...Mark Ensor; Sean E. Thatcher; Kristen McQuerry; Kory Heier; Heba M. Ali; Victoria English; Lisa A. Cassis; Yasir Alsiraj Cigarette smoking is a risk factor for abdominal aortic aneurysms (AAAs), with studies suggesting a higher smoking-related AAA risk in women than men. We examined nicotine’s...

..., the effects of nicotine alone on cardiopulmonary function remain largely unknown. Previously, we have shown that chronic nicotine vapor inhalation in mice leads to the development of pulmonary hypertension (PH) with right ventricular (RV) remodeling. The present study aims to further examine...

...Reiko Sakurai; Jie Liu; Ying Wang; John S. Torday; Virender K. Rehan Perinatal nicotine exposure drives the differentiation of alveolar lipofibroblasts (LIFs), which are critical for lung injury repair, to myofibroblasts (MYFs), which are the hallmark of chronic lung disease. Bone marrow-derived...

... proposed as a possible mechanism for the protective effect of smoking on ulcerative colitis. We have therefore compared the effects of corticosteroids including carbenoxolone, and nicotine on mucin synthesis, assessed by incorporation of N -[ 3 H]acetylglucosamine into mucin by colonic epithelial biopsies...

... abolished the response. 6. Measurements of plasma nicotine concentrations in some experiments showed that nicotine was absorbed from smoke in the lower airway and also suggested some absorption of nicotine from the tracheal segment. 7. We conclude that nicotine, absorbed either directly into the tracheal...

...D. F. Rogers; Deborah A. Williams; P. K. Jeffery 1. Nicotine is of interest as a major constituent of cigarette smoke and as an additive to chewing gum used to help patients to stop smoking. 2. Specific pathogen-free rats were given an aerosol or injections of nicotine hydrogen (+) tartrate ( l...

... or one of two types of special low tar cigarettes. These latter both had tar yields of about 8 mg with nicotine yields of 0.55 (LN) and 0.90 (MN) mg respectively. The test order was randomized between individuals and before using the special cigarettes the subjects were given a pack to accustomize...