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Keyword: nitric oxide
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Articles
Clin Sci (Lond) (2019) 133 (23): 2401–2413.
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide (NO...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (20): 2061–2067.
Published: 18 October 2019
...Niwanthi W. Rajapakse; Beverly Giam; Sanjaya Kuruppu; Geoffrey A. Head; David M. Kaye The precise mechanisms underlying resistant hypertension remain elusive. Reduced nitric oxide (NO) bioavailability is frequently documented in chronic kidney disease, obesity, diabetes and advanced age, all of...
Articles
Clin Sci (Lond) (2016) 130 (18): 1629–1640.
Published: 08 August 2016
... activation and as such may be an effective treatment for coronary artery disease. inflammation leucocyte adhesion nitrate tolerance nitric oxide nitroxyl • HNO donors are currently being assessed clinically for their therapeutic utility in cardiovascular disorders such as heart failure...
Articles
Clin Sci (Lond) (2016) 130 (7): 539–549.
Published: 17 February 2016
... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...
Articles
Clin Sci (Lond) (2015) 129 (8): 687–698.
Published: 22 July 2015
... and increases nitric oxide (NO) release via induction of inducible NO synthase (iNOS) within the vascular wall. Also, removal of endothelium prevented both NF-κB and iNOS expression in aortic rings. Among the proinflammatory factors released by LPS-treated endothelial cells, interleukin-6 accounts for...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 499–505.
Published: 17 June 2014
... acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models. We tested whether high-dose FA treatment improves renal endothelial function and albuminuria in human subjects with incipient diabetic nephropathy. Following a double-blind...
Articles
Clin Sci (Lond) (2014) 127 (4): 265–275.
Published: 29 April 2014
... metformin. If this translates to humans, metformin could have additional benefits for post-menopausal women treated with this drug for glycaemic control. mesenteric bed metformin nitric oxide ovariectomy oxidative stress vascular dysfunction • The post-menopausal period in women is...
Articles
Clin Sci (Lond) (2014) 126 (8): 545–556.
Published: 20 December 2013
... have critical effects on morphogenesis and embryonic development of the vasculature as well as of the heart [ 2 ]. S1P has direct vasoactive effect both on isolated vessel and in vivo [ 7 , 9 ]. eNOS (endothelial nitric oxide synthase) activation is a common feature of the S1P response in vascular...
Articles
Clin Sci (Lond) (2014) 126 (6): 401–415.
Published: 15 November 2013
... considered additional mechanisms by which statins lower cardiovascular risk. Correspondence: Dr John S. Floras (email john.floras@utoronto.ca ). 27 6 2013 27 8 2013 10 9 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 blood pressure nitric oxide...
Articles
Clin Sci (Lond) (2014) 126 (1): 19–29.
Published: 15 August 2013
... BP (blood pressure) in the SF rats. Correspondence: Dr Mohammed El-Hafidi (email medelhafidi@yahoo.com ). 25 3 2013 28 5 2013 6 6 2013 6 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 endothelial dysfunction glutathione nitric oxide...
Articles
Clin Sci (Lond) (2013) 125 (4): 183–189.
Published: 01 May 2013
... 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 nitric oxide renin inhibition reactive oxygen species (ROS) small artery vascular remodelling • Aliskiren represents an antihypertensive agent with a new mechanism based on the inhibition of a catalytic...
Articles
Clin Sci (Lond) (2013) 125 (2): 77–85.
Published: 26 March 2013
... ramaroson.andriantsitohaina@univ-angers.fr ). 20 8 2012 3 1 2013 4 2 2013 4 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 inflammation microparticle nitric oxide oxidative stress sepsis shock • Septic MPs may be protective in counteracting the fall...
Articles
Clin Sci (Lond) (2013) 124 (12): 719–728.
Published: 26 February 2013
... lara.delcampo@uam.es ). 21 12 2012 21 1 2013 21 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 nitric oxide sex hormone transglutaminase (TG) vascular remodelling vascular structure • Increasing evidence shows that sex hormones exert a...
Articles
Clin Sci (Lond) (2013) 124 (8): 543–552.
Published: 08 January 2013
.../licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. diabetic nephropathy mitochondrial proteins nitric oxide 3-nitrotyrosine oxidative stress proteomic analysis • During the...
Articles
Clin Sci (Lond) (2012) 123 (8): 509–518.
Published: 29 June 2012
... NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase (XO) In postmenopausal women, the incidence of CVD (cardiovascular disease) is much higher than in premenopausal women, implicating a potential impact of oestrogen in protecting cardiovascular health...
Articles
Clin Sci (Lond) (2012) 123 (8): 499–507.
Published: 27 June 2012
... relaxation of PCAs (porcine coronary arteries). Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on t BHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L -NMMA ( N G -monomethyl- L -arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin...
Articles
Clin Sci (Lond) (2012) 122 (7): 337–348.
Published: 07 December 2011
... portal vein ligation, and the mechanisms involved in these alterations, if any. For this purpose, we analysed the vasoconstrictor response to EFS (electrical field stimulation) and the effect of the α-antagonist phentolamine, the NOS (nitric oxide synthase) inhibitor L -NAME ( N G -nitro- L -arginine...
Articles
Clin Sci (Lond) (2012) 122 (7): 329–336.
Published: 07 December 2011
... compilation © 2012 Biochemical Society 2012 endothelial function endothelial progenitor cell erythropoietin ischaemia/reperfusion nitric oxide Animal models demonstrate marked tissue-protective effects of the glycoprotein EPO (erythropoietin) in cardiac and neural tissue [ 1 – 3 ]. These...
Articles
Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... nitric oxide oxidative stress Impaired oxidative phosphorylation is the hallmark of MDs (mitochondrial diseases), a heterogeneous group of prevalently genetic disorders, characterized by the uncoupling of electron transport and decreased ATP generation through the tricarboxylic acid cycle [ 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 122 (5): 239–251.
Published: 08 November 2011
... (inducible nitric oxide synthase), COX-2 (cyclooxygenase-2) and mPGES-1 (microsomal prostaglandin E synthase-1) induced by IL-1β. In contrast, the expression of HMGB1 (high-mobility group box 1) was not significantly modified. In addition, CoPP decreased the expression of iNOS and mPGES-1 in cells isolated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 122 (3): 105–111.
Published: 27 September 2011
...Nicole Lüneburg; Rouven-Alexander von Holten; Rudolf F. Töpper; Edzard Schwedhelm; Renke Maas; Rainer H. Böger Methylarginines have been shown to interfere with NO (nitric oxide) formation by inhibiting NOS (NO synthase)–ADMA (asymmetric dimethylarginine) and cellular L -arginine uptake into the...
Articles
Clin Sci (Lond) (2011) 121 (10): 449–458.
Published: 25 July 2011
...Luciana V. Rossoni; Mark Wareing; Camilla F. Wenceslau; Mahmood Al-Abri; Chris Cobb; Clare Austin Statins can have beneficial cholesterol-independent effects on vascular contractility, which may involve increases in the bioavailability of NO (nitric oxide) as a result of phosphorylation of eNOS...
Articles
Clin Sci (Lond) (2011) 121 (8): 331–341.
Published: 24 June 2011
... 2011 electrical field stimulation HgCl 2 noradrenaline nitric oxide vascular innervation Adverse effects of mercury exposure usually result from acute or chronic exposure to elemental mercury vapour, inorganic mercury salts or organic mercury compounds such as methylmercury. The toxic...
Articles
Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
... 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ischaemia/reperfusion ischaemic preconditioning liver nitric oxide reperfusion injury warm ischaemia Hepatic I/R (ischaemia/reperfusion) injury is an important clinical problem complicating liver...
Articles
Clin Sci (Lond) (2011) 121 (6): 257–266.
Published: 27 May 2011
...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...
Articles
Clin Sci (Lond) (2011) 120 (12): 525–536.
Published: 09 March 2011
... (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present...
Articles
Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
...-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular...
Articles
Clin Sci (Lond) (2010) 119 (7): 283–292.
Published: 25 June 2010
... 2010 11 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cirrhosis cyclo-oxygenase (COX) nitric oxide prostaglandin I 2 thromboxane A 2 Cirrhosis is associated with a hyperdynamic circulatory syndrome characterized by high cardiac output, and...
Articles
Clin Sci (Lond) (2010) 119 (1): 45–55.
Published: 07 April 2010
... equally to this work. Correspondence: Dr Han-Chieh Lin (email hclin@vghtpe.gov.tw ). 20 11 2009 27 1 2010 5 2 2010 5 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cirrhosis intrahepatic resistance microcirculation nitric oxide...
Articles
Clin Sci (Lond) (2010) 118 (10): 633–640.
Published: 23 February 2010
... likelihood of endothelial denudation as a consequence of sheath placement. Radial artery flow-mediated and endothelium-derived NO (nitric oxide)-dependent function (FMD) was assessed within the region of sheath placement (sheath site) and also above the sheath (catheter site). GTN (glyceryl trinitrate...
Articles
Clin Sci (Lond) (2010) 118 (5): 359–366.
Published: 01 December 2009
... atorvastatin. Correspondence: Dr Kristopher S Lyons (email kristopherlyons@hotmail.co.uk ). 22 7 2009 1 9 2009 9 9 2009 9 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 GTPase hyperlipidaemia isoprenoid nitric oxide statin platelet...
Articles
Clin Sci (Lond) (2010) 118 (5): 341–349.
Published: 23 November 2009
... endothelial vascular cell exercise nitric oxide pancreatic β-cell reactive oxygen species (ROS) The beneficial effects of aerobic exercise of moderate intensity in T2DM (Type 2 diabetes mellitus) are well documented with regard to glycaemic control and multiple CVD (cardiovascular disease) risk...
Articles
Clin Sci (Lond) (2009) 117 (10): 365–374.
Published: 07 September 2009
... through an increased vasodilator response. Correspondence: Dr Gloria Balfagón (email gloria.balfagon@uam.es ). 30 9 2008 3 2 2009 30 3 2009 30 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 acetylcholine aging nitric oxide portal...
Articles
Clin Sci (Lond) (2009) 117 (8): 293–303.
Published: 24 August 2009
... -dimethylarginine (ADMA) chronic haemodialysis endothelium-dependent vasodilation end-stage renal disease nitric oxide skin blood flow Cardiovascular complications are the most important cause of mortality in ESRD (end-stage renal disease) patients [ 1 ]. In this population, one contributing factor to...
Articles
Clin Sci (Lond) (2009) 117 (8): 305–312.
Published: 24 August 2009
... compilation © 2009 Biochemical Society 2009 dexamethasone electrical field stimulation hypertension glucocorticoid nitric oxide protein kinase C Glucocorticoid hormones play an important role in the control of vascular smooth muscle tone by acting on both endothelial and vascular smooth...
Articles
Clin Sci (Lond) (2009) 117 (1): 23–30.
Published: 02 June 2009
... arginine citrulline isotope nitric oxide septic shock Arginine is a dispensable amino acid in normal health, but may be conditionally essential in stressed states such as sepsis [ 1 ]. In addition to acting as a substrate for protein synthesis, arginine serves important physiological roles...
Articles
Clin Sci (Lond) (2009) 116 (9): 731–739.
Published: 02 April 2009
... (email morag.young@princehenrys.org ). 23 6 2008 2 9 2008 6 11 2008 6 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiac fibrosis glucocorticoid inflammation mineralocorticoid nitric oxide oxidative stress The action of...
Articles
Clin Sci (Lond) (2009) 116 (5): 433–441.
Published: 02 February 2009
.... Correspondence: Dr D. Walter Wray (email walter.wray@hsc.utah.edu ). 23 7 2008 27 8 2008 16 9 2008 16 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 antioxidant blood pressure elderly population exercise free radical nitric oxide...
Articles
Clin Sci (Lond) (2008) 115 (2): 57–68.
Published: 12 June 2008
..., mediated by anti-peroxinitrite-related effects. Correspondence: Dr María C. Ortiz (email clara@um.es ). 5 9 2007 19 12 2007 9 1 2008 9 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 biliary cirrhosis kidney nitric oxide nitrotyrosine...
Articles
Clin Sci (Lond) (2008) 114 (10): 651–659.
Published: 14 April 2008
.... Correspondence: Dr Silvia M. Arribas (email silvia.arribas@uam.es ). 12 10 2007 27 11 2007 19 12 2007 19 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 mesenteric resistance artery middle cerebral artery nitric oxide spontaneously hypertensive rat...
Articles
Clin Sci (Lond) (2009) 116 (3): 219–230.
Published: 08 January 2008
... circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease) accounts for over 500000 deaths annually in the United States. AMI (acute myocardial infarction), also known as a heart attack [ 1 ], is a common...
Articles
Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
... nephropathy glomerular filtration rate hyperfiltration nitric oxide rodent model Reviews on the pathogenesis of DN (diabetic nephropathy) have differed with respect to the importance of early elevations in GFR (glomerular filtration rate) commonly referred to as hyperfiltration. In the past...
Articles
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... 2007 amino acid arginine cancer metabolism nitric oxide stable isotope surgery We have described recently [ 1 ] that patients with malignant tumours inducing various degrees of metabolic derangements have decreased plasma arginine concentrations, even without weight loss being...
Articles
Clin Sci (Lond) (2007) 112 (2): 113–121.
Published: 11 December 2006
... mitochondrial permeability transition (MPT) nitric oxide adult rat cardiomyocyte Reperfusion therapy for acute myocardial infarction is known to reduce the infarct size, improve left ventricular function and reduce mortality. However, these beneficial effects are limited by acceleration of damage by...
Articles
Clin Sci (Lond) (2006) 111 (4): 275–280.
Published: 13 September 2006
...Anna R. Dover; Stanley Chia; James W. Ferguson; Nicholas L. Cruden; Ian L. Megson; Keith A. A. Fox; David E. Newby Enhanced iNOS (inducible nitric oxide synthase) activity may contribute to vascular dysfunction in patients with heart failure. In the present study, we aimed to determine whether iNOS...
Articles
Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA–albumin complexes derived from lauric (C 12:0 ), myristic (C 14:0 ), palmitic (C 16:0 ), stearic (C 18:0 ) and linolenic (C 18:3 ) acids. EDR induced by acetylcholine (0.1–10 μmol/l...
Articles
Clin Sci (Lond) (2006) 111 (1): 47–52.
Published: 14 June 2006
... track NO (nitric oxide)-mediated modulation of arterial smooth muscle tone. The changes in pressure pulse waveform morphology result from pulse wave reflection arising predominantly from smaller arteries and arterioles. Employing Doppler ultrasound to record the spectral flow velocity waveform in the...
Articles
Clin Sci (Lond) (2006) 110 (2): 227–233.
Published: 17 January 2006
... combination with a diruetic (hydrochlorothiazide) on BP (blood pressure) increase and renal injury induced by L -NAME ( N G -nitro- L -arginine methyl ester), an inhibitor of NO (nitric oxide) synthesis. Rats were untreated or received L -NAME alone, L -NAME+zofenopril+hydrochlorothiazide or L -NAME+enalapril...
Articles
Clin Sci (Lond) (2005) 109 (6): 523–530.
Published: 23 November 2005
...Melinda M. Parnell; Diane P. Holst; David M. Kaye We have reported previously a decrease in the clearance of the NO (nitric oxide) precursor L -arginine in the forearm circulation of CHF (congestive heart failure) patients, suggesting a potential rate-limiting mechanism contributing to the common...
Articles
Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
..., cell growth, apoptosis and hypertrophy. Furthermore, NADPH oxidase-derived superoxide contributes to the impairment of endothelium-dependent vasodilatation by inactivating nitric oxide; the resultant endothelial dysfunction is implicated in the pathophysiology of diseases such as atherosclerosis...