...-like macrophage aggregates and reduced their capacity of producing pro-fibrogenic mediators like osteopontin (OPN) and galectin-3 (Gal-3). This effect was related to an interference with the acquisition of a specific macrophage phenotype characterized by the expression of the Triggering Receptor...

... role in the regulation of sodium and potassium homoeostasis by binding to the mineralocorticoid receptor and contributes to kidney and cardiovascular damage. Aldosterone has been reported to induce IL-18, resulting in cardiac fibrosis with induced IL-18-mediated osteopontin (OPN). We therefore...

... eggs release factors that directly stimulate liver cells to produce osteopontin (OPN), a pro-fibrogenic protein that stimulates hepatic stellate cells to become myofibroblasts. We also investigated the utility of OPN as a biomarker of fibrosis and/or severity of portal hypertension. Cultured...

...Steve S. Choi; Lee C. Claridge; Ravi Jhaveri; Marzena Swiderska-Syn; Paul Clark; Ayako Suzuki; Thiago A. Pereira; Zhiyong Mi; Paul C. Kuo; Cynthia D. Guy; Fausto E. L. Pereira; Anna Mae Diehl; Keyur Patel; Wing-Kin Syn OPN (osteopontin)) is a Hh (Hedgehog)-regulated cytokine that is up-regulated...

...Mie Kurata; Takafumi Okura; Sanae Watanabe; Tomikazu Fukuoka; Jitsuo Higaki OPN (osteopontin), a pro-inflammatory cytokine, has recently emerged as a key factor in both vascular remodelling and the development of atherosclerosis. However, the relationship between OPN and atherosclerosis in patients...