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Keywords: oxidative stress
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Clin Sci (Lond) (2025) 139 (04): 309–323.
Published: 19 February 2025
...), and NGAL were quantified via assay kits or immunoblotting. Kidneys were processed for histological analysis to assess tubular injury and fibrosis, and for electron microscopy to examine mitochondrial morphology. Immunoblots on kidney homogenates were performed to determine oxidative stress and apoptosis...
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Clin Sci (Lond) (2025) 139 (03): 259–280.
Published: 03 February 2025
... and DNA structure and function. Ischaemia-reperfusion injury is a multifaceted pathological state characterised by excessive production of mROS. There is a significant clinical need for therapies mitigating mitochondrial oxidative stress. To date, a variety of strategies have been investigated, ranging...
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Clin Sci (Lond) (2023) 137 (10): 823–841.
Published: 31 May 2023
... HFD-induced obesity, Akt2 loss-of-function mitigated lipid accumulation and oxidative stress in the liver and heart tissue. Mechanistically, down-regulation of Akt2 promotes SIRT6 expression in L02 cells and NRCMs, the latter deacetylates SOD2, which promotes SOD2 activity and therefore alleviates...
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Clin Sci (Lond) (2022) 136 (22): 1711–1730.
Published: 30 November 2022
... also showed that SIRT6 suppressed intracellular oxidative stress upon FAs stimulation in PMHCs and L02 cells. Mechanistically, SIRT6, but not SIRT1 promoted PGC-1α expression. We further prove that ENDOG is downstream of PGC-1α. In addition, we evidenced that ENDOG protects hepatocytes from lipid...
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Clin Sci (Lond) (2022) 136 (13): 1019–1023.
Published: 01 July 2022
...Philip C. Calder Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004...
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Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and COPD involve significant local (i.e. lung, vasculature) and systemic inflammation and oxidative stress, of which current pharmacological treatments have limited efficacy, hence the urgency for the development of novel life-saving therapeutics. Currently these diseases must be treated individually...
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Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... oxidative stress as well as increased mesangial expansion and glomerulosclerosis when compared with vehicle-treated diabetic animals. Inhibition of the inflammasome by MCC950 in diabetic mice led to renal up-regulation of markers of inflammation ( Il1 β, Il18 and Mcp1 ), fibrosis ( Col1, Col4 , Fn1, α-SMA...
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Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress...
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Clin Sci (Lond) (2021) 135 (17): 2103–2119.
Published: 06 September 2021
... in 3-nitrotyrosine (18-fold). Combination of HFD and CS precipitated hepatosteatosis to NASH reflected by exacerbated makers of liver inflammation and fibrosis which were associated with much severe liver oxidative stress (90-fold increase in 3-nitrotyrisine along with 6-fold increase in carbonylated...
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Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... TMAO levels may also promote neuro-inflammation and cognitive dysfunction [ 51 ]. Ageing Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Figure 1 Dietary intake, TMAO metabolism and disease risk Animal food such as egg and red meat rich in choline...
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Clin Sci (Lond) (2021) 135 (6): 753–773.
Published: 17 March 2021
... normalised by fasudil and 4-PBA. Cerebral vessels in CADASIL patients exhibited significant oxidative damage. In conclusion, peripheral vascular dysfunction in CADASIL is associated with altered Ca 2+ homoeostasis, oxidative stress and blunted eNOS/sGC/cGMP signaling, processes involving Rho kinase and ER...
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Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
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Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... quality of life. Loss in muscle mass cannot alone account for the muscle weakness induced by RA, but instead intramuscular dysfunction appears as a critical factor underlying the decreased force generating capacity for patients afflicted by arthritis. Oxidative stress and associated oxidative post...
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Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
... oxidative stress and neuronal apoptosis, as well as decreased accumulation of Aβ and Tau in the hippocampus. Taken together, the data demonstrated that transplantation of Mito-Plt attenuated cognitive impairment and mitochondrial dysfunction in db/db mice. This method may be a potential therapeutic...
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Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... Oxidative stress The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. ...
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Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... and oxygen-induced retinopathy (OIR) models. The retina function was monitored by electroretinography (ERG) and retinal thickness was measured by optical coherence tomography (OCT). TUNEL and cell death ELISA were performed to measure the apoptosis. Oxidative stress was detected by the measurement...
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Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... and stiffening of the large elastic arteries (i.e., the aorta and carotid arteries), contribute importantly to the age-related increase in CVD risk. Vascular aging is driven in large part by oxidative stress, which reduces bioavailability of nitric oxide and promotes alterations in the extracellular matrix...
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Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
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Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose...
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Clin Sci (Lond) (2020) 134 (1): 73–74.
Published: 14 January 2020
... in cardiac cells [ 7 ] and superoxide production in monocytes [ 8 ]. Finally, Gal-3 decreases the protective fumarate hydratase promoting oxidative stress in human cardiac fibroblasts [ 9 ]. Considering all these findings, it is interesting to speculate that Gal-3-induced oxidative stress could be involved...
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Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
... function involving the inhibition of oxidative stress-induced injury via sGC-cGMP-PKG pathway and may be a promising therapeutic option for DCM. Seven-week-old male diabetic db/db mice were purchased from Model Animal Research Center of Nanjing University (Nanjing, China). Meanwhile, nondiabetic...
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Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... and poor diet but the underlying mechanisms have not been fully established. However, there is emerging and compelling experimental and clinical evidence to show that increased oxidative stress causes pulmonary inflammation and that the spill over of pro-inflammatory mediators from the lungs...
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Clin Sci (Lond) (2019) 133 (1): 117–134.
Published: 11 January 2019
... of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels...
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Clin Sci (Lond) (2018) 132 (16): 1811–1836.
Published: 30 August 2018
...Jay C. Jha; Florence Ho; Christopher Dan; Karin Jandeleit-Dahm Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD...
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Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
... that a single measurement provides global assessment of plasma oxidative stress. Rather, assessment of individual thiol pools and thiol-proteins specific to any given condition has more solid and logical perspective to yield novel relevant information on disease risk and prognosis. Correspondence...
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Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
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Clin Sci (Lond) (2018) 132 (8): 869–881.
Published: 30 April 2018
..., intracellular insulin and leptin mediators, and oxidative stress (OS) markers were also measured in islets isolated from each experimental group. HS rats had increased plasma triglyceride, insulin, leptin, and lipid peroxidation (OS marker) levels associated with an insulin-resistant state. Their islets...
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Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
... 01 2018 12 01 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Atherosclerosis cardiovascular disease Dyslipidemia Kidney stone metabolic syndromes oxidative stress Kidney stones and CVDs are complex multifactorial...
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Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
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Clin Sci (Lond) (2017) 131 (23): 2807–2812.
Published: 28 November 2017
... chemiluminescence (OBC Model 280i, NOA, Sievers, Boulder, CO, U.S.A.) following reduction by sodium iodide in acetic acid. The intra- and inter-assay CVs were both <5%. The ascorbate free radical (A •− ) was employed as a direct measure of global oxidative stress as previously described [ 11 ]. Plasma...
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Clin Sci (Lond) (2017) 131 (21): 2573–2599.
Published: 25 October 2017
... homeostasis may make older people more susceptible to many diseases. Chronic oxidative stress and defective protein homeostasis (proteostasis) are two major factors associated with the etiology of age-related disorders. In the present paper, we review the contribution of impaired responses to oxidative stress...
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