...) from 15 up to 28% following corticosteroid treatment. We observed no effect on bacterial phagocytosis. Corticosteroids alter the phenotype and function of COPD lung macrophages. Our findings suggest mechanisms by which corticosteroids exert therapeutic benefit in COPD, reducing iron available...

... and decreased plasma total antioxidant content and superoxide dismutase activity, but did not alter plasma complement-C3a desArg/C4a desArg/C5a concentrations. Moreover, this hypoxic exposure also increased the chemotaxis of PMNs by exposure to N -formyl-Met-Leu-Phe, the phagocytosis of PMNs to Escherichia coli...

... the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. Using an in vitro flow cytometry-based phagocytosis assay, we investigated the role of fetuin in apoptotic cell clearance. Bovine fetuin and human α 2 -HS glycoprotein significantly augmented the phagocytosis...

... macrophage neutrophil phagocytosis Clinical Science (2003) 105, 267 268 (Printed in Great Britain) 267 C O M M E N T A physiological role for 2-HS glycoprotein: stimulation of macrophage uptake of apoptotic cells A B S T R A C T This comment describes the study by Jersmann and co-workers in this issue...

..., there is another side to the inflammatory M ϕ . Evidence is provided that M ϕ s at the same sites possess the ability to aid cell proliferation, secrete and stabilize new matrix components and induce resident cells to secrete matrix components themselves. M ϕ phagocytosis of apoptotic cells brings about a change...

... 2002 apoptosis CD44 inflammation macrophage neutrophil phagocytosis 441Clinical Science (2002) 103, 441 449 (Printed in Great Britain) + G L A X O / M R S P A P E R Role of macrophage CD44 in the disposal of inflammatory cell corpses* Sharon VIVERS, Ian DRANSFIELD and Simon P. HART MRC...

... provide a protective mechanism against the inhibitory effect of adrenaline on superoxide production by neutrophils. Correspondence: Dr. Rui Curi. The Biochemical Society and the Medical Research Society © 1999 1999 adrenaline glutamine glucose phagocytosis neutrophils superoxide...

... in fibroblasts from subjects with familial hypercholesterolaemia by more than 80% but had no effect on binding at 4°C, consistent with a phagocytic uptake pathway. Collectively, the data suggest that chylomicron remnants bind to a cell-surface protein which initiates phagocytosis and that lactoferrin interferes...

.... These effects were independent of the presence of Ca 2+ in the extracellular solution. Some inhibition was also observed when the calcium antagonists were added during the course of a respiratory burst. Oxygen uptake by the cells was reduced in the presence of each calcium antagonist. Phagocytosis...

... superoxide anion radical formation) did not differ from the controls. 5. Sera from patients with SS significantly increased both spontaneous and induced CL of normal PMN. 6. Enhanced excitability of PMN to phagocytosis-related stimuli may provide a mechanism for the (leucocyte-mediated) endothelial injury...

... of lysosomal enzymes from blood leucocytes of normal and emphysematous subjects during phagocytosis of particulate material was studied In vitro. Acid phosphatase and acid ribonuclease were used as markers of lysosomal enzyme release, no sufficiently sensitive assay for elastase being available. Cigarette...

... 1 3 4 1 5 SHORT COMMUNICATION Tracing the fate of oxygen consumed during phagocytosis by human neutrophils with lsOz A. W . S E G A L , J . C L A R K * A N D A . C . A L L I S O N Clinical Research Centre, Harrow, Middlesex, U.K. and 'MRC Cyclotron Unit, Hammersmith Hospital, London (Received 3...

...A. W. Segal; A. J. Levi 1. The Nitroblue Tetrazolium (NBT) test is a measure of the phagocytosis of particulate complexes of NBT and heparin and/or fibrinogen by neutrophil leucocytes. 2. Humoral factors in the plasma of ill patients stimulate neutrophil leucocytes of normal subjects to ingest...

... the cytoplasm. 5. Neither complement nor immunoglobulins were obligatory for dye reduction in this system. 6. It is suggested that NBT only enters neutrophils in quantities visible by light microscopy, after stimulation which produces phagocytosis of a macromolecular complex of the dye and heparin...