavage (BAL) fluid from ventilated patients, cytotoxic oxidant activity is correlated with neutrophil activation. The aim of the present study was to investigate the hypothesis...
Annika TAKALA, Irma JOUSELA, Sten-Erik JANSSON, Klaus T. OLKKOLA, Olli TAKKUNEN, Arto ORPANA, Sirkka-Liisa KARONEN, Heikki REPO
Clin Sci (Lond) (1999) 97 (5): 529–538.
Published: 15 September 1999
...), soluble E-selectin and C-reactive protein, and neutrophil and monocyte CD11b expression] and routine blood cell counts in 20 patients with systemic inflammatory response syndrome and positive blood culture. Eight patients with shock due to community-acquired infection developed OF, whereas 11 normotensive...
Christophe MOINARD, Béatrice CHAUVEAU, Stéphane WALRAND, Catherine FELGINES, Jacques CHASSAGNE, Florence CALDEFIE, Luc A. CYNOBER, Marie-Paule VASSON
Clin Sci (Lond) (1999) 97 (1): 59–65.
Published: 21 May 1999
..., but not glutamine, was able to counteract the DEX effect on TNFα secretion. Glutamine, arginine and OKG supplementation increased H 2 O 2 production by monocytes and polymorphonuclear neutrophils from DEX-treated rats. All DEX-treated rats showed plasma and muscle glutamine depletion and also a decrease...
Carolina GARCIA, Tania C. PITHON-CURI, Maria DE LOURDES FIRMANO, Mariza PIRES DE MELO, Philip NEWSHOLME, Rui CURI
Clin Sci (Lond) (1999) 96 (6): 549–555.
Published: 28 April 1999
...-investigated topic. The present study has addressed the effects of adrenaline on the rates of utilization and oxidation of glucose and glutamine, the phagocytic capacity and the rate of superoxide production by rat neutrophils. Incubation of rat neutrophils in the presence of 50 µ M adrenaline caused a marked...
Clin Sci (Lond) (1996) 91 (3): 371–374.
Published: 01 September 1996
...Mr S. M. Plusa; N. Webster; J. N. Primrose 1. Total parenteral nutrition is associated with a high incidence of septic complications. This may be partly due to neutrophil dysfunction induced by the parenteral nutrition. 2. Neutrophil adhesion molecule expression and the expression of CD11b...
T. J. N. Hiltermann, J. Stolk, P. S. Hiemstra, P. H. B. Fokkens, P. J. A. Rombout, J. K. Sont, P. J. Sterk, J. H. Dijkman
Clin Sci (Lond) (1995) 89 (6): 619–624.
Published: 01 December 1995
... with exposure to air, in non-asthmatic as well as asthmatic subjects. These physiological changes were accompanied by a significant rise in the percentage of neutrophils in induced sputum ( P < 0.02). All changes had returned to baseline values 1 week after exposure to ozone. 5. Exposure to ozone causes...
Clin Sci (Lond) (1995) 89 (2): 171–176.
Published: 01 August 1995
...Tomasz Siminiak; Robin M. Egdell; Daniel J. O'Gorman; Julian F. Dye; Desmond J. Sheridan 1. Polymorphonuclear neutrophils are involved in the development of myocardial injury during ischaemia through the release of free oxygen radicals and by adhesion of activated polymorphonuclear neutrophils...
Clin Sci (Lond) (1995) 89 (1): 83–89.
Published: 01 July 1995
...Christine Fagny; Arnaud Marchant; Eric De Prez; Michel Goldman; Monique Deschodt-Lanckman 1. As lipopolysaccharide is a major stimulator of neutrophil responses during Gram-negative bacterial infections, we studied its effect on the membrane expression of neutral endopeptidase 24.11/CD10...
Luciano Ottonello, Patrizia Dapino, Maria C. Scirocco, Alessandro Balbi, Maurizio Bevilacqua, Franco Dallegri
Clin Sci (Lond) (1995) 88 (3): 331–336.
Published: 01 March 1995
...Luciano Ottonello; Patrizia Dapino; Maria C. Scirocco; Alessandro Balbi; Maurizio Bevilacqua; Franco Dallegri 1. It is well known that neutrophils act as mediators of tissue injury in a variety of inflammatory diseases. Their histotoxic activity is presently thought to involve proteinases...
Clin Sci (Lond) (1993) 85 (4): 455–463.
Published: 01 October 1993
...-activating factor production by leucocytes. To determine whether there are differences in acetyl-transferase activity between asthmatic patients and normal subjects, enzyme activity was assayed in neutrophil lysates from atopic asthmatic patients ( n = 20), aspirin-sensitive asthmatic patients ( n = 12...
Clin Sci (Lond) (1992) 83 (5): 511–518.
Published: 01 November 1992
...Adrian J. B. Brady; Frances M. Williams; Timothy J. Williams © 1992 The Biochemical Society and the Medical Research Society 1992 adenosine adhesion molecules complement endothelium inflammation leukotrienes myocardial ischaemia neutrophils oxygen free radicals reperfusion injury...
Clin Sci (Lond) (1988) 74 (6): 645–650.
Published: 01 June 1988
... microbial organisms is not due to defective chemotaxis as measured here. 3. Purulent sputum solphase demonstrates chemotactic activity against control PMN. This activity is greater ( P < 0.001) than that found with mucoid sputum solphase, which is consistent with the neutrophil content of the secretions...
Clin Sci (Lond) (1988) 74 (1): 53–56.
Published: 01 January 1988
...Walter Zidek; Agapios Sachinidis; Claus Spieker; Walter Storkebaum 1. The effects of plasma fractions from essential hypertensive subjects ( n = 14) and normotensive subjects ( n = 14) on Ca 2+ transport in permeabilized human neutrophils was studied using an ion-selective electrode. 2. Plasma...
Francesco Di Virgilio, Lorenzo Calò, Salvatore Cantaro, Silvana Favaro, Antonio Piccoli, Arturo Borsatti
Clin Sci (Lond) (1987) 72 (4): 483–488.
Published: 01 April 1987
...Francesco Di Virgilio; Lorenzo Calò; Salvatore Cantaro; Silvana Favaro; Antonio Piccoli; Arturo Borsatti 1. Cytosolic free calcium concentrations ([a 2+ ] i ) were measured in resting and chemotactic peptide-activated neutrophils from eight patients with Bartter's syndrome and compared with levels...
Clin Sci (Lond) (1986) 71 (3): 313–318.
Published: 01 September 1986
...A. J. K. Williams; R. E. Barry 1. Rat liver membrane vesicles were exposed to acetaldehyde, with or without reduction of the resultant adducts formed. 2. Superoxide anion production and degranulation of rat neutrophils, upon stimulation with the liver membrane vesicles, were measured by cytochrome...
Clin Sci (Lond) (1985) 69 (2): 227–230.
Published: 01 August 1985
... in neutrophils from normo- and hyper-tensive subjects, by trapping the fluorescent calcium indicator quin2 in intact cells. 2. Ten patients with untreated essential hypertension were compared with 10 age- and sex-matched normotensive subjects. The levels of cytosolic free calcium and intracellular calcium stores...
Clin Sci Mol Med (1976) 51 (1): 87–92.
Published: 01 July 1976
... in the protective mechanisms against endogenous proteases. 5 3 1976 © 1976 The Biochemical Society and the Medical Research Society 1976 α-globulins leucocytes macroglobulins neutrophils trypsin, trypsin inhibitors Clinical Science and Molecular Medicine (1976) 51, 87-92. The disappearance...