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Keywords: nitrate tolerance
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Clin Sci (Lond) (2015) 129 (2): 179–187.
Published: 24 April 2015
..., their therapeutic utility is limited due to the development of tolerance or diminished response with repeated use, their decreased efficacy under oxidative stress conditions and their potential cytotoxicity [ 2 ]. In the clinic, nitrate tolerance significantly limits the use of this class of nitrovasodilator...