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Keywords: peroxisome proliferator-activated receptors
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Articles
Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats
Available to PurchaseWilliam P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1485–1511.
Published: 03 November 2022
... protocol led to ∼ 20% weight loss, normalized metabolic parameters and was associated with reductions in indices of glomerular and proximal tubular injury. The transcriptomic response to DMT was dominated by changes in fenofibrate- and peroxisome proliferator-activated receptor-α (PPARα)-governed...
Includes: Supplementary data
