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Articles

Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity

In Collection

Anna Flavia R. Lima, Daniel Rodrigues, Mirele R. Machado, José Teles Oliveira-Neto, Alecsander F. M. Bressan, Carina A. Pedersoli, Juliano V. Alves, Júlio A. Silva-Neto, Paula R. Barros, Thiago B. Dias, Luis V. Garcia, Ariane Bruder-Nascimento, Thiago Bruder-Nascimento, Fernando S. Carneiro, Luiz Osório S. Leiria, Rita C. Tostes, Rafael M. Costa

Clin Sci (Lond) (2024) 138 (17): 1071–1087.

https://doi.org/10.1042/CS20240624

Published: 30 August 2024

... is the peptide endothelin-1 (ET-1), which induces oxidative stress and disrupts vascular function. The present study postulates that obesity augments ET-1 production in the PVAT, decreases the function of the nuclear factor erythroid 2-related factor-2 (Nrf2) transcription factor, further increasing reactive...

View article titled, Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity

Articles

Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis

Mitsuyoshi Yamagata, Mutsumi Tsuchishima, Takashi Saito, Mikihiro Tsutsumi, Joseph George

Clin Sci (Lond) (2024) 138 (5): 327–349.

https://doi.org/10.1042/CS20230533

Published: 05 March 2024

... steatohepatitis oxidative stress Kanazawa Medical University 501100004043 RP 2017-05 Metabolic dysfunction-associated steatotic liver disease (MASLD) is a clinicopathologic condition mostly associated with metabolic syndrome and a major health problem in developed nations [ 1 , 2...

View article titled, Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis

Articles

Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury

Jun Pei, Xiaomao Tian, Chengjun Yu, Jin Luo, Yifan Hong, Jie Zhang, Sheng Wen, Yi Hua, Guanghui Wei

Clin Sci (Lond) (2023) 137 (18): 1477–1498.

https://doi.org/10.1042/CS20230818

Published: 22 September 2023

... Glutathione peroxidase 3 (Gpx3) Inflammation Ischemia-reperfusion injury Kidney Oxidative stress Selenomethionine Acute kidney injuries (AKIs) are one of the common acute and critical clinical conditions, characterized by a rapid decrease in glomerular filtration rate within a short period...

View article titled, Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia–reperfusion injury

Articles

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Luís F. Grilo, João D. Martins, Mariana S. Diniz, Carolina Tocantins, Chiara H. Cavallaro, Inês Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira

Clin Sci (Lond) (2023) 137 (17): 1347–1372.

https://doi.org/10.1042/CS20230048

Published: 01 September 2023

... a possible risk-factor for some pregnancy-associated liver diseases (PALD) and hepatic diseases. PALD occur in approximately 3% of pregnancies and are characterized by maternal hepatic oxidative stress (OS) and mitochondrial dysfunction. Maternal hepatic disease increases maternal and fetal morbidity...

View article titled, Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Includes: Supplementary data

Articles

Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Weixian Kong, Yue Peng, Caoyu Ji, Zekun Liu, Shuya Gao, Yuexin Zhang, Jiawen Chen, Xie Li, Mengmeng Bao, Yubin Zhang, Qizhou Jiang, Fuqun Wang, Zhe Li, Xiaohong Bian, Junmei Ye

Clin Sci (Lond) (2023) 137 (10): 823–841.

https://doi.org/10.1042/CS20230433

Published: 31 May 2023

... HFD-induced obesity, Akt2 loss-of-function mitigated lipid accumulation and oxidative stress in the liver and heart tissue. Mechanistically, down-regulation of Akt2 promotes SIRT6 expression in L02 cells and NRCMs, the latter deacetylates SOD2, which promotes SOD2 activity and therefore alleviates...

View article titled, Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

Includes: Supplementary data

Articles

Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu

Clin Sci (Lond) (2023) 137 (10): 785–805.

https://doi.org/10.1042/CS20220625

Published: 23 May 2023

... in lipopolysaccharide (LPS) and polyinosinic:polycytidylic acid (POLY I:C)-induced ALI/ARDS models in vitro and in vivo . Human airway epithelial (BEAS-2B) cells exposed to LPS+POLY I:C significantly elevated oxidative stress and inflammatory signaling. Co-treatment with CGA (10 and 50 µM) prevented inflammation...

View article titled, Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

Includes: Supplementary data

Articles

Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein

Clin Sci (Lond) (2023) 137 (1): 47–63.

https://doi.org/10.1042/CS20220513

Published: 05 January 2023

... with aniline blue solution for 5 min. Total renal fibrosis was observed under light microscopy at 10× magnification and measured using ImageJ software. acute kidney injury cell death mitochondria dysfunction Myocardial infarction oxidative stress type I cardio-renal syndrome Cardiovascular...

View article titled, Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Includes: Supplementary data

Articles

Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye

Clin Sci (Lond) (2022) 136 (22): 1711–1730.

https://doi.org/10.1042/CS20220242

Published: 30 November 2022

... also showed that SIRT6 suppressed intracellular oxidative stress upon FAs stimulation in PMHCs and L02 cells. Mechanistically, SIRT6, but not SIRT1 promoted PGC-1α expression. We further prove that ENDOG is downstream of PGC-1α. In addition, we evidenced that ENDOG protects hepatocytes from lipid...

View article titled, Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling

Includes: Supplementary data

Articles

Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Philip C. Calder

Clin Sci (Lond) (2022) 136 (13): 1019–1023.

https://doi.org/10.1042/CS20220380

Published: 01 July 2022

...Philip C. Calder Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004...

View article titled, Early biochemical observations point to nutritional strategies to manage non-alcoholic fatty liver disease

Articles

Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos

Clin Sci (Lond) (2022) 136 (6): 405–423.

https://doi.org/10.1042/CS20210835

Published: 23 March 2022

... and COPD involve significant local (i.e. lung, vasculature) and systemic inflammation and oxidative stress, of which current pharmacological treatments have limited efficacy, hence the urgency for the development of novel life-saving therapeutics. Currently these diseases must be treated individually...

View article titled, Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics

Articles

Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm

Clin Sci (Lond) (2022) 136 (2): 167–180.

https://doi.org/10.1042/CS20210865

Published: 20 January 2022

... oxidative stress as well as increased mesangial expansion and glomerulosclerosis when compared with vehicle-treated diabetic animals. Inhibition of the inflammasome by MCC950 in diabetic mice led to renal up-regulation of markers of inflammation ( Il1 β, Il18 and Mcp1 ), fibrosis ( Col1, Col4 , Fn1, α-SMA...

View article titled, Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Includes: Supplementary data

Articles

Correction: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Clin Sci (Lond) (2021) 135 (24): 2665.

https://doi.org/10.1042/CS-2019-1235_COR

Published: 15 December 2021

... Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress This Correction follows an Expression of Concern relating to this article previously published by Portland Press. © 2021 The Author(s). 2021 This is an open access article published by Portland Press...

View article titled, Correction: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Includes: Supplementary data

Articles

Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni

Clin Sci (Lond) (2021) 135 (23): 2625–2641.

https://doi.org/10.1042/CS20210810

Published: 08 December 2021

... pathways developed. Vascular reactivity of TA and VC from HF post-MI and sham operated (SO) rats was assessed with a wire myograph, 4 weeks after coronary artery occlusion surgery. Nitric oxide (NO), H 2 O 2 production and oxidative stress were evaluated in situ with fluorescent probes, while protein...

View article titled, Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Includes: Supplementary data

Articles

Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching

Alyson Deprez, Zakaria Orfi, Alexandra Radu, Ying He, Daniela Ravizzoni Dartora, Junio Dort, Nicolas A. Dumont, Anne Monique Nuyt

Clin Sci (Lond) (2021) 135 (22): 2589–2605.

https://doi.org/10.1042/CS20210894

Published: 26 November 2021

... sodium (50 mg/kg) and maintained anesthetized during the dissection to keep the perfusion in the extensor digitorium longus (EDL, fast-twitch muscle). Muscle atrophy oxidative stress Preterm birth Skeletal muscle Improved neonatal care over the last three decades has allowed the survival...

View article titled, Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching

Includes: Supplementary data

Articles

Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species

Rhéure Alves-Lopes, Karla Bianca Neves, Anastasiya Strembitska, Adam P. Harvey, Katie Y. Harvey, Hiba Yusuf, Susan Haniford, Ross T. Hepburn, Jennifer Dyet, Wendy Beattie, Laura Haddow, John McAbney, Delyth Graham, Augusto C. Montezano

Clin Sci (Lond) (2021) 135 (20): 2429–2444.

https://doi.org/10.1042/CS20210643

Published: 28 October 2021

... Osteoprotegerin Oxidative stress syndecans Vascular Biology We assessed Nox1 and Nox4 mRNA expression in RAECs and WKY VSMCs after exposure to OPG. Stimulation with OPG did not alter gene expression of Nox1 (Supplementary Figure S9A) or Nox4 (Supplementary Figure S9B) in RAECs, but increased Nox1...

View article titled, Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species

Includes: Supplementary data

Articles

Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda

Clin Sci (Lond) (2021) 135 (20): 2409–2422.

https://doi.org/10.1042/CS20210405

Published: 22 October 2021

...DongZhu Xu; Nobuyuki Murakoshi; Kazuko Tajiri; Feng Duo; Yuta Okabe; Yoshiko Murakata; Zixun Yuan; Siqi Li; Kazuhiro Aonuma; Zonghu Song; Yuzuno Shimoda; Haruka Mori; Akira Sato; Akihiko Nogami; Kazutaka Aonuma; Masaki Ieda Oxidative stress could be a possible mechanism and a therapeutic target...

View article titled, Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats

Articles

Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Sherouk Fouda, Anwar Khan, Stanley M.H. Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye

Clin Sci (Lond) (2021) 135 (17): 2103–2119.

https://doi.org/10.1042/CS20210628

Published: 06 September 2021

... in 3-nitrotyrosine (18-fold). Combination of HFD and CS precipitated hepatosteatosis to NASH reflected by exacerbated makers of liver inflammation and fibrosis which were associated with much severe liver oxidative stress (90-fold increase in 3-nitrotyrisine along with 6-fold increase in carbonylated...

View article titled, Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress

Includes: Supplementary data

Articles

Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes

Clin Sci (Lond) (2021) 135 (15): 1845–1858.

https://doi.org/10.1042/CS20210468

Published: 04 August 2021

... are not completely understood. The present study tested the hypothesis that lysophosphatidylcholine (LPC), a proatherogenic component of oxLDL, induces endothelial calcium influx, which drives NOX5-dependent reactive oxygen species (ROS) production, oxidative stress, and endothelial cell dysfunction. Approach: Human...

View article titled, Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation – implications in atherosclerosis

Includes: Supplementary data

Articles

Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

George W. Booz, Gaelle P. Massoud, Raffaele Altara, Fouad A. Zouein

Clin Sci (Lond) (2021) 135 (14): 1767–1772.

https://doi.org/10.1042/CS20210524

Published: 27 July 2021

... 2021 13 07 2021 16 07 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 epigenetics intrauterine growth restriction mitochondrial dysfunction oxidative stress sex Genetics and lifestyle are two commonly...

View article titled, Unravelling the impact of intrauterine growth restriction on heart development: insights into mitochondria and sexual dimorphism from a non-hominoid primate

Articles

A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Lu Dai, Leon Schurgers, Paul G. Shiels, Peter Stenvinkel

Clin Sci (Lond) (2021) 135 (10): 1251–1272.

https://doi.org/10.1042/CS20201452

Published: 26 May 2021

... Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050...

View article titled, A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases

Articles

Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Karla B. Neves, Hannah E. Morris, Rhéure Alves-Lopes, Keith W. Muir, Fiona Moreton, Christian Delles, Augusto C. Montezano, Rhian M. Touyz

Clin Sci (Lond) (2021) 135 (6): 753–773.

https://doi.org/10.1042/CS20201412

Published: 17 March 2021

... normalised by fasudil and 4-PBA. Cerebral vessels in CADASIL patients exhibited significant oxidative damage. In conclusion, peripheral vascular dysfunction in CADASIL is associated with altered Ca 2+ homoeostasis, oxidative stress and blunted eNOS/sGC/cGMP signaling, processes involving Rho kinase and ER...

View article titled, Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO/sGC/cGMP pathway

Includes: Supplementary data

Articles

Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

Rui Zhou, Changpei Xiang, Guangzhao Cao, He Xu, Yi Zhang, Hongjun Yang, Jingjing Zhang

Clin Sci (Lond) (2021) 135 (4): 613–627.

https://doi.org/10.1042/CS20201145

Published: 18 February 2021

... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...

View article titled, Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes

Articles

Skeletal muscle redox signaling in rheumatoid arthritis

Maarten M. Steinz, Estela Santos-Alves, Johanna T. Lanner

Clin Sci (Lond) (2020) 134 (21): 2835–2850.

https://doi.org/10.1042/CS20190728

Published: 04 November 2020

... quality of life. Loss in muscle mass cannot alone account for the muscle weakness induced by RA, but instead intramuscular dysfunction appears as a critical factor underlying the decreased force generating capacity for patients afflicted by arthritis. Oxidative stress and associated oxidative post...

View article titled, Skeletal muscle redox signaling in rheumatoid arthritis

Articles

Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang

Clin Sci (Lond) (2020) 134 (16): 2161–2175.

https://doi.org/10.1042/CS20200530

Published: 24 August 2020

... oxidative stress and neuronal apoptosis, as well as decreased accumulation of Aβ and Tau in the hippocampus. Taken together, the data demonstrated that transplantation of Mito-Plt attenuated cognitive impairment and mitochondrial dysfunction in db/db mice. This method may be a potential therapeutic...

View article titled, Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice

Includes: Supplementary data

Articles

Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by down-regulating the renal 8-iso-PGF2α-activated COX-TXA 2 pathway

Yu-Lien Tsai, Chih-Wei Liu, Chien-Fu Hsu, Chia-Chang Huang, Ming-Wei Lin, Shiang-Fen Huang, Tzu-Hao Li, Kuei-Chuan Lee, Yun-Cheng Hsieh, Ying-Ying Yang, Tzung-Yan Lee, Hsuan-Miao Liu, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin

Clin Sci (Lond) (2020) 134 (15): 2055–2073.

https://doi.org/10.1042/CS20200452

Published: 10 August 2020

... treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks after bile duct ligation (BDL). Methods: Systemic, splanchnic, and renal hemodynamics and pathogenic...

View article titled, Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by down-regulating the renal 8-iso-PGF2α-activated COX-TXA 2 pathway

Articles

Expression of Concern: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Clin Sci (Lond) (2020) 134 (13): 1675.

https://doi.org/10.1042/CS-20191235_EOC

Published: 06 July 2020

... Oxidative stress The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. ...

View article titled, Expression of Concern: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Articles

Pathogenic role of human C-reactive protein in diabetic retinopathy

Fangfang Qiu, Xiang Ma, Young-Hwa Shin, Jianglei Chen, Qian Chen, Kelu Zhou, Wenjing Wu, Wentao Liang, Yalin Wu, Qing Song, Jian-Xing Ma

Clin Sci (Lond) (2020) 134 (13): 1613–1629.

https://doi.org/10.1042/CS20200085

Published: 30 June 2020

... and oxygen-induced retinopathy (OIR) models. The retina function was monitored by electroretinography (ERG) and retinal thickness was measured by optical coherence tomography (OCT). TUNEL and cell death ELISA were performed to measure the apoptosis. Oxidative stress was detected by the measurement...

View article titled, Pathogenic role of human C-reactive protein in diabetic retinopathy

Includes: Supplementary data

Articles

Targeting mitochondrial fitness as a strategy for healthy vascular aging

Matthew J. Rossman, Rachel A. Gioscia-Ryan, Zachary S. Clayton, Michael P. Murphy, Douglas R. Seals

Clin Sci (Lond) (2020) 134 (12): 1491–1519.

https://doi.org/10.1042/CS20190559

Published: 25 June 2020

... and stiffening of the large elastic arteries (i.e., the aorta and carotid arteries), contribute importantly to the age-related increase in CVD risk. Vascular aging is driven in large part by oxidative stress, which reduces bioavailability of nitric oxide and promotes alterations in the extracellular matrix...

View article titled, Targeting mitochondrial fitness as a strategy for healthy vascular aging

Articles

Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Yun Huang, Yang Li, Anni Lou, Guo zhen Wang, Ye Hu, Yijie Zhang, Weichang Huang, Jun Wang, Yue Li, Xintao Zhu, Tingting Chen, Jiayi Lin, Ying Meng, Xu Li

Clin Sci (Lond) (2020) 134 (7): 853–869.

https://doi.org/10.1042/CS20191235

Published: 09 April 2020

...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...

View article titled, Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS

Articles

Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Rachel Njeim, Theresa Farhat, Sahar Alkhansa, Natalie Youssef, Batoul Dia, Rasha Slika, Radwan Diab, Sami T. Azar, Assaad A. Eid

Clin Sci (Lond) (2020) 134 (4): 403–417.

https://doi.org/10.1042/CS20190584

Published: 25 February 2020

... to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose...

View article titled, Role of the Nox4/AMPK/mTOR signaling axe in adipose inflammation-induced kidney injury

Articles

(Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure

Natalia López-Andrés

Clin Sci (Lond) (2020) 134 (1): 73–74.

https://doi.org/10.1042/CS20191184

Published: 14 January 2020

.... galectins oxidative stress peroxiredoxins Molecular and cellular events underlying ischemia reperfusion (IR) injury are complex, representing the confluence of divergent biological pathways. Al-Salam et al. reported that Gal-3 could play a protective role on the myocardium following IR injury at 24 h...

View article titled, (Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure

Articles

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

Mei Xue, Ting Li, Yue Wang, Yunpeng Chang, Ying Cheng, Yunhong Lu, Xiangyang Liu, Linxin Xu, Xiaoyu Li, Xiaochen Yu, Bei Sun, Liming Chen

Clin Sci (Lond) (2019) 133 (15): 1705–1720.

https://doi.org/10.1042/CS20190585

Published: 02 August 2019

... function involving the inhibition of oxidative stress-induced injury via sGC-cGMP-PKG pathway and may be a promising therapeutic option for DCM. Correspondence: Liming Chen ( [email protected] ) or Bei Sun ( [email protected] ) 03 06 2019 19 07 2019 23 07 2019 23 07...

View article titled, Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

Includes: Supplementary data

Articles

RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress

Jia-nan Wang, Ming-ming Liu, Fang Wang, Biao Wei, Qin Yang, Yu-ting Cai, Xin Chen, Xue-qi Liu, Ling Jiang, Chao Li, Xiao-wei Hu, Ju-tao Yu, Tao-tao Ma, Juan Jin, Yong-gui Wu, Jun Li, Xiao-ming Meng

Clin Sci (Lond) (2019) 133 (14): 1609–1627.

https://doi.org/10.1042/CS20190599

Published: 25 July 2019

... ischemic reperfusion, nephrotoxic drugs and sepsis. It is characterized by a sudden decline in renal function, in addition to excessive inflammation, oxidative stress and programmed cell death of renal tubular epithelial cells. RIPK1-mediated necroptosis plays an important role in AKI. In the present study...

View article titled, RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress

Includes: Supplementary data

Articles

Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis

In Collection

Clinical and translational research highlights

Lara Matilla, Jaime Ibarrola, Vanessa Arrieta, Amaia Garcia-Peña, Ernesto Martinez-Martinez, Rafael Sádaba, Virginia Alvarez, Adela Navarro, Amaya Fernández-Celis, Alicia Gainza, Enrique Santamaría, Joaquín Fernández-Irigoyen, Antoni Bayes-Genis, Patrick Rossignol, Natalia López-Andrés

Clin Sci (Lond) (2019) 133 (14): 1537–1548.

https://doi.org/10.1042/CS20190475

Published: 17 July 2019

...: Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 effects on oxidative stress and inflammation in human cardiac fibroblasts and its pathological role in human aortic stenosis (AS). Methods and results...

View article titled, Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis

Includes: Supplementary data

Articles

New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease

Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos

Clin Sci (Lond) (2019) 133 (7): 885–904.

https://doi.org/10.1042/CS20180316

Published: 12 April 2019

... and poor diet but the underlying mechanisms have not been fully established. However, there is emerging and compelling experimental and clinical evidence to show that increased oxidative stress causes pulmonary inflammation and that the spill over of pro-inflammatory mediators from the lungs...

View article titled, New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease

Articles

Heme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat

Pamela L. Martín, Paula Ceccatto, María V. Razori, Daniel E.A. Francés, Sandra M.M. Arriaga, Gerardo B. Pisani, Alejandra I. Martínez, Enrique J. Sánchez Pozzi, Marcelo G. Roma, Cecilia L. Basiglio

Clin Sci (Lond) (2019) 133 (1): 117–134.

https://doi.org/10.1042/CS20180675

Published: 11 January 2019

... of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels...

View article titled, Heme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat

Includes: Supplementary data

Articles

Decreased expression of pigment epithelium-derived factor within the penile tissues contributes to erectile dysfunction in diabetic rats

Hongjie Qiao, Yuanyuan Zhang, Wenwen Lin, Yu-Feng Wang, Cristina M. Furdui, Qiuling Jiang, Xiao Li, Ting Long, Yunguang Wang, Da-nian Qin

Clin Sci (Lond) (2018) 132 (20): 2175–2188.

https://doi.org/10.1042/CS20180192

Published: 19 October 2018

... was significantly decreased at the levels of the mRNA and protein in the penis of diabetic rats compared with normal controls. To test the hypothesis that decreased the penile levels of PEDF are associated with oxidative stress and inflammation in DMED, an adenovirus expressing PEDF (Ad-PEDF) or the same titer...

View article titled, Decreased expression of pigment epithelium-derived factor within the penile tissues contributes to erectile dysfunction in diabetic rats

Articles

A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

Jay C. Jha, Florence Ho, Christopher Dan, Karin Jandeleit-Dahm

Clin Sci (Lond) (2018) 132 (16): 1811–1836.

https://doi.org/10.1042/CS20171459

Published: 30 August 2018

...Jay C. Jha; Florence Ho; Christopher Dan; Karin Jandeleit-Dahm Chronic renal and vascular oxidative stress in association with an enhanced inflammatory burden are determinant processes in the development and progression of diabetic complications including cardiovascular disease (CVD...

View article titled, A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

Articles

Implications of plasma thiol redox in disease

Percíllia V.S. Oliveira, Francisco R.M. Laurindo

Clin Sci (Lond) (2018) 132 (12): 1257–1280.

https://doi.org/10.1042/CS20180157

Published: 29 June 2018

... that a single measurement provides global assessment of plasma oxidative stress. Rather, assessment of individual thiol pools and thiol-proteins specific to any given condition has more solid and logical perspective to yield novel relevant information on disease risk and prognosis. Correspondence...

View article titled, Implications of plasma thiol redox in disease

Articles

Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy

Ming Zhan, Irtaza Usman, Jingbo Yu, Liemin Ruan, Xueyan Bian, Jun Yang, Shikun Yang, Lin Sun, Yashpal S. Kanwar

Clin Sci (Lond) (2018) 132 (12): 1297–1314.

https://doi.org/10.1042/CS20180005

Published: 26 June 2018

... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...

View article titled, Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy

Includes: Supplementary data

Articles

Impaired endocrine-metabolic homeostasis: underlying mechanism of its induction by unbalanced diet

Bárbara Maiztegui, Carolina Lisi Román, Juan José Gagliardino, Luis Emilio Flores

Clin Sci (Lond) (2018) 132 (8): 869–881.

https://doi.org/10.1042/CS20171616

Published: 30 April 2018

..., intracellular insulin and leptin mediators, and oxidative stress (OS) markers were also measured in islets isolated from each experimental group. HS rats had increased plasma triglyceride, insulin, leptin, and lipid peroxidation (OS marker) levels associated with an insulin-resistant state. Their islets...

View article titled, Impaired endocrine-metabolic homeostasis: underlying mechanism of its induction by unbalanced diet

Articles

Metformin attenuates effects of cyclophilin A on macrophages, reduces lipid uptake and secretion of cytokines by repressing decreased AMPK activity

Surya Ramachandran, Vinitha Anandan, V. R. Kutty, Ajit Mullasari, M. Radhakrishna Pillai, Cheranellore Chandrasekharan Kartha

Clin Sci (Lond) (2018) 132 (6): 719–738.

https://doi.org/10.1042/CS20171523

Published: 30 March 2018

... cytometer. Expression of CD36 and LOX-1 was also analyzed by immunoblotting experiments. Cyclophilin A is a secretory protein which stimulates pro-inflammatory signals in the vascular vessel wall by increasing oxidative stress and inflammation. Cyclophilin A is implicated as a crucial mediator...

View article titled, Metformin attenuates effects of cyclophilin A on macrophages, reduces lipid uptake and secretion of cytokines by repressing decreased AMPK activity

Includes: Supplementary data

Articles

Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases

Asokan Devarajan

Clin Sci (Lond) (2018) 132 (6): 615–626.

https://doi.org/10.1042/CS20171574

Published: 20 March 2018

... factors, such as cholesterol, phospholipids, and uric acid, contribute to kidney stone formation are described. Atherosclerosis cardiovascular disease Dyslipidemia Kidney stone metabolic syndromes oxidative stress Kidney stones and CVDs are complex multifactorial results from interactions...

View article titled, Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases

Articles

Oxidative stress and reactive oxygen species: a review of their role in ocular disease

Lawson Ung, Ushasree Pattamatta, Nicole Carnt, Jennifer L. Wilkinson-Berka, Gerald Liew, Andrew J.R. White

Clin Sci (Lond) (2017) 131 (24): 2865–2883.

https://doi.org/10.1042/CS20171246

Published: 04 December 2017

...Lawson Ung; Ushasree Pattamatta; Nicole Carnt; Jennifer L. Wilkinson-Berka; Gerald Liew; Andrew J.R. White For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging...

View article titled, Oxidative stress and reactive oxygen species: a review of their role in ocular disease

Articles

Post-prandial hyperlipidaemia results in systemic nitrosative stress and impaired cerebrovascular function in the aged

Christopher J. Marley, Danielle Hodson, Julien V. Brugniaux, Lewis Fall, Damian M. Bailey

Clin Sci (Lond) (2017) 131 (23): 2807–2812.

https://doi.org/10.1042/CS20171406

Published: 28 November 2017

... ( [email protected] ) 02 10 2017 20 10 2017 20 10 2017 20 10 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Aging Cerebrovascular Function High-Fat Meal Hyperlipidaemia oxidative stress Oxidative...

View article titled, Post-prandial hyperlipidaemia results in systemic nitrosative stress and impaired cerebrovascular function in the aged

Articles

Diminished stress resistance and defective adaptive homeostasis in age-related diseases

Naomi Lomeli, Daniela A. Bota, Kelvin J.A. Davies

Clin Sci (Lond) (2017) 131 (21): 2573–2599.

https://doi.org/10.1042/CS20160982

Published: 25 October 2017

... homeostasis may make older people more susceptible to many diseases. Chronic oxidative stress and defective protein homeostasis (proteostasis) are two major factors associated with the etiology of age-related disorders. In the present paper, we review the contribution of impaired responses to oxidative stress...

View article titled, Diminished stress resistance and defective adaptive homeostasis in age-related diseases

Articles

Biomarkers of disease can be detected in mice as early as 4 weeks after initiation of exposure to third-hand smoke levels equivalent to those found in homes of smokers

Neema Adhami, Yuxin Chen, Manuela Martins-Green

Clin Sci (Lond) (2017) 131 (19): 2409–2426.

https://doi.org/10.1042/CS20171053

Published: 15 September 2017

... and the liver damage biomarker aspartate aminotransferase (AST), increased in magnitude 1.5 and 2.5 times compared with controls, respectively. THS exposure for 2 months resulted in further damage and at 4 and 6 months, many factors related to oxidative stress were altered and caused molecular damage. We also...

View article titled, Biomarkers of disease can be detected in mice as early as 4 weeks after initiation of exposure to third-hand smoke levels equivalent to those found in homes of smokers

Articles

Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism

Marco D’Agostino, Francesco Martino, Sara Sileno, Francesco Barillà, Sara Beji, Lorenza Marchetti, Fabio Maria Gangi, Luca Persico, Mario Picozza, Anna Montali, Eliana Martino, Cristina Zanoni, Daniele Avitabile, Sandro Parrotto, Maurizio Colognesi Capogrossi, Alessandra Magenta

Clin Sci (Lond) (2017) 131 (18): 2397–2408.

https://doi.org/10.1042/CS20171121

Published: 08 September 2017

... the intracellular and the extracellular miR-200c expression levels. In conclusion, circulating miR-200c is up-regulated in FH, probably due to oxidative stress and inflammation and via a miR-33a/b -ZEB1-dependent mechanism. The present study could provide the first evidence to point to the use of miR-33a/b and miR...

View article titled, Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism

Includes: Supplementary data

Articles

Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries

Emanuele Amata, Valeria Pittalà, Agostino Marrazzo, Carmela Parenti, Orazio Prezzavento, Emanuela Arena, Seyed Mohammad Nabavi, Loredana Salerno

Clin Sci (Lond) (2017) 131 (14): 1701–1712.

https://doi.org/10.1042/CS20170157

Published: 30 June 2017

... bronchopulmonary dysplasia hyperoxic stress HO-1 hyperoxic lung injuries Nrf2 Oxidative stress In recent years, BPD clinical aspects have improved, due to gentler oxygen therapy, antenatal steroids, and surfactant supplementation during respiratory distress syndrome (RDS) [ 6 , 7 ]. The ‘new’ BPD when...

View article titled, Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries

Articles

Oxidative and inflammatory signals in obesity-associated vascular abnormalities

John J. Reho, Kamal Rahmouni

Clin Sci (Lond) (2017) 131 (14): 1689–1700.

https://doi.org/10.1042/CS20170219

Published: 30 June 2017

... provide an effective therapeutic approach to prevent the cardiovascular sequelae associated with excessive adiposity. In this review, we discuss the recent evidence supporting the role of oxidative stress and cytokines and inflammatory signals within the vasculature as well as the impact...

View article titled, Oxidative and inflammatory signals in obesity-associated vascular abnormalities

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