... patients with essential hypertension. Platelet-activating factor (PAF)-evoked rises in the intracellular calcium concentration ([Ca 2+ ] i ) were measured in Epstein–Barr-virus-immortalized lymphoblasts from 62 hypertensive patients with CHD and 34 patients without CHD. Na + /Li + CT activity was assessed...

... be avoided, an accelerated regimen of SK could be given, analagous to that used for other thrombolytic agents such as alteplase. The mechanism of the SK-induced hypotension is unknown, but there is some evidence that platelet-activating factor (PAF) plays a role. The potent PAF receptor antagonist lexipafant...

...-activating factor receptor antagonists BN52021 or BN50739. The platelet-activating factor concentrations detected in the plasma samples were not higher than those detected in plasma from healthy subjects. 5. These findings suggest that during acute myocardial infarction peripheral plasma contains soluble...

...Caroline B. Appleyard; Keith Hillier 1. Platelet-activating factor can be synthesized by two distinct biochemical pathways and is degraded by a number of enzymes, the first step of which is deacetylation by a specific acetyl hydrolase. 2. The biochemical pathway of platelet-activating factor...

...Ricardo Alonso; Angel Montero; Miguel Arévalo; Luis J. García; Concepción Sánchez-Vicente; Fernando Rodríguez-Nodal; José M López-NOVOA; José J. Calvo 1. We have assessed the role of platelet-activating factor in caerulein-induced acute pancreatitis (four subcutaneous injections of caerulein...

...T. D. Wardle; L. A. Turnberg 1. Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1β, prostaglandin E 2 , leukotriene C 4 and platelet-activating factor into the medium in which they were cultured than biopsies from patients with irritable bowel syndrome...

...Neil L. A. Misso; Robyn L. Gillon; Marcia L. Taylor; Geoffrey A. Stewart; Philip J. Thompson 1. Platelet-activating factor is a putative mediator of inflammation in asthma and the enzyme acetyl-CoA:lyso-platelet-activating factor acetyltransferase appears to be important in regulating platelet...

...L. J. Beilin; K. D. Croft; C. A. Michael; J. Ritchie; L. Schmidt; R. Vandongen; B. N. J. Walters 1. Platelet-activating factor is a phospholipid with potent vasodilator and platelet-activating properties. To test the hypothesis that a generalized change in cellular platelet-activating factor...

...Claus Kroegel; Ann Dewar; Tatsuo Yukawa; Per Venge; Peter J. Barnes; K. Fan Chung 1. Purified human eosinophils from asthmatic patients were stimulated with platelet-activating factor in vitro and examined for morphological changes by transmission electron and light microscopy. Changes were also...

...Atsushi Hiraide; Rhys D. Evans; Dermot H. Williamson 1. The aim of this work was to examine whether platelet-activating factor could mimic the hypoketonaemia seen in septic and endotoxic experimental animals. Platelet-activating factor was administered either by the intraperitoneal (high dose...

...K. F. Chung Clinical Science (1992) 83, 127-138 (Printed in Great Britain) I 27 Editorial Review Platelet-activating factor in inflammation and pulmonary disorders K. F. CHUNG Department of Thoracic Medicine, National Heart and lung Institute, Royal Brompton National Heart and lung Hospital...

...S. P. L. Travis; D. P. Jewell 1. Platelet-activating factor is an inflammatory mediator related to eicosanoids which is known to stimulate anion secretion in the distal colon. Since there are regional differences in ion transport within the colon, the influence of platelet-activating factors on ion...

...David G. McCormack; David E. Crawley; Peter J. Barnes; Timothy W. Evans 1. The role of platelet-activating factor in the attenuated hypoxic pulmonary vasoconstriction associated with lung injury was evaluated using specific platelet-activating factor antagonists and an isolated perfused lung...

...Jan O. Lötvall; Wayne Elwood; Kenichi Tokuyama; Peter J. Barnes; K. Fan Chung 1. To evaluate whether endogenous peptide release is involved in the airway responses to inhaled platelet-activating factor, we measured lung resistance and airway microvascular leakage in anaesthetized guinea pigs pre...

...Antonio López-Farré; Dulcenombre Gómez-Garre; Fernando Bernabeu; Santiago Ramón Y Cajal; Paloma Perez-Rodrigo; Pierre Braquet; José Miguel López-Novoa 1. We have studied the effect of inhibiting the interaction of platelet-activating factor with its receptor by using two structurally different...

...Fabio M. Leonelli; Lillian L. Leong; Marian J. Sturm; Julie A. Strophair; Geoffrey M. Clarke; Roger R. Taylor 1. Evidence suggests that activation of phospholipase A 2 and production of eicosanoids and platelet-activating factor (PAF) are involved in various responses associated with severe tissue...

...D. G. McCormack; P. J. Barnes; T. W. Evans 1. The effect of two structurally different platelet-activating factor (PAF) receptor antagonists, WEB 2086({3-[4-(2-chlorophenyl)-9-methyl-6 H -thieno[3,2- f ]-[1,2,4]-treazolo-[4,3- a ][1,4]-diazepine-2-yl]-1-(morpholinyl)-1-propanone}) and BN 52021...

...R. K. McCulloch; J. Summers; R. Vandongen; I. L. Rouse 1. At present it is unclear whether platelet-activating-factor (PAF)-induced aggregation is mediated by thromboxane. To obtain further information about this event we have compared the affects of aspirin on platelet aggregation and secretion...

... studied. 2. The effects of histamine, leukotriene (LT) D 4 and platelet-activating factor (PAF) on microvascular permeability in the nasal mucosa, larynx, trachea, main bronchi and intrapulmonary airways of the guinea pig were assessed by measuring the extravasation of intravenously administered Evans...

...Roger R. Taylor; Marian Sturm; Philip J. Kendrew; Robert Vandongen; Lawrence J. Beilin 1. The effect of age on the plasma level of the lyso-derivative of platelet-activating factor (lyso-PAF) was studied in 72 normal subjects, (32 females, 40 males) aged 12–64 years. Lyso-PAF was acetylated...

...H. M. McGowan; R. Vandongen; L. D. Kelly; K. J. Hill 1. This study analyses whole blood in acutely unclipped one-kidney, one-clip (1K,1C) hypertensive rats for the presence of platelet-activating factor (PAF), a potent vasodilator and a putative mediator of the rapid blood pressure (BP) fall seen...