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Keywords: ouabain
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (20): 1595–1618.
Published: 25 October 2023
... kinase signaling up-regulation and cerebral hypoperfusion. The review discusses the role of an endogenous cardiotonic steroid-like compound, ouabain, which binds to the Na,K-ATPase and initiates the intracellular cSrc signaling, in the pathophysiology of arterial hypertension. Currently, our...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (4): 497–502.
Published: 01 October 1996
...Toshiaki Kurashina; Kent A. Kirchner; Joey P. Granger; Ami R. Patel 1. Chronic Na + ,K + -ATPase inhibition with ouabain induces hypertension in the rat. To examine the role of the kidney in this process, the effect of changes in renal perfusion pressure on glomerular filtration rate, renal blood...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (1): 9–12.
Published: 01 January 1996
...Zhiming Zhu; Martin Tepel; Marcus Neusser; Walter Zidek 1. Low ouabain concentrations in the nanomolar range significantly increased cytosolic free calcium concentration. 2. The ouabain-induced cytosolic free calcium concentration increase was due to transplasmamembrane calcium influx, which could...
Articles
Mitsuisa Yoshimura, Tetsuya Oshima, Hideo Matsuura, Mitsuaki Watanabe, Yukihito Higashi, Norihisa Ono, Hiroyuki Hiraga, Masayuki Kambe, Goro Kajiyama
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (3): 293–298.
Published: 01 September 1995
... zero (low) or 5 mmol/l (high) external Mg 2+ concentrations. 3. Preincubation of platelets with 10 −4 mol/l ouabain effectively decreased the transmembrane Na + gradient. The ouabain-induced increase in [Mg 2+ ], was statistically significant after 30 min of exposure (14.6 ± 2.0%) and reached 24.6...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (3): 277–284.
Published: 01 September 1995
...D. G. Peckham; A. Conn; C. Chotai; S. Lewis; A. J. Knox 1. Airway epithelium in cystic fibrosis is characterized by a defect in chloride secretion across the apical membrane and an increase in sodium absorption. The increased rate of sodium absorption can be inhibited in vitro by ouabain, a Na + -K...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (6): 695–700.
Published: 01 June 1995
... was measured in human lymphocytes by determining ouabain-sensitive 86 Rb + influx at several concentrations of K + . The Na + -K + pump rate increased within the physiological range of extracellular free [K + ] (K 1/2 = 1.5 mmol/l). 3. To test the hypothesis that elevation of extracellular free [K + ] reduces...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (4): 391–397.
Published: 01 April 1994
...G. B. Pidgeon; A. M. Richards; M. G. Nicholls; L. K. Lewis; T. G. Yandle 1. The influence of single-dose intravenous ouabain on haemodynamics, renal function and vasoactive hormones was investigated in healthy subjects. 2. After ouabain injection there was a significant reduction in minimum...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (2): 185–190.
Published: 01 February 1992
...Roland Foulkes; Romana G. Ferrario; Patricia Salvati; Giuseppe Bianchi 1. Several observations support the hypothesis that in rats of the Milan hypertensive strain elevated levels of a circulating ouabain-like factor might normalize the elevated Na + reabsorption, but, on the other hand, might...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 525–529.
Published: 01 October 1991
...Robin G. Woolfson; Nicholas T. Richards; Lucilla Poston 1. Using a Mulvany-Halpern myograph to measure changes in isometric tension, we have investigated the effect of ouabain on noradrenaline-induced contraction of human subcutaneous resistance arteries. 2. Low concentrations of ouabain (10 nmol/l...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (4): 315–323.
Published: 01 October 1990
...Alan J. Knox; Paul Ajao; John R. Britton; Anne E. Tattersfield 1. To determine whether alterations in membrane sodium transport in airway smooth muscle can alter its contractility, we studied the effect of ouabain (a Na + /K + -adenosine triphosphatase inhibitor) and amiloride on contractile...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (3): 335–341.
Published: 01 March 1990
... min −1 and a saturable component with a K m of 61 ± 23 μmol/l and a V max. of 11.3 ± 4.5 × 10 −4 mmol min −1 l −1 . Ouabain and low extracellular concentrations of sodium partly inhibited influx. Uptake was predominantly into the cytosolic fraction of the cell with 12% entering the membrane-associated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (2): 169–174.
Published: 01 February 1990
...A. A. Brownlee; Paul Johnson; Ivor H. Mills 1. We have reported that the bufadienolide, bufalin (purified from toad skin), was more potent than ouabain in inhibiting the sodium/potassium-dependent adenosine triphosphatase from canine kidney (Sigma) [Brownlee, A. A., Lee, G. & Mills, I. H. J...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1989) 77 (5): 541–545.
Published: 01 November 1989
...Roberto Pedrinelli; Stefano Taddei; Antonio Salvetti 1. The interaction of ouabain, a Na + /K + adenosine 5′-triphosphatase inhibitor, with sympathetic mechanisms of vasoconstriction, as well as its possible site(s) of action, were investigated in forearm arterioles of patients with uncomplicated...
Articles
M. Afzal Mir, Kevin Morgan, Stephen Chappell, Mark Lewis, Gillian Spurlock, Peter Collins, Philip Collins, Malcolm Lewis, Maurice Scanlon
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (2): 197–202.
Published: 01 August 1988
... an identical effect on fresh strips. 3. Ouabain, used as a control, also caused a concentration-dependent increase in tension which reached a plateau at a concentration of 10 mmol/l. Both ouabain and ASTI caused a significant potentiation of the vasoconstrictor effect of noradrenaline at concentrations of 1...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 74 (2): 145–150.
Published: 01 February 1988
... ) and increase in intracellular potassium ([K] i ) in pregnancy with a return towards normal values in the post-partum period. 3. Maximum specific ouabain binding [number of Na + ,K + -adenosine triphosphatase (Na + ,K + -ATPase) units] was increased by 70% in pregnancy and returned slowly towards normal values...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (3): 263–269.
Published: 01 March 1986
... = 10) pre- and post-ovulation, at the same time intervals (days 7–10 and days 15–18) during a menstrual cycle. 2. With rubidium ( 86 Rb + ) used as a potassium analogue, co-transport (ouabain-resistant, fruse-mide-sensitive 86 Rb + influx) values were found to be lowest in non-O/C women (28 ± se 2.5...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (3): 365–368.
Published: 01 March 1985
...Kevin Morgan; Gillian Spurlock; M. Afzal Mir 1. Previous studies have shown that leukaemic immature cells, specifically promyelocytes but not mature leucocytes, contain and release an inhibitor of ouabain-insensitive sodium transport (inhibitin). 2. In the present study, medium from cultured...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (5): 535–540.
Published: 01 November 1984
...M. Cirillo; M. David-Dufilho; M. A. Devynck 1. Calmodulin and calcium effects on cardiac ouabain-sensitive adenosine triphosphatase (ATPase) activity were studied in young spontaneously hypertensive rats (SHR) and in their normotensive control Wistar—Kyoto rats (WKY). 2. Cardiac sarcolemmal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (4): 403–405.
Published: 01 October 1984
... system. 14 12 1983 28 3 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 diuresis frusemide natriuresis ouabain rat atrial peptides Clinical Science (1984) 67, 403-4G5 403 Atrial natriuretic factor: sodium transport in human erythrocytes NICK C...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (1): 79–83.
Published: 01 January 1983
... 0.395 ± sem 0.028 to 0.310 ± 0.018 ( P < 0.02), whereas a leucocyte extract had no significant effect. 3. The extract had an inhibitory effect after heating at 80° C for 30 min, and in the presence of ouabain and frusemide alone or in combination. 4. These studies suggest that myeloid leukaemic blast...
Articles
Motilal B. Pamnani, David R. Harder, Stephen J. Huot, Howard J. Bryant, Francis A. Kutyna, Francis J. Haddy
Journal:
Clinical Science
Clin Sci (Lond) (1982) 63 (s8): 31s–33s.
Published: 01 October 1982
... rats. 4. Boiled plasma supernatants from normotensive control rats had no effect on the E m of either animal. 5. Ouabain depolarized muscle cells of the normotensive artery only and the magnitude of depolarization induced was nearly the same as that produced by the supernatant from the hypertensive...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 57s–60s.
Published: 01 December 1981
... are associated with a heat-stable ouabain-like agent in the plasma. 3. In the volume-expanded rat, an anteroventral third ventricle (AV3V) lesion decreases the level of the ouabain-like humoral factor and increases vascular Na + —K + pump activity. These findings suggest that the humoral ouabain-like factor...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 37s–39s.
Published: 01 December 1981
...) over 30 min decreased the efflux rate constant. 3. The change after chronic sodium loading and the intravenous infusion of saline is in the ouabain-sensitive component (ouabain-sensitive Na + , K + ATPase pump activity) of total efflux. 4. The reduction in efflux by an acute sodium load occurred only...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (4): 391–397.
Published: 01 October 1981
...M. A. Mir 1. At a high dilution in Ringer solution (1:200), leukaemic plasma significantly ( P < 0.05) decreased the ouabain-sensitive and increased ouabain-insensitive components of sodium efflux from erythrocytes. At a low dilution (1:10) leukaemic plasma predominantly decreased the total...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 191s–193s.
Published: 01 December 1980
...R. P. Garay; G. Dagher; P. Meyer 1. In erythrocytes, the extrusion of a cell sodium load is accomplished by the ouabain-sensitive sodium-potassium pump and by the frusemide-sensitive sodium-potassium cotransport, which operate against the passive sodium permeability. All these three components...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 187s–189s.
Published: 01 December 1980
... old). Ouabain (10 −4 mol/l) was used to inhibit the sodium pump. 2. In all groups studied, dose-response curves to agonists were shifted to the left when ouabain was added to the perfusion medium. This potentiation in vascular reactivity produced by ouabain was expressed as ‘index for sodium-pump...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (5): 415–420.
Published: 01 November 1979
... to ouabain was apparent only at or above a concentration of 10 −7 mol/l (73 μg/l). 3. In the rabbit septum there was a net loss of potassium on exposure to ouabain if the concentration was greater than 10 −7 mol/l. There was no net loss, or gain, of potassium at lower concentrations. Loss of potassium...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (5): 445–453.
Published: 01 May 1979
... with that caused by high doses of ouabain. 4. Neurotransmitter blockade did not alter the low- and high-dose angiotensin II effects. In other sequential dose studies, valine 5 -angiotensin II and isoleucine 5 -angiotensin II did not differ in their effects on perfusate composition or arterial contraction. 5...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1975) 49 (1): 13–26.
Published: 01 July 1975
... with zona fasciculata cells, whose steroid output is unresponsive to external potassium concentration ([K + ]). 4. Ouabain at 10 −5 mol/l depressed the intracellular [K + ] of glomerulosa cells but did not alter basal or stimulated corticosterone output. Similar results were obtained with fasciculata cells...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1975) 48 (3): 213–218.
Published: 01 March 1975
...M. Afzal Mir; H. Bobinski 1. Sodium transport studies were performed in erythrocytes from normal subjects and from patients with acute myeloid leukaemia. Sodium influx and efflux rates were increased in erythrocytes from leukaemic patients. 2. The ouabain-sensitive component of sodium efflux...
