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Keyword: platelet aggregation
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Articles
Clin Sci (Lond) (2004) 106 (1): 27-34.
Published: 01 January 2004
... contribute to platelet aggregation and to maintain the response to diuretics in advanced cirrhosis. In the present study, we tested the effects of a dietary supplementation for 8 weeks with a triacylglycerol (triglyceride) enriched in AA (ARASCO®; 4 g/day) or oleic acid (OA) on plasma and membrane fatty acid...
Articles
Clin Sci (Lond) (2001) 100 (2): 127-135.
Published: 19 December 2000
...-dependent vasodilator, substance P, and the endothelium-independent vasodilator, sodium nitroprusside. These measurements, together with platelet aggregation studies, were performed on four occasions after double-blind randomized ingestion of placebo, methionine (0.1 mg/kg), vitamin C (2 g) and methionine...
Articles
Clin Sci (Lond) (1999) 97 (3): 345-353.
Published: 30 July 1999
... study. After a 30 min infusion of ⌊-NMMA or placebo, NO inhalation (30 p.p.m) was added during the remaining 30 min of infusion, on both occasions. Measurements included filtragometry ex vivo (reflecting platelet aggregability), flow-cytometric evaluation of platelets in whole blood (fibrinogen binding...
Articles
Clin Sci (Lond) (1996) 91 (2): 225-231.
Published: 01 August 1996
... inhaled nitric oxide influences platelet function in vivo in healthy subjects. 2. Platelet aggregability (filtragometry ex vivo , which reflects aggregability in vivo ), bleeding time and platelet secretion products and cGMP in plasma were studied during inhalation of two different doses of nitric oxide...
Articles
Clin Sci (Lond) (1996) 91 (1): 87-92.
Published: 01 July 1996
... decreased by fluoxetine, and we would predict a protective effect of fluoxetine against coronary thrombosis. 12 3 1996 29 3 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 5-hydroxytryptamine platelet aggregation Clinical Science (1996) 91, 87-92 (Printed...
Articles
Clin Sci (Lond) (1995) 88 (3): 277-283.
Published: 01 March 1995
... 10 −11 to 10 −6 mol/l had no effect on platelet aggregation or intracellular free calcium concentration but inhibited in a dose-dependent manner aggregation induced by 0.05 unit/ml thrombin (p D 2 for inhibition by endothelin = 8.1 ± 0.12). 3. Endothelin-1 at 10 −9 mol/l significantly decreased ( P...
Articles
Clin Sci (Lond) (1995) 88 (3): 269-275.
Published: 01 March 1995
... Research Society 1995 adrenaline cardiopulmonary bypass haemostasis hirudin human platelet aggregation Clinical Science (1995) 88, 269-275 (Printed in Great Britain) 269 Impaired platelet aggregation after cardiopu I monary bypass in man: enhancement of collagen-induced aggregation in whole...
Articles
Clin Sci (Lond) (1994) 87 (3): 303-310.
Published: 01 September 1994
...S. M. Bode-Böger; R. H. Böger; A. Creutzig; D. Tsikas; F.-M. Gutzki; K. Alexander; J. C. Frölich 1. L-Arginine is the physiological precursor of nitric oxide which induces vasodilatation and inhibits platelet aggregation by the formation of cyclic GMP. 2. In the present study we investigated the...
Articles
Clin Sci (Lond) (1993) 85 (5): 577-583.
Published: 01 November 1993
...N. Håkan Wallén; Claes Held; Nina Rehnqvist; Paul Hjemdahl 1. The impact of oral acetylsalicylic acid treatment on the enhancing effect of adrenaline on platelet aggregation in vitro was investigated in patients with stable angina pectoris. In addition, the influence of different anticoagulants...
Articles
Clin Sci (Lond) (1993) 84 (5): 517-524.
Published: 01 May 1993
... mg) or high dose (500 mg) of aspirin or placebo infused over a 60 min period on platelet aggregation, platelet thromboxane A 2 production and whole-body prostanoid synthesis in 10 healthy male subjects by gas chromatography-tandem mass spectrometry. 3. Before the study, blood flow rates in the...
Articles
Clin Sci (Lond) (1991) 81 (5): 691-694.
Published: 01 November 1991
... (0.05–0.1 μmol/l) was used to reduce the filter occlusion time ( t A , a measure of platelet aggregate formation in blood) from approximately 600 s to 71–101 s in the absence of other agents. 3. Adenosine was infused into the tubing system of the filtragometer, yielding a contact time of >25 s with...
Articles
Clin Sci (Lond) (1990) 78 (1): 113-116.
Published: 01 January 1990
... response of platelets to sodium arachidonate. 4. These results indicate that intraplatelet arginine vasopressin is released during aggregation and suggest that a local release of arginine vasopressin could occur after complete platelet aggregation in vivo. 24 7 1989 14 8 1989 © 1990 The...
Articles
Clin Sci (Lond) (1989) 77 (1): 99-103.
Published: 01 July 1989
...R. K. McCulloch; J. Summers; R. Vandongen; I. L. Rouse 1. At present it is unclear whether platelet-activating-factor (PAF)-induced aggregation is mediated by thromboxane. To obtain further information about this event we have compared the affects of aspirin on platelet aggregation and secretion...
Articles
Clin Sci (Lond) (1987) 73 (5): 507-513.
Published: 01 November 1987
..., platelet aggregation in response to α 2 -adrenergic agents is normal or even slightly increased. Aggregation responses to adrenergic agents correlate well with aggregation responses to adenosine 5′-diphosphate, suggesting that the effector system is a major determinant of the aggregation response. 3. α 2...
Articles
Clin Sci (Lond) (1987) 73 (1): 99-103.
Published: 01 July 1987
... the Medical Research Society 1970 adrenaline collagen noradrenaline platelet aggregation prostacyclin ...
Articles
Clin Sci (Lond) (1985) 68 (4): 449-454.
Published: 01 April 1985
... in eicosapentaenoic acid (EPA) for 4 weeks. The supplement was equivalent to 1.8 g of EPA daily. Thromboxane synthesis and platelet aggregation responses to sodium arachidonate, thrombin and the ionophore A23187 were also investigated. 2. A marked increase in the relative EPA content of...
Articles
Clin Sci (Lond) (1982) 63 (s8): 391s-393s.
Published: 01 October 1982
... predisposition. 2. The activity of platelet aggregation was significantly greater in men with a genetic predisposition to essential hypertension. 3. Platelet aggregation was activated directly or indirectly by an increased sodium intake. 4. This activation by an increased sodium intake was more pronounced in men...
Articles
Clin Sci (Lond) (1982) 62 (2): 177-181.
Published: 01 February 1982
... protein. 31 3 1981 30 9 1981 © 1982 The Biochemical Society and the Medical Research Society 1982 6-keto-prostaglandin E 1 6-ketoprostaglandin F 1α plasma platelet aggregation prostacyclin CIfnicalScience (1982) 62,177-181 177 Protection of prostacyclin-like activity in...
Articles
Clin Sci (Lond) (1982) 62 (2): 239-242.
Published: 01 February 1982
...M. Porta; E. Cagliero; E. M. Kohner 1. Abnormal plasma levels of von Willebrand factor are accompanied by abnormal platelet function in some disease states. 2. Platelet retention in glass bead columns, platelet aggregation in vitro , β-thromboglobulin and 6-oxo-prostaglandin F 1α were monitored in...