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Keywords: pharmacokinetics
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Articles
Clin Sci (Lond) (2017) 131 (11): 1179–1189.
Published: 22 May 2017
... on behalf of the Biochemical Society 2017 age etanercept psoriasis pharmacokinetics Psoriasis is a recurrent chronic immune-mediated inflammatory disorder of the skin, affecting 2–3% of the population worldwide. The disease has a strong genetic component but environmental factors...
Articles
Clin Sci (Lond) (2010) 119 (11): 483–491.
Published: 17 August 2010
... and undertaken immunogenicity and toxicology studies in Macaca fascicularis and pharmacokinetic and pharmacodynamic studies in rats. Two variants of the LR-fusion, one with a flexible linker (GH–LRv2) and the other without (GH–LRv3), were tested. Comparison was made with native human GH (growth hormone). GH–LRv2...
Articles
Clin Sci (Lond) (2006) 111 (2): 127–134.
Published: 13 July 2006
... is the clearance of glucose. The concentration resulting from endogenous production of glucose ( C en ) was simplified as: C en = k i ex / CL . The pharmacokinetics of the exogenous glucose load was analysed using a one-compartment turnover model [ 9 – 11 ]. Here, the plasma concentration ( C ex...
Articles
Clin Sci (Lond) (2005) 109 (1): 97–102.
Published: 23 June 2005
...Jocelyn DUPUIS; Alexandre CARON; Nathalie RUËL The biodistribution, pharmacokinetics and multi-organ clearance of the vasodilator peptide AM (adrenomedullin) were evaluated in rats and its single-pass pulmonary clearance was measured in dogs by the indicator-dilution technique. Intravenously...
Articles
Clin Sci (Lond) (2005) 108 (3): 217–224.
Published: 18 February 2005
... expansion. 18 10 2004 12 11 2004 12 11 2004 The Biochemical Society 2005 albumin antithrombin fibrinogen pharmacokinetics transcapillary leak Albumin (5%) and human plasma are colloid infusion fluids given to replace plasma volume and to raise its oncotic pressure...
Articles
Clin Sci (Lond) (2004) 106 (3): 307–313.
Published: 01 March 2004
... © 2004 The Biochemical Society 2004 crystalloid fluid pharmacokinetics pre-eclampsia pregnancy Clinical Science (2004) 106, 307 313 (Printed in Great Britain) 307 Distribution and elimination of crystalloid fluid in pre-eclampsia Dan DROBIN and Robert G. HAHN Department of Anaesthesia...
Articles
Clin Sci (Lond) (2000) 99 (5): 433–441.
Published: 19 October 2000
... supplementation may be beneficial in severe malaria. There have, however, been no studies that have examined the pharmacokinetics of acute retinol supplementation in severe illness. To establish whether mobilization of intramuscular retinyl palmitate (RP) and its availability as retinol are adequate...
Articles
Clin Sci (Lond) (1999) 96 (2): 199–207.
Published: 01 February 1999
... that this beneficial effect, which is thought to be related to the increased availability of nitric oxide, may not be sustained during chronic oral administration. Pharmacokinetic alterations may contribute to this observation. The present study was designed to examine the disposition of L -arginine...
Articles
Clin Sci (Lond) (1994) 87 (4): 459–465.
Published: 01 October 1994
... about the production of tumour necrosis factor-α in disease in vivo. 2. In the present study we aimed to estimate the extent and the kinetics of whole body tumour necrosis factor-α synthesis in experimental endotoxaemia in six healthy humans. For this purpose we first examined the pharmacokinetic...
Articles
Clin Sci (Lond) (1994) 86 (6): 723–730.
Published: 01 June 1994
... of brain natriuretic peptide in six healthy men on plasma brain natriuretic peptide levels and the pharmacokinetics of brain natriuretic peptide. Synthetic human brain natriuretic peptide-32 was infused intravenously, at an initial rate of 0.4 pmol min −1 kg −1 , doubling every 15 min until the dose rate...
Articles
Clin Sci (Lond) (1993) 84 (6): 675–679.
Published: 01 June 1993
... the following pharmacokinetic parameters: the area under the blood cyclosporin A concentration versus time curve (AUC, 0–4 h), the maximum blood concentration of cyclosporin A ( C max. ), the time to reach C max . ( t max. ), the absorption half-life ( t 1/2a ), the elimination half-life ( t 1/2λ...
Articles
Clin Sci (Lond) (1991) 80 (2): 155–160.
Published: 01 February 1991
...E. Burns; D. R. Triger; G. T. Tucker; N. D. S. Bax 1. The validity of a two-compartment pharmacokinetic model for the estimation of the hepatic extraction ratio of Indocyanine Green was tested in six patients with cirrhosis of the liver. 2. No agreement was found between the value of the hepatic...
Articles
Clin Sci (Lond) (1990) 79 (4): 299–305.
Published: 01 October 1990
...L. Hjelte; M. Larsson; A. Alvestrand; A.-S. Malmborg; B. Strandvik 1. Renal function was studied in 50-, 70-, 90- and 200-day-old rats with essential fatty acid deficiency. The pharmacokinetics of tobramycin was investigated in 90-day-old essential fatty acid-deficient rats. 2. A higher glomerular...
Articles
Clin Sci (Lond) (1988) 75 (5): 463–468.
Published: 01 November 1988
... of the investigated peptides as sources of free glutamine and free tyrosine. 16 3 1988 6 4 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 amino acid nutrition dipeptide utilization glutamine pharmacokinetics tyrosine Clinical Science (1988) 75,463-468 463...
Articles
Clin Sci (Lond) (1987) 73 (1): 47–52.
Published: 01 July 1987
...). There was no relationship between blood pressure or pretreatment heart rate and the slope of the concentration–effect relationship. 5. We conclude that pregnancy can significantly alter drug effect in the absence of any pharmacokinetic changes. These findings suggest that therapeutic ranges established in non-pregnant...
Articles
Clin Sci (Lond) (1987) 72 (2): 255–257.
Published: 01 February 1987
... 1986 8 9 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 oral administration pharmacokinetics somatostatin analogues ClinicalScience(1987) 72,255-257 255 SHORT COMMUNICATION Oral absorption of the somatostatin analogue SMS 20 1-995: theoretical...
Articles
Clin Sci (Lond) (1981) 60 (6): 707–710.
Published: 01 June 1981
... at equimolar dosage. 2. The plasma pharmacokinetics of the two salts of 5-fluorouracil (1.44 mmol/kg) were different after i.p. injection: higher plasma levels were achieved and were sustained for longer after the Tris salt than after the sodium salt. 3. No differences in plasma pharmacokinetics were observed...
Articles
Clin Sci (Lond) (1980) 59 (6): 479–483.
Published: 01 December 1980
... from 432 to 1870 ml/min, was also correlated with age ( r = −0.717). 4. It is concluded that the increased sensitivity of the elderly to diazepam is, at least in part, due to pharmacokinetic factors. 10 4 1980 30 7 1980 © 1980 The Biochemical Society and the Medical Research Society...
Articles
Clin Sci (Lond) (1979) 57 (s5): 393s–396s.
Published: 01 December 1979
... reached a peak at 2 h for each drug and this coincided with the interval at which maximal β-adrenoreceptor-blocking effect was observed. β-adrenoreceptor blockade hypertension pharmacokinetics pindolol propranolol © 1979 The Biochemical Society and the Medical Research Society 1979 Clinical...
Articles
Clin Sci Mol Med (1978) 55 (s4): 275s–277s.
Published: 01 December 1978
...M. E. Safar; N. Ph. Chau; J. A. Levenson; A. Ch. Simon; Y. A. Weiss 1. The pharmacokinetics of intravenous and oral pindolol were determined in 24 hypertensive patients with normal or impaired renal function. 2. In patients with normal renal function, the total clearance of the drug was the sum...
Articles
Clin Sci Mol Med (1976) 51 (s3): 473s–475s.
Published: 01 December 1976
...–100 ng/ml; oxprenolol, 500–1000 ng/ml; pindolol, 10–30 ng/ml; sotalol, 2–6 μg/ml. Higher concentrations are often found with high doses administered to hypertensive patients. © 1976 The Biochemical Society and the Medical Research Society 1976 alprenolol oxprenolol pharmacokinetics pindolol...
Articles
Clin Sci Mol Med (1976) 51 (s3): 639s–640s.
Published: 01 December 1976
... subjects. 3. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure. © 1976 The Biochemical Society and the Medical Research Society 1976 clonidine hypertension pharmacokinetics Clinical Science and Molecular...