... of novel clinical strategies for the management of sepsis/septic shock. © The Authors Journal compilation © 2013 Biochemical Society 2013 cyclo-oxygenase interleukin-1β lipopolysaccharide nitric oxide synthase P2X 7 receptor sepsis tumour necrosis factor In sepsis, the immune...

... considered to differ significantly if the P value was <0.05. Linear regression analysis was used for evaluation of relationships between studied parameters. N -acetylcysteine genetic hypertension nuclear factor κB (NF-κB) nitric oxide synthase reactive oxygen species (ROS) BP...

... testing using Tukey's test. Statistical significance was taken as P <0.05 (two-tailed). advanced glycation end-product (AGE) citrulline assay diabetes glucose nitric oxide synthase O-glycosylation serine phosphorylation NOS-3 protein expression was determined in HUVECs by Western...

... (50 μmol/l) for 3 h. arachidonic acid bone metabolism fatty acid nitric oxide synthase osteoblast A specific modulatory effect of PUFAs (polyunsaturated fatty acids) on bone metabolism has been suggested by several epidemiological, clinical and experimental studies [ 1 – 3 ]. Our...

... (Printed in Great Britain) Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure Masato OHNISHI*, Atsuyuki WADA*, Takayoshi TSUTAMOTO*, Masanori FUJII*, Takehiro MATSUMOTO*, Takashi YAMAMOTO*, Tomoyuki TAKAYAMA*, Xinwen WANG...

...). Then, 24 or 48h later, the dogs were anaesthetized with a mixture of α-chloralose and urethane and subjected to a 25min occlusion of the left anterior descending coronary artery. The control dogs (instrumented but not exercised) were subjected to the same procedure. In some dogs the nitric oxide synthase...

...Brian J. MORRIS; Cheryl L. GLENN; David E. L. WILCKEN; Xing Li WANG Pathophysiological processes in coronary artery disease (CAD) are influenced by genetic factors. Since (i) inducible nitric oxide synthase (iNOS) has important cardiovascular effects, and (ii) the promoter of the iNOS gene ( NOS2A...

... : angiotensin-converting enzyme, angiotensin type-1 receptor, aortic coarctation, B # kinin receptor, endothelium, hypertension, nitric oxide synthase. Abbreviations : ACE, angiotensin-converting enzyme; AT " receptor, angiotensin type-1 receptor ; AAC rats, rats having undergone abdominal aortic coarctation...

...J. L. DI IULIO; N. M. GUDE; R. G. KING; C. G. LI; M.J. RAND; S. P. BRENNECKE Endothelial nitric oxide synthase (NOS) protein and mRNA have been identified and calcium-dependent NOS activity has been measured in human placentae during normal pregnancy. Recently, mRNA and protein for the inducible...

... analysed the synthesis of nitric oxide by the lympho-mononuclear cells of peripheral blood from patients with chronic alcoholic and non-alcoholic liver disease and we identified the isoform of nitric oxide synthase involved in the increased nitric oxide synthesis. 2. Patients were classified following...

...S. P. Brennecke; N. M. Gude; J. L. Di Iulio; R. G. King 1. The role of the potent vasodilator nitric oxide in the pathogenesis of pre-eclampsia is unclear. We have tested the hypothesis that placental activity of the enzyme which synthesizes nitric oxide (nitric oxide synthase) is reduced in pre...

...H. T. Cook; V. Cattell © 1996 The Biochemical Society and the Medical Research Society 1996 immune complex diseases immunity inflammation mediators nitric oxide nitric oxide synthase Clinical Science (1996) 91, 37M84 (Printed in Great Britain) Editorial Review 375 Role of nitric...

...-fold in lipopolysaccharide-treated lungs and hearts respectively. Neither the down-regulation of COX-1 nor the upregulation of COX-2 mRNA induced by lipopolysaccharide was significantly affected by pretreatment with dexamethasone in lung and heart, although expression of inducible nitric oxide synthase...

...Sergei A. Kharitonov; Gert Lubec; Barbara Lubec; Magnus Hjelm; Peter J. Barnes 1. Endogenous nitric oxide plays an important physiological role and is synthesized by several isoforms of nitric oxide synthase from the semiessential amino acid l-arginine. Nitric oxide is detectable in the exhaled air...

...Helen F. Goode; Peter D. Howdle; Barry E. Walker; Nigel R. Webster 1. We measured nitric oxide synthase activity in peripheral blood polymorphonuclear leucocytes from 10 patients with sepsis syndrome and 10 healthy subjects. 2. Synthase activity was significantly higher in patients with sepsis than...

... synthase septic shock spleen Clinical Science (1594) 87, 179-186 (Printed in Great Britain) I 79 Cellular localization of inducible nitric oxide synthase in experimental endotoxic shock in the rat H. Terence COOK, Alison J. BUNE, Albertine S. JANSEN, G. Michael TAYLOR, Rashpal K. LO1 and Victoria...

... of endotheliumderived relaxing factor in regulation of renal hemdynamic responses. Am J Physiol 1990; W: H655-62. 12. Rees DD. Palmer RMJ. Schula R. Hudson HF, Moncada S. Characterization of three inhibiton d endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990; 101: 746-52. arginine. a novel L...