...). However, the precise pathophysiological mechanisms underlying acute coronary occlusion are not fully understood. We have analysed proteomic profiles of systemic plasma and plasma derived from the site of coronary plaque rupture of non-diabetic patients with STEMI (ST-segment elevation myocardial...

... themselves induces necrotic core formation, reinforcing plaque fragility [ 30 ]. In addition to macrophages, T-cells localize at sites of plaque rupture. Th1 cytokines (IFN-γ and TNF-α) inhibit the proliferation of SMCs and the production of collagen by SMCs, thereby reducing stability of the plaque...

... ). 17 3 2004 7 6 2004 1 7 2004 1 7 2004 The Biochemical Society 2004 apoptosis atherogenesis growth factor inflammation oxidative stress plaque rupture signalling pathway The arterial wall is composed of an innermost layer of endothelial cells resting on a thin...