... application of ET-1 prevented sustained basal cytosolic Ca 2+ uptake by the nuclei. The use of an ET-1 fluorescent probe demonstrated the presence of ET-1 receptors at both the sarcolemma membrane and the nuclear envelope membrane. Thus our results suggest that ET-1 receptors that are insensitive to BQ123...

... on isolated nuclei. 2. Nuclei were purified from rat liver and then treated for 2 h at 37°C with various concentrations of angiotensin II. Chromatin was then isolated and initiation-site number was estimated by utilizing exogenous Escherichia coli RNA polymerase. 3. Statistically significant increases...