...N. B. Roberts; W. H. Taylor 1. Eight cyclo-alkyl lactamimides have been investigated for potential inhibitory action upon the pepsins and pepsinogens. 2. Human pepsins 1, 3 and 5 and swine pepsin were inhibited only slightly. 3. Human and swine pepsinogens were inactivated progressively...

...Lesley A. Waft; N. B. Roberts; W. H. Taylor 1. Sixteen triterpenoid compounds, related to glycyrrhetic acid, have each been tested for anti-pepsin, anti-pepsinogen, anti-trypsin and anti-chymotrypsin activity. Their actions are compared with the known inhibitory actions of the triterpenoid...

... to the quantity of carbenoxolone suspended. 3. Carbenoxolone, in solution at pH 7·4 and pH 8·0, inhibits the activation of the total pepsinogens of human gastric mucosal extracts and of the individual pepsinogens 1, 3 and 5. Pepsinogen 1 was the most readily inhibited, pepsinogen 5 the least. 4. Chymotrypsin...