... and emerging evidence has shown that mitochondrial transplantation is a potential and effective strategy that can reduce brain injury and associated disorders. Platelets are abundant in blood and can be considered a readily available source of small-size mitochondria. These cells can be easily acquired from...

... from arterial diseases. We hypothesized interactions between prasugrel and enhanced vWF (von Willebrand Factor) release in a model of systemic inflammation, and compared the pharmacodynamic effects of prasugrel against placebo on agonist-induced platelet aggregation and shear-induced platelet plug...

... randomized to treatment with either atorvastatin or placebo; 20 normolipidaemic patients were also studied. Platelet nitrite, NO and superoxide were examined as was the cellular distribution of the GTPases Rho and Rac at baseline and after 8 weeks of treatment. Following atorvastatin therapy, platelet...

... relaxation and platelet function. Although the concentration of intracellular L -arginine is well above the K m for NO synthesis, in many cells and pathological conditions the transport of L -arginine is essential for NO production ( L -arginine paradox). The present study was designed to investigate...

... -nitrosocysteine, S -nitrosoglutathione and S -nitrosoalbumin, in which R is an amino acid, polypeptide and protein respectively. RSNOs have anti-platelet properties, a theoretical role in the treatment of asthma and the potential to be used as agents to treat infectious diseases ranging from the common cold...

...Marcus K. Ilton; Marcia L. Taylor; Neil L. A. Misso; Philip J. Thompson; Joseph Hung 1. Close contact between platelets and neutrophils modulates their cellular interactions in thrombotic and inflammatory states, with stimulation of P-selectin expression on platelets by agonists such as thrombin...

...K. Pritchard; A. E. G. Raine; C. C. Ashley; L. M. Castell; V. Somers; C. Osborn; J. G. G. Ledingham; J. Conway 1. Fifty-two normotensive and essential hypertensive subjects were studied. Intracellular free calcium concentration ([Ca 2+ ] i ) was measured in lymphocytes (37 subjects) and platelets...

...C. C. T. Smith; A. P. Wilson; B. N. C. Prichard; D. J. Betteridge 1. Endogenous noradrenaline release from washed platelets incubated under resting conditions and in the presence of thrombin was examined in 14 normal subjects and 10 subjects with type 1 (insulin-dependent) diabetes. 2. Irreversible...

...Susan M. Barr; Kennedy R. Lees; Daniel D. McBryan; James Reid; Elizabeth Farish; Peter C. Rubin 1. A positive correlation between blood pressure and platelet intracellular free calcium concentration ([Ca 2+ ] i ) has been reported. We examined the effect of acute changes in blood pressure...

...K. Berntorp; F. Lindgäurde; I. Mattiasson 1. The rate constants for the ouabain- and frusemide-sensitive 22 Na + efflux, the number of [ 3 H]ouabain binding sites and the effect of plasma on [ 3 H]ouabain binding were determined in platelets, as were blood pressure (BP) and serum urate...

...Serge Adnot; Nicolas Ferry; Jacques Hanoune; Marie-Use Lacombe 1. Plasmin was recently reported to inhibit platelet aggregation [1]. We report here on the interaction of plasmin with the adenylate cyclase system of human platelets. Human plasmin caused a dose-and time-dependent increase...

...J. C. Ferguson; N. Mackay; J. A. D. Philip; D. J. Sumner 1. Simultaneous platelet and fibrinogen survival studies were carried out on a group of seven normal persons and eleven diabetic patients. 2. Survival time was calculated: (a) by measuring the interval between 50% of the maximum radioactivity...