... activation and as such may be an effective treatment for coronary artery disease. inflammation leucocyte adhesion nitrate tolerance nitric oxide nitroxyl • HNO donors are currently being assessed clinically for their therapeutic utility in cardiovascular disorders such as heart failure...

... nitrate tolerance nitroxyl vasodilation • Pre-clincial studies have identified HNO, the reduced congener of NO • , as a potent vasodilator which is resistant to tolerance development. • The present study explores the efficacy of HNO in human blood vessels and describes, for the first time...