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Keywords: nitric oxide
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Articles

Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep

Open Access
Zoe McArdle, Reetu R. Singh, Sarah L. Walton, Karen M. Moritz, Kate M. Denton, Michiel F. Schreuder
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (05): 339–355.
https://doi.org/10.1042/CS20243031
Published: 13 March 2025
.... However, like the C-SFK group, the renal blood flow response to nitric oxide blockade was attenuated in the EA-SFK group compared with sham. In conclusion, long-term studies are needed to determine whether the higher hyperfiltration and disturbed vasodilator balance observed in EA-SFK sheep will cause...
View article titled, Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
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Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

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Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
https://doi.org/10.1042/CS20210462
Published: 18 October 2021
... adrenergic receptor density, G protein-coupled receptor kinase 2 (GRK2) and the putative role of nitric oxide (NO). Sepsis was induced in female mice by cecal ligation and puncture (CLP). Wildtype mice were treated with prazosin 12 h after CLP or nitric oxide synthase 2 (NOS-2) inhibitor, 30 min before and 6...
View article titled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury
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C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

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Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
https://doi.org/10.1042/CS20210049
Published: 11 May 2021
... Angiotensin II type 2 receptor Bradykinin type 2 receptor Compound 21 Diet-induced obesity Mas receptor Nitric oxide Obesity has reached epidemic dimensions and is nowadays a major public health concern. Affecting more than 1 billion people worldwide, obesity is directly connected...
View article titled, C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors
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Includes: Supplementary data
Articles

Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure

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Beverly Giam, Haru Nomura, Sanjaya Kuruppu, Po-Yin Chu, Sumia Essid, Helen Kiriazis, Xiao-Jun Du, David M. Kaye, Niwanthi W. Rajapakse
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (20): 2755–2769.
https://doi.org/10.1042/CS20200087
Published: 30 October 2020
..., Meylan, France) according to an established protocol [ 29 ]. The urinary albumin to creatinine ratio was calculated and used as a measure of renal function. It is now very well established that reduced nitric oxide (NO) levels per se lead to loss of renal function [ 5 , 6 ]. Intra-renal...
View article titled, Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure
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Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

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Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Eloisa Rubio-Beltrán, Janette J. van der Linden, René de Vries, Richard van Veghel, Martine de Boer, Matej Durik, Yanto Ridwan, Renata Brandt, Jeroen Essers, Robert I. Menzies, Rachel Thomas, Alain de Bruin, Dirk J. Duncker, Heleen M.M. van Beusekom, Mohsen Ghanbari, Jan H.J. Hoeijmakers, Radislav Sedlacek, Rhian M. Touyz, Augusto C. Montezano, Ingrid van der Pluijm, A.H. Jan Danser, Kristian A. Haanes, Anton J.M. Roks
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 727–746.
https://doi.org/10.1042/CS20190124
Published: 07 April 2020
... responses measured in organ baths were decreased in aorta, iliac and coronary artery EC-KO compared with WT, of which coronary artery was the earliest to be affected. Nitric oxide-mediated endothelium-dependent vasodilation was abolished in aorta and coronary artery, whereas endothelium-derived...
View article titled, Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction
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Includes: Supplementary data
Articles

Angiotensin II inhibits DDAH1–nNOS signaling via AT1R and μOR dimerization to modulate blood pressure control in the central nervous system

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Gwo-Ching Sun, Tzyy-Yue Wong, Hsin-Hung Chen, Chiu-Yi Ho, Tung-Chen Yeh, Wen-Yu Ho, Ching-Jiunn Tseng, Pei-Wen Cheng
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (23): 2401–2413.
https://doi.org/10.1042/CS20191005
Published: 04 December 2019
...) expression was abolished in the NTS of adult spontaneously hypertensive rats (SHRs). Endomorphin-2 was overexpressed in NTS of adult SHRs compared with that in 6-week-old Wistar-Kyoto rats (WKY). Administration of μOR agonist into the NTS of WKY increased blood pressure (BP), decreased nitric oxide...
View article titled, Angiotensin II inhibits DDAH1–nNOS signaling via AT1R and μOR dimerization to modulate blood pressure control in the central nervous system
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Includes: Supplementary data
Articles

Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension

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Niwanthi W. Rajapakse, Beverly Giam, Sanjaya Kuruppu, Geoffrey A. Head, David M. Kaye
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (20): 2061–2067.
https://doi.org/10.1042/CS20190851
Published: 18 October 2019
...Niwanthi W. Rajapakse; Beverly Giam; Sanjaya Kuruppu; Geoffrey A. Head; David M. Kaye The precise mechanisms underlying resistant hypertension remain elusive. Reduced nitric oxide (NO) bioavailability is frequently documented in chronic kidney disease, obesity, diabetes and advanced age, all...
View article titled, Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension
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Articles

Nitroxyl (HNO) reduces endothelial and monocyte activation and promotes M2 macrophage polarization

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Karen L. Andrews, Amanda K. Sampson, Jennifer C. Irvine, Waled A. Shihata, Danielle L. Michell, Natalie G. Lumsden, Chloe Lim, Olivier Huet, Grant R. Drummond, Barbara K. Kemp-Harper, Jaye P. F. Chin-Dusting
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1629–1640.
https://doi.org/10.1042/CS20160097
Published: 08 August 2016
... that precede atherosclerosis was examined. They reduced endothelial cell inflammation and monocyte activation and as such may be an effective treatment for coronary artery disease. inflammation leucocyte adhesion nitrate tolerance nitric oxide nitroxyl 1 These authors contributed...
View article titled, Nitroxyl (HNO) reduces endothelial and monocyte activation and promotes M2 macrophage polarization
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Articles

Mechanism of vascular dysfunction due to circulating factors in women with pre-eclampsia

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Cindy K. Kao, Jude S. Morton, Anita L. Quon, Laura M. Reyes, Patricio Lopez-Jaramillo, Sandra T. Davidge
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (7): 539–549.
https://doi.org/10.1042/CS20150678
Published: 17 February 2016
... after 20 weeks of gestation. However, the mechanisms leading to altered vascular reactivity remain unclear. We hypothesized that circulating factors lead to endothelial dysfunction by increasing oxidative stress and reducing nitric oxide (NO) and prostaglandin (PG) bioavailability. Pregnant rat uterine...
View article titled, Mechanism of vascular dysfunction due to circulating factors in women with pre-eclampsia
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Articles

Interaction in endothelium of non-muscular myosin light-chain kinase and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity

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Sylvain Recoquillon, Nunzia Carusio, Anne-Hélène Lagrue-Lakhal, Simon Tual-Chalot, Amelia Filippelli, Ramaroson Andriantsitohaina, M. Carmen Martinez
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (8): 687–698.
https://doi.org/10.1042/CS20140625
Published: 22 July 2015
... and increases nitric oxide (NO) release via induction of inducible NO synthase (iNOS) within the vascular wall. Also, removal of endothelium prevented both NF-κB and iNOS expression in aortic rings. Among the proinflammatory factors released by LPS-treated endothelial cells, interleukin-6 accounts...
View article titled, Interaction in endothelium of non-muscular myosin light-chain kinase and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity
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Includes: Supplementary data
Articles

Effects of folic acid on renal endothelial function in patients with diabetic nephropathy: results from a randomized trial

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Markus P. Schneider, Andreas Schneider, Agnes Jumar, Iris Kistner, Christian Ott, Roland E. Schmieder
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (7): 499–505.
https://doi.org/10.1042/CS20140111
Published: 17 June 2014
... acid (FA) improves nitric oxide synthase (NOS) function and reduces progression of diabetic nephropathy in animal models. We tested whether high-dose FA treatment improves renal endothelial function and albuminuria in human subjects with incipient diabetic nephropathy. Following a double-blind...
View article titled, Effects of folic acid on renal endothelial function in patients with diabetic nephropathy: results from a randomized trial
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Articles

Metformin ameliorates ovariectomy-induced vascular dysfunction in non-diabetic Wistar rats

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Phablo Wendell C. Oliveira, Glauciene J. de Sousa, Izabela F. Caliman, Aline Z. Lamas, Ana Raquel Santos de Medeiros, Tadeu U. de Andrade, Glaucia R. de Abreu, Suely G. de Figueiredo, Nazaré S. Bissoli
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (4): 265–275.
https://doi.org/10.1042/CS20130553
Published: 29 April 2014
... by metformin. If this translates to humans, metformin could have additional benefits for post-menopausal women treated with this drug for glycaemic control. mesenteric bed metformin nitric oxide ovariectomy oxidative stress vascular dysfunction • The post-menopausal period in women...
View article titled, Metformin ameliorates ovariectomy-induced vascular dysfunction in non-diabetic Wistar rats
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Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate

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Fiorentina Roviezzo, Antonella De Angelis, Luana De Gruttola, Antonio Bertolino, Nikol Sullo, Vincenzo Brancaleone, Mariarosaria Bucci, Raffaele De Palma, Konrad Urbanek, Bruno D’Agostino, Angela Ianaro, Raffaella Sorrentino, Giuseppe Cirino
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (8): 545–556.
https://doi.org/10.1042/CS20130272
Published: 20 December 2013
... -arginine methyl ester) [aNOS (nitric oxide synthase) inhibitor; 10 −4 mol/l] and wortmannin (PI3K inhibitor; 10 −7 mol/l); (iii) a specific S1P 1 receptor antagonist (W146; 10 μmol/l); and (iv) a monoclonal anti-PAR-2 primary antibody (SAM-11) [ 36 ] at a 1:1000 dilution. This antibody is directed to N...
View article titled, Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate
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Articles

Statins and the autonomic nervous system

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Philip J. Millar, John S. Floras
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (6): 401–415.
https://doi.org/10.1042/CS20130332
Published: 15 November 2013
... in the RVLM of hypertensive rats [ 33 , 34 ]. blood pressure nitric oxide oxidative stress sympathetic nervous system statin Statins or HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors act competitively on the mevalonate pathway to reduce endogenous production of cholesterol...
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Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats

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Angélica Ruiz-Ramírez, Ely Ortiz-Balderas, Guillermo Cardozo-Saldaña, Eulises Diaz-Diaz, Mohammed El-Hafidi
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (1): 19–29.
https://doi.org/10.1042/CS20130164
Published: 15 August 2013
...). Correspondence: Dr Mohammed El-Hafidi (email [email protected] ). 25 3 2013 28 5 2013 6 6 2013 6 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 endothelial dysfunction glutathione nitric oxide obesity oxidative stress vascular complication...
View article titled, Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats
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The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes

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Carmine Savoia, Emanuele Arrabito, Rosa Parente, Lidia Sada, Luca Madaro, Carmine Nicoletti, Luigi Zezza, Alessandro Alonzo, Speranza Rubattu, Serena Michelini, Dominik N. Muller, Massimo Volpe
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (4): 183–189.
https://doi.org/10.1042/CS20120395
Published: 01 May 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 nitric oxide renin inhibition reactive oxygen species (ROS) small artery vascular remodelling • Aliskiren represents an antihypertensive agent with a new mechanism based on the inhibition of a catalytic activity...
View article titled, The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes
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Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

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Hadj Ahmed Mostefai, Jean-Michel Bourget, Ferhat Meziani, Maria Carmen Martinez, Daniela Leonetti, Alain Mercat, Pierre Asfar, Lucie Germain, Ramaroson Andriantsitohaina
Journal: Clinical Science
Clin Sci (Lond) (2013) 125 (2): 77–85.
https://doi.org/10.1042/CS20120441
Published: 26 March 2013
.... inflammation microparticle nitric oxide oxidative stress sepsis shock 1 Present address: Service de réanimation médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; and Laboratoire de Biophotonique et Pharmacologie, UMR 7213 CNRS, Université de...
View article titled, Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media
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Testosterone and β-oestradiol prevent inward remodelling of rat small mesenteric arteries: role of NO and transglutaminase

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Lara del Campo, Bilge Guvenc Tuna, Mercedes Ferrer, Ed van Bavel, Erik N.T.P. Bakker
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (12): 719–728.
https://doi.org/10.1042/CS20120700
Published: 26 February 2013
... the contribution of NO in this response the competitive NO synthase inhibitor L -NAME ( N G -nitro- L -arginine methyl ester, 100 μmol/l) was added to the bath 30 min before construction of the concentration–response curves. nitric oxide sex hormone transglutaminase (TG) vascular remodelling vascular...
View article titled, Testosterone and β-oestradiol prevent inward remodelling of rat small mesenteric arteries: role of NO and transglutaminase
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Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats

Open Access
Naohito Ishii, Pamela K. Carmines, Masanori Yokoba, Hiroyuki Imaizumi, Tsuyoshi Ichikawa, Hideki Ikenagasa, Yoshio Kodera, Masamichi Oh-Ishi, Yoshikazu Aoki, Tadakazu Maeda, Tsuneo Takenaka, Masato Katagiri
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (8): 543–552.
https://doi.org/10.1042/CS20120251
Published: 08 January 2013
... and reproduction in any medium, provided the original work is properly cited. diabetic nephropathy mitochondrial proteins nitric oxide 3-nitrotyrosine oxidative stress proteomic analysis The methods used for in-gel digestion were described previously [ 16 ]. In brief, protein spots were...
View article titled, Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats
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Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis

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Ji-Youn Youn, Andrew Nguyen, Hua Cai
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (8): 509–518.
https://doi.org/10.1042/CS20110407
Published: 29 June 2012
... purchased from Calbiochem and Tocris Bioscience respectively. DES (7-days release) and 17β-oestradiol tablets were obtained from Innovative Research of America. combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion...
View article titled, Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis
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Articles

Red wine extract protects against oxidative-stress-induced endothelial senescence

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Ilse P. G. Botden, Hisko Oeseburg, Matej Durik, Frank P. J. Leijten, Leonie C. Van Vark-Van Der Zee, Usha M. Musterd-Bhaggoe, Ingrid M. Garrelds, Ann L. B. Seynhaeve, Janneke G. Langendonk, Eric J. G. Sijbrands, A. H. Jan Danser, Anton J. M. Roks
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (8): 499–507.
https://doi.org/10.1042/CS20110679
Published: 27 June 2012
... relaxation of PCAs (porcine coronary arteries). Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on t BHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L -NMMA ( N G -monomethyl- L -arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin...
View article titled, Red wine extract protects against oxidative-stress-induced endothelial senescence
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Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion

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Lindsey Tilling, Joanne Hunt, Ann Donald, Brian Clapp, Phil Chowienczyk
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (7): 329–336.
https://doi.org/10.1042/CS20110369
Published: 07 December 2011
... by increasing expression of the erythropoietin receptor and by a mechanism likely to involve Akt/NO rather than circulating EPCs. © The Authors Journal compilation © 2012 Biochemical Society 2012 endothelial function endothelial progenitor cell erythropoietin ischaemia/reperfusion nitric oxide...
View article titled, Darbepoetin enhances endothelium-dependent vasomotor function in patients with stable coronary artery disease only after preceding ischaemia/reperfusion
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Effect of short- and long-term portal hypertension on adrenergic, nitrergic and sensory functioning in rat mesenteric artery

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Esther Sastre, Gloria Balfagón, Elena Revuelta-López, Maria-Ángeles Aller, Maria-Paz Nava, Jaime Arias, Javier Blanco-Rivero
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (7): 337–348.
https://doi.org/10.1042/CS20110303
Published: 07 December 2011
... portal vein ligation, and the mechanisms involved in these alterations, if any. For this purpose, we analysed the vasoconstrictor response to EFS (electrical field stimulation) and the effect of the α-antagonist phentolamine, the NOS (nitric oxide synthase) inhibitor L -NAME ( N G -nitro- L -arginine...
View article titled, Effect of short- and long-term portal hypertension on adrenergic, nitrergic and sensory functioning in rat mesenteric artery
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Endothelial dysfunction and increased oxidative stress in mitochondrial diseases

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Pietro Minuz, Cristiano Fava, Gaetano Vattemi, Guido Arcaro, Matteo Riccadonna, Paola Tonin, Alessandra Meneguzzi, Maurizio Degan, Valeria Guglielmi, Alessandro Lechi, Giuliano Tomelleri
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (6): 289–299.
https://doi.org/10.1042/CS20110199
Published: 22 November 2011
... nitric oxide oxidative stress Impaired oxidative phosphorylation is the hallmark of MDs (mitochondrial diseases), a heterogeneous group of prevalently genetic disorders, characterized by the uncoupling of electron transport and decreased ATP generation through the tricarboxylic acid cycle [ 1...
View article titled, Endothelial dysfunction and increased oxidative stress in mitochondrial diseases
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Includes: Supplementary data
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Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage–subchondral bone explants from osteoarthritic patients

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Victoria Clérigues, Maria Isabel Guillén, Francisco Gomar, Maria José Alcaraz
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (5): 239–251.
https://doi.org/10.1042/CS20100519
Published: 08 November 2011
... nitric oxide synthase), COX-2 (cyclooxygenase-2) and mPGES-1 (microsomal prostaglandin E synthase-1) induced by IL-1β. In contrast, the expression of HMGB1 (high-mobility group box 1) was not significantly modified. In addition, CoPP decreased the expression of iNOS and mPGES-1 in cells isolated from...
View article titled, Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage–subchondral bone explants from osteoarthritic patients
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Includes: Supplementary data
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Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function

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Nicole Lüneburg, Rouven-Alexander von Holten, Rudolf F. Töpper, Edzard Schwedhelm, Renke Maas, Rainer H. Böger
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (3): 105–111.
https://doi.org/10.1042/CS20110013
Published: 27 September 2011
...Nicole Lüneburg; Rouven-Alexander von Holten; Rudolf F. Töpper; Edzard Schwedhelm; Renke Maas; Rainer H. Böger Methylarginines have been shown to interfere with NO (nitric oxide) formation by inhibiting NOS (NO synthase)–ADMA (asymmetric dimethylarginine) and cellular L -arginine uptake...
View article titled, Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function
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Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries

Open Access
Luciana V. Rossoni, Mark Wareing, Camilla F. Wenceslau, Mahmood Al-Abri, Chris Cobb, Clare Austin
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (10): 449–458.
https://doi.org/10.1042/CS20110259
Published: 25 July 2011
...Luciana V. Rossoni; Mark Wareing; Camilla F. Wenceslau; Mahmood Al-Abri; Chris Cobb; Clare Austin Statins can have beneficial cholesterol-independent effects on vascular contractility, which may involve increases in the bioavailability of NO (nitric oxide) as a result of phosphorylation of eNOS...
View article titled, Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries
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Chronic HgCl 2 treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervation

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Javier Blanco-Rivero, Lorena B. Furieri, Dalton V. Vassallo, Mercedes Salaices, Gloria Balfagón
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (8): 331–341.
https://doi.org/10.1042/CS20110072
Published: 24 June 2011
... in mesenteric arteries, as well as the mechanisms involved in these effects. © The Authors Journal compilation © 2011 Biochemical Society 2011 electrical field stimulation HgCl 2 noradrenaline nitric oxide vascular innervation The drugs used were L -NA ( N G -nitro- L -arginine...
View article titled, Chronic HgCl 2 treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervation
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Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury

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Narci C. Teoh
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (6): 253–255.
https://doi.org/10.1042/CS20110243
Published: 27 May 2011
... 2011 10 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ischaemia/reperfusion ischaemic preconditioning liver nitric oxide reperfusion injury warm ischaemia Hepatic I/R (ischaemia/reperfusion) injury is an important clinical problem complicating liver...
View article titled, Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury
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Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury

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Mahmoud Abu-Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Achala De Mel, Niteen Tapuria, Alexander Seifalian, Brian Davidson, Barry Fuller
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (6): 257–266.
https://doi.org/10.1042/CS20100598
Published: 27 May 2011
...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...
View article titled, Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury
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Articles

Impaired resistance artery function in patients with end-stage renal disease

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Natallia Luksha, Leanid Luksha, Juan Jesús Carrero, Folke Hammarqvist, Peter Stenvinkel, Karolina Kublickiene
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (12): 525–536.
https://doi.org/10.1042/CS20100277
Published: 09 March 2011
... (end-stage renal disease) patients starting peritoneal dialysis and 30 matched controls were studied using isolated small artery bioassays. Flow-mediated dilatation was attenuated in ESRD patients compared with controls. NO (nitric oxide) contribution to flow was lacking in ESRD patients, but present...
View article titled, Impaired resistance artery function in patients with end-stage renal disease
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Articles

Aging and vascular endothelial function in humans

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Douglas R. Seals, Kristen L. Jablonski, Anthony J. Donato
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (9): 357–375.
https://doi.org/10.1042/CS20100476
Published: 18 January 2011
...-dependent dilation) in response to chemical [typically ACh (acetylcholine)] or mechanical (intravascular shear) stimuli. Reduced bioavailability of the endothelium-synthesized dilating molecule NO (nitric oxide) as a result of oxidative stress is the key mechanism mediating reduced EDD with aging. Vascular...
View article titled, Aging and vascular endothelial function in humans
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Articles

Simultaneous inhibition of TXA 2 and PGI 2 synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats

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Fabiano E. Xavier, Javier Blanco-Rivero, Esther Sastre, Lina Badimón, Gloria Balfagón
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (7): 283–292.
https://doi.org/10.1042/CS20090536
Published: 25 June 2010
... [email protected] ). © The Authors Journal compilation © 2010 Biochemical Society 2010 cirrhosis cyclo-oxygenase (COX) nitric oxide prostaglandin I 2 thromboxane A 2 Cirrhosis is associated with a hyperdynamic circulatory syndrome characterized by high cardiac output, and reduced...
View article titled, Simultaneous inhibition of TXA 2 and PGI 2 synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats
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Articles

Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability

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Kuei-Chuan Lee, Ying-Ying Yang, Yi-Tsau Huang, Fa-Yauh Lee, Ming-Chih Hou, Han-Chieh Lin, Shou-Dong Lee
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (1): 45–55.
https://doi.org/10.1042/CS20090601
Published: 07 April 2010
... microcirculation nitric oxide phosphodiesterase inhibitor tetrahydrobiopterin (BH 4 ) Portal hypertension is responsible for major complications of liver cirrhosis and leads to significant morbidity and mortality. Increased resistance to portal blood inflow is the initial haemodynamic derangement...
View article titled, Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability
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Articles

Impact of catheter insertion using the radial approach on vasodilatation in humans

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Ellen A. Dawson, Sudhir Rathore, N. Timothy Cable, D. Jay Wright, John L. Morris, Daniel J. Green
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (10): 633–640.
https://doi.org/10.1042/CS20090548
Published: 23 February 2010
... of endothelial denudation as a consequence of sheath placement. Radial artery flow-mediated and endothelium-derived NO (nitric oxide)-dependent function (FMD) was assessed within the region of sheath placement (sheath site) and also above the sheath (catheter site). GTN (glyceryl trinitrate) endothelium...
View article titled, Impact of catheter insertion using the radial approach on vasodilatation in humans
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Articles

Statins have beneficial effects on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia

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Paul K. Hamilton, Sinead M.T. Hughes, Richard D. Plumb, Adrian Devine, William Leahey, Kristopher S. Lyons, Dennis Johnston, Gary E. McVeigh
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (5): 359–366.
https://doi.org/10.1042/CS20090388
Published: 01 December 2009
... preparations for 24 h prior to study. Blood was drawn with minimal agitation and was separated into whole-blood (for lipid and glucose) and platelet (NO, O 2 •− and GTPases) samples. GTPase hyperlipidaemia isoprenoid nitric oxide statin platelet superoxide radical Statins [HMG-CoA (3...
View article titled, Statins have beneficial effects on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia
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Articles

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

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Philip Newsholme, Paulo I. Homem De Bittencourt, Jr, Ciara O' Hagan, Giuseppe De Vito, Colin Murphy, Mauricio S. Krause
Journal: Clinical Science
Clin Sci (Lond) (2010) 118 (5): 341–349.
https://doi.org/10.1042/CS20090433
Published: 23 November 2009
... endothelial vascular cell exercise nitric oxide pancreatic β-cell reactive oxygen species (ROS) The beneficial effects of aerobic exercise of moderate intensity in T2DM (Type 2 diabetes mellitus) are well documented with regard to glycaemic control and multiple CVD (cardiovascular disease) risk...
View article titled, Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide
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Articles

Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I 2

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Javier Blanco-Rivero, Ma Angeles Aller, Jaime Arias, Mercedes Ferrer, Gloria Balfagón
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (10): 365–374.
https://doi.org/10.1042/CS20080499
Published: 07 September 2009
... [email protected] ). 30 9 2008 3 2 2009 30 3 2009 30 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 acetylcholine aging nitric oxide portal hypertension prostaglandin I 2 vasodilation PH (portal hypertension) is a clinical syndrome...
View article titled, Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I 2
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Articles

Haemodialysis acutely reduces the plasma levels of ADMA without reversing impaired NO-dependent vasodilation

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Rolf P. Engelberger, Daniel Teta, Hughes Henry, Olivier De Senarclens, Benoît Dischl, Lucas Liaudet, Michel Burnier, Bernard Waeber, François Feihl
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (8): 293–303.
https://doi.org/10.1042/CS20080561
Published: 24 August 2009
... vasodilation end-stage renal disease nitric oxide skin blood flow Cardiovascular complications are the most important cause of mortality in ESRD (end-stage renal disease) patients [ 1 ]. In this population, one contributing factor to increased cardiovascular risk might be the accumulation...
View article titled, Haemodialysis acutely reduces the plasma levels of ADMA without reversing impaired NO-dependent vasodilation
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Articles

Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation

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Rosa Aras-López, Fabiano E. Xavier, Mercedes Ferrer, Gloria Balfagón
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (8): 305–312.
https://doi.org/10.1042/CS20080178
Published: 24 August 2009
... electrical field stimulation hypertension glucocorticoid nitric oxide protein kinase C Glucocorticoid hormones play an important role in the control of vascular smooth muscle tone by acting on both endothelial and vascular smooth muscle cells through glucocorticoid receptors [ 1 ]. In endothelial...
View article titled, Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation
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Articles

Arginine, citrulline and nitric oxide metabolism in sepsis

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Christina C. Kao, Venkata Bandi, Kalpalatha K. Guntupalli, Manhong Wu, Leticia Castillo, Farook Jahoor
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (1): 23–30.
https://doi.org/10.1042/CS20080444
Published: 02 June 2009
... 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 arginine citrulline isotope nitric oxide septic shock Arginine is a dispensable amino acid in normal health, but may be conditionally essential in stressed states such as sepsis [ 1 ]. In addition to acting...
View article titled, Arginine, citrulline and nitric oxide metabolism in sepsis
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Articles

Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart

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Peter Wilson, James Morgan, John W. Funder, Peter J. Fuller, Morag J. Young
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (9): 731–739.
https://doi.org/10.1042/CS20080247
Published: 02 April 2009
[email protected] ). 23 6 2008 2 9 2008 6 11 2008 6 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiac fibrosis glucocorticoid inflammation mineralocorticoid nitric oxide oxidative stress Large clinical trials have demonstrated a key role...
View article titled, Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart
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Articles

Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome

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D. Walter Wray, Abhimanyu Uberoi, Lesley Lawrenson, Damian M. Bailey, Russell S. Richardson
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (5): 433–441.
https://doi.org/10.1042/CS20080337
Published: 02 February 2009
.... Spin trapping and EPR (electron paramagnetic resonance) spectroscopy (see below) were performed on these blood samples to establish the efficacy of the antioxidant cocktail in reducing free radical load. antioxidant blood pressure elderly population exercise free radical nitric oxide...
View article titled, Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome
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Articles

Role of TNF-α in vascular dysfunction

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Hanrui Zhang, Yoonjung Park, Junxi Wu, Xiu ping Chen, Sewon Lee, Jiyeon Yang, Kevin C. Dellsperger, Cuihua Zhang
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (3): 219–230.
https://doi.org/10.1042/CS20080196
Published: 08 January 2009
.... Correspondence: Professor Cuihua Zhang (email [email protected] ). 3 6 2008 22 7 2008 12 8 2008 inflammation macrovascular circulation microvascular circulation nitric oxide reactive oxygen species (ROS) tumour necrosis factor-α (TNF-α) IHD (ischaemic heart disease...
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Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation

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Antonia Alcaraz, David Hernández, David Iyú, Rubén Mota, Noemí M. Atucha, Antonio J. Ortiz, Joaquín García-Estañ, María C. Ortiz
Journal: Clinical Science
Clin Sci (Lond) (2008) 115 (2): 57–68.
https://doi.org/10.1042/CS20070312
Published: 12 June 2008
...-enediamine dihydrochloride was added and incubated for 15 min. The nitrite concentration was quantified in a spectrophotometer at A 540 against standards and after subtracting a blank from each individual sample. The final concentration is expressed in μg/day. biliary cirrhosis kidney nitric oxide...
View article titled, Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation
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Articles

Hypertension increases middle cerebral artery resting tone in spontaneously hypertensive rats: role of tonic vasoactive factor availability

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José M. González, Beatriz Somoza, M. Victoria Conde, Maria S. Fernández-Alfonso, M. Carmen González, Silvia M. Arribas
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (10): 651–659.
https://doi.org/10.1042/CS20070361
Published: 14 April 2008
... was considered significant. mesenteric resistance artery middle cerebral artery nitric oxide spontaneously hypertensive rat stroke superoxide anion It is well known that large cerebral arteries are important contributors to cerebrovascular resistance and CBF (cerebral blood flow) regulation [ 1...
View article titled, Hypertension increases middle cerebral artery resting tone in spontaneously hypertensive rats: role of tonic vasoactive factor availability
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Articles

Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties

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David Z. Levine
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (2): 109–118.
https://doi.org/10.1042/CS20070088
Published: 11 December 2007
... Biochemical Society 2008 diabetes mellitus diabetic nephropathy glomerular filtration rate hyperfiltration nitric oxide rodent model In T1DM, hyperfiltration appears to be absent early in the disease in approx. 30% of patients [ 13 ], whereas, in T2DM, hyperfiltration is probably absent...
View article titled, Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties
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Articles

Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice

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Yvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (10): 527–532.
https://doi.org/10.1042/CS20060340
Published: 12 April 2007
... with an attenuated acute-phase response. This indicates that altered arginine metabolism may be an important characteristic of the metabolic changes in cancer. amino acid arginine cancer metabolism nitric oxide stable isotope surgery SAP concentrations in plasma were measured using a sandwich ELISA...
View article titled, Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice
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Articles

Cardiac mitochondrial cGMP stimulates cytochrome c release

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Kazuhiko Seya, Shigeru Motomura, Ken-Ichi Furukawa
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (2): 113–121.
https://doi.org/10.1042/CS20060144
Published: 11 December 2006
... 2006 9 8 2006 8 9 2006 8 9 2006 The Biochemical Society 2007 apoptosis cytochrome c release hypoxia/re-oxygenation mitochondrial cGMP mitochondrial permeability transition (MPT) nitric oxide adult rat cardiomyocyte Reperfusion therapy for acute myocardial...
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Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure

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Anna R. Dover, Stanley Chia, James W. Ferguson, Nicholas L. Cruden, Ian L. Megson, Keith A. A. Fox, David E. Newby
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (4): 275–280.
https://doi.org/10.1042/CS20060104
Published: 13 September 2006
...Anna R. Dover; Stanley Chia; James W. Ferguson; Nicholas L. Cruden; Ian L. Megson; Keith A. A. Fox; David E. Newby Enhanced iNOS (inducible nitric oxide synthase) activity may contribute to vascular dysfunction in patients with heart failure. In the present study, we aimed to determine whether iNOS...
View article titled, Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure
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