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Keyword: oestrogen
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Clin Sci (Lond) (2016) 130 (14): 1147-1163.
Published: 01 June 2016
... inequalities oestrogen sex testosterone In My Fair Lady (1956), Professor Higgins asked this question rhetorically from an absurdly biased, male point of view. This classic Broadway musical was based on George Bernard Shaw's Pygmalion (1913), a theatrical play reflecting the old-fashioned views...
Clin Sci (Lond) (2016) 130 (1): 9-18.
Published: 30 November 2015
... oestrogen receptors. Each of these brain regions has also been implicated in mechanisms underlying risk factors for hypertension such as obesity, stress and inflammation. The present review brings together evidence that links actions of oestrogen at these receptors to modulate some of the common brain...
Clin Sci (Lond) (2015) 129 (10): 885-893.
Published: 01 September 2015
...;0.05). At each stage, HR correlated inversely ( P <0.05) with HF. In conclusion, ExFHA women demonstrate augmented vagal yet unchanged sympathetic HR modulation, both at rest and during orthostatic stress. Although the role of oestrogen deficiency is unclear, these findings are in contrast with...
Clin Sci (Lond) (2013) 125 (7): 311-318.
Published: 07 June 2013
... postmenopausal women are at increased risk of cardiovascular complications compared with premenopausal women. The pathophysiological mechanisms have not been elucidated, but are not likely to be as simple as the presence or absence of oestrogens, since hormone replacement therapy in elderly women in the Women's...
Clin Sci (Lond) (2010) 119 (12): 493-513.
Published: 01 September 2010
... oestrogens, androgens and progestins on the vessel wall is also reviewed, with particular attention to the actions of sex hormones on each of the three key cell types involved in atherogenesis: the endothelium, smooth muscle cells and macrophages. Where relevant, the systemic (metabolic) effects of sex...
Clin Sci (Lond) (2010) 118 (6): 375-389.
Published: 15 December 2009
...Hilary V.O. Carswell; I. Mhairi Macrae; Tracy D. Farr Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models. However, a recent clinical trial indicated that HRT (hormone-replacement therapy...
Clin Sci (Lond) (2009) 117 (10): 355-364.
Published: 07 September 2009
... cells are bone-marrow-derived cells involved in endothelial healing and angiogenesis, which promote cardiovascular health. Oestrogens are potent stimulators of endothelial progenitor cells, and previous findings have indicated that androgens may improve the biology of these cells as well. In the present...
Clin Sci (Lond) (2006) 111 (2): 107-118.
Published: 13 July 2006
...Shanhong Ling; Paul Komesaroff; Krishnankutty Sudhir Although pre-menopausal women enjoy relative cardiovascular protection, hormone (oestrogen±progestin)-replacement therapy has not shown cardiovascular benefits in post-menopausal women, suggesting that the effects of oestrogens on the...
Clin Sci (Lond) (2005) 109 (5): 457-463.
Published: 24 October 2005
... 2 2005 1 7 2005 21 7 2005 21 7 2005 The Biochemical Society 2005 17β-oestradiol oestrogen proteomics proliferation protein isoform vascular smooth muscle cell Epidemiological studies have suggested a protective effect of oestrogens on the cardiovascular...
Clin Sci (Lond) (2003) 105 (1): 67-71.
Published: 01 July 2003
...) atherosclerosis cardiovascular disease endothelial function oestrogen nitric oxide Clinical Science (2003) 105, 67 71 (Printed in Great Britain) 67 Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women T. TEERLINK , S. J. M. NEELE , S. DE JONG...
Clin Sci (Lond) (2002) 103 (s2002): 434S-437S.
Published: 01 September 2002
.../reperfusion increased significantly by approx. 2-fold over sham-operated rats, and this elevation was dose-dependently suppressed by the 17β-oestradiol treatment. These results suggest that oestrogen exhibits protective effects against renal dysfunction and tissue injury induced by ischaemia/reperfusion...
Clin Sci (Lond) (2001) 101 (4): 403-413.
Published: 14 September 2001
...Mariarosaria NAPOLITANO; Kelly V. BATT; Michael AVELLA; Elena BRAVO; Kathleen M. BOTHAM The effects of native and oxidized chylomicron remnants on the synthesis of cholesteryl ester and triacylglycerol in macrophages, and the way that this is influenced by exposure of the cells to oestrogen, was...
Clin Sci (Lond) (2001) 101 (1): 93-99.
Published: 13 June 2001
.... Correspondence: Dr R. E. Peverill (e-mail roger.peverill@med.monash.edu.au ). 5 12 2000 5 3 2001 6 4 2001 The Biochemical Society and the Medical Research Society © 2001 2001 coagulation factor VII hormone replacement therapy oestrogen progestin 93Clinical Science (2001) 101...
Clin Sci (Lond) (2001) 100 (5): 473-479.
Published: 29 March 2001
...Helena TEEDE; Andrea VAN DER ZYPP; Henryk MAJEWSKI Although gender and oestrogen treatment influence production of the vasorelaxant, NO, their influence on factors downstream in the NO signal-transduction pathway, specifically protein kinase G (PKG), remains unknown. We aimed to study the influence...
Clin Sci (Lond) (2001) 100 (4): 421-422.
Published: 08 March 2001
...N. G. L. ONAMBELE; D. A. SKELTON; S. A. BRUCE; R. C. WOLEDGE Correspondence : Professor R. C. Woledge (e-mail r.woledge@ucl.ac.uk ). 26 5 2000 11 12 2000 The Biochemical Society and the Medical Research Society © 2001 2001 adductor pollicis aging oestrogen post...
Clin Sci (Lond) (2001) 100 (2): 207-213.
Published: 09 January 2001
...Helena J. TEEDE; Barry P. MCGRATH; Alan TURNER; Harry MAJEWSKI The effects of combined oestrogen/progestin hormone replacement therapy (HRT) on platelet aggregation were studied using women on HRT or placebo. The study involved 32 postmenopausal women (aged 50–75 years) who were enrolled in a...
Clin Sci (Lond) (2000) 98 (2): 201-207.
Published: 11 January 2000
... Medical Research Society © 2000 2000 chronic pelvic pain menstrual cycle oestrogen pelvic congestion peripheral vascular flux 201Clinical Science (2000) 98, 201 207 (Printed in Great Britain) Reproducible assessment of vaginal and rectal mucosal and skin blood flow: laser doppler fluximetry...
Clin Sci (Lond) (1999) 97 (2): 225-232.
Published: 29 June 1999
...Gishel NEW; Stephen J. DUFFY; Karen L. BERRY; Richard W. HARPER; Ian T. MEREDITH Studies have recently demonstrated that long-term oestrogen therapy improves endothelium-dependent and endothelium-independent vasodilatation in the conductance vessels of biological males. We sought to determine if an...
Clin Sci (Lond) (1999) 97 (1): 79-84.
Published: 01 June 1999
... production isokinetic isometric oestrogen post-menopause progesterone 79Clinical Science (1999) 97, 79 84 (Printed in Great Britain) Changes in muscle strength in women following the menopause: a longitudinal assessment of the efficacy of hormone replacement therapy Julie P. GREEVES*, Nigel T. CABLE...
Clin Sci (Lond) (1999) 96 (4): 357-364.
Published: 01 April 1999
... strength (maximal voluntary force; MVF), muscle cross-sectional area and bone mineral density were measured. Women entering the trial had oestrogen levels below 150 pmolċl -1 , confirming their post-menopausal hormonal status. In the treated group, MVF increased by 12.4±1.0% (mean±S.E.M.) of initial MVF...
Clin Sci (Lond) (1985) 69 (2): 235-238.
Published: 01 August 1985
...N. Mishra; C. A. Hamilton; C. R. Jones; C. Leslie; J. L. Reid 1. α 2 -Adrenoceptors on blood platelets have been widely used as a model for α-adrenoceptors in less accessible tissues. 2. The effect of oestrogen (200 μg/day intramuscularly) on α 2 -adrenoceptor number and function was studied in...
Clin Sci (Lond) (1985) 68 (6): 639-645.
Published: 01 June 1985
... established Raynaud's phenomenon, suggesting that oestrogen has an important modulating effect in vivo on reflex peripheral vasomotor responses to thermal stimuli. 4. ‘Primary’ Raynaud's phenomenon may represent an exaggerated response to oestrogen. 5 12 1984 27 12 1984 © 1985 The Biochemical...
Clin Sci (Lond) (1980) 58 (3): 255-257.
Published: 01 March 1980
... premenopausal group. 3. Oestrogen therapy reduced both serum and urinary magnesium values in oophorectomized women to premenopausal concentrations. 4. Erythrocyte magnesium concentrations were not affected by menstrual status or oestrogen therapy. 31 8 1979 31 10 1979 © 1980 The Biochemical...
Clin Sci Mol Med (1978) 54 (2): 193-195.
Published: 01 February 1978
... skeletal response was measured by photon absorptiometry, bone mineral loss was prevented by both the oestrogen and the progestogen. 3. We confirm that mestranol significantly reduced the urinary output of hydroxyproline-containing peptide, but this did not occur during gestronol therapy, suggesting that...
Clin Sci Mol Med (1975) 48 (5): 457-460.
Published: 01 May 1975
...T. Saruta; R. Nakamura; I. Saito; K. Kondo; S. Matuki 1. A large dose of oestrogen elevated the blood pressure in male Wistar rats. 2. Plasma renin substrate and renin activity increased significantly but plasma renin concentration was unchanged. 3. The increase in blood pressure induced by...
Clin Sci Mol Med (1974) 47 (2): 179-187.
Published: 01 August 1974
... in the mestranol group as compared with the controls, but there was no significant difference in Na e . 5. These findings support the hypothesis that oestrogen-induced fluid retention is the result of primary water retention with secondary redistribution of body sodium. 12 3 1974 © 1974...