...Robert J. Moots 1. A panel of cells designed to express normal or mutated human HLA-A0201 was constructed and used to investigate the interactions between the peptide antigen, class I major histocompatibility complex, CD8 and cytotoxic T lymphocyte antigen receptor. 2. Analysis of the extensive...

...Gareth Williams; Helena M. Cardoso; Ying C. Lee; Joanna M. Ball; Mohammad A. Ghatei; Michael J. Stock; Stephen R. Bloom 1. Hypothalamic concentrations of nine peptides with experimental effects on energy balance were compared in obese ( fa/fa ) and lean (Fa/?) male Zucker rats. To determine whether...

... concentration at which the transport rate is half the maximal transport rate, and V max , the maximal transport rate, were more similar from one peptide to another than among amino acids, with the result that, over a wide range of concentrations, rates of influx of individual peptides varied much less than...

...J. S. Gill; Y. Yiangou; D. J. Webb; L. Meleagros; N. Benjamin; B. J. Chrysanthou; J. R. Cockcroft; R. C. Causon; A. J. Camm; S. R. Bloom 1. The effects of intravenous and intra-arterial infusion of the peptides derived from prepro-vasoactive intestinal peptide, vasoactive intestinal peptide...

...P. M. Rawcliffe; J. D. Priddle; D. P. Jewell 1. Fraction B from a peptic-tryptic digest of gluten from Scout 66 wheat has already been shown to cause histological damage to the jejunal mucosa of coeliac patients. Peptide fractions, designated P1-P4, have been prepared from it by a combination...

... enkephalin peptides spontaneously hypertensive rats vasopressin ClinicalScience (1980) 5 9 , 2 3 5 ~ 2 3 1 s 235s Increased pressor responsiveness to enkephalin in spontaneously hypertensive rats: the role of vasopressin R . W. R O C K H O L D , J . T . C R O F T O N A N D L. S H A R E Department...

...J. D. Cash; A. M. A. Gader; J. L. Mulder; J. H. Cort 1. The systemic plasminogen activator response has been examined after intravenous infusion of the following peptides related to neurohypophyseal hormones in approximately equimolar dosages into informed, consenting human volunteer subjects...

...P. D. Fairclough; D. B. A. Silk; J. P. W. Webb; M. L. Clark; A. M. Dawson 1. The validity of evidence for intact peptide absorption, derived from analysis of the relation of water and total solute absorption, has been tested. 2. Solute and water absorption from saline solutions of the disaccharide...

...% of the amino acids existed as small peptides, and also from an equivalent mixture of free amino acids. 2. The effect of a high concentration of the dipeptide glycylglycine on the absorption of amino acid residues from these preparations was studied to quantify the importance of mucosal uptake of intact...

..., which are attributable to mucosal uptake of small peptides, involve more rapid absorption from the enzymic hydrolysates of certain amino acids which are relatively slowly absorbed from the amino acid mixtures. This could lead to more effective utilization of amino acids from the enzymic hydrolysates...

...A. M. Asatoor; M. D. Milne; J. M. Walshe 1. A study has been made of peptide excretion in twenty cases of Wilson's disease, ligand-exchange column chromatography being used to separate peptides from free amino acids. Previous reports of excess of peptide output in the disease were confirmed...

...G. N. Hendy; P. M. Barling; J. L. H. O'Riordan 1. Immunological assay systems specific to the amino-terminal region of parathyroid hormone were used to study the properties of human parathyroid hormone (HPTH 1-84) and of synthetic peptides. One of these peptides (HPTH 1-34A) had the sequence...