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Keyword: parathyroid hormone
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Articles
Clin Sci (Lond) (2000) 99 (4): 285–292.
Published: 31 August 2000
... modifications in the renal tubular handling of magnesium and other electrolytes, or in the tissue deposition of magnesium, which may account for the hypomagnesaemia. We have also investigated whether parathyroid hormone has a role in the observed hypomagnesaemia. Two studies have been performed; in the first we...
Articles
Clin Sci (Lond) (1999) 97 (2): 157–163.
Published: 16 June 1999
... on a single occasion 1–30 days before transplantation. Six other patients undergoing transplantation received no pamidronate. We measured serum calcium, phosphate, albumin, bone-specific alkaline phosphatase, plasma parathyroid hormone and tartrate-resistant acid phosphatase before pamidronate...
Articles
Clin Sci (Lond) (1999) 96 (4): 427–430.
Published: 01 April 1999
...M. BLUM; Y. WEISMAN; S. TURGEMAN; S. CABILI; Y. WOLLMAN; G. PEER; N. STERN; D. SILVERBERG; D. SCHWARTZ; A. IAINA Normal pregnancy is associated with an increase in serum parathyroid hormone and 1,25-dihydroxyvitamin D 3 (calcitriol). The effect of pregnancy on these hormones in chronic renal...
Articles
Clin Sci (Lond) (1995) 88 (2): 197–201.
Published: 01 February 1995
...S. L. Carney; A. H. B. Gillies 1. It has been demonstrated that parathyroid hormone can increase adenylate cyclase activity in the rat papilla, produce a small antidiuretic effect and in vitro can interfere with the action of arginine vasopressin on water transport. Clearance studies were performed...
Articles
Clin Sci (Lond) (1993) 85 (2): 223–228.
Published: 01 August 1993
...Jean-Luc Riond 1. The influence of the time of the day of the administration of synthetic human parathyroid hormone fragment-(1-34) [hPTH-(1-34)] on its anabolic effect in bone was investigated in 23 60-day-old female Wistar rats. Rats were randomly assigned to the groups vehicle control morning...
Articles
Clin Sci (Lond) (1993) 84 (1): 11–19.
Published: 01 January 1993
...Christian Saussine; C. Judes; T. Massfelder; M.-J. Musso; U. Simeoni; T. Hannedouche; J.-J. Helwig 1. We have previously reported that pharmacological concentrations (125 nmol/l) of parathyroid hormone may stimulate renin release in the stable recirculating and non-filtering isolated rat kidney. 2...
Articles
Clin Sci (Lond) (1992) 83 (6): 711–715.
Published: 01 December 1992
... 3.97 s in the thyroparathyroidectomized rats, whereas no significant changes were detected in the properties of acidification in the control rats. 5. These data show that parathyroid hormone and cellular calcium are important factors involved in proximal tubular H + secretion, which appears to be...
Articles
Clin Sci (Lond) (1992) 82 (6): 651–658.
Published: 01 June 1992
... parathyroid hormone concentration were measured before dialysis, mid-dialysis and 30 min after dialysis. 2. Plasma ionized calcium concentration increased towards dialysate calcium concentrations, falling insignificantly after cessation of dialysis. Serum parathyroid hormone concentration fell by 39% during...
Articles
Clin Sci (Lond) (1991) 81 (s25): 465–470.
Published: 01 October 1991
... that parathyroid hormone participates in an important way in the defence against metabolic acidosis. 4. The effects of acidosis, thyroparathyroidectomy and aluminium treatment on renal function parameters were not additive, suggesting a common final mechanism. In normal or acidotic aluminium-treated...
Articles
Clin Sci (Lond) (1990) 79 (3): 233–238.
Published: 01 September 1990
...T. C. B. Stamp; P. W. Saphier; N. Loveridge; C. R. Kelsey; A. J. Goldstein; M. Katakity; M. V. Jenkins; G. A. Rose 1. To determine the relationships between parathyroid hormone activity and long-term sodium fluoride therapy in osteoporosis, cytochemical bioassays (for biologically active...
Articles
Clin Sci (Lond) (1990) 78 (3): 321–325.
Published: 01 March 1990
... and parathyroid hormone. 2. In addition to lowering urinary Ca 2+ ( P <0.001), hydrochlorothiazide also promoted a significant fall in urinary prostaglandin E 2 ( P <0.001), plasma bicyclo-prostaglandin E 2 ( P <0.001) and 1,25-dihydroxyvitamin D ( P <0.01), and an increase in plasma...
Articles
Clin Sci (Lond) (1988) 75 (5): 543–549.
Published: 01 November 1988
... of blood pressure reduction upon the metabolic indices with adjustment for the effects of the different antihypertensive agents. 3. Propranolol treatment increased the plasma ionized calcium and serum phosphate concentrations, and reduced the serum levels of parathyroid hormone, free fatty acids and...
Articles
Clin Sci (Lond) (1988) 75 (4): 395–402.
Published: 01 October 1988
... significant, there was a significant correlation between total calcium and systolic pressure ( r = 0.23, P < 0.05) which was maintained after correction for other variables. 4. There were no differences in plasma concentrations of parathyroid hormone or 1,25-dihydroxycholecalciferol between hypertensive...
Articles
Clin Sci (Lond) (1988) 75 (2): 143–146.
Published: 01 August 1988
... balance studies. 2. Mean serum calcium fell transiently within 24–48 h by 0.03 ±0.07 ( sd ) mmol/l ( P < 0.01) and phosphorus by 0.06±0.08 ( sd ) mmol/l ( P < 0.001). In a subgroup, ionized calcium fell and biologically active parathyroid hormone (bio-PTH) rose more than fivefold ( P < 0.01...
Articles
Clin Sci (Lond) (1986) 71 (3): 261–269.
Published: 01 September 1986
... each system was inhibited by a specific parathyroid hormone (PTH) antagonist. 3. Studies in two HPLC systems suggested that the adenylate cyclase-stimulating factors extracted from these tumours differed from each other and from synthetic human parathyroid hormone 1–34. 4. The presence of similar PTH...
Articles
Clin Sci (Lond) (1985) 68 (3): 311–319.
Published: 01 March 1985
...M. S. Seshadri; Y. L. Chan; M. R. Wilkinson; R. S. Mason; S. Posen 1. A renal adenylate cyclase system was assessed for its suitability in the performance of parathyroid hormone (PTH) bioassays. Membrane preparations from 1 week old chicks were found to be more sensitive to PTH than material from...
Articles
Clin Sci (Lond) (1985) 68 (3): 321–326.
Published: 01 March 1985
...M. S. Seshadri; Y. L. Chan; M. R. Wilkinson; R. S. Mason; S. Posen 1. An adenylate cyclase bioassay for parathyroid hormone (PTH) was evaluated in peripheral sera of ten normal subjects, 15 patients with various types of hypoparathyroidism, nine patients with malignancy-associated hypercalcaemia...
Articles
Clin Sci (Lond) (1985) 68 (2): 171–177.
Published: 01 February 1985
...G. N. Kent; N. Loveridge; J. Reeve; Joan M. Zanelli 1. Synthetic human parathyroid hormone (hPTH) 1-34 was given by intravenous injection to two healthy men. The time course of its appearance in and disappearance from the plasma was monitored both by cytochemical bioassay and by a specific...
Articles
Clin Sci (Lond) (1984) 67 (6): 591–599.
Published: 01 December 1984
...R. D. Podbesek; E. B. Mawer; G. D. Zanelli; J. A. Parsons; J. Reeve 1. Long-term studies of gastrointestinal radio-calcium absorption were undertaken in adult greyhounds before and during two treatment regimes with human parathyroid hormone fragment 1–34 (hPTH 1–34). The results were correlated...
Articles
Clin Sci (Lond) (1984) 66 (5): 557–559.
Published: 01 May 1984
... plasma levels of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) after an intravenous injection of glucagon in eight patients receiving long term lithium treatment and in six control subjects. Urinary cyclic AMP levels after an intravenous injection of bovine parathyroid hormone (PTH) were also...
Articles
Clin Sci (Lond) (1983) 64 (6): 623–627.
Published: 01 June 1983
...D. G. Waller; J. D. M. Albano; J. G. B. Millar; A. Polak 1. Urinary and plasma levels of adenosine 3′:5′-cyclic monophosphate (cyclic AMP) after an intravenous injection of bovine parathyroid hormone (PTH) were measured in 12 patients on long-term lithium treatment and in nine control subjects. The...
Articles
Clin Sci (Lond) (1982) 62 (4): 389–396.
Published: 01 April 1982
...E. Hefti; U. Trechsel; J.-P. Bonjour; H. Fleisch; R. Schenk 1. The effect of long-term administration of parathyroid hormone (PTH) on whole-body calcium and ash weight of individual bones has been studied in normal and osteoporotic adult female rats in order to examine whether such a treatment...
Articles
Clin Sci (Lond) (1982) 62 (4): 381–387.
Published: 01 April 1982
...I. G. Lewin; S. E. Papapoulos; G. N. Hendy; S. Tomlinson; J. L. H. O'riordan 1. The response to exogenous parathyroid hormone (PTH) was tested in normal subjects and patients with osteomalacia due to vitamin D deficiency; 200 MRC units of bovine PTH were administered intravenously. 2. The rise in...
Articles
Clin Sci (Lond) (1981) 60 (5): 549–554.
Published: 01 May 1981
...% respectively). These changes in urine potassium excretion followed alterations in distal-tubule function. Parathyroid hormone did not alter potassium excretion in any of the experimental groups in contrast with its effect on magnesium excretion. 3. These data support the concept of distal tubular control of...
Articles
Clin Sci (Lond) (1981) 60 (3): 273–282.
Published: 01 March 1981
... phosphate. Thyroparathyroidectomy 3 days before study in the dogs with a remnant kidney and moderate renal failure reduced fractional excretion of phosphate to near normal values, indicating a major role of parathyroid hormone in phosphate adaptation. Extracellular volume expansion in these...
Articles
Clin Sci (Lond) (1980) 58 (5): 365–371.
Published: 01 May 1980
...A. Berthelot; A. Gairard 1. Hypertension induced by treatment with deoxycorticosterone acetate and sodium chloride was studied in male Sprague-Dawley rats and related to parathyroid hormone secretion. 2. Lack of parathyroid hormone (due to parathyroidectomy) or decreased parathormone secretion (due...
Articles
Clin Sci Mol Med (1978) 55 (5): 429–434.
Published: 01 November 1978
... Research Society 1978 parathyroid hormone phosphate renal tubular reabsorption sickle-cell anaemia Clinical Science and Molecular Medicine (1978) 55,429-434 The tubular reabsorption of phosphate in sickle-cell nephropathy P . E . D E J O N G , L . T. W. D E J O N G - V A N D E N B E R G A N D L...
Articles
Clin Sci Mol Med (1978) 54 (4): 349–353.
Published: 01 April 1978
...N. Nijs-De Wolf; N. De Nutte; H. Brauman; J. Corvilain 1. The parathyroid hormone-like biological activity of concentrated urine was measured by the increase of plasma calcium concentration after intravenous injection of the sample into chickens. 2. Urine was tested in hypoparathyroid patients...
Articles
Clin Sci Mol Med (1977) 53 (5): 431–438.
Published: 01 November 1977
... patients with hyperparathyroidism secondary to vitamin D deficiency or malabsorption values ranged from 0·2 to 0·8 mmol/l. 2. Plasma parathyroid hormone concentrations measured by an immunoradiometric technique ranged from <0·15 to 0·9 ng/ml in the normal subjects and from 0·5 to 10 ng/ml in the...
Articles
Clin Sci Mol Med (1977) 52 (6): 577–583.
Published: 01 June 1977
... and the Medical Research Society 1977 calcitonin calcium creatinine parathyroid hormone renal failure thyrocalcitonin urea Clinical Science and Molecular Medicine (1 977) 52, 571-583. Plasma calcitonin in chronic renal failure: relation to other factors of importance in bivalent ion...
Articles
Clin Sci Mol Med (1977) 52 (3): 329–332.
Published: 01 March 1977
... Research Society 1977 calcitonin Paget's disease of bone parathyroid hormone radioimmunoassay Clinical Science and Molecular Medicine (1977) 52, 329-332. SHORT COMM UNICA TION Plasma calcitonin in Paget's disease of bone J. A. KANIS G. HEYNEN AND R. J. WALTON") ("Nufleld Orthopaedic Centre...
Articles
Clin Sci Mol Med (1976) 51 (4): 345–351.
Published: 01 October 1976
...R. A. L. Sutton; N. L. M. Wong; J. H. Dirks 1. The effect of purified bovine parathyroid hormone on renal tubular reabsorption of sodium and calcium has been studied by micropuncture in intact and recently thyroparathyroidectomized dogs. 2. Parathyroid hormone increased the rejection of sodium and...
Articles
Clin Sci Mol Med (1976) 51 (2): 161–168.
Published: 01 August 1976
... evidence of augmented tubular reabsorption of magnesium in response to magnesium deprivation in any of the three groups of subjects. 6. The tubular reabsorption of magnesium was not altered detectably by a moderate deficiency or excess of parathyroid hormone. Changes in parathyroid hormone secretion are...
Articles
Clin Sci Mol Med (1976) 51 (1): 59–69.
Published: 01 July 1976
...S. Tomlinson; G. N. Hendy; D. M. Pemberton; J. L. H. O'Riordan 1. Normal subjects showed a highly reproducible, rapid increase in plasma adenosine 3′:5′-cyclic monophosphate (cyclic AMP) after an intravenous injection of 200 MRC units of highly purified bovine parathyroid hormone. 2. No significant...
Articles
Clin Sci Mol Med (1976) 50 (6): 473–478.
Published: 01 June 1976
... vitro , nor did they inhibit the rise in cyclic AMP induced by bovine parathyroid hormone. 3. Pretreatment of mice for 3 days with Cl 2 MDP also had no effect on cyclic AMP under basal conditions or after incubation of explanted calvaria with parathyroid hormone in vitro. EHDP under similar conditions...
Articles
Clin Sci Mol Med (1976) 50 (1): 79–81.
Published: 01 January 1976
...S. Epstein; J. Sagel; H. Brodovcky; S. Tuff; L. Eales 1. There was no significant change in plasma renin activity over 6 h in five subjects given calcium gluconate or in four subjects given parathyroid hormone. 2. It is concluded that acute hypercalcaemia does not increase plasma renin activity and...
Articles
Clin Sci Mol Med (1975) 48 (5): 349–365.
Published: 01 May 1975
... parathyroid hormone. No formation of 1,25-(OH) 2 D 3 was detectable in vitamin D-replete individuals, who appeared to form labelled 24,25-(OH) 2 D 3 preferentially. 4. No control subject produced significant amounts of both labelled 1,25-(OH) 2 D 3 and labelled 24,25-(OH) 2 D 3 simultaneously. 5. All subjects...
Articles
Clin Sci Mol Med (1975) 48 (5): 461–463.
Published: 01 May 1975
... calcitonin. 3. A vasoactive compound in parathyroid extract appears to provide the most likely explanation of this effect. 28 1 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 parathyroid hormone renin Clinical Science and Molecular Medicine (1975) 48, 461-463...
Articles
Clin Sci Mol Med (1974) 47 (6): 567–576.
Published: 01 December 1974
...G. N. Hendy; P. M. Barling; J. L. H. O'Riordan 1. Immunological assay systems specific to the amino-terminal region of parathyroid hormone were used to study the properties of human parathyroid hormone (HPTH 1-84) and of synthetic peptides. One of these peptides (HPTH 1-34A) had the sequence...
Articles
Clin Sci Mol Med (1974) 47 (5): 481–492.
Published: 01 November 1974
...S. Tomlinson; P. M. Barling; J. D. M. Albano; B. L. Brown; J. L. H. O'Riordan 1. Administration of highly purified bovine parathyroid hormone (BPTH) (200 MRC units) increased the concentration of adenosine 3′,5′-cyclic monophosphate (cyclic AMP) in the peripheral plasma of normal subjects within...
Articles
Clin Sci (1972) 43 (5): 715–718.
Published: 01 November 1972
...W. G. Robertson; M. Peacock; D. Atkins; L. A. Webster 1. Bovine parathyroid hormone at a concentration of 1 unit/ml caused an immediate transient uptake of calcium from the bathing medium by 5-day-old mouse calvaria in tissue culture. 2. The uptake of calcium by bone was followed by the release of...
Articles
Clin Sci (1972) 42 (2): 235–241.
Published: 01 February 1972
...C. J. Robinson; B. Rafferty; J. A. Parsonsy 1. Parathyroid hormone (PTH) injected intravenously into rats caused a small rapid uptake of simultaneously administered radioactive calcium into the skeleton. 2. This skeletal uptake of calcium occurs in many other species, including the monkey and...
Articles
Clin Sci (1972) 42 (1): 113–116.
Published: 01 January 1972
...B. I. Joffe; W. H. L. Hackeng; H. C. Seftel; R. G. Hartdegen 1. Elevated concentrations of immunoreactive parathyroid hormone (P.T.H.) were detected in the pre-treatment plasma samples of seven out of ten children with nutritional rickets. The three normal values occurred in an inactive case, an...