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Keywords: oxidative stress
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Articles
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050 [ 1 ]. Despite the improvement of lifespan, health...
Articles
Clin Sci (Lond) (2021) 135 (6): 753–773.
Published: 17 March 2021
... normalised by fasudil and 4-PBA. Cerebral vessels in CADASIL patients exhibited significant oxidative damage. In conclusion, peripheral vascular dysfunction in CADASIL is associated with altered Ca 2+ homoeostasis, oxidative stress and blunted eNOS/sGC/cGMP signaling, processes involving Rho kinase and ER...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
Articles
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... quality of life. Loss in muscle mass cannot alone account for the muscle weakness induced by RA, but instead intramuscular dysfunction appears as a critical factor underlying the decreased force generating capacity for patients afflicted by arthritis. Oxidative stress and associated oxidative post...
Articles
Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
..., attenuated oxidative stress and neuronal apoptosis, as well as decreased accumulation of Aβ and Tau in the hippocampus. Taken together, the data demonstrated that transplantation of Mito-Plt attenuated cognitive impairment and mitochondrial dysfunction in db/db mice. This method may be a potential...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (15): 2055–2073.
Published: 10 August 2020
... treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks after bile duct ligation (BDL). Methods: Systemic, splanchnic, and renal hemodynamics and pathogenic...
Articles
Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... Oxidative stress The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. ...
Articles
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... oxygen-induced retinopathy (OIR) models. The retina function was monitored by electroretinography (ERG) and retinal thickness was measured by optical coherence tomography (OCT). TUNEL and cell death ELISA were performed to measure the apoptosis. Oxidative stress was detected by the measurement of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... stiffening of the large elastic arteries (i.e., the aorta and carotid arteries), contribute importantly to the age-related increase in CVD risk. Vascular aging is driven in large part by oxidative stress, which reduces bioavailability of nitric oxide and promotes alterations in the extracellular matrix. A...
Articles
Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
Articles
Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of...
Articles
Clin Sci (Lond) (2020) 134 (1): 73–74.
Published: 14 January 2020
.... Correspondence: Natalia López-Andrés ( natalia.lopez.andres@navarra.es ) 15 11 2019 23 12 2019 03 01 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 galectins oxidative stress peroxiredoxins Molecular and cellular...
Articles
Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
... function involving the inhibition of oxidative stress-induced injury via sGC-cGMP-PKG pathway and may be a promising therapeutic option for DCM. To detect reactive oxygen species (ROS) production in myocardium, the frozen heart sections were incubated with 5 μmol/ml ROS Fluorescent Probe-DHE (US...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1609–1627.
Published: 25 July 2019
... ischemic reperfusion, nephrotoxic drugs and sepsis. It is characterized by a sudden decline in renal function, in addition to excessive inflammation, oxidative stress and programmed cell death of renal tubular epithelial cells. RIPK1-mediated necroptosis plays an important role in AKI. In the present study...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1537–1548.
Published: 17 July 2019
...: Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 effects on oxidative stress and inflammation in human cardiac fibroblasts and its pathological role in human aortic stenosis (AS). Methods and results...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... and poor diet but the underlying mechanisms have not been fully established. However, there is emerging and compelling experimental and clinical evidence to show that increased oxidative stress causes pulmonary inflammation and that the spill over of pro-inflammatory mediators from the lungs into the...
Articles
Clin Sci (Lond) (2019) 133 (1): 117–134.
Published: 11 January 2019
... unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels. This...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (20): 2175–2188.
Published: 19 October 2018
... significantly decreased at the levels of the mRNA and protein in the penis of diabetic rats compared with normal controls. To test the hypothesis that decreased the penile levels of PEDF are associated with oxidative stress and inflammation in DMED, an adenovirus expressing PEDF (Ad-PEDF) or the same titer of...
Articles
Clin Sci (Lond) (2018) 132 (16): 1811–1836.
Published: 30 August 2018
...Jay C. Jha; Florence Ho; Christopher Dan; Karin Jandeleit-Dahm Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD...
Articles
Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
.... Overall, it is unlikely that a single measurement provides global assessment of plasma oxidative stress. Rather, assessment of individual thiol pools and thiol-proteins specific to any given condition has more solid and logical perspective to yield novel relevant information on disease risk and prognosis...
Articles
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (8): 869–881.
Published: 30 April 2018
..., intracellular insulin and leptin mediators, and oxidative stress (OS) markers were also measured in islets isolated from each experimental group. HS rats had increased plasma triglyceride, insulin, leptin, and lipid peroxidation (OS marker) levels associated with an insulin-resistant state. Their islets...
Articles
Clin Sci (Lond) (2018) 132 (6): 719–738.
Published: 30 March 2018
...@rgcb.res.in ) 14 11 2017 15 12 2017 20 12 2017 30 01 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 AMPK atherosclerosis Cyclophilin A metformin Macrovascular complications oxidative stress Cyclophilin A...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
... Dyslipidemia Kidney stone metabolic syndromes oxidative stress Kidney stones and CVDs are complex multifactorial results from interactions between environmental and genetic factors [ 1–3 ]. According to National Health and Nutrition Examination Survey (NHANES), the prevalence of history of kidney...
Articles
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
Articles
Clin Sci (Lond) (2017) 131 (23): 2807–2812.
Published: 28 November 2017
... meal were mediated by a reduction in NO bioavailability, at least in the aged. However, this does not appear to be caused by an increase in oxidative stress, since no additional elevations in A •− were observed post-prandially. It was interesting to note that the baseline A •− to which the aged were...
Articles
Clin Sci (Lond) (2017) 131 (21): 2573–2599.
Published: 25 October 2017
... homeostasis may make older people more susceptible to many diseases. Chronic oxidative stress and defective protein homeostasis (proteostasis) are two major factors associated with the etiology of age-related disorders. In the present paper, we review the contribution of impaired responses to oxidative stress...
Articles
Clin Sci (Lond) (2017) 131 (19): 2409–2426.
Published: 15 September 2017
... liver damage biomarker aspartate aminotransferase (AST), increased in magnitude 1.5 and 2.5 times compared with controls, respectively. THS exposure for 2 months resulted in further damage and at 4 and 6 months, many factors related to oxidative stress were altered and caused molecular damage. We also...
Articles
Clin Sci (Lond) (2017) 131 (18): 2397–2408.
Published: 08 September 2017
... intracellular and the extracellular miR-200c expression levels. In conclusion, circulating miR-200c is up-regulated in FH, probably due to oxidative stress and inflammation and via a miR-33a/b -ZEB1-dependent mechanism. The present study could provide the first evidence to point to the use of miR-33a/b and miR...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (14): 1689–1700.
Published: 30 June 2017
... provide an effective therapeutic approach to prevent the cardiovascular sequelae associated with excessive adiposity. In this review, we discuss the recent evidence supporting the role of oxidative stress and cytokines and inflammatory signals within the vasculature as well as the impact of the...
Articles
Clin Sci (Lond) (2017) 131 (14): 1701–1712.
Published: 30 June 2017
... the Biochemical Society 2017 bronchopulmonary dysplasia hyperoxic stress HO-1 hyperoxic lung injuries Nrf2 Oxidative stress Preterm newborns – described as birth prior to 37 weeks of gestation – are estimated to be approximately 15 million every year and one of the main features is...
Articles
Clin Sci (Lond) (2017) 131 (13): 1449–1463.
Published: 28 June 2017
... 25 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Calcitriol Inflammation Oxidative stress Paricalcitol Phosphate VSMCs High serum phosphate levels are an independent predictor of mortality in chronic kidney...
Articles
Clin Sci (Lond) (2017) 131 (13): 1419–1428.
Published: 23 June 2017
...D. La Russa; E. Brunelli; D. Pellegrino In both humans and animals, essential hypertension acts as a risk factor for subclinical kidney damage and precedes renal dysfunction. Several lines of evidence indicate that hypertension and oxidative stress are closely related. The increase in vascular...
Articles
Clin Sci (Lond) (2017) 131 (10): 981–990.
Published: 04 May 2017
...Jay C. Jha; Anna M.D. Watson; Geetha Mathew; Lisanne C. de Vos; Karin Jandeleit-Dahm Oxidative stress is a consequence of up-regulation of pro-oxidant enzyme-induced reactive oxygen species (ROS) production and concomitant depletion of antioxidants. Elevated levels of ROS act as an intermediate and...
Articles
Clin Sci (Lond) (2017) 131 (9): 803–822.
Published: 19 April 2017
... resistance to oxidative stress. In turn, sex hormones regulate mitochondrial function and biogenesis. Mutations in genes encoding mitochondrial proteins are the origin of serious mitochondrial genetic diseases. Mitochondrial dysfunction is also an important parameter for a large panel of pathologies...
Articles
Clin Sci (Lond) (2017) 131 (6): 471–485.
Published: 06 March 2017
... colibactin colorectal cancer Escherichia coli microsatellite instability mutL homologue 1 (MLH1) oxidative stress • The study presents the first clinical evidence for an interaction between pathogenic colibactin-producing E. coli and DNA MMR deficiency in CRC. • Moreover, this work...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (2): 139–140.
Published: 23 December 2016
...Michael J. Ryan Correspondence: Professor Michael J. Ryan (email mjryan@umc.edu ) 6 11 2016 19 11 2016 22 11 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 oxidative stress reactive oxygen species...
Articles
Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
...Elyse Di Marco; Stephen P. Gray; Phyllis Chew; Kit Kennedy; Mark E. Cooper; Harald H.H.W. Schmidt; Karin A.M. Jandeleit-Dahm Oxidative stress and inflammation are central mediators of atherosclerosis particularly in the context of diabetes. The potential interactions between the major producers of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
... aging and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the...
Articles
Clin Sci (Lond) (2016) 130 (12): 1027–1038.
Published: 06 May 2016
... display decreased oxidative stress and apoptosis, as well as macrophage infiltration and monocyte chemoattractant protein-1 (MCP1) expression, in elastase-induced AAA. In conclusion, decreased circulating PON1 activity is associated with human and experimental AAA. PON1 overexpression in mice protects...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (11): 853–870.
Published: 22 April 2016
... degenerative features of this disease. Furthermore, the concurrent dys-regulation of cellular antioxidant defense, which coincides with frataxin deficiency, exacerbates oxidative stress. Hence, the pathogenesis of FA underscores the importance of the integrated homeostasis of cellular iron metabolism and the...
Articles
Clin Sci (Lond) (2016) 130 (7): 525–538.
Published: 17 February 2016
... deleterious oxidative stress environment appears to be the underlying mechanism. These changes might contribute to the progression of CKD in these patients. Correspondence: Gema Ruiz-Hurtado (gemaruiz@h12o.es). 23 7 2015 4 12 2015 4 1 2016 4 1 2016 © 2016 Authors; published...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (5): 301–315.
Published: 26 January 2016
...Theophilus I. Emeto; Joseph V. Moxon; Minnie Au; Jonathan Golledge Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress...
Articles
Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
... bioavailable inhibitor of Nox1. Correspondence: Professor Francis J. Miller, Jr (email francis-miller@uiowa.edu ). 4 6 2015 5 10 2015 6 10 2015 © 2016 Authors; published by Portland Press Limited 2016 cell signalling NADPH oxidase oxidative stress reactive oxygen species...
Articles
Clin Sci (Lond) (2015) 129 (12): 1143–1150.
Published: 30 October 2015
...Martin Kolisek; Augusto C. Montezano; Gerhard Sponder; Aikaterini Anagnostopoulou; Juergen Vormann; Rhian M. Touyz; Joerg R. Aschenbach Disturbed magnesium (Mg 2+ ) homoeostasis and increased levels of OS (oxidative stress) are associated with poor clinical outcomes in patients suffering from...
Articles
Clin Sci (Lond) (2015) 129 (12): 1115–1129.
Published: 22 October 2015
... more regenerative, less scarring healing. Using heat-induced burn injury in rats, we show that burns treated with dressings containing 0.04 mg insulin/cm 2 every 3 days for 9 days have faster closure, a higher rate of disintegration of dead tissue and decreased oxidative stress. In addition, in insulin...
Articles
Clin Sci (Lond) (2015) 129 (12): 989–999.
Published: 18 September 2015
...Othman Al-Sawaf; Tim Clarner; Athanassios Fragoulis; Yuet Wai Kan; Thomas Pufe; Konrad Streetz; Christoph Jan Wruck The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator of oxidative stress defence in the human body. As Nrf2 regulates the expression of a...
Articles
Clin Sci (Lond) (2015) 129 (12): 1011–1023.
Published: 18 September 2015
... airway epithelial cells, which was associated with enhanced pro-inflammatory cytokine expression. Moreover, KL depletion increased cell sensitivity to cigarette smoke-induced inflammation and oxidative stress-induced cell damage. These effects involved the NF-κB (nuclear factor κB), MAPK (mitogen...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... cardiomyopathy ER stress heart failure iron deficiency iron overload lipocalin 2 (Lcn2) mitochondrial dysfunction NGAL oxidative stress Iron is an essential micronutrient and its crucial role in many physiological functions is often underestimated [ 1 ]. Altered iron metabolism is implicated in a...
Articles
Clin Sci (Lond) (2015) 129 (8): 721–739.
Published: 22 July 2015
...Marta B. Afonso; Pedro M. Rodrigues; Tânia Carvalho; Marta Caridade; Paula Borralho; Helena Cortez-Pinto; Rui E. Castro; Cecília M.P. Rodrigues Hepatocyte cell death, inflammation and oxidative stress constitute key pathogenic mechanisms underlying non-alcoholic fatty liver disease (NAFLD). We...