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Keywords: oxidative stress
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (18): 1477–1498.
Published: 22 September 2023
... of apoptosis in the kidney tissues of rats in each group. **** stands for P<0.0001,** stands for P<0.01, and * stands for P<0.05. Figure 11 Assessment of oxidative stress level in rat kidney tissues Panel ( A ) represents immunohistochemical plots of antioxidant Nrf2, HO-1 and SOD1...
Articles
Luís F. Grilo, João D. Martins, Mariana S. Diniz, Carolina Tocantins, Chiara H. Cavallaro, Inês Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1347–1372.
Published: 01 September 2023
... a possible risk-factor for some pregnancy-associated liver diseases (PALD) and hepatic diseases. PALD occur in approximately 3% of pregnancies and are characterized by maternal hepatic oxidative stress (OS) and mitochondrial dysfunction. Maternal hepatic disease increases maternal and fetal morbidity...
Includes: Supplementary data
Articles
Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (10): 823–841.
Published: 31 May 2023
... HFD-induced obesity, Akt2 loss-of-function mitigated lipid accumulation and oxidative stress in the liver and heart tissue. Mechanistically, down-regulation of Akt2 promotes SIRT6 expression in L02 cells and NRCMs, the latter deacetylates SOD2, which promotes SOD2 activity and therefore alleviates...
Includes: Supplementary data
Articles
Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (10): 785–805.
Published: 23 May 2023
... in lipopolysaccharide (LPS) and polyinosinic:polycytidylic acid (POLY I:C)-induced ALI/ARDS models in vitro and in vivo . Human airway epithelial (BEAS-2B) cells exposed to LPS+POLY I:C significantly elevated oxidative stress and inflammatory signaling. Co-treatment with CGA (10 and 50 µM) prevented inflammation...
Includes: Supplementary data
Articles
Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (1): 47–63.
Published: 05 January 2023
... kidney injury cell death mitochondria dysfunction Myocardial infarction oxidative stress type I cardio-renal syndrome Cardiovascular diseases (CVDs) remain the leading cause of death in both sexes with tremendous health and economic burdens worldwide [ 1–3 ]. According to the world health...
Includes: Supplementary data
Articles
Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1711–1730.
Published: 30 November 2022
... also showed that SIRT6 suppressed intracellular oxidative stress upon FAs stimulation in PMHCs and L02 cells. Mechanistically, SIRT6, but not SIRT1 promoted PGC-1α expression. We further prove that ENDOG is downstream of PGC-1α. In addition, we evidenced that ENDOG protects hepatocytes from lipid...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1019–1023.
Published: 01 July 2022
...Philip C. Calder Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and COPD involve significant local (i.e. lung, vasculature) and systemic inflammation and oxidative stress, of which current pharmacological treatments have limited efficacy, hence the urgency for the development of novel life-saving therapeutics. Currently these diseases must be treated individually...
Articles
Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... oxidative stress as well as increased mesangial expansion and glomerulosclerosis when compared with vehicle-treated diabetic animals. Inhibition of the inflammasome by MCC950 in diabetic mice led to renal up-regulation of markers of inflammation ( Il1 β, Il18 and Mcp1 ), fibrosis ( Col1, Col4 , Fn1, α-SMA...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress...
Includes: Supplementary data
Articles
Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (23): 2625–2641.
Published: 08 December 2021
... pathways developed. Vascular reactivity of TA and VC from HF post-MI and sham operated (SO) rats was assessed with a wire myograph, 4 weeks after coronary artery occlusion surgery. Nitric oxide (NO), H 2 O 2 production and oxidative stress were evaluated in situ with fluorescent probes, while protein...
Includes: Supplementary data
Articles
Alyson Deprez, Zakaria Orfi, Alexandra Radu, Ying He, Daniela Ravizzoni Dartora, Junio Dort, Nicolas A. Dumont, Anne Monique Nuyt
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (22): 2589–2605.
Published: 26 November 2021
... ) * These authors contributed equally to this work. 14 09 2021 03 11 2021 05 11 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Muscle atrophy oxidative stress Preterm birth Skeletal muscle Improved neonatal care over...
Includes: Supplementary data
Articles
Rhéure Alves-Lopes, Karla Bianca Neves, Anastasiya Strembitska, Adam P. Harvey, Katie Y. Harvey, Hiba Yusuf, Susan Haniford, Ross T. Hepburn, Jennifer Dyet, Wendy Beattie, Laura Haddow, John McAbney, Delyth Graham, Augusto C. Montezano
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2429–2444.
Published: 28 October 2021
... contributed equally to this work. 17 06 2021 18 10 2021 19 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 NADPH oxidase Osteoprotegerin Oxidative stress syndecans Vascular Biology In cardiovascular diseases...
Includes: Supplementary data
Articles
DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2409–2422.
Published: 22 October 2021
...DongZhu Xu; Nobuyuki Murakoshi; Kazuko Tajiri; Feng Duo; Yuta Okabe; Yoshiko Murakata; Zixun Yuan; Siqi Li; Kazuhiro Aonuma; Zonghu Song; Yuzuno Shimoda; Haruka Mori; Akira Sato; Akihiko Nogami; Kazutaka Aonuma; Masaki Ieda Oxidative stress could be a possible mechanism and a therapeutic target...
Articles
Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2103–2119.
Published: 06 September 2021
... in 3-nitrotyrosine (18-fold). Combination of HFD and CS precipitated hepatosteatosis to NASH reflected by exacerbated makers of liver inflammation and fibrosis which were associated with much severe liver oxidative stress (90-fold increase in 3-nitrotyrisine along with 6-fold increase in carbonylated...
Includes: Supplementary data
Articles
Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1845–1858.
Published: 04 August 2021
... are not completely understood. The present study tested the hypothesis that lysophosphatidylcholine (LPC), a proatherogenic component of oxLDL, induces endothelial calcium influx, which drives NOX5-dependent reactive oxygen species (ROS) production, oxidative stress, and endothelial cell dysfunction. Approach: Human...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1767–1772.
Published: 27 July 2021
... 2021 13 07 2021 16 07 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 epigenetics intrauterine growth restriction mitochondrial dysfunction oxidative stress sex Figure 1 Mitochondrion-nucleus crosstalk...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050 [ 1 ]. Despite the improvement of lifespan, health...
Articles
Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (6): 753–773.
Published: 17 March 2021
... normalised by fasudil and 4-PBA. Cerebral vessels in CADASIL patients exhibited significant oxidative damage. In conclusion, peripheral vascular dysfunction in CADASIL is associated with altered Ca 2+ homoeostasis, oxidative stress and blunted eNOS/sGC/cGMP signaling, processes involving Rho kinase and ER...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... quality of life. Loss in muscle mass cannot alone account for the muscle weakness induced by RA, but instead intramuscular dysfunction appears as a critical factor underlying the decreased force generating capacity for patients afflicted by arthritis. Oxidative stress and associated oxidative post...
Articles
Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
... oxidative stress and neuronal apoptosis, as well as decreased accumulation of Aβ and Tau in the hippocampus. Taken together, the data demonstrated that transplantation of Mito-Plt attenuated cognitive impairment and mitochondrial dysfunction in db/db mice. This method may be a potential therapeutic...
Includes: Supplementary data
Articles
Yu-Lien Tsai, Chih-Wei Liu, Chien-Fu Hsu, Chia-Chang Huang, Ming-Wei Lin, Shiang-Fen Huang, Tzu-Hao Li, Kuei-Chuan Lee, Yun-Cheng Hsieh, Ying-Ying Yang, Tzung-Yan Lee, Hsuan-Miao Liu, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2055–2073.
Published: 10 August 2020
... treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks after bile duct ligation (BDL). Methods: Systemic, splanchnic, and renal hemodynamics and pathogenic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Autophagy Hepatic fibrosis NADPH oxidase Oxidative stress ...
Articles
Fangfang Qiu, Xiang Ma, Young-Hwa Shin, Jianglei Chen, Qian Chen, Kelu Zhou, Wenjing Wu, Wentao Liang, Yalin Wu, Qing Song, Jian-Xing Ma
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... and oxygen-induced retinopathy (OIR) models. The retina function was monitored by electroretinography (ERG) and retinal thickness was measured by optical coherence tomography (OCT). TUNEL and cell death ELISA were performed to measure the apoptosis. Oxidative stress was detected by the measurement...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... and stiffening of the large elastic arteries (i.e., the aorta and carotid arteries), contribute importantly to the age-related increase in CVD risk. Vascular aging is driven in large part by oxidative stress, which reduces bioavailability of nitric oxide and promotes alterations in the extracellular matrix...
Articles
Yun Huang, Yang Li, Anni Lou, Guo zhen Wang, Ye Hu, Yijie Zhang, Weichang Huang, Jun Wang, Yue Li, Xintao Zhu, Tingting Chen, Jiayi Lin, Ying Meng, Xu Li
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
Articles
Rachel Njeim, Theresa Farhat, Sahar Alkhansa, Natalie Youssef, Batoul Dia, Rasha Slika, Radwan Diab, Sami T. Azar, Assaad A. Eid
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (1): 73–74.
Published: 14 January 2020
... in cardiac cells [ 7 ] and superoxide production in monocytes [ 8 ]. Finally, Gal-3 decreases the protective fumarate hydratase promoting oxidative stress in human cardiac fibroblasts [ 9 ]. Considering all these findings, it is interesting to speculate that Gal-3-induced oxidative stress could be involved...
Articles
Mei Xue, Ting Li, Yue Wang, Yunpeng Chang, Ying Cheng, Yunhong Lu, Xiangyang Liu, Linxin Xu, Xiaoyu Li, Xiaochen Yu, Bei Sun, Liming Chen
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
... function involving the inhibition of oxidative stress-induced injury via sGC-cGMP-PKG pathway and may be a promising therapeutic option for DCM. Table 1 Effects of empagliflozin treatment on cardiac function in db/db mice db/m db/db db/db +Empa Heart rate (beats/min) 585 ± 35 568 ± 49...
Includes: Supplementary data
Articles
Jia-nan Wang, Ming-ming Liu, Fang Wang, Biao Wei, Qin Yang, Yu-ting Cai, Xin Chen, Xue-qi Liu, Ling Jiang, Chao Li, Xiao-wei Hu, Ju-tao Yu, Tao-tao Ma, Juan Jin, Yong-gui Wu, Jun Li, Xiao-ming Meng
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1609–1627.
Published: 25 July 2019
... ischemic reperfusion, nephrotoxic drugs and sepsis. It is characterized by a sudden decline in renal function, in addition to excessive inflammation, oxidative stress and programmed cell death of renal tubular epithelial cells. RIPK1-mediated necroptosis plays an important role in AKI. In the present study...
Includes: Supplementary data
Articles
In Collection
Clinical and translational research highlights
Lara Matilla, Jaime Ibarrola, Vanessa Arrieta, Amaia Garcia-Peña, Ernesto Martinez-Martinez, Rafael Sádaba, Virginia Alvarez, Adela Navarro, Amaya Fernández-Celis, Alicia Gainza, Enrique Santamaría, Joaquín Fernández-Irigoyen, Antoni Bayes-Genis, Patrick Rossignol, Natalia López-Andrés
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1537–1548.
Published: 17 July 2019
...: Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 effects on oxidative stress and inflammation in human cardiac fibroblasts and its pathological role in human aortic stenosis (AS). Methods and results...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... and poor diet but the underlying mechanisms have not been fully established. However, there is emerging and compelling experimental and clinical evidence to show that increased oxidative stress causes pulmonary inflammation and that the spill over of pro-inflammatory mediators from the lungs...
Articles
Pamela L. Martín, Paula Ceccatto, María V. Razori, Daniel E.A. Francés, Sandra M.M. Arriaga, Gerardo B. Pisani, Alejandra I. Martínez, Enrique J. Sánchez Pozzi, Marcelo G. Roma, Cecilia L. Basiglio
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (1): 117–134.
Published: 11 January 2019
... of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels...
Includes: Supplementary data
Articles
Hongjie Qiao, Yuanyuan Zhang, Wenwen Lin, Yu-Feng Wang, Cristina M. Furdui, Qiuling Jiang, Xiao Li, Ting Long, Yunguang Wang, Da-nian Qin
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2175–2188.
Published: 19 October 2018
... was significantly decreased at the levels of the mRNA and protein in the penis of diabetic rats compared with normal controls. To test the hypothesis that decreased the penile levels of PEDF are associated with oxidative stress and inflammation in DMED, an adenovirus expressing PEDF (Ad-PEDF) or the same titer...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1811–1836.
Published: 30 August 2018
...Jay C. Jha; Florence Ho; Christopher Dan; Karin Jandeleit-Dahm Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
... that a single measurement provides global assessment of plasma oxidative stress. Rather, assessment of individual thiol pools and thiol-proteins specific to any given condition has more solid and logical perspective to yield novel relevant information on disease risk and prognosis. Correspondence...
Articles
Ming Zhan, Irtaza Usman, Jingbo Yu, Liemin Ruan, Xueyan Bian, Jun Yang, Shikun Yang, Lin Sun, Yashpal S. Kanwar
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (8): 869–881.
Published: 30 April 2018
..., intracellular insulin and leptin mediators, and oxidative stress (OS) markers were also measured in islets isolated from each experimental group. HS rats had increased plasma triglyceride, insulin, leptin, and lipid peroxidation (OS marker) levels associated with an insulin-resistant state. Their islets...
Articles
Surya Ramachandran, Vinitha Anandan, V. R. Kutty, Ajit Mullasari, M. Radhakrishna Pillai, Cheranellore Chandrasekharan Kartha
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 719–738.
Published: 30 March 2018
... by increasing oxidative stress and inflammation. Cyclophilin A is implicated as a crucial mediator of vascular remodeling in abdominal aortic aneurysms [ 1 ] and atherosclerosis [ 2 ]. We have previously shown that cyclophilin A levels secreted by monocytes are increased in the blood of patients with diabetes...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
... syndromes oxidative stress Kidney stones and CVDs are complex multifactorial results from interactions between environmental and genetic factors [ 1–3 ]. According to National Health and Nutrition Examination Survey (NHANES), the prevalence of history of kidney stones is 10.6% in men and 7.1...
Articles
Lawson Ung, Ushasree Pattamatta, Nicole Carnt, Jennifer L. Wilkinson-Berka, Gerald Liew, Andrew J.R. White
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Published: 04 December 2017
...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2807–2812.
Published: 28 November 2017
... Meal Hyperlipidaemia oxidative stress Oxidative-Nitrosative Stress The consumption of a high-fat meal is characterized by a state of post-prandial hyperlipidaemia (PPH) that can last for as long as 8 h [ 1 ]. During this time course, PPH has been shown to acutely impair systemic vascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (21): 2573–2599.
Published: 25 October 2017
... homeostasis may make older people more susceptible to many diseases. Chronic oxidative stress and defective protein homeostasis (proteostasis) are two major factors associated with the etiology of age-related disorders. In the present paper, we review the contribution of impaired responses to oxidative stress...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (19): 2409–2426.
Published: 15 September 2017
... and the liver damage biomarker aspartate aminotransferase (AST), increased in magnitude 1.5 and 2.5 times compared with controls, respectively. THS exposure for 2 months resulted in further damage and at 4 and 6 months, many factors related to oxidative stress were altered and caused molecular damage. We also...
Articles
Marco D’Agostino, Francesco Martino, Sara Sileno, Francesco Barillà, Sara Beji, Lorenza Marchetti, Fabio Maria Gangi, Luca Persico, Mario Picozza, Anna Montali, Eliana Martino, Cristina Zanoni, Daniele Avitabile, Sandro Parrotto, Maurizio Colognesi Capogrossi, Alessandra Magenta
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (18): 2397–2408.
Published: 08 September 2017
... the intracellular and the extracellular miR-200c expression levels. In conclusion, circulating miR-200c is up-regulated in FH, probably due to oxidative stress and inflammation and via a miR-33a/b -ZEB1-dependent mechanism. The present study could provide the first evidence to point to the use of miR-33a/b and miR...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1689–1700.
Published: 30 June 2017
... provide an effective therapeutic approach to prevent the cardiovascular sequelae associated with excessive adiposity. In this review, we discuss the recent evidence supporting the role of oxidative stress and cytokines and inflammatory signals within the vasculature as well as the impact...
Articles
Emanuele Amata, Valeria Pittalà, Agostino Marrazzo, Carmela Parenti, Orazio Prezzavento, Emanuela Arena, Seyed Mohammad Nabavi, Loredana Salerno
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1701–1712.
Published: 30 June 2017
... of the disease and may support novel approaches for the management of BPD. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 bronchopulmonary dysplasia hyperoxic stress HO-1 hyperoxic lung injuries Nrf2 Oxidative stress In premature infants...
Articles
Julio M. Martínez-Moreno, Carmen Herencia, Addy Montes de Oca, Juan M. Díaz-Tocados, Noemi Vergara, M. José Gómez-Luna, Silvia D. López-Argüello, Antonio Camargo, Esther Peralbo-Santaella, Maria E. Rodríguez-Ortiz, Antonio Canalejo, Mariano Rodríguez, Juan R. Muñoz-Castañeda, Yolanda Almadén
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1449–1463.
Published: 28 June 2017
... 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Calcitriol Inflammation Oxidative stress Paricalcitol Phosphate VSMCs High serum phosphate levels are an independent predictor of mortality in chronic kidney disease (CKD...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (13): 1419–1428.
Published: 23 June 2017
...D. La Russa; E. Brunelli; D. Pellegrino In both humans and animals, essential hypertension acts as a risk factor for subclinical kidney damage and precedes renal dysfunction. Several lines of evidence indicate that hypertension and oxidative stress are closely related. The increase in vascular...
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