...P. N. Durrington 1. Further observations from an earlier study in which phenobarbitone in a dose of 180 mg daily was administered to ten normal men and women for 3 weeks are reported. There was a significant increase in plasma high-denity-lipoprotein (HDL) cholesterol concentration...

... the relative storage capacity ( S ) was normal. Phenobarbitone treatment in four patients resulted in an increase in T m , and S decreased in two patients and remained unchanged in the other two. 5. These results support the hypothesis that there are several variants of Gilbert's syndrome...

...A. R. Marsh; H. S. Fraser; A. Breckenridge; B. Lewis; G. R. Thompson 1. Four groups of rats received a liquid formula diet, given alone (control), or supplemented with either ethanol or phenobarbitone, or both together. 2. The ethanol-treated group showed a fall in plasma triglyceride and a rise...

...P. N. Durrington; C. J. C. Roberts; Lyn Jackson; R. A. Branch; M. Hartog 1. Phenobarbitone in a dose of 180 mg daily was administered to ten normal subjects for 3 weeks. There was a significant increase in total plasma cholesterol, plasma low-density-lipoprotein cholesterol, plasma low-density...

... affinity constant ( K m ) was altered in these studies. 3. In contrast, administration of phenobarbitone in doses of 0·34 mmol 24 h −1 kg −1 (80 mg 24 h −1 kg −1 ) caused a significant increase in the microsomal protein content but there was no significant change in the values for the apparent V max...

... was significantly impaired in the patients with Gilbert's syndrome and in those with congenital non-haemolytic jaundice when compared with the normal subjects, and was normal in the patient with haemolytic jaundice. 2. Treatment for 2 weeks with phenobarbitone (180 mg/day) lowered the plasma bilirubin concentration...

...N. E. Miller; P. J. Nestel 1. The effects of phenobarbitone on cholesterol and bile acid metabolism have been examined in healthy humans. 2. In three of four subjects the faecal excretion of bile acids was increased by phenobarbitone. This was associated with an increased pool size and turnover...