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Keywords: non-coding RNA
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Clin Sci (Lond) (2022) 136 (15): 1157–1178.
Published: 10 August 2022
.... With the advancement of the sequencing technology, it is revealed that the majority of our genome is non-coding. A growing body of literature demonstrates the critical role of long non-coding RNAs (lncRNAs) as epigenetic regulators of gene expression. LncRNAs can regulate cellular biological processes through various...
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Clin Sci (Lond) (2021) 135 (10): 1289–1293.
Published: 28 May 2021
.... 48 , 747 – 757 27213290 10.1038/ng.3568 21. Gupta R.A. , Shah N. , Wang K.C. , Kim J. , Horlings H.M. , Wong D.J. et al . ( 2010 ) Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis . Nature 464 , 1071 – 1076...
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Clin Sci (Lond) (2014) 126 (2): 95–110.
Published: 13 September 2013
..., a novel class of non-coding RNA, microRNA (miRNA), have emerged as being important regulators of numerous biological functions. Among these functions are basic maintenance of cell signalling and tissue architecture. Disruption of miRNA levels can contribute not only to the development of the chronic...
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Clin Sci (Lond) (2013) 125 (4): 151–166.
Published: 26 April 2013
... congenital heart disease microRNA non-coding RNA At the molecular level, complex gene regulatory networks involving a number of transcription factors, transcriptional co-activators and repressors, their corresponding enhancer and promoter elements and chromatin-modifying enzymes co-ordinate heart...
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Clin Sci (Lond) (2012) 123 (11): 611–625.
Published: 01 August 2012
.... Correspondence: Professor Andrea Münsterberg (email a.munsterberg@uea.ac.uk ). 7 12 2011 5 4 2012 21 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 microRNA muscle-associated disease muscle-specific miRNA (myomiR) muscular dystrophy non-coding RNA...
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Clin Sci (Lond) (2011) 121 (4): 141–158.
Published: 20 April 2011
.... Gene expression profiling based on mRNA has led to further refinement of the classification and diagnosis of cancer. More recently, miRNAs (microRNAs), among other small non-coding RNA molecules, have been discovered and found to be major players in cell biology. miRNAs, having both oncogenic...