... mechanisms. TLRs (Toll-like receptors), widely expressed by the ocular surface, are able to recognize microbial pathogens and to trigger the earliest immune response leading to inflammation. Increasing evidence highlights the crucial role of TLRs in regulating innate immune responses during ocular surface...

...Joann M. McDermid; Andrew M. Prentice There are many lines of evidence illustrating that iron plays a pivotal role in modulating the battle for survival between mammalian hosts and their pathogens. Each displays considerable genetic investment in a wide range of mechanisms for acquiring...

... Stephen A. Bustin (email [email protected] ). 11 3 2005 5 4 2005 20 4 2005 The Biochemical Society 2005 RNA viruses constitute the most abundant group of pathogens in man, animals and plants and are classified according to their RNA genome. The low efficiency...

...Nazia Chaudhuri; Steven K. Dower; Moira K. B. Whyte; Ian Sabroe TLRs (Toll-like receptors) comprise a family of proteins whose function is principally to facilitate the detection of, and response to, pathogens. Protozoa, helminths, viruses, bacteria and fungi can all activate TLR signalling...