...P. E. Hall; S. R. Smith; M. J. Kendall 1. Plasma ammonia and heart rate were measured in normal volunteers before, during and after an exercise test following administration of placebo, propranolol, pindolol, metoprolol and nadolol. 2. Small changes in plasma ammonia occurred during exercise after...

... lipoproteins during chronic β-adrenoceptor blockade in patients with stable angina pectoris treated with propranolol (without ISA) (n = 21) or pindolol (with ISA) ( n = 19). 2. No significant changes occurred in the lipoprotein profile of the patients taking pindolol. In those taking propranolol, very low...

... for the chronotropic and vascular effects of this drug. Similar cardiac and vascular supersensitivity was observed for salbutamol. Cardiac chronotropic supersensitivity to prenalterol was less pronounced as compared with isoprenaline and salbutamol. The patients were treated with pindolol, 15 mg daily, divided...

..., pindolol or slow-release propranolol. 3. Drugs were administered in a once-daily variable dose regimen for a period of 3–8 months (mean 5.0 ± sd 1.4). 4. All four drugs reduced blood pressure significantly 24 h after the last dose but there were considerable differences in control when each intervening...

... 6 weeks after withdrawal of the β-blocker from combination therapy. 4. In group II (18 men), low-density lipoprotein cholesterol was increased by 13% ( P < 0.025) after 4 weeks of monotherapy with clopamide (5 mg/day) but restored to control levels 4 weeks after addition of pindolol (10 mg/day...

...G. Koch; I.-W. Franz; F. W. Lohmann 1. The effects on glucose and lipid metabolism and on plasma catecholamines at rest and during exercise, of 4 weeks treatment with non-selective β-blockade (pindolol, 15 mg daily) and with cardio-selective blockade (metoprolol, 200 mg, and acebutolol, 500 mg...

...L. A. Salako; A. O. Falase; A. Fadeke Aderounmu 1. The β-adrenoreceptor-blocking effects of pindolol were compared with those of propranolol and a placebo in a double-blind cross-over trial involving nine hypertensive African patients. 2. Heart rate, systolic blood pressure and diastolic blood...

...J. D. F. England; A. S. P. Hua; J. Shaw 1. Chlorothiazide twice a day plus atenolol, metoprolol, pindolol and propranolol in single daily doses administered to patients with essential hypertension achieved effective control of blood pressure. 2. Each β-adrenoreceptor-blocking drug was associated...

... with control subjects, either in supine or in upright positions, whereas no significant differences were found in plasma noradrenaline. 3. Six hypertensive patients were chronically treated with β-adrenoreceptor-blocking agents (five with propranolol and one with pindolol). Plasma noradrenaline...

...M. Wilson; G. Morgan; T. Morgan 1. Blood pressure was controlled to the same extent whether propranolol or pindolol was given once or three times/day. 2. The anti-hypertensive action of β-receptor-blocking drugs persisted for 36–48 h when administration ceased. © 1976 The Biochemical Society...

...–100 ng/ml; oxprenolol, 500–1000 ng/ml; pindolol, 10–30 ng/ml; sotalol, 2–6 μg/ml. Higher concentrations are often found with high doses administered to hypertensive patients. © 1976 The Biochemical Society and the Medical Research Society 1976 alprenolol oxprenolol pharmacokinetics pindolol...

... doses of 100 mg of propranolol, 400 mg of practolol, 100 mg of oxprenolol, 10 mg of timolol, 5 mg of pindolol or 100 mg of ICI 66082. 3. All beta-blocking agents tested significantly and markedly reduced plasma renin activity during upright exercise. Renin suppression was not related to either β 1...