... is facilitated by plasmin. In the ascitic fluid of patients with cirrhosis, there is massive cleavage of high- M r kininogen and activation of fibrinolysis, but bradykinin has never been measured directly. In the ascitic fluid of 24 patients with cirrhosis, we measured bradykinin-(1-9)-nonapeptide levels by RIA...

...Serge Adnot; Nicolas Ferry; Jacques Hanoune; Marie-Use Lacombe 1. Plasmin was recently reported to inhibit platelet aggregation [1]. We report here on the interaction of plasmin with the adenylate cyclase system of human platelets. Human plasmin caused a dose-and time-dependent increase...

..., acid-activated renin was reversibly inactivated in a time-dependent manner during incubation at 37°C above pH 5. The maximal rate of reversal occurred in the pH 7–8 range. Reversal was prevented by prior incubation with trypsin, plasmin, glandular kallikrein or plasma kallikrein. 4. By kinetic analysis...

...F. H. M. Derkx; B. N. Bouma; H. L. Tan-Tjiong; M. A. D. H. Schalekamp 1. Human plasma was treated at 4°C with acid, trypsin, plasmin, streptokinase, urokinase, active Hageman factor fragment (β-XIIa) and β-XIIa-activated plasma prekallikrein (Fletcher factor). The conversion of inactive into active...

... but is not dependent on kallikrein activation of plasminogen. © 1979 The Biochemical Society and the Medical Research Society 1979 kallikrein plasmin prorenin Clinical Science (1979) 5 1 . 9 7 ~ 9 9 9 Plasmin can activate plasma prorenin but is not required for the alkaline phase of acid activation J E...

...G. P. M. Crawford; D. Ogston; A. S. Douglas 1. Human plasma contains a variety of proteins that are capable of inhibiting plasmin activity. Whole plasma possesses ‘rapid’ and ‘progressive’ plasmin-neutralizing activity: this study assesses the contribution of individual protease inhibitors...

...Robyn J. Herbert; B. Bennett; D. Ogston 1. Crude preparations of β-lipoprotein inhibited the fibrinolytic and caseinolytic activity of plasmin: they were contaminated by α 2 -macroglobulin and α 1 -antitrypsin, known inhibitors of plasmin. 2. Purified β-lipoprotein, free from α 2 -macroglobulin...