... at the cellular level is poorly understood. Nuclear receptors (NRs) are key signalling proteins capable of integrating environmental factors and mitochondrial function, thereby providing a potential link between exercise and mitochondrial biogenesis. The aim of this review is to highlight the function of NRs...

... to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding...

... inflammatory bowel disease nuclear receptor peroxisome-proliferator-activated receptor β/δ (PPARβ/δ) Figure 3 Hypothetical roles of PPARβ/δ in colon carcinogenesis (A) Ligand activation of PPARβ/δ potentiates colon cancer. In this model, PPARβ/δ is a downstream target of the APC/β-catenin/Tcf4...

... of the physiological mechanisms of bile secretion, including the nature of the transporters involved and their role in bile formation; (ii) the changes induced by nuclear receptors and hepatocyte-enriched transcription factors in the constitutive expression of hepatocellular transporters in cholestasis, either...