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Keywords: nitric oxide
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Clin Sci (Lond) (2025) 139 (05): 339–355.
Published: 13 March 2025
.... However, like the C-SFK group, the renal blood flow response to nitric oxide blockade was attenuated in the EA-SFK group compared with sham. In conclusion, long-term studies are needed to determine whether the higher hyperfiltration and disturbed vasodilator balance observed in EA-SFK sheep will cause...
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Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
... adrenergic receptor density, G protein-coupled receptor kinase 2 (GRK2) and the putative role of nitric oxide (NO). Sepsis was induced in female mice by cecal ligation and puncture (CLP). Wildtype mice were treated with prazosin 12 h after CLP or nitric oxide synthase 2 (NOS-2) inhibitor, 30 min before and 6...
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Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
... Angiotensin II type 2 receptor Bradykinin type 2 receptor Compound 21 Diet-induced obesity Mas receptor Nitric oxide Obesity has reached epidemic dimensions and is nowadays a major public health concern. Affecting more than 1 billion people worldwide, obesity is directly connected...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (20): 2755–2769.
Published: 30 October 2020
..., Meylan, France) according to an established protocol [ 29 ]. The urinary albumin to creatinine ratio was calculated and used as a measure of renal function. It is now very well established that reduced nitric oxide (NO) levels per se lead to loss of renal function [ 5 , 6 ]. Intra-renal...
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Clin Sci (Lond) (2019) 133 (23): 2401–2413.
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (20): 2061–2067.
Published: 18 October 2019
...Niwanthi W. Rajapakse; Beverly Giam; Sanjaya Kuruppu; Geoffrey A. Head; David M. Kaye The precise mechanisms underlying resistant hypertension remain elusive. Reduced nitric oxide (NO) bioavailability is frequently documented in chronic kidney disease, obesity, diabetes and advanced age, all...
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Clin Sci (Lond) (2016) 130 (18): 1629–1640.
Published: 08 August 2016
... that precede atherosclerosis was examined. They reduced endothelial cell inflammation and monocyte activation and as such may be an effective treatment for coronary artery disease. inflammation leucocyte adhesion nitrate tolerance nitric oxide nitroxyl 1 These authors contributed...
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Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...
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Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models. We tested whether high-dose FA treatment improves renal endothelial function and albuminuria in human subjects with incipient diabetic nephropathy. Following a double-blind...
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Clin Sci (Lond) (2014) 127 (4): 265–275.
Published: 29 April 2014
... by metformin. If this translates to humans, metformin could have additional benefits for post-menopausal women treated with this drug for glycaemic control. mesenteric bed metformin nitric oxide ovariectomy oxidative stress vascular dysfunction • The post-menopausal period in women...
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Clin Sci (Lond) (2014) 126 (8): 545–556.
Published: 20 December 2013
... -arginine methyl ester) [aNOS (nitric oxide synthase) inhibitor; 10 −4 mol/l] and wortmannin (PI3K inhibitor; 10 −7 mol/l); (iii) a specific S1P 1 receptor antagonist (W146; 10 μmol/l); and (iv) a monoclonal anti-PAR-2 primary antibody (SAM-11) [ 36 ] at a 1:1000 dilution. This antibody is directed to N...
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Clin Sci (Lond) (2014) 126 (6): 401–415.
Published: 15 November 2013
... in the RVLM of hypertensive rats [ 33 , 34 ]. blood pressure nitric oxide oxidative stress sympathetic nervous system statin Statins or HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors act competitively on the mevalonate pathway to reduce endogenous production of cholesterol...
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Clin Sci (Lond) (2013) 124 (12): 719–728.
Published: 26 February 2013
... the contribution of NO in this response the competitive NO synthase inhibitor L -NAME ( N G -nitro- L -arginine methyl ester, 100 μmol/l) was added to the bath 30 min before construction of the concentration–response curves. nitric oxide sex hormone transglutaminase (TG) vascular remodelling vascular...
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Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... relaxation of PCAs (porcine coronary arteries). Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on t BHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L -NMMA ( N G -monomethyl- L -arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin...
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Clin Sci (Lond) (2012) 122 (7): 337–348.
Published: 07 December 2011
... portal vein ligation, and the mechanisms involved in these alterations, if any. For this purpose, we analysed the vasoconstrictor response to EFS (electrical field stimulation) and the effect of the α-antagonist phentolamine, the NOS (nitric oxide synthase) inhibitor L -NAME ( N G -nitro- L -arginine...
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Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... nitric oxide oxidative stress Impaired oxidative phosphorylation is the hallmark of MDs (mitochondrial diseases), a heterogeneous group of prevalently genetic disorders, characterized by the uncoupling of electron transport and decreased ATP generation through the tricarboxylic acid cycle [ 1...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 122 (3): 105–111.
Published: 27 September 2011
...Nicole Lüneburg; Rouven-Alexander von Holten; Rudolf F. Töpper; Edzard Schwedhelm; Renke Maas; Rainer H. Böger Methylarginines have been shown to interfere with NO (nitric oxide) formation by inhibiting NOS (NO synthase)–ADMA (asymmetric dimethylarginine) and cellular L -arginine uptake...
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Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
... 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ischaemia/reperfusion ischaemic preconditioning liver nitric oxide reperfusion injury warm ischaemia Hepatic I/R (ischaemia/reperfusion) injury is an important clinical problem complicating liver...
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Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
... (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present...
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Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
...-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular...
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Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
... of endothelial denudation as a consequence of sheath placement. Radial artery flow-mediated and endothelium-derived NO (nitric oxide)-dependent function (FMD) was assessed within the region of sheath placement (sheath site) and also above the sheath (catheter site). GTN (glyceryl trinitrate) endothelium...
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Clin Sci (Lond) (2009) 117 (8): 293–303.
Published: 24 August 2009
... vasodilation end-stage renal disease nitric oxide skin blood flow Cardiovascular complications are the most important cause of mortality in ESRD (end-stage renal disease) patients [ 1 ]. In this population, one contributing factor to increased cardiovascular risk might be the accumulation...
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Clin Sci (Lond) (2009) 117 (1): 23–30.
Published: 02 June 2009
... 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 arginine citrulline isotope nitric oxide septic shock Arginine is a dispensable amino acid in normal health, but may be conditionally essential in stressed states such as sepsis [ 1 ]. In addition to acting...
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Clin Sci (Lond) (2009) 116 (9): 731–739.
Published: 02 April 2009
[email protected] ). 23 6 2008 2 9 2008 6 11 2008 6 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiac fibrosis glucocorticoid inflammation mineralocorticoid nitric oxide oxidative stress Large clinical trials have demonstrated a key role...
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Clin Sci (Lond) (2009) 116 (5): 433–441.
Published: 02 February 2009
.... Spin trapping and EPR (electron paramagnetic resonance) spectroscopy (see below) were performed on these blood samples to establish the efficacy of the antioxidant cocktail in reducing free radical load. antioxidant blood pressure elderly population exercise free radical nitric oxide...
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Clin Sci (Lond) (2009) 116 (3): 219–230.
Published: 08 January 2009
.... Correspondence: Professor Cuihua Zhang (email [email protected] ). 3 6 2008 22 7 2008 12 8 2008 inflammation macrovascular circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease...
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Clin Sci (Lond) (2008) 115 (2): 57–68.
Published: 12 June 2008
...-enediamine dihydrochloride was added and incubated for 15 min. The nitrite concentration was quantified in a spectrophotometer at A 540 against standards and after subtracting a blank from each individual sample. The final concentration is expressed in μg/day. biliary cirrhosis kidney nitric oxide...
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Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
... Biochemical Society 2008 diabetes mellitus diabetic nephropathy glomerular filtration rate hyperfiltration nitric oxide rodent model In T1DM, hyperfiltration appears to be absent early in the disease in approx. 30% of patients [ 13 ], whereas, in T2DM, hyperfiltration is probably absent...
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Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery SAP concentrations in plasma were measured using a sandwich ELISA...
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Clin Sci (Lond) (2007) 112 (2): 113–121.
Published: 11 December 2006
... 2006 9 8 2006 8 9 2006 8 9 2006 The Biochemical Society 2007 apoptosis cytochrome c release hypoxia/re-oxygenation mitochondrial cGMP mitochondrial permeability transition (MPT) nitric oxide adult rat cardiomyocyte Reperfusion therapy for acute myocardial...
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