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Keywords: osteoporosis
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1131–1143.
Published: 09 August 2023
...Chuncha Bao; Tao Wu; Siyi Zhu; Xiaoyi Wang; Yujia Zhang; Xiangxiu Wang; Lin Yang; Chengqi He Osteoporosis is a metabolic bone disease that affects hundreds of millions of people worldwide and is characterized by excessive loss of bone protein and mineral content. The incidence and mortality...
Articles
Jia-Wen Gao, Min-Kai Song, Di-Zheng Wu, Tao Yan, Kai Zhao, Yu-Sheng Huang, Xing-Yu Chen, Chen Tu, Guang-Xu Deng, Zi-Shuo Chen, Ming-Ming Zhang, Jun-Long Huang, Chao Zhang, Zhao-Ming Zhong
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (6): 495–510.
Published: 24 March 2023
... cells (MSCs) in bone marrow contributes to the adipocytes accumulation and bone loss, which leads to the development of osteoporosis (OP). The circular RNA (circRNA), circRBM23, was generated from the RNA binding motif protein 23 (RBM23) gene. It was reported that circRBM23 was down-regulated in OP...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1657–1659.
Published: 21 November 2022
...Elena L. Dent; Michael J. Ryan The precise control of whole-body calcium is essential for the maintenance of normal physiological function. Disruptions in calcium homeostasis can lead to pathology including osteoporosis, kidney stone formation, and cardiac arrythmias. During the 1960s and early...
Articles
Zhiyuan Guan, Jialin Jia, Chenggui Zhang, Tiantong Sun, Wang Zhang, Wanqiong Yuan, Huijie Leng, Chunli Song
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3159–3174.
Published: 09 December 2020
... Limited on behalf of the Biochemical Society 2020 antibiotic gender inflammation factors microbiome osteoarthritis osteoporosis The fixed knees were decalcified in 10% ethylenediaminetetraacetic acid (EDTA) for 14 days and embedded in paraffin, and frontal sections were cut (5 μm...
Includes: Supplementary data
Articles
Satoko Nozato, Koichi Yamamoto, Hikari Takeshita, Yoichi Nozato, Yuki Imaizumi, Taku Fujimoto, Serina Yokoyama, Motonori Nagasawa, Masao Takeda, Kazuhiro Hongyo, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masaki Mogi, Masatsugu Horiuchi, Hiromi Rakugi
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (18): 2005–2018.
Published: 24 September 2019
... of the A1-7-Mas pathway could alleviate sarcopenia and osteoporosis in aged mice. Correspondence: Koichi Yamamoto ( [email protected] ) 28 05 2019 30 08 2019 12 09 2019 13 09 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (5): 233–241.
Published: 01 August 2007
.... Data from twin studies and the three main published meta-analyses are presented. Possible mechanisms by which smoking affects bone mass are reviewed. Despite smoking being a major lifestyle risk factor for osteoporosis, the mechanisms underlying smoking-associated bone loss and fracture risk remain...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (2): 77–91.
Published: 11 December 2006
... leads to severe osteoporosis; (ii) genetic ablation of RANKL results in osteopetrosis because RANKL is necessary for normal osteoclast formation; and (iii) genetic ablation of RANK also leads to osteopetrosis because it is the receptor for RANK. As this signalling pathway is also functional in immune...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (2): 111–123.
Published: 27 July 2004
... glucocorticoids 11β-hydroxysteroid dehydrogenase osteoblasts osteoporosis prednisolone The epidemiology of GIOP has been difficult to define due to the wide variability in glucocorticoid doses used clinically, the impact of the underlying disease being treated and the large numbers of subjects...
Articles
Reiko OKABE, Masaaki INABA, Shinrei SAKAI, Eiji ISHIMURA, Atsushi MORIGUCHI, Tetsuo SHOJI, Yoshiki NISHIZAWA
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (6): 613–618.
Published: 01 June 2004
... hemiparesis intima-media thickness osteoporosis pulse wave velocity Correspondence: Dr Masaaki Inaba ( [email protected] ). 24 11 2003 26 1 2004 5 2 2004 5 2 2004 © 2004 The Biochemical Society 2004 Clinical Science (2004) 106, 613 618 (Printed in Great...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (2): 209–215.
Published: 01 February 1999
... and normal peptides were determined in normal adults, children, post-menopausal control subjects and subjects with osteoporosis. A lower ratio of β-peptide to α-peptide was observed in children's urine, indicative of a higher rate of bone metabolism allowing less time for the isomerization to occur...
Articles
Type I Collagen Biosynthesis by Skin Fibroblasts from Patients with Idiopathic Juvenile Osteoporosis
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (1): 69–73.
Published: 01 July 1995
...Andrew E. Pocock; Martin J. O. Francis; Roger Smith 1. Skin fibroblast lines were cultured from nine patients who had the features of idiopathic juvenile osteoporosis, six relatives, five unrelated control subjects and three unrelated patients with osteogenesis imperfecta type I. Some patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (2): 223–228.
Published: 01 August 1993
... © 1993 The Biochemical Society and the Medical Research Society 1993 bone formation calcium metabolism osteoporosis parathyroid hormone Clinical Science (1993) 85, 223-228 (Printed in Great Britain) 223 Modulation of the anabolic effect of synthetic human parathyroid hormone fragment+34...
Articles
Richard Eastell, Patricia S. Simmons, Antony Colwell, Adel M. A. Assiri, Mary F. Burritt, R. Graham, G. Russell, B. Lawrence Riggs
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (3): 375–382.
Published: 01 September 1992
... nyctohemeral osteocalcin osteoporosis pyridinium cross-links of collagen Clinical Science (1992) 83, 375-382 (Printed in Great Britain) 375 N yctohemeral changes in bone turnover assessed by serum bone Gla-protein concentration and urinary deoxypyridinoline excretion: effects of growth and ageing Richard...
Articles
Richard Eastell, Nancy E. Vieira, Alfred L. Yergey, Heinz W. Wahner, Murray N. Silverstein, Rajiv Kumar, B. Lawrence RIGGS
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (6): 681–685.
Published: 01 June 1992
.... 22 11 1991 20 1 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 bone density osteocalcin osteoporosis pernicious anaemia Clinical Science (1992) 82, 681 -685 (Printed in Great Britain) 68 I Pernicious anaemia as a risk factor for osteoporosis Richard...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (6): 799–802.
Published: 01 December 1991
...Trevor Stamp; Monica Katakity; A. J. Goldstein; M. V. Jenkins; C. R. Kelsey; G. A. Rose 1. We studied the effect of mineral supplementation and its duration is osteoporosis by analysing the calcium and phosphorus balances of 49 treated osteoporotic patients whose median length of calcium treatment...
Articles
S. J. S. Ryde, D. Clements, W. D. Evans, R. Motley, W. D. Morgan, C. Evans, J. Rhodes, J. E. Compston
Journal:
Clinical Science
Clin Sci (Lond) (1991) 80 (4): 319–324.
Published: 01 April 1991
..., no relationship was found between the rates of change in bone mass at these sites. 5. The rapid bone loss observed in some subjects emphasizes the importance of early detection of osteoporosis by bone densitometry and the need for effective prophylactic measures to be established in this group of patients. 24...
Articles
T. C. B. Stamp, P. W. Saphier, N. Loveridge, C. R. Kelsey, A. J. Goldstein, M. Katakity, M. V. Jenkins, G. A. Rose
Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (3): 233–238.
Published: 01 September 1990
...T. C. B. Stamp; P. W. Saphier; N. Loveridge; C. R. Kelsey; A. J. Goldstein; M. Katakity; M. V. Jenkins; G. A. Rose 1. To determine the relationships between parathyroid hormone activity and long-term sodium fluoride therapy in osteoporosis, cytochemical bioassays (for biologically active...
Articles
E. V. McCloskey, S. A. Murray, D. Charlesworth, C. Miller, J. Fordham, K. Clifford, R. Atkins, J. A. Kanis
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (2): 221–225.
Published: 01 February 1990
... as a reproducible, rapid, radiation-free assessment of skeletal status. 27 9 1989 26 10 1989 © 1990 The Biochemical Society and the Medical Research Society 1990 bone density broadband ultrasound attenuation os calcis osteoporosis quantitative computed tomography Clinical Science (1990...
Articles
E. V. McCloskey, S. A. Murray, C. Miller, D. Charlesworth, W. Tindale, D. P. O'Doherty, D. R. Bickerstaff, N. A. T. Hamdy, J. A. Kanis
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (2): 227–233.
Published: 01 February 1990
... of which contributes to an increase in fracture risk. Key words: broadband ultrasound attenuation, 0s calcis, osteoporosis, photon absorptiometry. Correspondence: Dr J. A. Kanis, Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield S10...
Articles
Trevor C. B. Stamp, Michael V. Jenkins, Nigel Loveridge, Peter W. Saphier, Monica Katakity, Sarah E. MacArthur
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (2): 143–146.
Published: 01 August 1988
... these effects may be relevant to long-term therapeutic results. 3 12 1987 22 1 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 Clinical Science ( 1988) 75,143- 146 143 Fluoride therapy in osteoporosis: acute effects on parathyroid and mineral homoeostasis TREVOR C.B...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (3): 265–271.
Published: 01 September 1985
... oestrogens osteoporosis parathyroid hormones progestational hormones vitamin D Clinical Science (1985) 69, 265-271 265 Early effects of ethinyloestradiol and norethisterone treatment in post-menopausal women on bone resorption and calcium, regulating hormones PETER L. SELBY, MUNRO PEACOCK, STUART...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (6): 745–748.
Published: 01 June 1984
... of the renal synthesis of 1,25-(OH) 2 D 3 . 4. It is proposed that this phenomenon may, in part, explain the reduction in calcium absorption which occurs after oophorectomy or the menopause. 1,25-dihydroxyvitamin D receptors calcium metabolism oestrogens osteoporosis small intestine 28 11 1983...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (1): 103–107.
Published: 01 January 1984
... absorption, osteoporosis, vitamin D metabolites. Abbreviations: (OH)D, hydroxyvitamin D; FTH, parathyroid hormone. Correspondence: Dr M. Peacock, MRC Mineral Metabolism Unit, The General Infirmary, Leeds LS1 3EX, U.K. Introduction Calcium absorption is lower in women with verte- bral crush fractures than...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 66 (1): 109–112.
Published: 01 January 1984
...R. Hesp; A. C. Deacon; Patricia Hulme; J. Reeve 1. Mean linear attenuation coefficients for trabecular bone (T) in the distal radius and total absorption coefficients (TA) in the radial mid-shafts of 22 patients with crush fracture osteoporosis were measured serially for a year by using computed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (5): 537–540.
Published: 01 May 1983
... periods may predispose to spinal osteoporosis. 8 10 1982 23 11 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 bone mineral content immobilization osteoporosis spine Clinical Science (1983) 64,537-540 537 Vertebral bone loss: an unheeded side effect...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (5): 541–546.
Published: 01 May 1983
.... Physical exercise may prevent spinal osteoporosis. bone mineral content fractures osteoporosis physical exercise prophylaxis spine 8 10 1982 23 11 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 Clinical Science ( 1 983) 64,54 1-546 54 1 Physical...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (2): 153–160.
Published: 01 August 1982
...J. Reeve; J. R. Green; R. Hesp; Patricia Hulme 1. Calcium balances and formation rates of new bone measured with an improved tracer technique using 85 Sr have been determined simultaneously in 21 patients with idiopathic osteoporosis and vertebral crush fractures. 2. A weak positive association...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (4): 389–396.
Published: 01 April 1982
... could induce a positive calcium balance. 2. Osteoporosis was induced by calcium restriction during pregnancy and lactation. Sequential measurements of whole-body calcium were made by neutron activation. 3. In non-osteoporotic intact and thyroparathyroidectomized rats a daily dose of 75 units of human...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (3): 329–336.
Published: 01 March 1982
...B. Krølner; S. Pors Nielsen 1. Bone mineral content of the second, third and fourth lumbar vertebrae was determined in normal women and women with clinical osteoporosis by using dual-photon ( 153 Gd) absorptiometry. 2. A cross-sectional study of 70 normal women (aged 19–88 years) showed a bone loss...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (2): 221–226.
Published: 01 February 1982
...N. C. Thalassinos; D. H. Gutteridge; G. F. Joplin; T. R. Fraser 1. The effect of a high calcium intake (1 mmol day −1 kg −1 ) alone or with the concomitant administration of oestradiol and testosterone derivatives was monitored by serial calcium balances in 48 patients with osteoporosis of various...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (2): 137–142.
Published: 01 August 1980
...-menopausal women with various degrees of simple osteoporosis, but a few cases of hyperparathyroidism and other calcium disorders were included. 2. Calcium balance, bone resorption rate, urinary hydroxyproline and plasma alkaline phosphatase were shown to be related to the rate of bone loss; patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 58 (4): 341–342.
Published: 01 April 1980
... osteoporosis alkaline phosphatase Clinical Science (1980) 58,341-342 SHORT COMMUNICATION Rise in plasma alkaline phosphatase at the menopause R. G . CRILLY, M. M. JONES, A. H O R S M A N AND B. E. C. N O R D I N MRC Mineral Metabolism Unir, General Iqfirmaty, Lee&, U.K. (Received 28 September 1979...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (4): 317–324.
Published: 01 April 1979
... and intestinal malabsorption of calcium, together with a dialysate calcium of only 1·5 mmol/l, may be more important causes of bone loss in patients in this study. haemodialysis heparin metacarpal morphometry osteoporosis physical activity renal osteodystrophy 10 4 1978 24 11 1978 ©...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (4): 439–446.
Published: 01 April 1978
... diseases, calcium dietary, menopause, oophorectomy, osteoporosis. Introduction Calcium deprivation without vitamin D deficiency causes osteoporosis in several species, including the mouse (Shah, Krishnarao & Draper, 1967), rat (Crawford, Gribetz, Diner, Hurst & Castleman, 1957; Harrison & Fräser, 1960...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (2): 193–195.
Published: 01 February 1978
... that progestogen has a different action on bone, perhaps stimulating bone formation. 29 8 1977 1 11 1977 © 1978 The Biochemical Society and the Medical Research Society 1978 bone oestrogen osteoporosis progestogen SHORT COMMUNICATION Comparative effects of oestrogen and a progestogen...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (5): 439–446.
Published: 01 November 1977
... vitamin D metabolism osteoporosis Clinical Science and Molecular Medicine (1977) 53,439-446. Vitamin D metabolism in adult rats at low and normal calcium intake and the effect of cadmium exposure R. LORENTZON AND S.-E. LARSSON Department of Orthopaedic Surgery, Unioersity of Umed, Umeci, Sweden...
Articles
Journal:
Clinical Science
Clin Sci (1972) 43 (6): 789–797.
Published: 01 December 1972
... device attached to a digital computer. 2. Areas of uncalcified osteoid are quantified by visual inspection during photography and the skeletal lesions of hyperparathyroidism are assessed semi-quantitatively. 3. This system makes it possible to define osteoporosis and osteomalacia according...
Articles
Journal:
Clinical Science
Clin Sci (1972) 42 (2): 235–241.
Published: 01 February 1972
... of osteoporosis. 4 11 1971 © 1972 The Biochemical Society and the Medical Research Society 1972 parathyroid hormone calcitonin bone calcium osteoporosis vitamin D Clinical Science (1972) 42,235-241. SHORT COMM UNICA TI0 N CALCIUM SHIFT INTO BONE: A CALCITONIN- RESISTANT PRIMARY ACTION O...