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Keywords: pathogen
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Clin Sci (Lond) (2011) 120 (10): 441–450.
Published: 28 January 2011
... mechanisms. TLRs (Toll-like receptors), widely expressed by the ocular surface, are able to recognize microbial pathogens and to trigger the earliest immune response leading to inflammation. Increasing evidence highlights the crucial role of TLRs in regulating innate immune responses during ocular surface...
Clin Sci (Lond) (2006) 110 (5): 503–524.
Published: 11 April 2006
...Joann M. McDermid; Andrew M. Prentice There are many lines of evidence illustrating that iron plays a pivotal role in modulating the battle for survival between mammalian hosts and their pathogens. Each displays considerable genetic investment in a wide range of mechanisms for acquiring and...
Includes: Supplementary data
Clin Sci (Lond) (2005) 109 (4): 365–379.
Published: 23 September 2005
... particular run and increases confidence when reporting negative results. The same argument applies to running samples in duplicate or, preferably, in triplicate and in this qRT-PCR is no different from any clinical diagnostic assay. RNA viruses constitute the most abundant group of pathogens in man...
Clin Sci (Lond) (2005) 109 (2): 125–133.
Published: 25 July 2005
...Nazia Chaudhuri; Steven K. Dower; Moira K. B. Whyte; Ian Sabroe TLRs (Toll-like receptors) comprise a family of proteins whose function is principally to facilitate the detection of, and response to, pathogens. Protozoa, helminths, viruses, bacteria and fungi can all activate TLR signalling, and...