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Keyword: noradrenaline
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Articles
Clin Sci (Lond) (2013) 124 (9): 589-595.
Published: 21 January 2013
.... Compared with 50 mg daily, losartan 200 mg/day decreased MSNA significantly ( P <0.05), by approximately 15 bursts/min, and increased MSNA variability within the 0.27–0.33 Hz high-frequency range by 0.11 units 2 /Hz ( P =0.06). PNE [plasma noradrenaline (norepinephrine)] fell in parallel with changes in...
Articles
Clin Sci (Lond) (2012) 122 (7): 337-348.
Published: 07 December 2011
... methyl ester) and the CGRP (calcitonin gene-related peptide) receptor antagonist CGRP-(8–37) in mesenteric segments from ST (short-term; 1 month) and LT (long-term; 21 months) SO (sham-operated) and pre-hepatic PH (portal hypertensive) rats. The vasomotor responses to NA (noradrenaline), the NO donor DEA...
Articles
Clin Sci (Lond) (2011) 121 (8): 331-341.
Published: 24 June 2011
... the mechanisms involved. Rats were divided into two groups: (i) control, and (ii) HgCl 2 -treated rats (30 days; first dose, 4.6 μg/kg of body weight; subsequent dose, 0.07 μg·kg −1 of body weight·day −1 , intramuscularly). Vasomotor response to EFS (electrical field stimulation), NA (noradrenaline...
Articles
Clin Sci (Lond) (2008) 114 (7): 489-497.
Published: 29 February 2008
... hypoxia and hypercapnia (i.e. HVR and HCVR), compared with those with normal chemosensitivity, had significantly (all P <0.01) higher noradrenaline (norepinephrine) and BNP (B-type natriuretic peptide) levels, higher prevalence of daytime and night-time CSR, worse NYHA (New York Heart Association...
Articles
Clin Sci (Lond) (2008) 114 (5): 375-380.
Published: 01 February 2008
..., catecholamines and ACE activity were determined in plasma. Circulating noradrenaline levels were significantly elevated in SGA girls compared with AGA girls ( P =0.036). In addition, angiotensin II and ACE activity were higher in SGA boys ( P =0.024 and P =0.050 respectively). There was a significant association...
Articles
Clin Sci (Lond) (2008) 114 (2): 157-164.
Published: 11 December 2007
...Fatemeh Amirahmadi; Lynne Turnbull; Xiao-Jun Du; Robert M. Graham; Elizabeth A. Woodcock Reperfusion of ischaemic rat or mouse hearts causes NE [noradrenaline (‘norepinephrine’)] release, stimulation of α 1 -ARs (α 1 -adrenergic receptors), PLC (phospholipase C) activation, Ins(1,4,5) P 3...
Articles
Clin Sci (Lond) (2006) 111 (2): 163-169.
Published: 13 July 2006
... and during both exercise work bouts for measurements of WBC count, leucocyte subset counts, cortisol, adrenaline (epinephrine) and noradrenaline (norepinephrine). WBC, neutrophil and lymphocyte counts increased significantly ( P <0.05) during rest and exercise from SL to PreIAE and decreased ( P...
Articles
Clin Sci (Lond) (2006) 110 (3): 329-336.
Published: 10 February 2006
... present study, we studied the acute effects of the imidazoline-receptor agonist moxonidine on haemodynamics, NA (noradrenaline) kinetics and myocardial metabolism. Fifteen patients with CHF (chronic heart failure) were randomized to a single dose of 0.6 mg of sustained-release moxonidine or matching...
Articles
Clin Sci (Lond) (2006) 110 (3): 369-377.
Published: 10 February 2006
... patients with Parkinson's disease (PD) with Hoehn and Yahr stages 1–4. Patients were investigated once with their regular treatment and once after 12 h of interruption of L -dopa treatment. L -Dopa intake significantly reduced systolic and diastolic blood pressure, heart rate and plasma noradrenaline and...
Articles
Clin Sci (Lond) (2005) 109 (5): 431-437.
Published: 24 October 2005
... present in the brain, kidney, heart and vasculature. However, each differentially influences blood pressure and sympathetic transmission. Activation of α 2A -ARs in cardiovascular control centres of the brain lowers blood pressure and decreases plasma noradrenaline (norepinephrine), activation of...
Articles
Clin Sci (Lond) (2003) 105 (3): 315-322.
Published: 01 September 2003
... adrenaline concentration (from 0.19±0.03 to 1.68±0.32 nmol/l; P <0.001), and a modest 1.3-fold increase in the plasma noradrenaline concentration (from 1.74±0.22 to 2.02±0.19 nmol/l; P <0.05) compared with baseline. Furthermore, we observed significant decreases in diastolic blood pressure (from 68±3...
Articles
Clin Sci (Lond) (2003) 104 (6): 649-654.
Published: 01 June 2003
...David S. GOLDSTEIN; Courtney HOLMES; Nicholas PATRONAS; Irwin J. KOPIN In multiple system atrophy (MSA) and pure autonomic failure (PAF), orthostatic hypotension (OH) results from deficient noradrenaline release from sympathetic nerves during standing. Post-mortem findings have indicated loss of...
Articles
Clin Sci (Lond) (2002) 103 (4): 397-402.
Published: 05 September 2002
... during the exogenous infusion of noradrenaline. We studied groups of non-diabetic normotensive subjects: eight with the wild-type Trp64Trp β 3 AR and eight with the Trp64Arg variant. The subjects each received, on two different days (randomized, double-blind fashion), a 4h infusion of either...
Articles
Clin Sci (Lond) (2002) 102 (6): 661-666.
Published: 14 May 2002
... antagonist of ET-1 has not been evaluated in the forearm. The present study investigated the effects of BQ-123 on changes in FBF in response to ET-1 and noradrenaline (NA; norepinephrine), taking into account the possible influence of vasodilator effects of BQ-123 on responses to vasoconstrictors. Six...
Articles
Clin Sci (Lond) (2001) 101 (4): 377-383.
Published: 14 September 2001
... before the first exercise session. Compared with sea level, hypoxia progressively decreased the maximal heart rate from day 1 and onwards; also, hypoxia by itself increased plasma noradrenaline levels after maximal exercise. Domperidone further increased maximal noradrenaline concentrations, but had no...
Articles
Clin Sci (Lond) (2000) 99 (1): 57-63.
Published: 14 June 2000
... activity in CHF. Correspondence : Dr Bronwyn Kingwell (e-mail b.kingwell@alfred.org.au ). 19 10 1999 14 1 2000 16 3 2000 The Biochemical Society and the Medical Research Society © 2000 2000 acetylcholine heart failure nitric oxide noradrenaline oxygen 57Clinical...
Articles
Clin Sci (Lond) (2000) 98 (2): 193-200.
Published: 11 January 2000
... effects with those of noradrenaline (NA; norepinephrine). All sheep were chronically instrumented. Six sheep received l -NMMA (7 mg·kg -1 ·h -1 ), six sheep received NA, and seven sheep received the carrier alone (0.9% NaCl). The NA dosage was continuously and individually adjusted to achieve the same...
Articles
Clin Sci (Lond) (1999) 97 (6): 639-647.
Published: 29 October 1999
... in normal renal interlobular and subcutaneous vessels from uraemic patients. In human subcutaneous arteries from uraemic subjects, noradrenaline- and KCl-induced vasoconstrictions were enhanced when nitric oxide (NO) production was blocked with N G -nitro- L -arginine methyl ester ( L -NAME), but...
Articles
Clin Sci (Lond) (1999) 97 (5): 539-546.
Published: 17 September 1999
...-arterial cannulation in either the dominant or the non-dominant forearm. Cannulation of a forearm brachial artery has a small effect on baseline blood flow. Responses to intra-arterially infused noradrenaline (norepinephrine) were not influenced by left or right arm dominance. Intravenous infusion of...
Articles
Clin Sci (Lond) (1999) 97 (3): 277-282.
Published: 15 July 1999
...; an inhibitor of NO biosynthesis), relative to the response to noradrenaline, has been reported in hypertensive patients and interpreted as evidence of reduced basal NO biosynthesis. We sought to determine whether reduced sensitivity of forearm vasculature to the vasoconstrictor action of l -NMMA...
Articles
Clin Sci (Lond) (1999) 96 (6): 613-621.
Published: 11 May 1999
... healthy subjects), but the acceleratory response to atropine, or to 60 ° head-up tilt, was maintained. Resting plasma noradrenaline levels were high in acute GBS, but the secretory response to tilt was preserved. Desensitization to noradrenaline was observed in acute GBS with a reduced pressor action of...
Articles
Clin Sci (Lond) (1999) 96 (6): 589-595.
Published: 07 May 1999
... and the Medical Research Society © 1999 1999 adrenaline catecholamines cortisol glucose infarct size myocardial infarction noradrenaline unstable angina 589Clinical Science (1999) 96, 589ñ595 (Printed in Great Britain) Circulating stress hormone and insulin concentrations in acute...
Articles
Clin Sci (Lond) (1999) 96 (5): 483-491.
Published: 14 April 1999
... -, β 2 - and β 3 -adrenoreceptors. Twenty-four-hour energy expenditure was 3.6% greater (8965±1301 versus 8648±1347 kJ, P < 0.05) with ephedrine than with placebo, but mechanical work was not different between the ephedrine and placebo periods. Noradrenaline excretion was lower with ephedrine (0.032...
Articles
Clin Sci (Lond) (1999) 96 (2): 191-197.
Published: 01 February 1999
... neurotransmitter stemming from the brain. By combining this technique with a noradrenaline and adrenaline isotope dilution method for examining neuronal transmitter release, we were able to examine the association between central nervous system neurotransmitters and efferent sympathetic nervous outflow and...
Articles
Clin Sci (Lond) (1998) 96 (1): 41-47.
Published: 01 January 1999
... operated. In rat aorta, there was no significant difference between portal hypertensive and sham-operated animals in the contractile potency of KCl, noradrenaline or phenylephrine. In aortas from Wistar rats, the maximum response to KCl (0.71±0.12 ;g) and noradrenaline (1.00±0.17 ;g) but not phenylephrine...
Articles
Clin Sci (Lond) (1998) 95 (1): 59-66.
Published: 01 July 1998
... calorimetry and sympathetic nervous system activity from noradrenaline kinetics using [ 3 H]noradrenaline in 12 older men (70±4 years) and 12 older women (66±4 years) at rest and during 30 min of submaximal exercise (45% of peak oxygen consumption). 3. At rest, men oxidized more fat than women on both an...
Articles
Clin Sci (Lond) (1998) 94 (6): 601-607.
Published: 01 June 1998
... nitroprusside (5 and 10 μg/min), before and after 1 h of sustained hypertension, induced by noradrenaline given intravenously. Identical measurements were made in 11 subjects before and during concomitant local intra-arterial infusion of noradrenaline without change in blood pressure and eight subjects were...
Articles
Clin Sci (Lond) (1998) 94 (6): 609-614.
Published: 01 June 1998
... the endogenous insulin response was inhibited with subcutaneous octreotide. 3. After placebo, hypertensive patients had slightly but significantly higher blood glucose levels than controls ( P < 0.0001), but comparable insulin concentrations ( P > 0.5). Plasma noradrenaline levels were...
Articles
Clin Sci (Lond) (1998) 94 (1): 21-28.
Published: 01 January 1998
... antibody. Plasma levels of endothelin-1, atrial and brain natriuretic peptides and noradrenaline were also measured. 3. Plasma levels of adrenomedullin were higher in patients with hypertrophic cardiomyopathy (8.43 ± 3.73 pmol/l) than in normal controls (5.24 ± 0.44 pmol/l, P < 0.005). There was no...
Articles
Clin Sci (Lond) (1997) 93 (6): 519-525.
Published: 01 December 1997
... occlusion venous plethysmography combined with brachial artery infusions of the nitric oxide synthase inhibitor, N G -monomethyl-l-arginine (l-NMMA; 1, 2 and 4 μmol/min) with noradrenaline (60, 120 and 240 pmol/min) as a control vasoconstrictor. We also measured urinary nitrate excretion after a controlled...
Articles
Clin Sci (Lond) (1997) 93 (3): 227-234.
Published: 01 September 1997
...-arginine to adriamycin-pregnant rats or of N G -nitro-l-arginine-methyl ester (l-NAME) to normal pregnant rats. In other experiments, we assessed the response of isolated perfused arterial mesenteric vessels, precontracted with noradrenaline, to acetylcholine, l-arginine or l-NAME. 3. Blood pressure was...
Articles
Clin Sci (Lond) (1997) 92 (4): 423-430.
Published: 01 April 1997
... Medical Research Society 1997 amino acid catecholamine dihydroxyphenylacetic acid 3,4-dihydroxyphenylalanine noradrenaline sympathetic activity Clinical Science (1997) 92,423-430 (Printed in Great Britain) 423 Effects of ordinary meals on plasma concentrations of 3,4=dihydroxyphenylalanine...
Articles
Clin Sci (Lond) (1997) 92 (3): 285-289.
Published: 01 March 1997
...Guido Grassi; Giambattista Bolla; Gino Seravalle; Carlo Turri; Antonio Lanfranchi; Giuseppe Mancia 1. Although plasma noradrenaline and muscle sympathetic nerve traffic have been shown to be suitable markers of sympathetic activity in man, no study has systematically compared the reproducibility...
Articles
Clin Sci (Lond) (1997) 92 (2): 133-138.
Published: 01 February 1997
... inhibitor, N G -monomethyl- l -arginine, and a control vasoconstrictor, noradrenaline. 2. Substance P and acetylcholine caused dose-dependent increases in forearm blood flow ( P < 0.001). When separated by 30 min saline infusions, repeated responses did not undergo tachyphylaxis. 3. Noradrenaline caused...
Articles
Clin Sci (Lond) (1996) 91 (5): 621-626.
Published: 01 November 1996
... subjects the proportion of natural killer cells was correlated with cAMP production in lymphocytes and inversely correlated with plasma noradrenaline level. 3. In 16 elderly non-smokers plasma noradrenaline was negatively correlated with the natural killer cell subset CD3–CD16+. Lymphocyte cAMP responses...
Articles
Clin Sci (Lond) (1996) 90 (5): 337-343.
Published: 01 May 1996
... catecholaminergic responses to lower body negative pressure depends on the intensity of the stimulus (−15 versus −40 mmHg). 2. In 14 healthy subjects, responses of forearm blood flow and noradrenaline spillover and of total body noradrenaline and adrenaline spillover were assessed during infusion of [ 3 H...
Articles
Clin Sci (Lond) (1995) 89 (4): 343-348.
Published: 01 October 1995
...Daniel Green; Gerry O'driscoll; Brian Blanksby; Roger Taylor 23 6 1995 23 6 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 antioxidants blood flow cigarette smoking forearm nitric oxide noradrenaline Clinical Science (1995) 89, 343-348...
Articles
Clin Sci (Lond) (1995) 89 (2): 145-154.
Published: 01 August 1995
... nervous activity in healthy, lean subjects. 2. In nine male subjects, noradrenaline spillover was measured from the heart, kidney and liver using isotope dilution, both while fasting and after consumption of a high-energy liquid meal of composition 53% carbohydrate, 32% fat and 15% protein (energy value...
Articles
Clin Sci (Lond) (1995) 88 (5): 533-542.
Published: 01 May 1995
... from plasma measurements of these metabolites in a number of clinical conditions (hypertension, cardiac failure, bilateral adrenalectomy and X-chromosomal deletions of the gene for monoamine oxidase), and before and during activation of sympathetic outflow or infusions of noradrenaline and adrenaline...
Articles
Clin Sci (Lond) (1995) 88 (5): 525-531.
Published: 01 May 1995
...Florence Wong; Arieh Bomzon; Alexander Logan; Laurence Blendis 1. This study assesses the effects of sodium status on venous responsiveness to noradrenaline and the neurohumoral profile in pre-ascitic cirrhotic patients. Eight cirrhotic patients and ten control subjects were studied after both a...
Articles
Clin Sci (Lond) (1995) 88 (4): 421-426.
Published: 01 April 1995
... microvascular disease. We have previously found that vasoconstrictive responses to noradrenaline are exaggerated in insulin-dependent diabetic patients with microalbuminuria as compared with both normoalbuminuric insulin-dependent diabetic patients and non-diabetic control subjects. 2. To determine whether this...
Articles
Clin Sci (Lond) (1995) 88 (4): 439-446.
Published: 01 April 1995
...Kjell Larsson; Per Carlens; Sture Bevegård; Paul Hjemdahl 1. Bronchoconstriction does not seem to be a stimulus for sympathoadrenal activation, as judged by venous plasma concentrations of noradrenaline, adrenaline or neuropeptide Y-like immunoreactivity. However, venous measurements have...
Articles
Clin Sci (Lond) (1994) 87 (1): 69-74.
Published: 01 July 1994
... shamfeeding (with the sight and smell of an English breakfast) and for 5 h after they had ingested the meal (3514kJ, 50% fat, 35% carbohydrate). The post-obese women had maintained their normal body weight for at least 3 months before the study. 2. The plasma noradrenaline concentration was not different...
Articles
Clin Sci (Lond) (1994) 86 (3): 245-249.
Published: 01 March 1994
... rabbit kidney perfused in the presence of indomethacin (10 μmol/l) and preconstricted with noradrenaline (7.2 nmol/min). 2. Under control conditions, bolus administrations of acetylcholine (10 μmol/l), an NO-dependent renal vasodilator, verapamil (0.1 mmol/l), an NO-independent renal vasodilator, and...
Articles
Clin Sci (Lond) (1994) 86 (2): 177-184.
Published: 01 February 1994
...A. Kurpad; K. Khan; A. G. Calder; S. Coppack; K. Frayn; I. MaCdonald; M. Elia 1. The effect of infusion of noradrenaline (0.42 μmol min −1 kg −1 ) on the exchange of non-esterified fatty acids, glycerol and other metabolites across subcutaneous abdominal adipose tissue was investigated in five...
Articles
Clin Sci (Lond) (1994) 86 (2): 149-158.
Published: 01 February 1994
... central α 2 -agonist clonidine at a dose that diminished cerebrospinal fluid noradrenaline, nor did cerebrospinal fluid dopamine β-hydroxylase correspond between subjects to cerebrospinal fluid concentrations of noradrenaline or methoxyhydroxyphenylglycol; thus, cerebrospinal fluid dopamine β-hydroxylase...
Articles
Clin Sci (Lond) (1994) 86 (2): 203-208.
Published: 01 February 1994
... displacement technique. 3. Basal forearm blood flow was increased and vascular resistance was decreased in the patients with alcoholic cirrhosis compared with healthy control subjects. Noradrenaline and N G -monomethyl-l-arginine caused dose-dependent falls in forearm blood flow in both healthy control...
Articles
Clin Sci (Lond) (1994) 86 (1): 35-41.
Published: 01 January 1994
... stress. 2. To assess the biological variability within individuals, ten subjects were sampled on five occasions over 8–30 h. The intra-individual coefficients of variation for plasma and platelet noradrenaline levels were 193 +10% and 9.5 +4.2%, respectively, and for plasma and platelet adrenaline levels...
Articles
Clin Sci (Lond) (1993) 85 (1): 45-49.
Published: 01 July 1993
...-individual variability of cardiovascular and plasma noradrenaline responses to sustained isometric contraction. 3. The results of this study indicate that inter-individual variability is generally greater than intra-individual variability. Diastolic blood pressure was the most sensitive as well as the least...
Articles
Clin Sci (Lond) (1993) 84 (4): 413-417.
Published: 01 April 1993
...Alastair J. McCance; J. Colin Forfar 1. To investigate the effects of acute β 1 -adrenoceptor blockade on sympathetic nervous activity, cardiac and whole-body noradrenaline kinetics were determined during intravenous infusions of saline placebo and of metoprolol (10-15 mg plus 150 μg min −1 kg −1...