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Keywords: obesity
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Articles

Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics

Open Access
Wang-Hsin Lee, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Evelyn A. Bates, Olufunto O. Badmus, David E. Stec, Terry D. Hinds, Jr
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (02): 171–198.
https://doi.org/10.1042/CS20242825
Published: 28 January 2025
... mechanisms, analyzes the sex differences that might cause a dichotomy in responses, and examines the potential use of HMOX and bilirubin nanoparticle therapies in treating metabolic diseases. Bilir Blvra Hmox1 Inflammation Masld Metabolism Obesity Reactive oxygen species Ugt1a1 Urobilin...
View articletitled, Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics
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Articles

Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge

Open Access
Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt Jr.
Journal: Clinical Science
Clin Sci (Lond) (2025) 139 (02): 85–113.
https://doi.org/10.1042/CS20243515
Published: 23 January 2025
...Helena Trevisan Schroeder; Carlos Henrique de Lemos Muller; Maria Inês Lavina Rodrigues; Marcela Alves de Azevedo; Thiago Gomes Heck; Mauricio Krause; Paulo Ivo Homem de Bittencourt Jr. Chronic inflammatory diseases, e.g., obesity, cardiovascular disease and type-2 diabetes, progressively suppress...
View articletitled, Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge
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Includes: Supplementary data
Articles

Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity

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In Collection
Endothelin XVIII Conference Collection
Anna Flavia R. Lima, Daniel Rodrigues, Mirele R. Machado, José Teles Oliveira-Neto, Alecsander F. M. Bressan, Carina A. Pedersoli, Juliano V. Alves, Júlio A. Silva-Neto, Paula R. Barros, Thiago B. Dias, Luis V. Garcia, Ariane Bruder-Nascimento, Thiago Bruder-Nascimento, Fernando S. Carneiro, Luiz Osório S. Leiria, Rita C. Tostes, Rafael M. Costa
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1071–1087.
https://doi.org/10.1042/CS20240624
Published: 30 August 2024
... Osório S. Leiria; Rita C. Tostes; Rafael M. Costa Perivascular adipose tissue (PVAT) negatively regulates vascular muscle contraction. However, in the context of obesity, the PVAT releases vasoconstrictor substances that detrimentally affect vascular function. A pivotal player in this scenario...
View articletitled, Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity
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Articles

Astrocytes at the intersection of ageing, obesity, and neurodegeneration

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In Collection
The biology of ageing: Geroscience and the exposome
Wyn Firth, Katherine R Pye, Paul G Weightman Potter
Journal: Clinical Science
Clin Sci (Lond) (2024) 138 (8): 515–536.
https://doi.org/10.1042/CS20230148
Published: 23 April 2024
..., a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration...
View articletitled, Astrocytes at the intersection of ageing, obesity, and neurodegeneration
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Articles

Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model

Open Access
Carolyn J. Wang, Jeremy T. Smith, David Lu, Peter B. Noble, Kimberley C.W. Wang
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1547–1562.
https://doi.org/10.1042/CS20230792
Published: 03 October 2023
...Carolyn J. Wang; Jeremy T. Smith; David Lu; Peter B. Noble; Kimberley C.W. Wang Airway-associated adipose tissue increases with body mass index and is a local source of pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing with obesity. Genetic susceptibility...
View articletitled, Airway-associated adipose tissue accumulation is increased in a kisspeptin receptor knockout mouse model
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Articles

Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer

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Vanda Marques, Fabiola Arella, Marta B. Afonso, André A. Santos, Cecília M.P. Rodrigues
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1095–1114.
https://doi.org/10.1042/CS20230411
Published: 02 August 2023
...Vanda Marques; Fabiola Arella; Marta B. Afonso; André A. Santos; Cecília M.P. Rodrigues The increasing prevalence of obesity brings forward its importance as a risk factor for cancer development, particularly in the gastrointestinal tract. Obesity may trigger cancer development through several...
View articletitled, Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer
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Articles

The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies

Open Access
In Collection
Reproductive Physiology and Disease
Kyle M. Siemers, Michelle L. Baack
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (1): 31–34.
https://doi.org/10.1042/CS20220657
Published: 03 January 2023
...Kyle M. Siemers; Michelle L. Baack In this commentary, we highlight a new study by Bidne and colleagues that identifies changes in placental lipids and lipid metabolic enzymes that happen not only in the context of parental obesity but also from as early as 4 weeks of gestation. Their assessment...
View articletitled, The importance of placental lipid metabolism across gestation in obese and non-obese pregnancies
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Articles

Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways

Open Access
Olufunto O. Badmus, Sarah A. Hillhouse, Christopher D. Anderson, Terry D. Hinds, Jr, David E. Stec
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (18): 1347–1366.
https://doi.org/10.1042/CS20220572
Published: 23 September 2022
...Olufunto O. Badmus; Sarah A. Hillhouse; Christopher D. Anderson; Terry D. Hinds, Jr; David E. Stec The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin...
View articletitled, Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways
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Articles

Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes

Open Access
Naila Rabbani
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (11): 819–824.
https://doi.org/10.1042/CS20220099
Published: 30 May 2022
... A. , Waldron M. et al . ( 2016 ) Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation . Diabetes 65 , 2282 – 2294 27207552 10.2337/db16-0153 25. Karachalias N. , Babaei-Jadidi R. , Rabbani N. and Thornalley...
View articletitled, Methylglyoxal and glyoxalase 1—a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes
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Articles

AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

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Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A. Boisvert, Thomas Unger, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2763–2780.
https://doi.org/10.1042/CS20210971
Published: 17 December 2021
... AT 2 R agonist, on the prevention of endothelial dysfunction, extracellular matrix (ECM) remodeling and arterial stiffness associated with diet-induced obesity (DIO). Five-week-old male C57BL/6J mice were fed a standard (Chow) or high-fat diet (HF) for 6 weeks. Half of the animals of each group were...
View articletitled, AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet
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Includes: Supplementary data
Articles

Asthma and obesity: endotoxin another insult to add to injury?

Open Access
Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2729–2748.
https://doi.org/10.1042/CS20210790
Published: 17 December 2021
...Nikita Lad; Alice M. Murphy; Cristina Parenti; Carl P. Nelson; Neil C. Williams; Graham R. Sharpe; Philip G. McTernan Low-grade inflammation is often an underlying cause of several chronic diseases such as asthma, obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Defining...
View articletitled, Asthma and obesity: endotoxin another insult to add to injury?
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Articles

Sex differences in white adipose tissue expansion: emerging molecular mechanisms

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Simon T. Bond, Anna C. Calkin, Brian G. Drew
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2691–2708.
https://doi.org/10.1042/CS20210086
Published: 15 December 2021
...Simon T. Bond; Anna C. Calkin; Brian G. Drew The escalating prevalence of individuals becoming overweight and obese is a rapidly rising global health problem, placing an enormous burden on health and economic systems worldwide. Whilst obesity has well described lifestyle drivers, there is also...
View articletitled, Sex differences in white adipose tissue expansion: emerging molecular mechanisms
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Articles

Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

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Osvaldo Rivera-Gonzalez, Natalie A. Wilson, Laura E. Coats, Erin B. Taylor, Joshua S. Speed
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
https://doi.org/10.1042/CS20210549
Published: 30 July 2021
...Osvaldo Rivera-Gonzalez; Natalie A. Wilson; Laura E. Coats; Erin B. Taylor; Joshua S. Speed Endothelin-1 (ET-1) is elevated in patients with obesity; however, its contribution to the pathophysiology related to obesity is not fully understood. We hypothesized that high ET-1 levels cause dyslipidemia...
View articletitled, Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice
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Includes: Supplementary data
Articles

Nutrient regulation of inflammatory signalling in obesity and vascular disease

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Timothy M. Palmer, Ian P. Salt
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
https://doi.org/10.1042/CS20190768
Published: 07 July 2021
...Timothy M. Palmer; Ian P. Salt Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade...
View articletitled, Nutrient regulation of inflammatory signalling in obesity and vascular disease
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Articles

Obesity-associated cardiovascular risk in women: hypertension and heart failure

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Jessica L. Faulkner
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
https://doi.org/10.1042/CS20210384
Published: 23 June 2021
...Jessica L. Faulkner The pathogenesis of obesity-associated cardiovascular diseases begins long prior to the presentation of a cardiovascular event. In both men and women, cardiovascular events, and their associated hospitalizations and mortality, are often clinically predisposed by the presentation...
View articletitled, Obesity-associated cardiovascular risk in women: hypertension and heart failure
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Articles

The complex role of adipokines in obesity, inflammation, and autoimmunity

Open Access
Erin B. Taylor
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (6): 731–752.
https://doi.org/10.1042/CS20200895
Published: 17 March 2021
...Erin B. Taylor The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since the discovery of leptin in 1994, a multitude of studies have characterized the pathological changes that occur within adipose tissue in the obese state. One significant...
View articletitled, The complex role of adipokines in obesity, inflammation, and autoimmunity
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Articles

Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids

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Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (1): 185–200.
https://doi.org/10.1042/CS20201060
Published: 08 January 2021
...Helena L. Fisk; Caroline E. Childs; Elizabeth A. Miles; Robert Ayres; Paul S. Noakes; Carolina Paras-Chavez; Ondrej Kuda; Jan Kopecký; Elie Antoun; Karen A. Lillycrop; Philip C. Calder Obesity is believed to be associated with a dysregulated endocannabinoid system which may reflect enhanced...
View articletitled, Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids
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Includes: Supplementary data
Articles

Expression of Concern: Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker Fatty Rats

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Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2789.
https://doi.org/10.1042/CS-20200107_EOC
Published: 02 November 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Green tea polyphenols insulin receptor substrate-1 insulin resistance obesity protein kinase C-θ Zucker fatty rats The Editorial Office has been made aware of potential issues...
View articletitled, Expression of Concern: Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker Fatty Rats
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Articles

The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

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Anissa Viveiros, Gavin Y. Oudit
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
https://doi.org/10.1042/CS20201028
Published: 25 September 2020
...Anissa Viveiros; Gavin Y. Oudit The global prevalence of obesity has been rising at an alarming rate, accompanied by an increase in both childhood and maternal obesity. The concept of metabolic programming is highly topical, and in this context, describes a predisposition of offspring of obese...
View articletitled, The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue
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Articles

Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle

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Anwar Khan, Sherouk Fouda, Ali Mahzari, Stanley M.H. Chan, Xiu Zhou, Cherubina Ratnam, Ross Vlahos, Ji-Ming Ye
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1659–1673.
https://doi.org/10.1042/CS20200173
Published: 01 July 2020
... from lipolysis and lipodystrophy of adipose tissues. This may explain why smokers may not benefit from insulin sensitising effects of reduced body weight gain. Indeed, the effect of obesity on lipid metabolism and insulin action is evidenced by the fact that weight loss generally attenuates...
View articletitled, Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle
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Includes: Supplementary data
Articles

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets

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Adipose biology, cardiovascular and cardiometabolic disease
Manal Muin Fardoun, Dina Maaliki, Nabil Halabi, Rabah Iratni, Alessandra Bitto, Elias Baydoun, Ali H. Eid
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1403–1432.
https://doi.org/10.1042/CS20200356
Published: 18 June 2020
... on behalf of the Biochemical Society 2020 adipose tissue inflammation atherosclerosis cardiovascular disease flavonoids obesity The leading cause of morbidity and mortality worldwide is cardiovascular disease (CVD) [ 1 ], with atherosclerosis being the major contributor to this mortality...
View articletitled, Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets
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Articles

Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats

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Jing Cheng, Yi Tan, Jiong Zhou, Linda Xiao, Michael Johnson, Xianqin Qu
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (10): 1167–1180.
https://doi.org/10.1042/CS20200107
Published: 27 May 2020
... associated with significantly decreased activation of the inhibitory (muscle-specific) protein kinase (PKC) isoform, PKC-θ. Taken together, the present study has shown that regular ingestion of GTP exerts a number of favourable metabolic and molecular effects in an established animal model of obesity...
View articletitled, Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats
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Articles

Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease

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In Collection
Adipose biology, cardiovascular and cardiometabolic disease
Rim Rafeh, Anissa Viveiros, Gavin Y. Oudit, Ahmed F. El-Yazbi
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 827–851.
https://doi.org/10.1042/CS20190227
Published: 09 April 2020
...Rim Rafeh; Anissa Viveiros; Gavin Y. Oudit; Ahmed F. El-Yazbi Major shifts in human lifestyle and dietary habits toward sedentary behavior and refined food intake triggered steep increase in the incidence of metabolic disorders including obesity and Type 2 diabetes. Patients with metabolic disease...
View articletitled, Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease
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Articles

Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

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In Collection
Adipose biology, cardiovascular and cardiometabolic disease
Miroslava Kacířová, Anna Zmeškalová, Lucia Kořínková, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (5): 547–570.
https://doi.org/10.1042/CS20191313
Published: 13 March 2020
... play a role in inflammation. In this review, we try to elucidate the connections between peripheral inflammation at obesity and Type 2 diabetes and the central inflammatory process. Multiple lines of evidence highlight the importance of peripheral inflammation and its link to neuroinflammation, which...
View articletitled, Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?
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Articles

Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury

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Adipose biology, cardiovascular and cardiometabolic disease
Rachel Njeim, Theresa Farhat, Sahar Alkhansa, Natalie Youssef, Batoul Dia, Rasha Slika, Radwan Diab, Sami T. Azar, Assaad A. Eid
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (4): 403–417.
https://doi.org/10.1042/CS20190584
Published: 25 February 2020
... 02 2020 10 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Adipose Inflammation Diabetes Diabetic Kidney Disease NADPH oxidase obesity Oxidative Stress Diabetes mellitus (DM) [ 1 ] is one of the major public...
View articletitled, Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury
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Articles

Obesity and adiposity: the culprit of dietary protein efficacy

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In Collection
Adipose biology, cardiovascular and cardiometabolic disease
Carla El-Mallah, Omar Obeid
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (4): 389–401.
https://doi.org/10.1042/CS20190583
Published: 17 February 2020
...Carla El-Mallah; Omar Obeid Obesity and increased body adiposity have been alarmingly increasing over the past decades and have been linked to a rise in food intake. Many dietary restrictive approaches aiming at reducing weight have resulted in contradictory results. Additionally, some policies...
View articletitled, Obesity and adiposity: the culprit of dietary protein efficacy
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Articles

Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats

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Chayodom Maneechote, Siripong Palee, Nattayaporn Apaijai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
https://doi.org/10.1042/CS20190960
Published: 16 December 2019
...Chayodom Maneechote; Siripong Palee; Nattayaporn Apaijai; Sasiwan Kerdphoo; Thidarat Jaiwongkam; Siriporn C. Chattipakorn; Nipon Chattipakorn Obese insulin resistance impairs cardiac mitochondrial dynamics by increasing mitochondrial fission and decreasing mitochondrial fusion, leading...
View articletitled, Mitochondrial dynamic modulation exerts cardiometabolic protection in obese insulin-resistant rats
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Articles

Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis

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Adipose biology, cardiovascular and cardiometabolic disease
Sarah R. Anthony, Adrienne R. Guarnieri, Anamarie Gozdiff, Robert N. Helsley, Albert Phillip Owens, III, Michael Tranter
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (22): 2329–2344.
https://doi.org/10.1042/CS20190578
Published: 28 November 2019
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 adipokines brown adipose tissue cardiac fibrosis cardiac hypertrophy cardiovascular disease obesity Adipose tissue biology is intricately linked to cardiovascular health, and the growing obesity...
View articletitled, Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis
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Articles

Adipocyte dedifferentiation in health and diseases

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Tongxing Song, Shihuan Kuang
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (20): 2107–2119.
https://doi.org/10.1042/CS20190128
Published: 25 October 2019
... to induce the expression of PPARγ and Klf15 [ 38 ]. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 adipocyte dedifferentiation differentiation metabolism obesity Obesity and overweight driven by abnormal deposition of adipose tissues...
View articletitled, Adipocyte dedifferentiation in health and diseases
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Articles

Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism

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Ting Xie, Wing Yan So, Xing Yu Li, Po Sing Leung
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (19): 2029–2044.
https://doi.org/10.1042/CS20190093
Published: 14 October 2019
... Press Limited on behalf of the Biochemical Society 2019 Apoptosis CVX343 Insulin Islets Obesity Type 2 diabetes Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and hyperlipidemia. Most patients with T2DM are overweight or obese, and thus...
View articletitled, Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism
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Includes: Supplementary data
Articles

Exosomal microRNA-122 mediates obesity-related cardiomyopathy through suppressing mitochondrial ADP-ribosylation factor-like 2

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Yongshun Wang, Pianpian Jin, Jingjin Liu, Xiang Xie
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (17): 1871–1881.
https://doi.org/10.1042/CS20190558
Published: 10 September 2019
... with several consequence of heart diseases in clinical studies, and overexpression of miR-122 impaired cardiomyocyte function. However, it was unknown whether miR-122 could regulate cardiac biology in obesity. Therefore, present study was to disclose the role of miR-122 in cardiac metabolic disorders...
View articletitled, Exosomal microRNA-122 mediates obesity-related cardiomyopathy through suppressing mitochondrial ADP-ribosylation factor-like 2
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Includes: Supplementary data
Articles

Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons

Open Access
Hiranya Pintana, Grazyna Lietzau, Ingrid Lovise Augestad, Fausto Chiazza, Thomas Nyström, Cesare Patrone, Vladimer Darsalia
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1367–1386.
https://doi.org/10.1042/CS20190180
Published: 01 July 2019
... on long-term stroke recovery. However, the effects of obesity-induced T2D are mostly unknown. We aimed to investigate whether obesity-induced T2D worsens long-term stroke recovery through the impairment of brain’s self-repair mechanisms – stroke-induced neurogenesis and parvalbumin (PV)+ interneurons...
View articletitled, Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons
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Includes: Supplementary data
Articles

Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training

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Kenneth Verboven, Rudi Stinkens, Dominique Hansen, Inez Wens, Ines Frederix, Bert O. Eijnde, Johan W.E. Jocken, Gijs H. Goossens, Ellen E. Blaak
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1685–1698.
https://doi.org/10.1042/CS20180453
Published: 14 August 2018
...Kenneth Verboven; Rudi Stinkens; Dominique Hansen; Inez Wens; Ines Frederix; Bert O. Eijnde; Johan W.E. Jocken; Gijs H. Goossens; Ellen E. Blaak Obesity-related adipose tissue (AT) dysfunction, in particular subcutaneous AT (SCAT) lipolysis, is characterized by catecholamine resistance and impaired...
View articletitled, Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training
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Includes: Supplementary data
Articles

Probiotic Lactobacillus paracasei HII01 protects rats against obese-insulin resistance-induced kidney injury and impaired renal organic anion transporter 3 function

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Keerati Wanchai, Sakawdaurn Yasom, Wannipa Tunapong, Titikorn Chunchai, Sathima Eaimworawuthikul, Parameth Thiennimitr, Chaiyavat Chaiyasut, Anchalee Pongchaidecha, Varanuj Chatsudthipong, Siriporn Chattipakorn, Nipon Chattipakorn, Anusorn Lungkaphin
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1545–1563.
https://doi.org/10.1042/CS20180148
Published: 31 July 2018
... and obesity is currently acknowledged to be a health topic which causes low-grade systemic inflammation and insulin resistance and may damage the kidney. Organic anion transporter 3 (Oat3) has been shown as a transporter responsible for renal handling of gut microbiota products which are involved...
View articletitled, Probiotic Lactobacillus paracasei HII01 protects rats against obese-insulin resistance-induced kidney injury and impaired renal organic anion transporter 3 function
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Articles

Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance

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Pei-Chi Chan, Ting-Ni Wu, Ying-Chuan Chen, Chieh-Hua Lu, Martin Wabitsch, Yu-Feng Tian, Po-Shiuan Hsieh
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1581–1596.
https://doi.org/10.1042/CS20180041
Published: 31 July 2018
...Pei-Chi Chan; Ting-Ni Wu; Ying-Chuan Chen; Chieh-Hua Lu; Martin Wabitsch; Yu-Feng Tian; Po-Shiuan Hsieh Adipose tissue (AT) inflammation is crucial to the development of obesity-associated insulin resistance. Our aim was to investigate the contribution of cyclooxygenase-2 (COX-2)/macrophage...
View articletitled, Targeted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance
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Includes: Supplementary data
Articles

Recent advances in the detection of brown adipose tissue in adult humans: a review

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Frank J. Ong, Basma A. Ahmed, Stephan M. Oreskovich, Denis P. Blondin, Tahniyah Haq, Norman B. Konyer, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Katherine M. Morrison, Gregory R. Steinberg
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1039–1054.
https://doi.org/10.1042/CS20170276
Published: 25 May 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...
View articletitled, Recent advances in the detection of brown adipose tissue in adult humans: a review
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Includes: Supplementary data
Articles

Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

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Redin A. Spann, William J. Lawson, Gene L. Bidwell, III, C. Austin Zamarripa, Rodrigo O. Maranon, Sibali Bandyopadhyay, Erin R. Taylor, Jane F. Reckelhoff, Michael R. Garrett, Bernadette E. Grayson
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (2): 295–312.
https://doi.org/10.1042/CS20171416
Published: 25 January 2018
...Redin A. Spann; William J. Lawson; Gene L. Bidwell, III; C. Austin Zamarripa; Rodrigo O. Maranon; Sibali Bandyopadhyay; Erin R. Taylor; Jane F. Reckelhoff; Michael R. Garrett; Bernadette E. Grayson Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co...
View articletitled, Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development
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Includes: Supplementary data
Articles

Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy

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Gabriela Placoná Diniz, Zhan-Peng Huang, Jianming Liu, Jinghai Chen, Jian Ding, Renata Inzinna Fonseca, Maria Luiza Barreto-Chaves, Jose Donato, Jr, Xiaoyun Hu, Da-Zhi Wang
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2885–2900.
https://doi.org/10.1042/CS20171368
Published: 04 December 2017
...Gabriela Placoná Diniz; Zhan-Peng Huang; Jianming Liu; Jinghai Chen; Jian Ding; Renata Inzinna Fonseca; Maria Luiza Barreto-Chaves; Jose Donato, Jr; Xiaoyun Hu; Da-Zhi Wang Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR...
View articletitled, Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy
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Includes: Supplementary data
Articles

Oxidative and inflammatory signals in obesity-associated vascular abnormalities

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John J. Reho, Kamal Rahmouni
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1689–1700.
https://doi.org/10.1042/CS20170219
Published: 30 June 2017
...John J. Reho; Kamal Rahmouni Obesity is associated with increased cardiovascular morbidity and mortality in part due to vascular abnormalities such as endothelial dysfunction and arterial stiffening. The hypertension and other health complications that arise from these vascular defects increase...
View articletitled, Oxidative and inflammatory signals in obesity-associated vascular abnormalities
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Articles

GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction

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Emilie Pastel, Laura J. McCulloch, Rebecca Ward, Shivam Joshi, Kim M. Gooding, Angela C. Shore, Katarina Kos
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (5): 343–353.
https://doi.org/10.1042/CS20160803
Published: 15 February 2017
...Emilie Pastel; Laura J. McCulloch; Rebecca Ward; Shivam Joshi; Kim M. Gooding; Angela C. Shore; Katarina Kos Glucagon-like peptide-1 (GLP-1) analogues aid weight loss that improves obesity-associated adipose tissue (AT) dysfunction. GLP-1 treatment may however also directly influence...
View articletitled, GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction
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Includes: Supplementary data
Articles

Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice

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Laurence Poekes, Vanessa Legry, Olivier Schakman, Christine Detrembleur, Anne Bol, Yves Horsmans, Geoffrey C. Farrell, Isabelle A. Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (4): 285–296.
https://doi.org/10.1042/CS20160469
Published: 20 January 2017
...Laurence Poekes; Vanessa Legry; Olivier Schakman; Christine Detrembleur; Anne Bol; Yves Horsmans; Geoffrey C. Farrell; Isabelle A. Leclercq Fatty liver diseases are complications of the metabolic syndrome associated with obesity, insulin resistance and low grade inflammation. Our aim was to uncover...
View articletitled, Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice
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Includes: Supplementary data
Articles

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

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Christina M. van der Beek, Emanuel E. Canfora, Kaatje Lenaerts, Freddy J. Troost, Steven W.M. Olde Damink, Jens J. Holst, Ad A.M. Masclee, Cornelis H.C. Dejong, Ellen E. Blaak
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2073–2082.
https://doi.org/10.1042/CS20160263
Published: 11 October 2016
... factors. The present study aim was to investigate the effects of proximal and distal colonic infusions with the SCFA acetate on fat oxidation and other metabolic parameters in men. In this randomized, double-blind crossover trial, six overweight/obese men [body mass index (BMI) 25–35 kg/m 2 ] underwent...
View articletitled, Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men
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Includes: Supplementary data
Articles

Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice

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Kelvin H.M. Kwok, Kenneth K.Y. Cheng, Ruby L.C. Hoo, Dewei Ye, Aimin Xu, Karen S.L. Lam
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (22): 2087–2100.
https://doi.org/10.1042/CS20160465
Published: 11 October 2016
...Kelvin H.M. Kwok; Kenneth K.Y. Cheng; Ruby L.C. Hoo; Dewei Ye; Aimin Xu; Karen S.L. Lam Both atherosclerosis and obesity, an independent atherosclerotic risk factor, are associated with enhanced systemic inflammation. Obesity is also characterized by increased adipose tissue inflammation. However...
View articletitled, Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice
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Includes: Supplementary data
Articles

Molecular mechanisms of appetite and obesity: a role for brain AMPK

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Pablo B. Martínez de Morentin, Adela Urisarri, María L. Couce, Miguel López
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (19): 1697–1709.
https://doi.org/10.1042/CS20160048
Published: 23 August 2016
.... Failure of this physiological response can lead to energy imbalance, ultimately with extreme consequences, such as leanness or obesity. Here, we will review the data that put brain AMPK in the spotlight as a regulator of appetite. As energy is long-term stored as lipid, understanding the role of AMPK...
View articletitled, Molecular mechanisms of appetite and obesity: a role for brain AMPK
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Articles

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

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Matthias Blüher
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1603–1614.
https://doi.org/10.1042/CS20160005
Published: 08 August 2016
...Matthias Blüher The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may...
View articletitled, Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?
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Articles

The importance of gene–environment interactions in human obesity

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Hudson Reddon, Jean-Louis Guéant, David Meyre
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1571–1597.
https://doi.org/10.1042/CS20160221
Published: 08 August 2016
...Hudson Reddon; Jean-Louis Guéant; David Meyre The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made...
View articletitled, The importance of gene–environment interactions in human obesity
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Articles

Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

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Kenneth Verboven, Dominique Hansen, Cedric Moro, Bert O. Eijnde, Nicole Hoebers, Joep Knol, Wim Bouckaert, Anne Dams, Ellen E. Blaak, Johan W.E. Jocken
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1105–1114.
https://doi.org/10.1042/CS20160220
Published: 23 May 2016
...Kenneth Verboven; Dominique Hansen; Cedric Moro; Bert O. Eijnde; Nicole Hoebers; Joep Knol; Wim Bouckaert; Anne Dams; Ellen E. Blaak; Johan W.E. Jocken Catecholamines and atrial natriuretic peptide (ANP) are major regulators of adipocyte lipolysis. Although obesity is characterized by catecholamine...
View articletitled, Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men
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Includes: Supplementary data
Articles

Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease

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Dennis Dahlmans, Alexandre Houzelle, Patrick Schrauwen, Joris Hoeks
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (11): 843–852.
https://doi.org/10.1042/CS20150780
Published: 22 April 2016
...Dennis Dahlmans; Alexandre Houzelle; Patrick Schrauwen; Joris Hoeks The western dietary habits and sedentary lifestyle largely contributes to the growing epidemic of obesity. Mitochondria are at the front line of cellular energy homoeostasis and are implicated in the pathophysiology of obesity...
View articletitled, Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease
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Articles

Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity

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Lina Zhao, Zhuo Fu, Jing Wu, Kevin W. Aylor, Eugene J. Barrett, Wenhong Cao, Zhenqi Liu
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1025–1036.
https://doi.org/10.1042/CS20150143
Published: 18 September 2015
.... We conclude that microvascular insulin resistance is an early event in diet-induced obesity and insulin resistance and inflammation plays an essential role in this process. Our data suggest microvascular insulin resistance contributes to the development of metabolic insulin resistance in muscle...
View articletitled, Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity
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Articles

Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome

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Laurence Poekes, Nicolas Lanthier, Isabelle A. Leclercq
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (11): 933–949.
https://doi.org/10.1042/CS20150339
Published: 10 September 2015
... contributes to energy expenditure and glucose homoeostasis. Brown fat activation has thus emerged as an attractive therapeutic target for the treatment of obesity and the metabolic syndrome. In the present review, we integrate the recent advances on the metabolic role of BAT and its relation with other...
View articletitled, Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome
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