...Lei Zhang; Zhi-Gang She; Hongliang Li; Xiao-Jing Zhang Non-alcoholic fatty liver disease (NAFLD) has become the fastest growing chronic liver disease, with a prevalence of up to 25% worldwide. Individuals with NAFLD have a high risk of disease progression to cirrhosis, hepatocellular carcinoma (HCC...

.... Induction of endogenous BAT function had a significant therapeutic impact on obesity, glucose tolerance and liver complications and is a potential new avenue for therapy of non-alcoholic fatty liver disease (NAFLD). Correspondence: Isabelle A. Leclercq (email [email protected] ). 23...

...Kate Hallsworth; Christian Thoma; Kieren G. Hollingsworth; Sophie Cassidy; Quentin M. Anstee; Christopher P. Day; Michael I. Trenell Although lifestyle changes encompassing weight loss and exercise remain the cornerstone of non-alcoholic fatty liver disease (NAFLD) management, the effect...

... Limited 2015 We found that moDCs (monocyte-derived dendritic cells) sustain hepatic inflammation during the progression of experimental NASH (non-alcoholic steatohepatitis). chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease...

...Daniel J. Cuthbertson; Andrew Irwin; Victoria S. Sprung; Helen Jones; Christopher J. A. Pugh; Christina Daousi; Valerie L. Adams; William E. Bimson; Fariba Shojaee-Moradie; Paul Richardson; A. Margot Umpleby; John P. Wilding; Graham J. Kemp Non-alcoholic fatty liver disease (NAFLD), characterized...

... has led to decreased physical activity and overeating, which dramatically increase the risks of obesity-related Type 2 diabetes, cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). These conditions each have insulin resistance as a common denominator. In this metabolic context...

.... NAFLD (non-alcoholic fatty liver disease) is becoming one of the most common liver diseases worldwide [ 1 ]. One still open issue in NAFLD pathogenesis concerns the mechanisms responsible for the switching from simple steatosis to NASH (non-alcoholic steatohepatitis). This aspect is clinically relevant...

...Adriana L. Burgueño; Tomas F. Gianotti; Noelia G. Mansilla; Carlos J. Pirola; Silvia Sookoian CVD (cardiovascular disease) is associated with abnormal liver enzymes, and NAFLD (non-alcoholic fatty liver disease) is independently associated with cardiovascular risk. To gain insights...

...Virginia Maina; Salvatore Sutti; Irene Locatelli; Matteo Vidali; Cristina Mombello; Cristina Bozzola; Emanuele Albano In humans, there is large inter-individual variability in the evolution of NAFLD (non-alcoholic fatty liver disease) to NASH (non-alcoholic steatohepatitis). To investigate...

... is implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In the present study, hepatic and plasma oxidative stress-related parameters were measured and correlated with clinical and histological findings in 31 NAFLD patients showing increased body mass index. Liver protein carbonyl content...

...Isabelle A. LECLERCQ This comment discusses the study by Videla and colleagues in this issue of Clinical Science in which they have analysed surgical liver biopsies from obese patients with non-alcoholic fatty liver disease and demonstrate that fatty liver is associated with a state of oxidative...