...Masanori HONDA; Koichi HAYASHI; Hiroto MATSUDA; Eiji KUBOTA; Hirobumi TOKUYAMA; Ken OKUBO; Yuri OZAWA; Takao SARUTA This study examined the effects of different types of calcium channel antagonists on renal haemodynamics and natriuresis. The intravenous infusion of nifedipine (L-type blocker...

... or nifedipine. All pups in the study had blood pressure determined at 4 and 12 weeks of age using a tail cuff. Animals exposed to the low-protein diet in utero and not subjected to drug treatment had elevated blood pressure relative to control rats (mean increase of 27 mmHg; P < 0.001). Treatment of rats...

...P. G. McNally; F. Baker; N. Mistry; J. Walls; J. Feehally 1. Nifedipine ameliorates cyclosporin A-induced renal impairment in surgically intact (two-kidney) rats. This study investigates the effect of nifedipine on cyclosporin A nephrotoxicity in spontaneously hypertensive rats after either...

...Niels Eske Bruun; Hans Ibsen; Peter Skøtt; Dorthe Toftdahl; Jørn Giese; Niels Henrik Holstein-Rathlou 1. In two separate studies the lithium clearance method was used to evaluate the influence of acute and long-term nifedipine treatment on renal tubular sodium reabsorption. 2. In the acute study...

...N. Bishop; G. Hart; M. S. Elamin; N. P. Silverton; R. Boyle; J. B. Stoker; D. R. Smith; D. A. S. G. Mary; R. J. Linden 1. Nifedipine is used in patients with stable angina of effort and any resulting change in symptoms is attributed to several effects of nifedipine. However, there have been...

...N. Schoenfeld; J. Aelion; Y. Beigel; O. Epstein; A. Atsmon 1. Treatment of monolayers of chick embryo hepatocytes with the calcium channel blocking drugs nifedipine and verapamil resulted in a decrease in the activity of uroporphyrinogen decarboxylase, an increase in the activity of δ...

...Bernward Garthoff; Wolfgang Ebsen; Georg Luckhaus; Stanislav Kazda; Drori Ben-Ishay 1. The effects of chronic dietary salt-loading and nifedipine therapy on hypertension-prone (SBH), -resistant (SBN) and parental (SB) Sabra rats were investigated. Salt diet for 12 weeks resulted in a sustained...

... response (phase I) is followed by a response of slower onset but longer duration (phase II). We have examined the effects of manipulation of arterial blood gases, a Ca 2+ -entry blocker, nifedipine, and an ACE inhibitor, teprotide, on the pressor responses to a series of α-adrenoceptor agonists. In each...

...V. A. Alabaster; A. M. Solca 1. The effect of nifedipine on pressor dose-response curves to phenylephrine, α-methylnoradrenaline and angiotensin II was determined in anaesthetized cats pretreated with propranolol and atropine. 2. The selectivity of phenylephrine and α-methylnoradrenaline...

...Gloria Valdés; M. Eugenia Soto; Hector R. Croxatto; Teresa Bellolio; Ramón Corbalán; Pablo Casanegra 1. Nifedipine (20 mg) was given by mouth to seven patients with moderate essential hypertension receiving a low, normal or high sodium intake. The drug produced an important hypotensive effect...

...Harbans S. Wasir; Seshagiri P. Rao 1. Nifedipine, a slow-channel calcium blocker, causes smooth muscle relaxation and thereby results in falls in peripheral vascular resistance and systemic arterial pressure. 2. In an uncontrolled open study nifedipine was given sublingually to 10 patients...

...B. Garthoff; S. Kazda; G. Luckhaus; G. Nash 1. Addition of nifedipine to a high salt diet prevented the development of malignant hypertension in the Dahl salt-sensitive strain (Brookhaven) of rats (DS rats). 2. In DS rats with a pre-existent malignant hypertension nifedipine normalized blood...

... by concomitant calcium gluconate infusion, and after 2 weeks of treatment with nifedipine. 2. Pre-infusion plasma levels of angiotensin II, renin or aldosterone were not altered by acute mild hypercalcaemia or administration of nifedipine. The angiotensin II-induced increases in plasma aldosterone were also...

... hypertensive patients (PVP = 4.69 ± 1.45 pmol/l, P < 0.005; UVP = 107 ± 17 pmol/day, P < 0.01). 3. In a group of 12 moderately hypertensive patients the blood pressure reduction induced by a single 20 mg dose of nifedipine was associated with an increase in PVP from 1.48 ± 0.57 to 2.48 ± 0.74 pmol/l ( P...

...J. A. Millar; Kathleen McLean; J. L. Reid 1. The effect of the calcium antagonist nifedipine on the pressor and aldosterone responses to angiotensin II was studied in six normal subjects. 2. Blood pressure, pulse rate and plasma aldosterone, potassium and cortisol were measured during paired...