...Ashley E. Walker; Rachelle E. Kaplon; Gary L. Pierce; Molly J. Nowlan; Douglas R. Seals Habitual aerobic exercise prevents age-related impairments in endothelium-dependent dilation (EDD). We have hypothesized that the pro-inflammatory transcription factor nuclear factor κB (NF-κB) impairs EDD...

... regulatory network may be a mechanism by which SMAD7 protects kidney from hypertensive kidney injury. Thus SMAD7 may be a novel therapeutic agent for hypertensive kidney disease. hypertensive nephropathy miR-29 nuclear factor κB (NF-κB) SMAD3 SMAD7 Sp1 • Pre-treatment with SMAD7...

... (AngII) hypertension inflammation integrin-linked kinase (ILK) kidney nuclear factor κB (NF-κB) oxidative stress Ubiquitously expressed ILK (integrin-linked kinase) predominantly localizes at focal adhesions to interact with β-integrins. Although ILK was originally considered to be a serine...

... be a potential therapeutic target for inflammatory renal diseases. angiotensin II (AngII) inflammation integrin-linked kinase (ILK) kidney monocyte chemoattractant protein-1 (MCP-1) nuclear factor κB (NF-κB) For Western blot analysis, cytosolic fractions and total protein levels were...

... inflammation kidney nuclear factor κB (NF-κB) Toll-like receptor 2 Toll-like receptor 4 Diabetic nephropathy is the leading cause of ESKD (end-stage kidney disease), affecting approximately one-third of all patients with diabetes mellitus [ 1 ]. The disease is relentlessly increasing...

... collagen were determined using a hydroxyproline assay in undigested and CNBr (cyanogen bromide)-digested samples as described previously [ 8 , 18 , 19 ]. angiotensin II collagen fibrosis inflammation lymphocyte lysyl oxidase (LOX) N -acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) nuclear factor...

...: Professor Derek A. Mann (email derek.mann@newcastle.ac.uk ). 3 11 2009 6 1 2010 2 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 fibrosis hepatocellular carcinoma ischaemia/reperfusion injury non-alcoholic fatty liver disease (NAFLD) nuclear factor...

... The Authors Journal compilation © 2009 Biochemical Society 2009 cancer inflammation intracellular signalling nuclear factor κB (NF-κB) Rel The secondary lymphoid organs, including the lymph nodes, Peyer's patches, MALT and spleen, are sites where organized arrangement of cells allows proximal...

... Biosciences) from 0–10 μmol/l in DMEM containing 2.5% (v/v) FCS for various lengths of time [24 h for RT-PCR (reverse transcription–PCR), Northern blotting and Western blotting, and 5 min, 30 min and 4 h for NF-κB (nuclear factor κB) determination]. endothelin-1 (ET-1) ET A gelatinase nuclear factor...

... + N -acetylcysteine genetic hypertension nuclear factor κB (NF-κB) nitric oxide synthase reactive oxygen species (ROS) NO (nitric oxide) plays an important role in the maintenance of vascular tone, which affects the level of BP (blood pressure) [ 1 – 3 ]. In various models of hypertension...