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Keywords: phenylephrine
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Clin Sci (Lond) (1998) 96 (1): 41–47.
Published: 01 January 1999
... operated. In rat aorta, there was no significant difference between portal hypertensive and sham-operated animals in the contractile potency of KCl, noradrenaline or phenylephrine. In aortas from Wistar rats, the maximum response to KCl (0.71±0.12 ;g) and noradrenaline (1.00±0.17 ;g) but not phenylephrine...
Clin Sci (Lond) (1996) 91 (6): 733–738.
Published: 01 December 1996
... and that of the endothelium in the response to phenylephrine and acetylcholine of isolated aortic rings from chronic bile duct-ligated (29 days) rats and their corresponding controls. Experiments were performed in rings with or without endothelium, in rings pretreated with N -ω-nitro-l-arginine methyl ester (10 −4 mol/l...
Clin Sci (Lond) (1996) 91 (5): 601–606.
Published: 01 November 1996
... to study contraction after pressure recording. 3. Octreotide treatment significantly reduced portal pressure and plasma glucagon concentrations compared with the vehicle-treated group. Both phenylephrine and vasopressin induced concentration-dependent contractile responses in the aorta and mesenteric...
Clin Sci (Lond) (1995) 88 (4): 421–426.
Published: 01 April 1995
... this is due to increased sensitivity at α 1 - or α 2 -adrenergic receptors, we compared vascular responses to the α 1 -adrenergic agonist phenylephrine and the α 2 -adrenergic agonist clonidine. 3. We studied 15 insulin-dependent diabetic patients with microalbuminuria, 15 insulin-dependent diabetic patients...
Clin Sci (Lond) (1992) 82 (4): 357–362.
Published: 01 April 1992
... heart rate responses to perturbations in mean arterial pressure induced with injections of nitroprusside and phenylephrine. The method provides a sigmoidal relationship between changes in heart rate and blood pressure. The upper plateau (maximum tachycardia in response to blood pressure reduction...
Clin Sci (Lond) (1992) 82 (2): 163–168.
Published: 01 February 1992
... to catecholamines could be due to either a postsynaptic increase in vascular sensitivity or to decreased catecholamine uptake into peripheral sympathetic nerve endings. 2. To differentiate between these possible mechanisms we have measured the responsiveness in vivo to noradrenaline and phenylephrine with local...
Clin Sci (Lond) (1991) 81 (6): 733–737.
Published: 01 December 1991
...Seiki Harada; Tsutomu Imaizumi; Michiko Momohara; Hiroyuki Masaki; Shin-Ichi Ando; Akira Takeshita 1. The aim of this study was to examine whether arginine vasopressin modulates the vasoconstricting action of phenylephrine in human forearms. 2. In seven healthy subjects, we determined...
Clin Sci (Lond) (1985) 68 (5): 489–493.
Published: 01 May 1985
... of 27 conscious rabbits was assessed by both the ‘steady-state’ and ‘ramp’ methods in response to injections of phenylephrine (2.5-30 μg/kg). 2. Animals with differing baroreflex sensitivities were then given 4 weeks treatment with 8% NaCl and 1.3% KCl in food (treatment A), or DOCA (25 mg pellet...
Clin Sci (Lond) (1982) 63 (s8): 305s–308s.
Published: 01 October 1982
... phenylephrine. 2. Oral prazosin (1 mg) lowered erect (but not supine) blood pressure in both groups by a comparable amount: in young and old groups the respective maximal falls in systolic pressure were 19.5 ± 15.7 and 29.3 ± 11.4 mmHg (mean ± sd) and for diastolic pressure the maximal falls were 13 ± 13.3...
Clin Sci (Lond) (1981) 61 (s7): 203s–206s.
Published: 01 December 1981
...M. J. Stevens; R. E. Rittinghausen; R. F. W. Moulds 1. The effects of various α-receptor agonists and antagonists on pre- and post-synaptic α-receptors of human isolated digital arteries and metacarpal (or metatarsal) veins have been studied. 2. The relative potency of phenylephrine compared...
Clin Sci (Lond) (1980) 59 (s6): 401s–404s.
Published: 01 December 1980
... baroreflex sensitivity as measured by various methods (phenylephrine, neck suction etc.). 5. It is concluded that blood pressure variability increases and heart rate variability decreases with age, but that changes in variability are not so obvious in hypertension. Also, differences in variability among...
Clin Sci (Lond) (1979) 57 (s5): 161s–163s.
Published: 01 December 1979
...R. Vandongen; K. D. Strang; Marianne H. Poesse; W. H. Birkenhager 1. The effect of α-adrenergic stimulation, with phenylephrine, on isoprenaline-provoked renin secretion was studied in the isolated perfused rat kidney. 2. Infusion of phenylephrine increased renal perfusion pressure and prevented...
Clin Sci Mol Med (1978) 55 (s4): 279s–281s.
Published: 01 December 1978
...%; the phenylephrine-induced rise of systolic brachial artery pressure was reduced by 36%. 3. During labetalol brachial artery pressure was lowered by 29/15 mmHg in the recumbent position, by 41/23 mmHg at rest sitting, and by 53/23 mmHg at maximal exercise; total peripheral resistance was not significantly affected...