... on behalf of the Biochemical Society 2018 cancer therapy mechanistic target of rapamycin phosphoinositide 3-kinase protein kinase B rapalogs Mechanistic (formerly mammalian) target of rapamycin (mTOR) is the serine/threonine kinase subunit of two large and functionally distinct...

...Darnel Prakoso; Miles J. De Blasio; Chengxue Qin; Sarah Rosli; Helen Kiriazis; Hongwei Qian; Xiao-Jun Du; Kate L. Weeks; Paul Gregorevic; Julie R. McMullen; Rebecca H. Ritchie Phosphoinositide 3-kinase [PI3K (p110α)] is able to negatively regulate the diabetes-induced increase in NADPH oxidase...

... of type I fibres and with the oxidative/glycolytic enzyme activity ratio [ 44 ]. © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary disease exercise inflammation phosphoinositide 3-kinase pulmonary rehabilitation skeletal muscle COPD...

... targeting inflammatory proteins for the treatment of atherosclerosis. The PI3K (phosphoinositide 3-kinase) family, which catalyses the phosphorylation of the 3-OH position of phosphoinositides and generates phospholipids, controls a wide variety of intracellular signalling pathways. Recent studies provide...

... and enhanced phospholipase D and phosphoinositide 3-kinase activity in neutrophil priming. 4. Recent work has also revealed the potential for neutrophils to spontaneously and fully ‘de-prime’ after an initial challenge with platelet-activating factor. This ability of neutrophils to undergo a complete cycle...