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Keywords: pathogenesis
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Articles
Clin Sci (Lond) (2020) 134 (12): 1295–1300.
Published: 16 June 2020
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . circulating DNA COVID19 Neutrophil pathogenesis Traps December 2019 saw the emergence of the Severe acute respiratory syndrome – Coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease-2019 (COVID-19) [ 1 ]. Several clinical...
Articles
Clin Sci (Lond) (2019) 133 (12): 1321–1339.
Published: 20 June 2019
.... The pathogenesis of DKD is twofold, so is the principle of treatments. As the underlying disease, diabetes per se is the root cause of DKD and thus a primary focus of therapy. Meanwhile, aberrant molecular signaling in kidney parenchymal cells and inflammatory cells may directly contribute to DKD. Evidence...
Articles
Clin Sci (Lond) (2019) 133 (7): 805–819.
Published: 02 April 2019
... Forte ( forte.amalia@gmail.com ) 17 12 2018 27 02 2019 18 03 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 autophagy aortopathy bicuspid aortic valve hemodynamics pathogenesis Autophagy (also defined...
Articles
Clin Sci (Lond) (2017) 131 (24): 2847–2863.
Published: 04 December 2017
... by which genetic variants contribute to COPD and have led to novel insights in COPD pathogenesis. Through functional investigations of causal variants in COPD, from the proteinase–antiproteinase theory to emerging roles of developmental pathways (such as Hedgehog and Wnt pathways) in COPD, we have greatly...
Articles
Clin Sci (Lond) (2017) 131 (14): 1723–1735.
Published: 30 June 2017
...Richard J. Russell; Christopher Brightling The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse range of underlying dominant disease processes and pathways despite apparent similarities in clinical expression. Here, we present the current understanding of asthma...
Articles
Clin Sci (Lond) (2015) 128 (7): 405–410.
Published: 09 December 2014
... Journal Compilation © 2015 Biochemical Society 2015 aetiology obesity pathogenesis Type 2 diabetes weight loss BMI body mass index MODY maturity onset diabetes of youth PFT personal fat threshold T2DM Type 2 diabetes UKPDS United Kingdom Prospective Diabetes...
Articles
Clin Sci (Lond) (2012) 122 (12): 575–580.
Published: 05 March 2012
... Since Alexander Fleming discovered the antibacterial property of penicillin in 1929, large numbers of antibiotics have been developed, making an important contribution to human health in the fight against infectious diseases. Accumulating knowledge on bacterial pathogenesis and antibiotic resistance has...
Articles
Clin Sci (Lond) (2009) 117 (2): 49–65.
Published: 15 June 2009
... ‘membranous webs’ or ‘membrane-associated foci’, whereas viral assembly probably occurs on lipid droplets and endoplasmic reticulum. Liver inflammation plays a central role in the liver damage seen in hepatitis C, but many HCV proteins also directly contribute to HCV pathogenesis. In the present review...
Includes: Multimedia, Supplementary data
Articles
Clin Sci (Lond) (2008) 114 (8): 509–531.
Published: 13 March 2008
... risk factors for the development and progression of atherosclerosis, which can be identified and modified, may be important therapeutic targets. Infectious agents, such as Chlamydia pneumoniae , have been proposed as contributory factors in the pathogenesis of atherosclerosis. In the present review, we...
Articles
Clin Sci (Lond) (2006) 111 (1): 1–20.
Published: 14 June 2006
... 2006 cellular homoeostasis host defence NADPH oxidase pathogenesis phagocyte reactive oxygen species (ROS) superoxide anion ROS (reactive oxygen species) represent a diverse family of molecules that play roles in a myriad of physiological and pathophysiological events. ROS...
Articles
Clin Sci (Lond) (2006) 110 (6): 627–639.
Published: 15 May 2006
.... The discovery of animal models of T1DM in the late 1970s and early 1980s, particularly the NOD (non-obese diabetic) mouse and the BB (BioBreeding) diabetes-prone rat, had a fundamental impact on our ability to understand the genetics, aetiology and pathogenesis of this disease. NOD and BB diabetes-prone rats...
Articles
Clin Sci (Lond) (2002) 102 (5): 475–486.
Published: 12 April 2002
... neurological syndromes. Correspondence: Dr I. Sutton, Department of Neurology, Room 475, Blackburn Building (D06), University of Sydney, NSW 2006, Australia (e-mail iansutton@hotmail.com ). The Biochemical Society and the Medical Research Society © 2002 2002 paraneoplastic pathogenesis...
Articles
Clin Sci (Lond) (1982) 63 (s8): 371s–374s.
Published: 01 October 1982
... pathogenesis stress vascular reactivity Clinical Science (1982) 63,371s-374s 371s Different haemodynamic reaction patterns during noise exposure in normotensive subjects with and without heredity for essential hypertension L. A N D R B N , S. P I R O S , L. H A N S S O N , H . H E R L I T Z A N D 0. J O N...
Articles
Clin Sci Mol Med (1978) 55 (s4): 363s–366s.
Published: 01 December 1978
...K. Abe; M. Yasujima; N. Irokawa; M. Seino; S. Chiba; Y. Sakurai; M. Sato; Y. Imai; K. Saito; T. Ito; T. Haruyama; Y. Otsuka; K. Yoshinaga To investigate the role of renal vasoactive substances in the pathogenesis of essential hypertension, urinary prostaglandin E excretion, urinary kallikrein...