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1-17 of 17
Keywords: nitric oxide synthase
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Articles
P2X 7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction
Available to PurchaseChin-Wei Chiao, J. Eduardo da Silva-Santos, Fernanda R. Giachini, Rita C. Tostes, Ming-Jai Su, R. Clinton Webb
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (3): 131–141.
Published: 12 April 2013
... of novel clinical strategies for the management of sepsis/septic shock. © The Authors Journal compilation © 2013 Biochemical Society 2013 cyclo-oxygenase interleukin-1β lipopolysaccharide nitric oxide synthase P2X 7 receptor sepsis tumour necrosis factor All values...
Articles
Effect of chronic N -acetylcysteine treatment on the development of spontaneous hypertension
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 235–242.
Published: 17 January 2006
... parameters. N -acetylcysteine genetic hypertension nuclear factor κB (NF-κB) nitric oxide synthase reactive oxygen species (ROS) NO (nitric oxide) plays an important role in the maintenance of vascular tone, which affects the level of BP (blood pressure) [ 1 – 3 ]. In various models...
Articles
Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end-products but not glucose: relevance to diabetes
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (5): 439–446.
Published: 24 October 2005
... ). 9 6 2005 15 7 2005 15 7 2005 15 7 2005 The Biochemical Society 2005 advanced glycation end-product (AGE) citrulline assay diabetes glucose nitric oxide synthase O-glycosylation serine phosphorylation Diabetes mellitus, whatever its cause, is characterized...
Articles
Specific effect of arachidonic acid on inducible nitric oxide synthase mRNA expression in human osteoblastic cells
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Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (2): 177–182.
Published: 25 July 2005
... nitric oxide synthase osteoblast A specific modulatory effect of PUFAs (polyunsaturated fatty acids) on bone metabolism has been suggested by several epidemiological, clinical and experimental studies [ 1 – 3 ]. Our laboratory is extremely interested in the study of the relationships between...
Articles
Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure
Available to PurchaseMasato OHNISHI, Atsuyuki WADA, Takayoshi TSUTAMOTO, Masanori FUJII, Takehiro MATSUMOTO, Takashi YAMAMOTO, Tomoyuki TAKAYAMA, Xinwen WANG, Masahiko KINOSHITA
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 241S–244S.
Published: 01 September 2002
... (Printed in Great Britain) Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure Masato OHNISHI*, Atsuyuki WADA*, Takayoshi TSUTAMOTO*, Masanori FUJII*, Takehiro MATSUMOTO*, Takashi YAMAMOTO*, Tomoyuki TAKAYAMA*, Xinwen WANG...
Articles
Delayed cardioprotective effects of exercise in dogs are aminoguanidine sensitive: possible involvement of nitric oxide
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Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (4): 435–445.
Published: 08 March 2002
...). Then, 24 or 48h later, the dogs were anaesthetized with a mixture of α-chloralose and urethane and subjected to a 25min occlusion of the left anterior descending coronary artery. The control dogs (instrumented but not exercised) were subjected to the same procedure. In some dogs the nitric oxide synthase...
Articles
Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease
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Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (5): 551–556.
Published: 10 April 2001
...Brian J. MORRIS; Cheryl L. GLENN; David E. L. WILCKEN; Xing Li WANG Pathophysiological processes in coronary artery disease (CAD) are influenced by genetic factors. Since (i) inducible nitric oxide synthase (iNOS) has important cardiovascular effects, and (ii) the promoter of the iNOS gene ( NOS2A...
Articles
Enhanced angiotensin-converting enzyme activity and impaired endothelium-dependent vasodilation in aortae from hypertensive rats: evidence for a causal link
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Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (2): 165–174.
Published: 16 June 1999
...., London WC1E 6JJ, U.K. The Biochemical Society and the Medical Research Society © 1999 1999 angiotensin-converting enzyme angiotensin type-1 receptor aortic coarctation B2 kinin receptor endothelium hypertension nitric oxide synthase 165Clinical Science (1999) 97, 165 174 (Printed...
Articles
Human placental nitric oxide synthase activity is not altered in diabetes
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (1): 123–128.
Published: 15 June 1999
...J. L. DI IULIO; N. M. GUDE; R. G. KING; C. G. LI; M.J. RAND; S. P. BRENNECKE Endothelial nitric oxide synthase (NOS) protein and mRNA have been identified and calcium-dependent NOS activity has been measured in human placentae during normal pregnancy. Recently, mRNA and protein for the inducible...
Articles
Increased Nitric Oxide Synthesis and Inducible Nitric Oxide Synthase Expression in Patients with Alcoholic and Non-Alcoholic Liver Cirrhosis
Available to PurchaseA. Sánchez-Rodríguez, M. Criado, A. M. Rodríguez-López, A. Esteller, A. Martín De Arriba, J. M. López-Novoa
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (6): 637–643.
Published: 01 June 1998
... analysed the synthesis of nitric oxide by the lympho-mononuclear cells of peripheral blood from patients with chronic alcoholic and non-alcoholic liver disease and we identified the isoform of nitric oxide synthase involved in the increased nitric oxide synthesis. 2. Patients were classified following...
Articles
Reduction of Placental Nitric Oxide Synthase Activity in Pre-Eclampsia
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Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (1): 51–55.
Published: 01 July 1997
...S. P. Brennecke; N. M. Gude; J. L. Di Iulio; R. G. King 1. The role of the potent vasodilator nitric oxide in the pathogenesis of pre-eclampsia is unclear. We have tested the hypothesis that placental activity of the enzyme which synthesizes nitric oxide (nitric oxide synthase) is reduced in pre...
Articles
Role of Nitric Oxide in Immune-Mediated Diseases
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (4): 375–384.
Published: 01 October 1996
...H. T. Cook; V. Cattell © 1996 The Biochemical Society and the Medical Research Society 1996 immune complex diseases immunity inflammation mediators nitric oxide nitric oxide synthase Clinical Science (1996) 91, 37M84 (Printed in Great Britain) Editorial Review 375 Role of nitric...
Articles
Differential Regulation of Cyclo-Oxygenase-1 and Cyclo-Oxygenase-2 Gene Expression by Lipopolysaccharide Treatment in vivo in the Rat
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (4): 301–306.
Published: 01 April 1996
...-fold in lipopolysaccharide-treated lungs and hearts respectively. Neither the down-regulation of COX-1 nor the upregulation of COX-2 mRNA induced by lipopolysaccharide was significantly affected by pretreatment with dexamethasone in lung and heart, although expression of inducible nitric oxide synthase...
Articles
l-Arginine Increases Exhaled Nitric Oxide in Normal Human Subjects
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (2): 135–139.
Published: 01 February 1995
...Sergei A. Kharitonov; Gert Lubec; Barbara Lubec; Magnus Hjelm; Peter J. Barnes 1. Endogenous nitric oxide plays an important physiological role and is synthesized by several isoforms of nitric oxide synthase from the semiessential amino acid l-arginine. Nitric oxide is detectable in the exhaled air...
Articles
Nitric Oxide Synthase Activity is Increased in Patients with Sepsis Syndrome
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (2): 131–133.
Published: 01 February 1995
...Helen F. Goode; Peter D. Howdle; Barry E. Walker; Nigel R. Webster 1. We measured nitric oxide synthase activity in peripheral blood polymorphonuclear leucocytes from 10 patients with sepsis syndrome and 10 healthy subjects. 2. Synthase activity was significantly higher in patients with sepsis than...
Articles
Cellular Localization of Inducible Nitric Oxide Synthase in Experimental Endotoxic Shock in the Rat
Available to PurchaseH. Terence Cook, Alison J. Bune, Albertine S. Jansen, G. Michael Taylor, Rashpal K. Loi, Victoria Cattell
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
... synthase septic shock spleen Clinical Science (1594) 87, 179-186 (Printed in Great Britain) I 79 Cellular localization of inducible nitric oxide synthase in experimental endotoxic shock in the rat H. Terence COOK, Alison J. BUNE, Albertine S. JANSEN, G. Michael TAYLOR, Rashpal K. LO1 and Victoria...
Articles
Involvement of Nitric Oxide in the Vasodilatory Response to Parathyroid Hormone-Related Peptide in the Isolated Rabbit Kidney
Available to PurchaseUmberto Simeoni, Thierry Massfelder, Christian Saussine, Clément Judes, Jean Geisert, Jean-Jacques Helwig
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (3): 245–249.
Published: 01 March 1994
... of endotheliumderived relaxing factor in regulation of renal hemdynamic responses. Am J Physiol 1990; W: H655-62. 12. Rees DD. Palmer RMJ. Schula R. Hudson HF, Moncada S. Characterization of three inhibiton d endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990; 101: 746-52. arginine. a novel L...